Cited by 211Genomics and Chromatin DynamicsCancer-related Molecular PathwaysLymphoma Diagnosis and Treatment

The DOI matches its Crossref record; 1,273 of the 1,273 references it cites were found in a registry or an index.

The c‐myc Promoter: Still MysterY and Challenge

Inken Wierstra, Jürgen Alves·2008·Advances in Cancer Research

Open this paper in CoChat — free account

Abstract

The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy. This review on the c-myc promoter describes its organization, the different levels of its normal regulation (including initiation and elongation of transcription, the dual P1/P2 promoters, chromatin structure, c-Myc autosuppression) as well as its deregulation in Burkitt's lymphoma. Furthermore, it summarizes the many different transcription factors, signal transduction pathways, and feedback loops that activate or repress c-myc transcription. Finally, a concept for regulation of the c-myc promoter in different biological settings, for example, immediate-early induction, constant expression throughout the cell cycle in continuously cycling cells, repression during terminal differentiation and deregulation in cancer, is formulated.

Integrity signals

Registry

Crossref · 10.1016/s0065-230x(07)99004-1

Cites

1273 of 1273 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

3 retracted

Items 1,001–1,200 of 1,273

Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-beta.
Houck, K. A., Gk, M., & Strom, S. C. (1989) · PubMed · Cited by 69
Interaction between JCV large T-antigen and β-catenin
Gan, D.-D., & Khalili, K. (2004) · Oncogene · doi:10.1038/sj.onc.1207018 · Cited by 69
Transient recruitment of the hnRNP K protein to inducibly transcribed gene loci
Ostrowski, J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg452 · Cited by 69
CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant
Sauvé, F., McBroom, L. D. B., Gallant, J., Moraitis, A. N., Labrie, F., & Giguère, V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.343-353.2001 · Cited by 69
Expression of the c-myb and c-myc genes is regulated independently in differentiating mouse erythroleukemia cells by common processes of premature transcription arrest and increased mRNA turnover.
Watson, R. J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3938 · Cited by 68
Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia
Flores, I., Murphy, D. J., Swigart, L. B., Knies, U. E., & Evan, G. I. (2004) · Oncogene · doi:10.1038/sj.onc.1207796 · Cited by 68
Inhibition of Smad Antiproliferative Function by CDK Phosphorylation
Liu, F., & Matsuura, I. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1366 · Cited by 67
Regulation of c‐myc expression by sodium butyrate in the colon carcinoma cell line Caco‐2
Souleimani, A., & Asselin, C. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81758-r · Cited by 67
A Permissive Role for Phosphatidylinositol 3-Kinase in the Stat5- mediated Expression of Cyclin D2 by the Interleukin-2 Receptor*
Moon, J., Rubio, E. D., Martino, A., Krumm, A., & Nelson, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308998200 · Cited by 67
Regulation of the Resident Chromosomal Copy of c-myc by c-Myb Is Involved in Myeloid Leukemogenesis
Schmidt, M., Nazarov, V., Stevens, L. M., Watson, R., & Wolff, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.1970-1981.2000 · Cited by 67
Elevated SMAD1/β-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice
Hu, M., Piscione, T. D., & Rosenblum, N. D. (2003) · Development · doi:10.1242/dev.00478 · Cited by 66
Src Inhibits Adriamycin-Induced Senescence and G2 Checkpoint Arrest by Blocking the Induction of p21waf1
Vigneron, A. M., Roninson, I. B., Gamelin, E. C., & Coqueret, O. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0461 · Cited by 66
Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter
Pyrc, J. J., Moberg, K. H., & Hall, D. J. (1992) · Biochemistry · doi:10.1021/bi00131a029 · Cited by 65
New and unexpected: forkhead meets ARF
Costa, R. H., Kalinichenko, V. V., Major, M. L., & Raychaudhuri, P. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.007 · Cited by 65
Ten Years of TFIIHPreprint
Coin, F., & Egly, J. (1998) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1998.63.105 · Cited by 65
Functional Analysis of p53 Binding under Differential Stresses
Krieg, A. J., Hammond, E. M., & Giaccia, A. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00322-06 · Cited by 65
mel-18 Negatively Regulates Cell Cycle Progression upon B Cell Antigen Receptor Stimulation through a Cascade Leading to c-myc/cdc25
Tetsu, O., Ishihara, H., Kanno, R., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80627-5 · Cited by 65
Constitutive Activation of Wnt/β-Catenin Signaling Pathway in Migration-Active Melanoma Cells: Role of LEF-1 in Melanoma with Increased Metastatic Potential
Murakami, T., Toda, S., Fujimoto, M., Ohtsuki, M., Byers, H. R., Etoh, T., & Nakagawa, H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5719 · Cited by 64
The c-MYC allele that is translocated into the IgH locus undergoes constitutive hypermutation in a Burkitt's lymphoma line
Bemark, M., & Neuberger, M. S. (2000) · Oncogene · doi:10.1038/sj.onc.1203686 · Cited by 64
Growth Hormone Exerts Antiapoptotic and Proliferative Effects through Two Different Pathways Involving Nuclear Factor- B and Phosphatidylinositol 3-Kinase
Jeay, S., Sonenshein, G. E., Kelly, P. A., Postel-Vinay, M. C., & Baixerás, E. (2001) · Endocrinology · doi:10.1210/endo.142.1.7892 · Cited by 63
The Chromatin Structure of the Dual c-myc Promoter P1/P2 Is Regulated by Separate Elements
Albert, T., Wells, J. M., Funk, J.-O., Pullner, A., Raschke, E. E., Stelzer, G., Meisterernst, M., Farnham, P., & Eick, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100265200 · Cited by 63
Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression
Oster, S. K., Marhin, W. W., Asker, C., Facchini, L. M., Dion, P. A., Funa, K., Post, M., Sedivy, J. M., & Penn, L. Z. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6768-6778.2000 · Cited by 63
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.
