The c‐myc Promoter: Still MysterY and Challenge

Regulation of c-myc transcription in vitro: dependence on the guanine-rich promoter element ME1a1.

Dj, H. (1990) · PubMed · Cited by 23

Carboxyl-Terminal Repressor Domain of MBP-1 is Sufficient for Regression of Prostate Tumor Growth in Nude Mice

Ghosh, A. K., Steele, R., & Ray, R. B. (2005) · Cancer Research · doi:10.1158/0008-5472.718.65.3 · Cited by 22

Antisense Oligonucleotides Targeted against Protein Kinase Cβ and CβII Block 1,25-(OH)2D3-induced Differentiation

Simpson, R. U., O’Connell, T. D., Pan, Q., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19587 · Cited by 22

Phosphorylation regulates Myc expression via prolonged activation of the mitogen‐activated protein kinase pathway

Wang, Z., Ge, L., Wang, M., & Carr, B. I. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20649 · Cited by 22

c-myc expression is activated by the immunoglobulin kappa-enhancers from a distance of at least 30 kb but not by elements located within 50 kb of the unaltered c-myc locus in vivo.

Mautner, J., Behrends, U., Hörtnagel, K., et al. (1996) · PubMed · Cited by 22

Dioctanoylglycerol and phorbol esters regulate transcription of c-myc in human promyelocytic leukemia cells.

Salehi, Z., Taylor, J. D., & Niedel, J. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77962-9 · Cited by 21

Regulation of Cellular Genes in a Chromosomal Context by the Retinoblastoma Tumor Suppressor Protein

Buchmann, A. M., Swaminathan, S., & Thimmapaya, B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4565 · Cited by 21

Enhanced expression of heregulin in c-erb B-2 and c-Ha-ras transformed mouse and human mammary epithelial cells

Mincione, G., Bianco, C., Kannan, S., Colletta, G., Ciardiello, F., Sliwkowski, M. X., Yarden, Y., Normanno, N., Pramaggiore, A., Kim, N., et al. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19960315)60:4 · Cited by 21

A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells.

Ishida, S., Shudo, K., Takada, S., et al. (1995) · PubMed · Cited by 21

Transcriptional repression and activation in the same cell type of the human c-MYC promoter by the retinoblastoma gene protein: antagonisation of both effects by SV40 T antigen.

Batsché, É., Lipp, M., & Crémisi, C. (1994) · PubMed · Cited by 20

?-amyloid protein induces the formation of purine dimers in cellular DNA

Duker, N. J., Sperling, J. M., Soprano, K. J., Druin, D. P., Davis, A., & Ashworth, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010601)81:3 · Cited by 20

Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU

Wittekindt, N. E. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.3.800 · Cited by 20

MBP-1 mediated apoptosis involves cytochrome c release from mitochondria

Ghosh, A. K., Majumder, M., Steele, R., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205384 · Cited by 20

The block of elongation in c-myc exon 1 is abolished in Burkitt's lymphoma cell lines with variant translocation.

Eick, D., Polack, A., Kofler, E., et al. (1988) · PubMed · Cited by 20

Trans-activation of human MYC: the second promoter is target for the stimulation by adenovirus E1a proteins.

Lipp, M., Schilling, R., & Bernhardt, G. (1989) · PubMed · Cited by 20

Role of the Rel-Family of Transcription Factors in the Regulation of c-myc Gene Transcription and Apoptosis of WEHI 231 Murine B-Cells

Lee, H., Wu, M., Rosa, F. A. L., et al. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79275-5_29 · Cited by 19

Activation of two discrete signaling pathways by erythropoietin.

Patel, H. R., Choi, H., & Sytkowski, A. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36607-4 · Cited by 19

Role for CD40-Mediated Activation of c-Rel and Maintenance of c-myc RNA Levels in Mitigating Anti-IgM-Induced Growth Arrest

Siebelt, F., Berberich, I., Shu, G. L., et al. (1997) · Cellular Immunology · doi:10.1006/cimm.1997.1198 · Cited by 19

The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.