Wilson, A. J., Velcich, A., Arango, D., Kurland, A. R., Shenoy, S. M., Pezo, R. C., Levsky, J. M., Singer, R. H., & Augenlicht, L. H. (2002) · PubMed · Cited by 63
In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction
Raffel, G. D., Parmar, K., & Rosenberg, N. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4640 · Cited by 63
Identification of Epstein-Barr Virus (EBV) Nuclear Antigen 2 (EBNA2) Target Proteins by Proteome Analysis: Activation of EBNA2 in Conditionally Immortalized B Cells Reflects Early Events after Infection of Primary B Cells by EBV
Schlee, M., Krug, T., Gires, O., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.8.3941-3952.2004 · Cited by 63
The Platelet-derived Growth Factor Controls c-myc Expression through a JNK- and AP-1-dependent Signaling Pathway
Iavarone, C., Catania, A., Marinissen, M. J., Visconti, R., Acunzo, M., Tarantino, C., Carlomagno, M. S., Bruni, C. B., Gutkind, J. S., & Chiariello, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308617200 · Cited by 63
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo
Majello, B., Napolitano, G., Giordano, A., & Lania, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202822 · Cited by 63
Three distinct elements within the murine c-myc promoter are required for transcription.
Moberg, K. H., Logan, T. J., Tyndall, W. A., et al. (1992) · PubMed · Cited by 62
C/EBPα Regulation of the Growth-Arrest-Associated Gene gadd45
Constance, C. M., Morgan, J. I., & Umek, R. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3878 · Cited by 62
Thermodynamics of i-tetraplex formation in the nuclease hypersensitive element of human c-myc promoter
Mathur, V., Verma, A., Maiti, S., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.074 · Cited by 62
ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells
Tamura, T., Kong, H. J., Tunyaplin, C., Tsujimura, H., Calame, K. L., & Ozato, K. (2003) · Blood · doi:10.1182/blood-2003-01-0291 · Cited by 61
Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation
Liu, L., Li, L., Rao, J. N., Zou, T., Zhang, H. M., Boneva, D., Bernard, M. S., & Wang, J.-Y. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00326.2004 · Cited by 61
Cooperation between core promoter elements influences transcriptional activity in vivo.
Colgan, J. D., & Manley, J. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1955 · Cited by 61
Molecular Targets of the Oncogenic Transcription Factor Jun
Hartl, M., Bader, A. G., & Bister, K. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033333781 · Cited by 61
Modular organization of the E2F1 activation domain and its interaction with general transcription factors TBP and TFIIH
Pearson, A., & Greenblatt, J. (1997) · Oncogene · doi:10.1038/sj.onc.1201451 · Cited by 61
Human breast carcinoma cells transfected with the gene encoding a c-myc promoter-binding protein (MBP-1) inhibits tumors in nude mice.
Ray, R., Steele, R., Seftor, E. A., et al. (1995) · PubMed · Cited by 60
A novel function for Myc: inhibition of C/EBP-dependent gene activation.
Mink, S., Mutschler, B., Weiskirchen, R., Bister, K., & Klempnauer, K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6635 · Cited by 60
Deregulation of the proto-oncogene c-myc through t(8;22) translocation in Burkitt's lymphoma
Gerbitz, A., Mautner, J., Geltinger, C., Hörtnagel, K., Christoph, B., Asenbauer, H., Klobeck, G., Polack, A., & Bornkamm, G. W. (1999) · Oncogene · doi:10.1038/sj.onc.1202468 · Cited by 60
Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor
He, L. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4558 · Cited by 60
TFIIH Operates through an Expanded Proximal Promoter To Fine-Tune c -myc Expression
Weber, A., Liu, J., Collins, I. J., & Levens, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.147-161.2005 · Cited by 60
Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region
Liu, L., Guo, X., Rao, J. N., Zou, T., Marasa, B. S., Chen, J., Greenspon, J., Casero, R. A., & Wang, J. (2006) · Biochemical Journal · doi:10.1042/bj20060217 · Cited by 59
Polyoma Enhancer Activator 3, an Ets Transcription Factor, Mediates the Induction of Cyclooxygenase-2 by Nitric Oxide in Colorectal Cancer Cells
Liu, Y., Borchert, G. L., & Phang, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308136200 · Cited by 59
c-Myc-Induced Genomic Instability
Mai, S., & Mushinski, J. F. (2003) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvpathtoxoncol.v22.i3.30 · Cited by 59
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation
Ghosh, A. K., Grigorieva, I., Steele, R., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00206-1 · Cited by 58
Mxi1 Is a Repressor of the c-myc Promoter and Reverses Activation by USF
Lee, T. C., & Ziff, E. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.595 · Cited by 58
The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor β–Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer
Buck, A., Buchholz, M., Wagner, M., Adler, G., Gress, T. M., & Ellenrieder, V. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0081 · Cited by 58
Genetic dissection of c-myc apoptotic pathways
Nesbit, C. E., Tersak, J. M., Grove, L. E., Drzal, A., Choi, H.-J., & Prochownik, E. V. (2000) · Oncogene · doi:10.1038/sj.onc.1203636 · Cited by 58
FOXM1c transactivates the human c‐myc promoter directly via the two TATA boxes P1 and P2
Wierstra, I., & Alves, J. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05468.x · Cited by 57
Self-citation
v-Abl Activates c- myc Transcription through the E2F Site
Wong, K., Zou, X., Merrell, K. T., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6535 · Cited by 57
Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer
Giuriato, S., Rabin, K. R., Fan, A. C., Shachaf, C. M., & Felsher, D. W. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2003.11.002 · Cited by 57
The LEF1/β-catenin complex activates movo 1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation
Li, B., Mackay, D. R., Dai, Q., Li, T. W. H., Nair, M., Fallahi, M., Schonbaum, C. P., Fantes, J. A., Mahowald, A. P., Waterman, M. L., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092137099 · Cited by 57
DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene
Carbone, G. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh527 · Cited by 57
Signaling disrupts mSin3A binding to the Mad1‐like Sin3‐interacting domain of TIEG2, an Sp1‐like repressor
Ellenrieder, V., Zhang, J., Kaczynski, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2451 · Cited by 57
Chartreusin, Elsamicin A and Related Anti-Cancer Antibiotics
Portugal, J. (2003) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011033482215 · Cited by 56
Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP
Cui, Q., Lim, S. K., Zhao, B. M., & Hoffmann, F. M. (2005) · Oncogene · doi:10.1038/sj.onc.1208556 · Cited by 56
Signals for TBP/TATA box recognition † 1 †This paper is dedicated to the memory of Paul B. Sigler. 1Edited by T. Richmond
Bareket‐Samish, A., Cohen, I., & Haran, T. E. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3797 · Cited by 56
c-abl has a sequence-specific enhancer binding activity
Dikstein, R., Heffetz, D., Ben‐Neriah, Y., & Shaul, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90287-m · Cited by 56
NF-κB Activity Is Required for the Deregulation of c-myc Expression by the Immunoglobulin Heavy Chain Enhancer
Kanda, K., Hu, H., Zhang, L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004148200 · Cited by 56
Key Effectors of Signal Transduction and G 1 Progression
Roussel, M. F. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60763-0 · Cited by 55
Cloning and Characterization of a Human c- myc Promoter-Binding Protein
Ray, R., & Miller, D. M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2154 · Cited by 55
Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc.
Sasaki, T., Suzuki, H., Yagi, K., Furuhashi, M., Yao, R., Susa, S., Noda, T., Arai, Y., Miyazono, K., & Kato, M. (2003) · PubMed · Cited by 55
Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src
Aziz, N. A., Cherwinski, H. M., & McMahon, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1101 · Cited by 55
Wild‐type murine p53 represses transcription from the murine c‐myc promoter in a human glial cell line
Moberg, K. H., Tyndall, W. A., & Hall, D. J. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240490213 · Cited by 55
Activation of the Murine Dihydrofolate Reductase Promoter by E2F1
Fry, C. J., Pearson, A., Malinowski, E., Bartley, S. M., Greenblatt, J., & Farnham, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15883 · Cited by 55
c-myc Intron Element-binding Proteins Are Required for 1,25-Dihydroxyvitamin D3 Regulation of c-myc during HL-60 Cell Differentiation and the Involvement of HOXB4
Pan, Q., & Simpson, R. U. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8437 · Cited by 55
Functions of Myc:Max in the Control of Cell Proliferation and Tumorigenesis
Hurlin, P. J., & Dezfouli, S. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)38004-6 · Cited by 54
NF-κB Sites Function as Positive Regulators of Expression of the Translocated c- myc Allele in Burkitt's Lymphoma
Ji, L., Arcinas, M., & Boxer, L. M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7967-7974.1994 · Cited by 54
Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex
Mei, J. M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.12.2119 · Cited by 54
Regulatory elements in the immunoglobulin kappa locus induce c‐myc activation and the promoter shift in Burkitt's lymphoma cells.
Polack, A., Feederle, R., Klobeck, G., & Hörtnagel, K. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06069.x · Cited by 54
1,25-Dihydroxyvitamin D3 Regulation of c-myc Protooncogene Transcription
Simpson, R. U., Hsu, T., Wendt, M. D., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47171-8 · Cited by 53
Expression of c-Myc in Response to Colony-stimulating Factor-1 Requires Mitogen-activated Protein Kinase Kinase-1
Cheng, M. M., Wang, D., & Roussel, M. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6553 · Cited by 53
The Cochaperone p23 Differentially Regulates Estrogen Receptor Target Genes and Promotes Tumor Cell Adhesion and Invasion
Oxelmark, E., Roth, J., Brooks, P., Braunstein, S., Schneider, R., & Garabedian, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00009-06 · Cited by 53
Negative regulation of c-myc transcription involves myc family proteins.
Cleveland, J. L., Huleihel, M., Bressler, P. B., et al. (1988) · PubMed · Cited by 53
Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene.
Negishi, Y., Nishita, Y., Saëgusa, Y., et al. (1994) · PubMed · Cited by 52
c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells.
Collins, J. F., Herman, P., Schuch, C., et al. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115744 · Cited by 52
Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation
Mulholland, N., Soeth, E., & Smith, C. L. (2003) · Oncogene · doi:10.1038/sj.onc.1206722 · Cited by 52
Single Strand DNA Specificity Analysis of Human Nucleoside Diphosphate Kinase B
Agou, F., Raveh, S., Mesnildrey, S., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19630 · Cited by 52
Functional Domains of c-myc Promoter Binding Protein 1 Involved in Transcriptional Repression and Cell Growth Regulation
Ghosh, A. K., Steele, R., & Ray, R. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2880 · Cited by 52
Activation of Estrogen Receptor ? by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7
CHEN, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00014-9 · Cited by 52
LR1 regulates c-myc transcription in B-cell lymphomas.
Brys, A., & Maizels, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4915 · Cited by 51
Myc Target Transcriptomes
Lee, L. A., & Dang, C. V. (2006) · Springer eBooks · doi:10.1007/3-540-32952-8_6 · Cited by 50
Role of Epstein-Barr Virus in Burkitt’s Lymphoma
Takada, K. (2001) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-56515-1_9 · Cited by 50
Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c- myc expression in the absence of TGF-β signaling
Lim, S. K., & Hoffmann, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604773103 · Cited by 50
Regulatory Elements in the Immunoglobulin Heavy Chain Gene 3′-Enhancers Induce c-myc Deregulation and Lymphomagenesis in Murine B Cells
Wang, J., & Boxer, L. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412446200 · Cited by 50
Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene
Shimizu, K., Chen, W., Ashique, A. M., et al. (2003) · Gene · doi:10.1016/s0378-1119(03)00406-2 · Cited by 49
Induction of c-fos and c-myc Proto-oncogene Expression by Epidermal Growth Factor and Transforming Growth Factor α Is Calcium-independent
Cutry, A. F., Kinniburgh, A. J., Krabak, M. J., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47169-x · Cited by 48
Cytoplasmic YY1 Is Associated with Increased Smooth Muscle-Specific Gene Expression
Favot, L., Hall, S., Haworth, S. G., & Kemp, P. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61236-9 · Cited by 48
Thyroid Hormones Stabilize Acetylcholinesterase mRNA in Neuro-2A Cells That Overexpress the β1 Thyroid Receptor
Puymirat, J., Étongué-Mayer, P., & Dussault, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30651 · Cited by 48
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer
Fang, J. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i23.3394 · Cited by 48
Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells.
Mj, S., Litz-Jackson, S., Gs, B., et al. (1995) · PubMed · Cited by 48
Erythropoietin Activates Two Distinct Signaling Pathways Required for the Initiation and the Elongation of c-myc
Chen, C., & Sytkowski, A. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105702200 · Cited by 48
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells
Vietor, I., Vadivelu, S. K., Wick, N., Hoffman, R. M., Cotten, M. L., Seiser, C., Fialka, I., Wunderlich, W., Haase, A. D. D., Kořínková, G., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf461 · Cited by 48
Interaction of the v-and c-Myb proteins with regulatory sequences of the human c-myc gene.
Zobel, A., Kalkbrenner, F., Güehmann, S., et al. (1991) · PubMed · Cited by 48
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Dannenberg, J.-H., & te Riele, H. P. J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_002 · Cited by 47
SUMOylation Interferes with CCAAT/Enhancer-Binding Protein β-Mediated c- myc Repression, but Not IL-4 Activation in T Cells
Berberich‐Siebelt, F., Berberich, I., Andrulis, M., Santner‐Nanan, B., Jha, M. K., Klein‐Hessling, S., Schimpl, A., & Serfling, E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4843 · Cited by 47
Transcriptional Repression from the c-myc P2 Promoter by the Zinc Finger Protein ZF87/MAZ
Izzo, M. W., Strachan, G. D., Stubbs, M. C., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19498 · Cited by 47
Endothelin-1–Dependent Nuclear Factor of Activated T Lymphocyte Signaling Associates With Transcriptional Coactivator p300 in the Activation of the B Cell Leukemia-2 Promoter in Cardiac Myocytes
Kawamura, T., Ono, K., Morimoto, T., Akao, M., Iwai‐Kanai, E., Wada, H., Sowa, N., Kita, T., & Hasegawa, K. (2004) · Circulation Research · doi:10.1161/01.res.0000129701.14494.52 · Cited by 47
Novel estrogen receptor coregulators and signaling molecules in human diseases
Barnes, C. J., Vadlamudi, R. K., & Kumar, R. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3222-5 · Cited by 47
Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma.
Arcinas, M., Heckman, C. A., Mehew, J. W., et al. (2001) · PubMed · Cited by 46
The c-myc Promoter Binding Protein (MBP-1) and TBP Bind Simultaneously in the Minor Groove of the c-myc P2 Promoter
Chaudhary, D., & Miller, D. M. (1995) · Biochemistry · doi:10.1021/bi00010a036 · Cited by 46
Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFβ
Hu, B., Tack, D. C., Liu, T., Wu, Z., Ullenbruch, M. R., & Phan, S. H. (2005) · Oncogene · doi:10.1038/sj.onc.1209140 · Cited by 46
A plasmacytoma-specific factor binds the c-myc promoter region.
Kakkis, E., & Calame, K. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7031 · Cited by 45
Structural Aspects of Interactions Within the Myc/Max/Mad Network
Nair, S. K., & Burley, S. K. (2006) · Springer eBooks · doi:10.1007/3-540-32952-8_5 · Cited by 45
Expression of prostaglandin endoperoxide H synthase‐2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells
Mei, J. M., Hord, N. G., Winterstein, D., Donald, S. P., & Phang, J. M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1188 · Cited by 44
NMR-Driven Discovery of Benzoylanthranilic Acid Inhibitors of Far Upstream Element Binding Protein Binding to the Human Oncogene c-myc Promoter
Huth, J. R., Yu, L. P., Collins, I. J., Mack, J. C., Mendoza, R. R., Isaac, B., Braddock, D. T., Muchmore, S. W., Comess, K. M., Fesik, S. W., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0497803 · Cited by 44
Regulation of cell cycle molecules by the Ras effector system
Takuwa, N., & Takuwa, Y. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00439-7 · Cited by 44
Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN‐γ production induced by IL‐12 alone or together with IL‐18
Sugimoto, N., Nakahira, M., Ahn, H., Micallef, M. J., Hamaoka, T., Kurimoto, M., & Fujiwara, H. (2003) · European Journal of Immunology · doi:10.1002/immu.200390027 · Cited by 44
Conditionally MYC:insights from novel transgenic models
Arvanitis, C., & Felsher, D. W. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.10.043 · Cited by 44
The development and application of imatinib
Jones, R. L., & Judson, I. R. (2005) · Expert Opinion on Drug Safety · doi:10.1517/14740338.4.2.183 · Cited by 44
HMG Box Transcriptional Repressor HBP1 Maintains a Proliferation Barrier in Differentiated Liver Tissue
Shih, H. H., Xiu, M., Berasi, S. P., Sampson, E. M., Leiter, A. B., Paulson, K. E., & Yee, A. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5723-5732.2001 · Cited by 44
Regulation of transforming growth factor beta receptors in H-ras oncogene-transformed rat intestinal epithelial cells.
Zhao, J., & Buick, R. (1995) · PubMed · Cited by 43