Polack, A., Strobl, L. J., Feederle, R., et al. (1991) · PubMed · Cited by 19

Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter.

Meulia, T., Krumm, A., Spencer, C., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4590 · Cited by 19

Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product

Luo, Q., Li, J., Cenkci, B., & Kretzner, L. (2004) · Oncogene · doi:10.1038/sj.onc.1207225 · Cited by 18

Construction of a novel DNA decoy that inhibits the oncogenic β-catenin/T-cell factor pathway

Seki, Y., Yamamoto, H., Ngan, C. Y., Yasui, M., Tomita, N., Kitani, K., Takemasa, I., Ikeda, M., Sekimoto, M., Matsuura∥, N., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0388 · Cited by 18

Transcription from the P2 promoter of human protooncogene myc is suppressed by retinoic acid through an interaction between the E2F element and its binding proteins.

Ishida, S., Shudo, K., Takada, S., & Koike, K. (1994) · PubMed · Cited by 18

The Max network: coordinated transcriptional regulation of cell growth and proliferation.

Eisenman, R. N. (2002) · PubMed · Cited by 18

Interactions of the transcription factors MIBP1 and RFX1 with the EP element of the hepatitis B virus enhancer

Blake, M. C., Nikliński, J., & Zajac‐Kaye, M. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.6060-6066.1996 · Cited by 17

Pharmacological inactivation of MYC for the treatment of cancer

Felsher, D. W., & Bradon, N. (2003) · Drug News & Perspectives · doi:10.1358/dnp.2003.16.6.829309 · Cited by 17

Imatinib mesylate—gold standards and silver linings

Peggs, K. S. (2004) · Clinical and Experimental Medicine · doi:10.1007/s10238-004-0032-5 · Cited by 17

Regulation of c-myc Transcription by Interleukin-2 (IL-2)

Grigorieva, I., Grigoriev, V. G., Rowney, M. K., & Hoover, R. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7343 · Cited by 17

Analysis of the c‐myc P2 promoter

Moberg, K. H., Tyndall, W. A., Pyrc, J. J., et al. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041480110 · Cited by 17

1,25-Dihydroxyvitamin D3-regulated binding of nuclear proteins to a c-myc intron element.

Pan, Q., Martell, R. E., O’Connell, T. D., et al. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828471 · Cited by 17

Essential role of c-myc in ara-C-induced differentiation of human erythroleukemia cells.

Baker, S. J., Pawlita, M., Leutz, A., et al. (1994) · PubMed · Cited by 17

Differential promoter utilization by the c-myc gene in mitogen- and interleukin-2-stimulated human lymphocytes.

Broome, H. E., Reed, J. C., Godillot, E. P., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2988 · Cited by 17

Chromosomal Localization of the Human Gene Encoding c-myc Promoter-Binding Protein (MPB1) to Chromosome 1p35–pter

White, R. A., Adkison, L. R., Dowler, L. L., et al. (1997) · Genomics · doi:10.1006/geno.1996.4499 · Cited by 16

A computerized database-scan to identify c-MYC targets

Schuldiner, O., Shor, S., & Benvenisty, N. (2002) · Gene · doi:10.1016/s0378-1119(02)00668-6 · Cited by 16

HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1)

RAY, R., SHEIKH, S., Fontana, J. A., et al. (1994) · International Journal of Oncology · doi:10.3892/ijo.5.6.1433 · Cited by 16

The mechanism of inactivation of the normal c-myc gene locus in human Burkitt lymphoma cells.

Nishikura, K., & Jm, M. (1988) · PubMed · Cited by 16

A Novel Glucocorticoid Receptor Binding Element within the Murine c-myc Promoter

Ma, T., Copland, J. A., Brasier, A. R., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.9.0524 · Cited by 15

Separate domains of MBP-1 involved in c-myc promoter binding and growth suppressive activity

Ray, R. B., & Steele, R. (1997) · Gene · doi:10.1016/s0378-1119(96)00693-2 · Cited by 15

The Human Homologue of Drosophila TRF-proximal Protein Is Associated with an RNA Polymerase II-SRB Complex

Xiao, H., Tao, Y., & Roeder, R. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.3937 · Cited by 15

Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters.