The Myc Intron-Binding Polypeptide Associates with RFX1 In Vivo and Binds to the Major Histocompatibility Complex Class II Promoter Region, to the Hepatitis B Virus Enhancer, and to Regulatory Regions of Several Distinct Viral Genes
Reinhold, W. C., Emens, L. A., Itkes, A. V., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3041 · Cited by 43
Myc—Is this the oncogene from Hell?
Soucek, L., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00077-6 · Cited by 43
A Novel 16-Kilodalton Cellular Protein Physically Interacts with and Antagonizes the Functional Activity of c- myc Promoter-Binding Protein 1
Ghosh, A. K., Majumder, M., Steele, R., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.2.655-662.2001 · Cited by 43
Binding of THZif-1, a MAZ-like Zinc Finger Protein to the Nuclease-hypersensitive Element in the Promoter Region of the c-MYC Protooncogene
Sakatsume, O., Tsutsui, H., Wang, Y., Gao, H., Tang, X., Yamauchi, T., Murata, T., Itakura, K., & Yokoyama, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31322 · Cited by 42
Flexible DNA Binding of the BTB/POZ-domain Protein FBI-1
Peßler, F., & Hernandez, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302980200 · Cited by 42
Nm23/PuF Does Not Directly Stimulate Transcription through the CT Element in Vivo
Michelotti, E. F., Sanford, S., Freije, J. M. P., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22526 · Cited by 42
Phosphorylation-dependent binding of a 138-kDa myc intron factor to a regulatory element in the first intron of the c-myc gene.
Zajac‐Kaye, M., & Levens, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39597-3 · Cited by 41
Regulation of c-myc Gene by Nitric Oxide via Inactivating NF-κB Complex in P19 Mouse Embryonal Carcinoma Cells
Park, S. W., & Wei, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303306200 · Cited by 41
The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
Pelengaris, S., & Khan, M. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.5.623 · Cited by 41
Unrestraining Genetic Processes with a Protein–DNA Hinge
Tomonaga, T., Michelotti, G. A., Libutti, D. E., Uy, A., Sauer, B., & Levens, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80075-1 · Cited by 40
Activation of Protein Kinase C Induces Nuclear Translocation of RFX1 and Down-regulates c-myc via an Intron 1 X Box in Undifferentiated Leukemia HL-60 Cells
Chen, L., Smith, L., Johnson, M. R., Wang, K., Diasio, R. B., & Smith, J. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002645200 · Cited by 40
Interaction between TGFβ Signaling Proteins and C/EBP Controls Basal and Tat-Mediated Transcription of HIV-1 LTR in Astrocytes
Coyle-Rink, J., Sweet, T., Abraham, S., Sawaya, B. E., Batuman, O., Khalili, K., & Amini, S. (2002) · Virology · doi:10.1006/viro.2002.1439 · Cited by 39
Id2 leaves the chromatin of the E2F4–p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
Rodrı́guez, J. L., Sandoval, J., Serviddio, G., Sastre, J., Morante, M., Perrelli, M.-G., Martínez‐Chantar, M. L., Viña, J., Vinã, J. R., Mato, J. M., et al. (2006) · Biochemical Journal · doi:10.1042/bj20060380 · Cited by 39
Nuclear Translocation of Integrin Cytoplasmic Domain-associated Protein 1 Stimulates Cellular Proliferation
Fournier, H.-N., Dupé-Manet, S., Bouvard, D., et al. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0744 · Cited by 39
Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells
Krupitza, U. J. G., Harant, H., Dittrich, E., et al. (1995) · Carcinogenesis · doi:10.1093/carcin/16.5.1199 · Cited by 38
Sp1 Control of Gene Expression in Myeloid Cells
Resendes, K. K., & Rosmarin, A. G. (2004) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v14.i3.20 · Cited by 38
Identification of two enhancer elements downstream of the human c-mycgene
Mautner, J., Joos, S., Werner, T. A., et al. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.1.72 · Cited by 37
Evidence for a labile intermediate in the butyrate induced reduction of the level of c-myc RNA in SW837 rectal carcinoma cells.
Herold, K. M., & Rothberg, P. G. (1988) · PubMed · Cited by 37
ΔNp73 can modulate the expression of various genes in a p53-independent fashion
Kartasheva, N. N., Lenz-Bauer, C., Hartmann, O., Schäfer, H., Eilers, M., & Dobbelstein, M. (2003) · Oncogene · doi:10.1038/sj.onc.1207138 · Cited by 37
Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains
Wierstra, I., & Alves, J. (2006) · Biological Chemistry · doi:10.1515/bc.2006.120 · Cited by 37
Self-citation
MAZ, a Myc-associated zinc finger protein, is essential for the ME1a1-mediated expression of the c-myc gene during neuroectodermal differentiation of P19 cells
Komatsu, M., Li, H., Tsutsui, H., et al. (1997) · Oncogene · doi:10.1038/sj.onc.1201283 · Cited by 37
Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
Pelengaris, S., Abouna, S., Cheung, L., Ifandi, V., Zervou, S., & Khan, M. (2004) · BMC Biology · doi:10.1186/1741-7007-2-26 · Cited by 37
Transcription of c-myc in human mononuclear cells is regulated by an elongation block.
Eick, D., Berger, R., Polack, A., et al. (1987) · PubMed · Cited by 37
Absence of a paused transcription complex from the c-myc P2 promoter of the translocation chromosome in Burkitt's lymphoma cells: implication for the c-myc P1/P2 promoter shift.
Lj, S., Kohlhuber, F., Mautner, J., et al. (1993) · PubMed · Cited by 37
Differential Regulation of the c-MYC P1 and P2 Promoters in the Absence of Functional Tumor Suppressors: Implications for Mechanisms of Deregulated MYC Transcription
Marcu, K. B., Patel, A. J., & Yang, Y. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_4 · Cited by 36
Molecular cloning of MSSP-2, a c-rnyc gene single-strand binding protein: characterization of binding specificity and DNA replication activity
Takai, T., Nishita, Y., Iguchi‐Ariga, S. M. M., et al. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.25.5576 · Cited by 36
Loss of transforming growth factor beta 1 (TGF-beta 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells.
Longstreet, M., Miller, B., & Ph, H. (1992) · PubMed · Cited by 36
Cyclooxygenase-2 Regulation in Colon Cancer Cells
Tong, X., Yin, L., Joshi, S., Rosenberg, D. W., & Giardina, C. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411978200 · Cited by 36
Sensitivity of nuclear c-myc levels and induction to differentiation-inducing agents in human colon tumor cell lines
Taylor, C. W., Kim, Y. S., Childress‐Fields, K. E., et al. (1992) · Cancer Letters · doi:10.1016/0304-3835(92)90179-y · Cited by 36
Kinetic resolution of bimolecular hybridization versus intramolecular folding in nucleic acids by surface plasmon resonance: application to G-quadruplex/duplex competition in human c-myc promoter
Halder, K. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki750 · Cited by 36
Regulation of the expression of c-Myc by β1 integrins in epithelial cells
Benaud, C. M., & Dickson, R. B. (2001) · Oncogene · doi:10.1038/sj.onc.1204152 · Cited by 36
The c-myc Story: Where we’ve been, Where we seem to be Going
Potter, M., & Marcu, K. B. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_1 · Cited by 35
Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression
Toyo‐oka, K., Bowen, T. J., Hirotsune, S., Li, Z., Jain, S., Ota, S., Escoubet‐Lozach, L., García-Bassets, I., Lozach, J., Rosenfeld, M. G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2683 · Cited by 35
Down‐regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: Altered mesenchymal‐epithelial interactions*
Chinoy, M. R., Chi, X., & Cilley, R. E. (2001) · Pediatric Pulmonology · doi:10.1002/ppul.1099 · Cited by 35
Induction of cell death in murine fibroblasts by a c-myc promoter binding protein.
Ray, R. (1995) · PubMed · Cited by 35
ANDROGEN-INDUCED CELL GROWTH ANDC-MYCEXPRESSION IN HUMAN NON-TRANSFORMED EPITHELIAL PROSTATIC CELLS IN PRIMARY CULTURE
Brum, I. S., Morsch, D. M., Urnauer, L., & Spritzer, P. M. (2001) · Endocrine Research · doi:10.1081/erc-100107177 · Cited by 35
Sequences in the Human c-myc P2 Promoter Affect the Elongation and Premature Termination of Transcripts Initiated from the Upstream P1 Promoter
Meulia, T., Krumm, A., Spencer, C. A., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4590-4600.1992 · Cited by 34
The Intracellular Form of Notch Blocks Transforming Growth Factor β-Mediated Growth Arrest in Mv1Lu Epithelial Cells
Rao, P. K., & Kadesch, T. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6694-6701.2003 · Cited by 34
Nm23-M2/NDP kinase B induces endogenous c-myc and nm23-M1/NDP kinase A overexpression in BAF3 cells. Both NDP kinases protect the cells from oxidative stress-induced death
Dabernat, S., Massé, K. L., Smani, M., Peuchant, E., Landry, M., Bourbon, P.-M., LeFloch, R., Daniel, J. Y., & Larou, M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.026 · Cited by 34
Lessons Learned from Myc/Max/Mad Knockout Mice
Pirity, M. K., Blanck, J. K., & Schreiber‐Agus, N. (2006) · Springer eBooks · doi:10.1007/3-540-32952-8_8 · Cited by 34
Somatic mutations in c-myc intron I cluster in discrete domains that define protein binding sequences.
Yu, B., Ichinose, I., Bonham, M. A., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36556-1 · Cited by 33
Rehabilitation of cancer through oncogene inactivation
Shachaf, C. M., & Felsher, D. W. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.05.003 · Cited by 33
Premature termination of transcription from the P1 promoter of the mouse c-myc gene.
Wright, S. C., Mirels, L. F., Calayag, M. C., & Bishop, J. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11383 · Cited by 33
Kinetics of cellular oncogene expression in mouse lymphocytes II. Regulation of c‐fos and c‐myc gene expression
Schneider‐Schaulies, J., Schimpl, A., & Wecker, E. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170521 · Cited by 33
Phosphatidylinositol 3-Kinase Potentiates, but Does Not Trigger, T Cell Proliferation Mediated by the IL-2 Receptor1
Moon, J., & Nelson, B. (2001) · Journal of Immunology · doi:10.4049/jimmunol.167.5.2714 · Cited by 33
TIS7 Regulation of the β-Catenin/Tcf-4 Target Gene Osteopontin (OPN) Is Histone Deacetylase-dependent
Vietor, I., Kurzbauer, R., Brosch, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509836200 · Cited by 33
4-Hydroxynonenal affects pRb/E2F pathway in HL-60 human leukemic cells
Barrera, G., Pizzimenti, S., Laurora, S., Moroni, E., Giglioni, B., & Dianzani, M. U. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00649-6 · Cited by 32
Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor.
Watanabe, S., Ishida, S., Koike, K., et al. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.6.627 · Cited by 32
Wnt signaling – 20 years and counting
Cadigan, K. M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02707-5 · Cited by 32
DNA Conformation, Topology, and the Regulation of c-myc Expression
Levens, D., DUNCAN, R. C., Tomonaga, T., et al. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_3 · Cited by 32
The role of immunoglobulin kappa elements in c-myc activation.
Hörtnagel, K., Mautner, J., Lj, S., et al. (1995) · PubMed · Cited by 32
A transactivator of c-myc is coordinately regulated with the proto-oncogene during cellular growth.
Bazar, L. S., Harris, Sunitha, I., et al. (1995) · PubMed · Cited by 32
NF-kappa B sites function as positive regulators of expression of the translocated c-myc allele in Burkitt's lymphoma.
Ji, L., Arcinas, M., & Boxer, L. M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7967 · Cited by 32
Primary biliary cirrhosis and hepatocellular carcinoma
Findor, J., He, X.-S., Sord, J., Terg, R., & Gershwin, M. E. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00050-2 · Cited by 31
Myc Inhibits CCAAT/Enhancer-Binding Protein alpha-Gene Expression in HIB-1B Hibernoma Cells Through Interactions with the Core Promoter Region
Antonson, P., Pray, M. G., Jacobsson, A., & Xanthopoulos, K. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.397zz.x · Cited by 31
Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein
Kolluri, R., & Kinniburgh, A. J. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.17.4771 · Cited by 31
Tetraplex DNA Transitions within the Human c-myc Promoter Detected by Multivariate Curve Resolution of Fluorescence Resonance Energy Transfer