Kohlhuber, F., Lj, S., & Eick, D. (1993) · PubMed · Cited by 15

Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype.

Mei, J. M., Hord, N. G., Winterstein, D., et al. (2000) · PubMed · Cited by 14

Ubiquitylation and Destruction of Endogenous c-MycS by the Proteasome: Are Myc Boxes Dispensable?

Chen, L., Smith, L., Accavitti-Loper, M. A., Ōmura, S., & Smith, J. B. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1603 · Cited by 14

The double life of HOXB4

Morgan, R., Pettengell, R., & Sohal, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.002 · Cited by 14

Molecular Cloning and Expression Analysis of Five Novel Genes in Chromosome 1p36

Onyango, P. O., Lubyová, B., Gardellin, P., et al. (1998) · Genomics · doi:10.1006/geno.1997.5186 · Cited by 14

Smads “Freeze” When They Ski

Frederick, J. P., & Wang, X. (2002) · Structure · doi:10.1016/s0969-2126(02)00914-0 · Cited by 14

Knockdown of MBP-1 in Human Prostate Cancer Cells Delays Cell Cycle Progression

Ghosh, A. K., Steele, R., & Ray, R. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602930200 · Cited by 14

No exit strategy? No problem: APC inhibits β-catenin inside the nucleus: Figure 1.Preprint

Xiong, Y., & Kotake, Y. (2006) · Genes & Development · doi:10.1101/gad.1413206 · Cited by 14

Protein kinase inhibitors exert stage specific and inducer dependent effects on HL-60 cell differentiation.

Savickienė, J., Gineitis, A. A., Vp, S., et al. (1995) · PubMed · Cited by 13

E2F-independent transcriptional repression by p107, a member of the retinoblastoma family of proteins.

Dagnino, L., Zhu, L. W., Skorecki, K., et al. (1995) · PubMed · Cited by 13

Specific Regulation of Gene Expression by Antisense Nucleic Acids: A Summary of Methodologies and Associated Problems

Kawasaki, H., Machida, M., Komatsu, M., et al. (1996) · Artificial Organs · doi:10.1111/j.1525-1594.1996.tb04556.x · Cited by 12

Regulation of c-myc and Immunoglobulin κ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II

Schneider, E. E., Albert, T., Wolf, D. A., et al. (1999) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60162-0_28 · Cited by 11

Regulatory domains within the P0 promoter of human c-myc.

Lang, J. C., Wilkie, N. M., Clark, A., et al. (1991) · PubMed · Cited by 11

The central domain of transcription factor FOXM1c directly interacts with itself in vivo and switches from an essential to an inhibitory domain depending on the FOXM1c binding site

Wierstra, I., & Alves, J. (2007) · Biological Chemistry · doi:10.1515/bc.2007.094 · Cited by 11

Dysfunction of the Myc-induced apoptosis mechanism accompanies c-myc activation in the tumorigenic L929 cell line.

Facchini, L. M., Chen, S., & Penn, L. Z. (1994) · PubMed · Cited by 11

Regulation of c-myc transcription initiation and elongation.

Snyder, R. C., & Miller, D. M. (1992) · PubMed · Cited by 11

Coexistence of a c-myc mRNA initiated in intron 1 with the normal c-myc mRNA and similar regulation of both transcripts in mammalian cells.

Ray-Gallet, D., & Robert-Lézénès, J. (1989) · PubMed · Cited by 11

A Myc-associated Zinc Finger Protein-related Factor Binding Site Is Required for the Deregulation of c-mycExpression by the Immunoglobulin Heavy Chain Gene Enhancers in Burkitt's Lymphoma

Hu, H., Arcinas, M., & Boxer, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111426200 · Cited by 10

A protein binding site from the murine c-myc promoter contributes to transcriptional block.

Dufort, D., Drolet, M., & Nepveu, A. (1993) · PubMed · Cited by 10

Positive and Negative Regulation of c-Myc Transcription

Zou, X., Lin, Y., Rudchenko, S., & Calame, K. L. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_5 · Cited by 9

Fluorescence Resonance Energy Transfer-Based Assay for DNA-Binding Protein Tagged by Green Fluorescent Protein

Aoki, T., Imamura, T., OZAKI, H., et al. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60085 · Cited by 8

The Binding Mode of Human Nucleoside Diphosphate Kinase B to Single-Strand DNA

Agou, F., Raveh, S., & Véron, M. (2000) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005593130867 · Cited by 7

c-myc Repression of Promoter Activity through Core Promoter Elements

Lucas, J. M., Wilkie, N. M., & Lang, J. C. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1987 · Cited by 6

Relationship between differentiation mechanisms involving cAMP-dependent protein kinase and protein kinase C in uninduced and differentiating HL-60 cells.

Savickienė, J., Gineitis, A. A., Vp, S., et al. (1997) · PubMed · Cited by 6

Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells

ZAJAC-KAYE, M., Ben-Baruch, N., Kastanos, E. K., et al. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3450535 · Cited by 6

Novel DNase I Hypersensitive Sites in the 3′-Flanking Region of the Human c- myc Gene

Murphy, L. C., Huzel, N. J., & Davie, J. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.543 · Cited by 5

Editorial: Twists in the Tail—Change-of-Function Mutations in Thyroid Hormone Receptors

Forrest, D. (2002) · Endocrinology · doi:10.1210/endo.143.7.8964 · Cited by 5

Multiprotein complexes present at the MIF motifs flanking the promoter of the human c‐myc gene

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Old Livers: C/EBPa Meets New Partners

Timchenko, N. A. (2003) · Cell Cycle · doi:10.4161/cc.2.5.467 · Cited by 5

Tumor necrosis factor and gamma-interferon repress transcription from the c-myc P2 promoter by reducing E2F binding activity.

Carlberg, A. L., Moberg, K. H., & Hall, D. J. (1999) · International Journal of Oncology · doi:10.3892/ijo.15.1.121 · Cited by 4

Transcriptional down-regulation of c-myc expression by protein synthesis-dependent and -independent pathways in a human T lymphoblastic tumor cell line.

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Distinct mechanisms of c-myc and lymphokine gene expression in an antigen specific T cell clone.

Se, H., Gelmann, E. P., & Matis, L. A. (1988) · PubMed · Cited by 2

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Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

Duncan, J. S., Whittle, M. C., Nakamura, K., Abell, A. N., Midland, A. A., Zawistowski, J. S., Johnson, N. L., Granger, D. A., Jordan, N. V., Darr, D. B., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.053 · Cited by 732

MYC: Connecting selective transcriptional control to global RNA production

Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521

An Overview of MYC and Its Interactome

Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172

Molecular Basis of Transient Repression of β-Galactosidase in Escherichia coli

Tyler, B., & Magasanik, B. (1969) · Journal of Bacteriology · doi:10.1128/jb.97.2.550-556.1969 · Cited by 34

Mechanism of Temperature Regulator and Application of Home Produced Regulator

Wang, Y.-Y., & Shanghai, S. (2006) · Pharmaceutical & Engineering Design

Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae.

Flick, J. S., & Johnston, M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4757 · Cited by 179

Su(z)2 Antagonizes Auto-Repression of Myc in Drosophila, Increasing Myc Levels and Subsequent Trans-Activation

Khan, A. A., Shover, W., & Goodliffe, J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005076 · Cited by 12

Multiple mechanisms mediate glucose repression of the yeast GAL1 gene.

Lamphier, M. S., & Ptashne, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5922 · Cited by 55