Kumar, P., Verma, A., Maiti, S., et al. (2005) · Biochemistry · doi:10.1021/bi051452x · Cited by 31
FOXM1c is activated by cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1, but repressed by GSK-3α
Wierstra, I., & Alves, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.008 · Cited by 31
Self-citation
Nucleosomal Structure of Active and Inactive c-myc Genes
Pullner, A., Mautner, J., Albert, T., & Eick, D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31452 · Cited by 30
IGF-1 activates p21 to inhibit UV-induced cell death
Murray, S. A., Zheng, H., Gu, L., & Xiao, Z. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206327 · Cited by 30
Binding of NF-KB-like Factors to Regulatory Sequences of the c-myc Gene
Duyao, M. P., Kessler, D. J., Spicer, D. B., et al. (1990) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-75889-8_27 · Cited by 29
Members of the MAZ Family: A Novel cDNA Clone for MAZ from Human Pancreatic Islet Cells
Tsutsui, H., Sakatsume, O., Itakura, K., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1432 · Cited by 29
The Role of Apoptosis in the Pathophysiology of Chronic Neutropenias Associated with Bone Marrow Failure
Papadaki, H. Α., & Eliopoulos, G. D. (2003) · Cell Cycle · doi:10.4161/cc.2.5.463 · Cited by 29
Beating a path to Myc
Eisenman, R. N., & Cooper, J. A. (1995) · Nature · doi:10.1038/378438a0 · Cited by 29
Characterization of the Biological Functions of a Transcription Factor, c-mycIntron Binding Protein 1 (MIBP1)
Fukuda, S., Yamasaki, Y., Iwaki, T., et al. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003109 · Cited by 29
FOXM1c and Sp1 transactivate the P1 and P2 promoters of human c-myc synergistically
Wierstra, I., & Alves, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.151 · Cited by 28
Self-citation
The cis-acting elements known to regulate c-myc expression ex vivo are not sufficient for correct transcription in vivo.
Lavenu, A., Vandormael‐Pournin, S., Babinet, C., et al. (1994) · PubMed · Cited by 28
A novel NF-kappa B element within exon 1 of the murine c-myc gene.
Kessler, D. J., Spicer, D. B., Rosa, F. A. L., et al. (1992) · PubMed · Cited by 28
Identification of Myc-mediated Death Response Pathways by Microarray Analysis
Yu, Q., He, M., Lee, N. H., & Liu, E. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111403200 · Cited by 27
Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells
Napoli, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj473 · Cited by 27
A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription.Preprint
Roberts, S., Purton, T., & Bentley, D. L. (1992) · Genes & Development · doi:10.1101/gad.6.8.1562 · Cited by 27
Signalling networks that cause cancer
McCormick, F. P. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01480-2 · Cited by 27
Sequences involved in accurate and efficient transcription of human c-myc genes microinjected into frog oocytes.
Nishikura, K. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.4093 · Cited by 26
Modulation of DNA‐protein interactions in the P1 and P2 c‐myc promoters by two intercalating drugs
Vaquero, A., & Portugal, J. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2510435.x · Cited by 26
Tumor Dormancy: Death and Resurrection of Cancer As Seen through Transgenic Mouse Models
Felsher, D. W. (2006) · Cell Cycle · doi:10.4161/cc.5.16.3111 · Cited by 26
MBP-1 Physically Associates with Histone Deacetylase for Transcriptional Repression
Ghosh, A. K., Steele, R., & Ray, R. B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0921 · Cited by 26
Nucleosomal Structures of c-myc Promoters with Transcriptionally Engaged RNA Polymerase II
Albert, T., Mautner, J., Funk, J. O., et al. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4363 · Cited by 25
Differential Promoter Utilization by the c- myc Gene in Mitogen- and Interleukin-2-Stimulated Human Lymphocytes
Broome, H. E., Reed, J. C., Godillot, E. P., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2988-2993.1987 · Cited by 25
How Cancers Escape Their Oncogene Habit
Giuriato, S., & Felsher, D. W. (2003) · Cell Cycle · doi:10.4161/cc.2.4.415 · Cited by 25
Quadruplex–duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association
Halder, K., Mathur, V., Chugh, D., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.137 · Cited by 25
Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells
Zajac‐Kaye, M., Ben-Baruch, N. E., Kastanos, E. K., et al. (2000) · Biochemical Journal · doi:10.1042/bj3450535 · Cited by 25
Transactivation of the human c-myc gene by c-Myb
Zobel, A., Kalkbrenner, F., Vorbrüggen, G., & Moelling, K. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90805-u · Cited by 25
TATA box and Sp1 sites mediate the activation of c-myc promoter P1 by immunoglobulin kappa enhancers.
Geltinger, C., Hörtnagel, K., & Polack, A. (1996) · PubMed · Cited by 25
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.
Schreiber‐Agus, N., Chin, L., Chen, K., TORRES, R. A., Thomson, C. T., Sacchettini, J. C., & DePinho, R. A. (1994) · PubMed · Cited by 25
Variable pause positions of RNA polymerase II lie proximal to the c-mycpromoter irrespective of transcriptional activity
Wolf, D. A., Strobl, L. J., Pullner, A., et al. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.17.3373 · Cited by 24
Purification of a Model Substrate for Transcription Factor Phosphorylation by ERK2
Waas, W. F., & Dalby, K. N. (2001) · Protein Expression and Purification · doi:10.1006/prep.2001.1491 · Cited by 24
c-Myc Promotes Survival of WEHI 231 B Lymphoma Cells from Apoptosis
Wu, M., Yang, W. E., Bellas, R. E., et al. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_9 · Cited by 24
Identification of human DNA helicase V with the far upstream element-binding protein
Vindigni, A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.5.1061 · Cited by 24
Different Sensitivity of the Transforming Growth Factor-β Cell Cycle Arrest Pathway to c-Myc and MDM-2
Blain, S. W., & Massagué, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006496200 · Cited by 23

Research works printed but not linked: 3

Bareket‐Samish, 2000, Signals for TBP/TATA‐box recognition, J. Mol. Biol., 299, 965
Liu, 2006, Making Myc, Curr. Top. Microbiol. Immunol., 302, 1
Skokowa, 2006, LEF‐1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia, Nat. Med., 12, 1191, 10.1038/nm1474 · DOI

Sorted by citations

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
Duncan, J. S., Whittle, M. C., Nakamura, K., Abell, A. N., Midland, A. A., Zawistowski, J. S., Johnson, N. L., Granger, D. A., Jordan, N. V., Darr, D. B., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.053 · Cited by 732
MYC: Connecting selective transcriptional control to global RNA production
Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521
An Overview of MYC and Its Interactome
Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396
Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches
Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
“While being essential for normal Myc regulation in minimizing undesired Myc expression, the integrated biological output from the multiple-input signaling networks poses the risks of driving pathological conditions [33].”
BackgroundInfluential

See all 211

Authors: Wierstra, I., & Alves, J.
Affiliations: Medizinische Hochschule Hannover (DE)
Corresponding author: Inken Wierstra
Venue: Advances in Cancer Research
Publisher: Elsevier
Published: 2008
Volume: 99
Pages: 113-333
ISSN: 0065-230X (ISSN-L)
DOI: 10.1016/s0065-230x(07)99004-1
OpenAlex: W1870041030
Cited by: 211
References: 1,273
Citations by year: 2025: 6 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 9 · 2020: 18 · 2019: 12 · 2018: 11 · 2017: 16 · 2016: 11 · 2015: 9 · 2014: 12 · 2013: 17 · 2012: 13
FWCI: 15.49
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Advances in cancer research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
Keywords: c-Myc, c-myc promoter, transcriptional regulation, chromatin structure, Burkitt lymphoma, proto-oncogenes, signaling pathways, transcription factors, cell cycle, terminal differentiation
MeSH terms: Proto-Oncogene Mas, Animals, Burkitt Lymphoma, Chromatin, Gene Expression Regulation, Humans, Neoplasms, Promoter Regions, Genetic, Proto-Oncogenes, Repressor Proteins, Transcription Factors, Signal Transduction, Genes, myc

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The c‐myc Promoter: Still MysterY and Challenge

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks