The c‐myc Promoter: Still MysterY and Challenge

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

Shibuyà, H., Yoneyama, M., Ninomiya‐Tsuji, J., Matsumoto, K., & Taniguchi, T. (1992) · Cell · doi:10.1016/0092-8674(92)90533-i · Cited by 229

Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation.Preprint

Krumm, A., Hickey, L. B., & Groudine, M. T. (1995) · Genes & Development · doi:10.1101/gad.9.5.559 · Cited by 229

Human transcription factor USF stimulates transcription through the initiator elements of the HIV‐1 and the Ad‐ML promoters.

Du, H., Roy, A. L., & Roeder, R. G. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05682.x · Cited by 227

The multiple roles of transcription/repair factor TFIIH

Svejstrup, J. Q., Vichi, P., & Egly, J. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10046-3 · Cited by 227

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

O’Connell, B. C., Cheung, A. F., Simkevich, C. P., Tam, W., Ren, X., Mateyak, M. K., & Sedivy, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210462200 · Cited by 227

Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo

Michelotti, G. A., Michelotti, E., Pullner, A., Duncan, R. C., Eick, D., & Levens, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2656 · Cited by 227

Targets and mechanisms for the regulation of translation in malignant transformation

Clemens, M. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207544 · Cited by 225

γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-cateninPreprint

Kolligs, F. T., Kolligs, B., Hajra, K. M., Hu, G., Tani, M., Cho, K. R., & Fearon, E. R. (2000) · Genes & Development · doi:10.1101/gad.14.11.1319 · Cited by 224

Transcriptional repression by Myc

Wanzel, M., Herold, S., & Eilers, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00003-5 · Cited by 224

The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling

Dunn, K. L., Espino, P. S., Drobic, B., He, S., & Davie, J. (2005) · Biochemistry and Cell Biology · doi:10.1139/o04-121 · Cited by 222

Id and development

Yokota, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1205090 · Cited by 222

Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Frederick, J. P., Liberati, N. T., Waddell, D. S., Shi, Y., & Wang, X. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2546-2559.2004 · Cited by 221

The basic region/helix – loop – helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation

Lüscher, B., & Larsson, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202750 · Cited by 220

Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins

Bouchard, C., Marquardt, J., Brás, A., Medema, R. H., & Eilers, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600279 · Cited by 220

Stabilization of the c-myc gene promoter quadruplex by specific ligands’ inhibitors of telomerase

Lemarteleur, T., Gómez, D., Boujemaa‐Paterski, R., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.150 · Cited by 220

Ski and SnoN: negative regulators of TGF-β signaling

Luo, K. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.003 · Cited by 219

Nuclear export of proteins and RNAs

Nakielny, S., & Dreyfuss, G. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80016-6 · Cited by 219

Multiple functions of Notch signaling in self‐renewing organs and cancer

Wilson, A., & Radtke, F. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.024 · Cited by 217

ovo/svb integrates Wingless and DER pathways to control epidermis differentiation

Payre, F., Vincent, A., & Carreno, S. (1999) · Nature · doi:10.1038/22330 · Cited by 216

c-Myc Mediates Activation of the cad Promoter via a Post-RNA Polymerase II Recruitment Mechanism

Eberhardy, S. R., & Farnham, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109014200 · Cited by 215

The Serotonin 1a Receptor Gene Contains a TATA-less Promoter that Responds to MAZ and Sp1

Parks, C. L., & Shenk, T. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4417 · Cited by 214

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

Cesarman, E., Dalla‐Favera, R., Bentley, D. L., & Groudine, M. T. (1987) · Science · doi:10.1126/science.3685977 · Cited by 213

The role of p53 in hypoxia-induced apoptosis

Hammond, E. M., & Giaccia, A. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.154 · Cited by 213

The history of biological warfare

Frischknecht, F. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor849 · Cited by 212

A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions

Yang, C., Shapiro, L. H., Rivera, M., Kumar, A., & Brindle, P. K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2218 · Cited by 212

TFIID binds in the minor groove of the TATA box

Starr, D. B., & Hawley, D. K. (1991) · Cell · doi:10.1016/0092-8674(91)90299-e · Cited by 209

T‐cell factors: turn‐ons and turn‐offs

Hurlstone, A. F. L., & Clevers, H. C. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2303 · Cited by 208

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

Klinakis, A., Szabolcs, M. J., Politi, K. A., Kiaris, H., Artavanis‐Tsakonas, S., & Efstratiadis, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603371103 · Cited by 208

Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy

Shao, W., & Brown, M. A. (2003) · Breast Cancer Research · doi:10.1186/bcr742 · Cited by 204

E2F and cell cycle control: a double-edged sword

Stevens, C., & Thangue, N. B. L. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00054-7 · Cited by 203

Transcriptional repression mediated by the p53 tumour suppressor

Ho, J., & Benchimol, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401191 · Cited by 203

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

Liu, B. P., & Burridge, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7160-7169.2000 · Cited by 203

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells.

Dani, C., Mechti, N., Piechaczyk, M., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.15.4896 · Cited by 203

Induction of Duplex to G-quadruplex Transition in the c-myc Promoter Region by a Small Molecule

Rangan, A., Fedoroff, O. Y., & Hurley, L. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005962200 · Cited by 203

TCF: Lady Justice Casting the Final Verdict on the Outcome of Wnt Signalling

Brantjes, H., Barker, N., van Es, J. H., & Clevers, H. C. (2002) · Biological Chemistry · doi:10.1515/bc.2002.027 · Cited by 202

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

Hewitt, S. M., Hamada, S., McDonnell, T. J., Rauscher, F. J., & Saunders, G. F. (1995) · PubMed · Cited by 200

Activating transcription from single stranded DNA.

Tomonaga, T., & Levens, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5830 · Cited by 199

Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and beta-catenin.

Enam, S., Valle, L. D., Lara, C., et al. (2002) · PubMed · Cited by 198

Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

Imbert, A., Eelkema, R., Jordan, S., Feiner, H. D., & Cowin, P. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.555 · Cited by 198

MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

Poortinga, G., Hannan, K., Snelling, H., Walkley, C. R., Jenkins, A., Sharkey, K., Wall, M., Brandenburger, Y., Palatsides, M., Pearson, R., et al. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600335 · Cited by 198

GATA-1-Mediated Proliferation Arrest during Erythroid Maturation

Rylski, M., Welch, J. J., Chen, Y., Letting, D. L., Diehl, J. A., Chodosh, L. A., Blobel, G. A., & Weiss, M. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.5031-5042.2003 · Cited by 195

Activation of c- myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain

Frazier, M. W., He, X., Wang, J., Gu, Z., Cleveland, J. L., & Zambetti, G. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3735 · Cited by 194

p53-Independent Role of MDM2 in TGF-β1 Resistance

Sun, P., Dong, P., Dai, K., Hannon, G. J., & Beach, D. (1998) · Science · doi:10.1126/science.282.5397.2270 · Cited by 194

Acetylation of β-Catenin by CREB-binding Protein (CBP)

Wolf, D., Rodova, M., Miska, E. A., Calvet, J. P., & Kouzarides, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201196200 · Cited by 194

Cooperation between C/EBPα TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiationPreprint

Pedersen, T. Å., Kowenz‐Leutz, E., Leutz, A., & Nerlov, C. (2001) · Genes & Development · doi:10.1101/gad.209901 · Cited by 194

TCF Transcription Factors, Mediators of Wnt-Signaling in Development and Cancer

van Noort, M., & Clevers, H. C. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0566 · Cited by 194

Formation of an IKKα-Dependent Transcription Complex Is Required for Estrogen Receptor-Mediated Gene Activation

Park, K.-J., Krishnan, V., O’Malley, B. W., Yamamoto, Y., & Gaynor, R. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.006 · Cited by 193

ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin

Chang, D. D., Wong, C., Smith, H., & Liu, J. X. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.1149 · Cited by 192

Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells.

Wang, G., & Vasquez, K. M. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0405116101 · Cited by 191

Roles of TATA and initiator elements in determining the start site location and direction of RNA polymerase II transcription.

O'Shea-Greenfield, A., & Smale, S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48443-8 · Cited by 190

Synergism in transcriptional activation: a kinetic view.

Herschlag, D., & Johnson, F. B. (1993) · Genes & Development · doi:10.1101/gad.7.2.173 · Cited by 190

Ras/Mitogen-Activated Protein Kinase Signaling Activates Ets-1 and Ets-2 by CBP/p300 Recruitment

Foulds, C. E., Nelson, M. L., Blaszczak, A. G., & Graves, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10954-10964.2004 · Cited by 190

Molecular Cloning and Characterization of TIEG2Reveals a New Subfamily of Transforming Growth Factor-β-inducible Sp1-like Zinc Finger-encoding Genes Involved in the Regulation of Cell Growth

Cook, T. A., Gebelein, B. A., Mesa, K., Mladek, A. C., & Urrutia, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25929 · Cited by 189

Epigenetic Inactivation of Wnt Inhibitory Factor-1 Plays an Important Role in Bladder Cancer through Aberrant Canonical Wnt/β-Catenin Signaling Pathway

Urakami, S., Shiina, H., Enokida, H., Kawakami, T., Tokizane, T., Ogishima, T., Tanaka, Y., Li, L.-C., Ribeiro‐Filho, L. A., Terashima, M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1344 · Cited by 189

More than just proliferation: Myc function in stem cells

Murphy, M., Wilson, A., & Trumpp, A. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.01.008 · Cited by 188

Yin-yang 1 activates the c-myc promoter.

Riggs, K. J., Saleque, S., Wong, K., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7487 · Cited by 187

FoxM1 dances with mitosis

Costa, R. H. (2005) · Nature Cell Biology · doi:10.1038/ncb0205-108 · Cited by 187

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

Frye, M., Gardner, C., Li, E. R., Arnold, I., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00462 · Cited by 187

The Far Upstream Element-binding Proteins Comprise an Ancient Family of Single-strand DNA-binding Transactivators

Davis-Smyth, T., DUNCAN, R. C., Zheng, T., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31679 · Cited by 187

The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication.

Bergemann, A. D., & Johnson, E. M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.1257 · Cited by 186

Heterogeneous Nuclear Ribonucleoprotein K Is a DNA-binding Transactivator

Tomonaga, T., & Levens, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4875 · Cited by 186

Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin

Yin, N., Wang, D., Zhang, H., Yi, X., Sun, X., Shi, B., Wu, H., Wu, G., Wang, X., & Shang, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0655 · Cited by 184

Hold back of RNA polymerase II at the transcription start site mediates down‐regulation of c‐myc in vivo.

Strobl, L. J., & Eick, D. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05409.x · Cited by 184

The Max Network Gone Mad

Baudino, T. A., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.691-702.2001 · Cited by 183

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

Mao, D. Y. L., Watson, J. D., Yan, P. S., Baršytė-Lovejoy, D., Khosravi, F., Wong, W. W.-L., Farnham, P., Huang, T. H. ‐., & Penn, L. Z. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00297-5 · Cited by 183

Differential Complementation of Bcr-Abl Point Mutants with c-Myc

Afar, D., Goga, A., McLaughlin, J., Witte, O. N., & Sawyers, C. L. (1994) · Science · doi:10.1126/science.8153630 · Cited by 183

RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest

Lai, A., Kennedy, B. K., Barbie, D. A., Bertos, N., Yang, X. J., Théberge, M.-C., Tsai, S., Seto, E., Zhang, Y., Kuzmichev, A., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2918-2932.2001 · Cited by 183

New Myc-interacting proteins: a second Myc network emerges

Sakamuro, D., & Prendergast, G. C. (1999) · Oncogene · doi:10.1038/sj.onc.1202725 · Cited by 182

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Kanazawa, S., Soucek, L., Evan, G. I., Okamoto, T., & Peterlin, B. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206800 · Cited by 181

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

Boxer, R. B., Jang, J. W.-U., Sintasath, L., & Chodosh, L. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.013 · Cited by 180

c-myc Inhibition of MyoD and Myogenin-Initiated Myogenic Differentiation

Miner, J. H., & Wold, B. J. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.5.2842 · Cited by 179

c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations

Luo, H., Li, Q., O’Neal, J., Kreisel, F. H. C., Beau, M. M. L., & Tomasson, M. H. (2005) · Blood · doi:10.1182/blood-2005-02-0734 · Cited by 179

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A

Yeyati, P. L., Shaknovich, R., Boterashvili, S., Li, J., Ball, H. J., Waxman, S., Nason-Burchenal, K., Dmitrovsky, E., Zelent, A., & Licht, J. D. (1999) · Oncogene · doi:10.1038/sj.onc.1202375 · Cited by 179

Role of polyamines in gastrointestinal mucosal growth

McCormack, S. A., & Johnson, L. R. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.260.6.g795 · Cited by 179

Myc oncogenes: the enigmatic family

Ryan, K. M., & Birnie, G. D. (1996) · Biochemical Journal · doi:10.1042/bj3140713 · Cited by 179

HATs on and beyond chromatin

Chen, H.-W., Tini, M., & Evans, R. M. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00200-3 · Cited by 178

Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1Preprint

Rezai‐Zadeh, N., Zhang, X. M., Namour, F., Fejér, G., Wen, Y., Yao, Y., Győry, I., Wright, K. L., & Seto, E. (2003) · Genes & Development · doi:10.1101/gad.1068003 · Cited by 178

Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters

Cheng, A. S. L., Jin, V. X., Fan, M., Smith, L. T., Liyanarachchi, S., Yan, P. S., Leu, Y., Chan, M. W. Y., Plass, C., Nephew, K. P., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.016 · Cited by 177

Contributions of Myc to tumorigenesis

Lutz, W., Leon, J., & Eilers, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00036-7 · Cited by 177

Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

Baumann, B., Weber, C. K., Troppmair, J., Whiteside, S. T., Israël, A., Rapp, U. R., & Wirth, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080583397 · Cited by 177

BAF53 Forms Distinct Nuclear Complexes and Functions as a Critical c-Myc-Interacting Nuclear Cofactor for Oncogenic Transformation

Park, J. H., Wood, M. A., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.5.1307-1316.2002 · Cited by 177

The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins

Doyle, G. A. R., Leeds, P., Fleisig, A. J., Ross, J., Betz, N. A., & Prokipcak, R. D. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.22.5036 · Cited by 176

Structure of the Biologically Relevant G-Quadruplex in The c-MYC Promoter

Yang, D., & Hurley, L. H. (2006) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770600809913 · Cited by 176

Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.

Bentley, D. L., & Groudine, M. T. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.10.3481 · Cited by 175

Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.

Filippova, G. N., Qi, C., Ulmer, J. E., Moore, J. M., Ward, M. D., Hu, Y. J., Loukinov, D. I., Pugacheva, E. M., Klenova, E. M., Grundy, P. E., et al. (2002) · PubMed · Cited by 174

Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function

Hann, S. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.08.004 · Cited by 173

Expanding functional diversity of the coactivators

Lonard, D. M., & O'Malley, B. W. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.001 · Cited by 172

Premature Expression of the Winged Helix Transcription Factor HFH-11B in Regenerating Mouse Liver Accelerates Hepatocyte Entry into S Phase

Ye, H., Holterman, A., Yoo, K. W., Franks, R. R., & Costa, R. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8570 · Cited by 172

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targetsPreprint

Bush, A., Mateyak, M. K., Dugan, K. A., Obaya, Á. J., Adachi, S., Sedivy, J. M., & Cole, M. D. (1998) · Genes & Development · doi:10.1101/gad.12.24.3797 · Cited by 172

Epidermal growth factor signaling via Ras controls the Smad transcriptional co‐repressor TGIF

Lo, R. S., Wotton, D., & Massagué, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.1.128 · Cited by 171

Signaling control of mRNA translation in cancer pathogenesis

Holland, E. C., Sonenberg, N., Pandolfi, P. P., & Thomas, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207590 · Cited by 171

Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor

Lemkine, G. F., Raji, A., Alfama, G., Turque, N., Hassani, Z., Alegria-Prévot, O., Samarut, J., Levi, G., & DEMENEIX, B. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-2916fje · Cited by 170

Cancer therapeutics: Targeting the dark side of Myc

Ponzielli, R., Katz, S., Baršytė-Lovejoy, D., & Penn, L. Z. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.017 · Cited by 170

Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase

Yamauchi, T., Kaburagi, Y., Ueki, K., Tsuji, Y., Stark, G. R., Kerr, I. M., Tsushima, T., Akanuma, Y., Komuro, I., Tobe, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15719 · Cited by 170

Opportunities and challenges in the development of kinase inhibitor therapy for cancerPreprint

Sawyers, C. L. (2003) · Genes & Development · doi:10.1101/gad.1152403 · Cited by 170

Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21 WAF1/CIP1/SDI1 *

Coqueret, O., & Gascan, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001601200 · Cited by 169

Function of the c-Myc oncoprotein in chromatin remodeling and transcription

Amati, B. B., Frank, S. R., Donjerković, D., & Taubert, S. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00020-8 · Cited by 169

The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis

Shaknovich, R., Yeyati, P. L., Ivins, S. M., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5533 · Cited by 169

Selective Estrogen Receptor Modulation and Reduction in Risk of Breast Cancer, Osteoporosis, and Coronary Heart Disease

Jordan, V. C., Gapstur, S. M., & Morrow, M. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.19.1449 · Cited by 169

β-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription

Song, L.-N., Herrell, R., Byers, S., Shah, S., Wilson, E. M., & Gelmann, E. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1674-1687.2003 · Cited by 169

Altered expression of β-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis

Takahashi, M., Mutoh, M., Kawamori, T., Sügimura, T., & Wakabayashi, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.7.1319 · Cited by 168

The role of c-myc in regulation of translation initiation

Schmidt, E. V. (2004) · Oncogene · doi:10.1038/sj.onc.1207548 · Cited by 166

Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation

Kim, M. J., Park, B.-J., Kang, Y.-S., Kim, H. J., Park, J., Kang, J. W., Lee, S., Han, J. M., Lee, H., & Kim, S. (2003) · Nature Genetics · doi:10.1038/ng1182 · Cited by 166

The dynamic response of upstream DNA to transcription-generated torsional stress

Kouzine, F., Liu, J.-H., Sanford, S., Chung, H.-J., & Levens, D. (2004) · Nature Structural &Molecular Biology · doi:10.1038/nsmb848 · Cited by 165

Structure and dynamics of KH domains from FBP bound to single-stranded DNA

Braddock, D. T., Louis, J. M., Baber, J. L., Levens, D., & Clore, G. M. (2002) · Nature · doi:10.1038/4151051a · Cited by 165

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

Kerkhoff, E., & Rapp, U. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2576 · Cited by 164

Regulation of TGF‐β signaling and its roles in progression of tumors

Miyazono, K., Suzuki, H., & Imamura, T. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01425.x · Cited by 164

Targeted activation of β-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia

Teulière, J., Faraldo, M. M., Deugnier, M., Shtutman, M. S., Ben‐Ze'ev, A., Thiery, J. P., & Glukhova, M. A. (2004) · Development · doi:10.1242/dev.01583 · Cited by 163

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

McCarthy, S. A., Chen, D. W., Yang, B.-S., Garcı́a-Ramı́rez, J. J., Cherwinski, H. M., Chen, X., Klagsbrun, M., Hauser, C. A., Ostrowski, M. C., & McMahon, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2401 · Cited by 163

Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation

Kurisaki, K., Kurisaki, A., Valcourt, U., Terentiev, A. A., Pardali, K., ten Dijke, P., Heldin, C., Ericsson, J., & Moustakas, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4494-4510.2003 · Cited by 163

HDAC1 Acetylation Is Linked to Progressive Modulation of Steroid Receptor-Induced Gene Transcription

Qiu, Y., Zhao, Y., Becker, M., John, S., Parekh, B. S., Huang, S., Hendarwanto, A., Martinez, E. D., Chen, Y., Lu, H., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.019 · Cited by 162

DNA Bending is an Important Component of Site-specific Recognition by the TATA Binding Protein

Starr, B. D., Hoopes, B. C., & Hawley, D. K. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0388 · Cited by 161

c-myc protein expression in untransformed fibroblasts.

Waters, C. M., Littlewood, T. D., Hancock, D. C., Moore, J. P., & Evan, G. I. (1991) · PubMed · Cited by 160

Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B.

Duyao, M. P., Kessler, D. J., Spicer, D. B., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41998-9 · Cited by 160

Signalling networks that cause cancer

McCormick, F. P. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01668-2 · Cited by 160

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

Kim, D. W. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.871 · Cited by 160

The FBP Interacting Repressor Targets TFIIH to Inhibit Activated Transcription

Liu, J., He, L., Collins, I. J., Ge, H., Libutti, D. E., Li, J., Egly, J., & Levens, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80428-1 · Cited by 159

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

Ragimov, N., Krauskopf, A., Navot, N., Rotter, V., Oren, M., & Aloni, Y. (1993) · PubMed · Cited by 159

The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c‐myc expression

Liu, J.-H., Kouzine, F., Nie, Z., Chung, H.-J., Elisha-Feil, Z., Weber, A., Zhao, K.-J., & Levens, D. (2006) · EMBO Journal · doi:10.1038/sj.emboj.7601101 · Cited by 158

Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc.

Larsson, L., Pettersson, M., Oberg, F. G., Nilsson, K., & Lüscher, B. (1994) · PubMed · Cited by 158

Jak2 is involved in c-Myc induction by Bcr-Abl

Xie, S., Lin, H., Sun, T., & Arlinghaus, R. B. (2002) · Oncogene · doi:10.1038/sj.onc.1205942 · Cited by 157

Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway

Minami, Y., Nakagawa, Y., Kawahara, A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90081-0 · Cited by 157

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

Lee, H., Arsura, M., Wu, M., Duyao, M. P., Buckler, A., & Sonenshein, G. E. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1169 · Cited by 157

Sequential Roles of Brg, the ATPase Subunit of BAF Chromatin Remodeling Complexes, in Thymocyte Development

Chi, T. H., Wan, M., Lee, P. P., Akashi, K., METZGER, D., Chambon, P., Wilson, C. B., & Crabtree, G. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00199-7 · Cited by 155

Identification of c-myc as a Down-stream Target for Pituitary Tumor-transforming Gene

Pei, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009654200 · Cited by 154

Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells

Satoh, Y., Matsumura, I., Tanaka, H., Ezoe, S., Sugahara, H., Mizuki, M., Shibayama, H., Ishiko, E., Ishiko, J., Nakajima, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400407200 · Cited by 154

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

Karlsson, A. E., Deb-Basu, D., Cherry, A. M., Turner, S., Ford, J. M., & Felsher, D. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732638100 · Cited by 153

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

Gotoh, N., Toyoda, M., & Shibuya, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1824 · Cited by 153

Retinoblastoma family genes

Du, W., & Pogoriler, J. E. (2006) · Oncogene · doi:10.1038/sj.onc.1209651 · Cited by 152

Negative regulation of the Wnt–β‐catenin pathway by the transcriptional repressor HBP1

Sampson, E. M., Haque, Z. K., Ku, M., Tevosian, S. G., Albanese, C., Pestell, R. G., Paulson, K. E., & Yee, A. S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4500 · Cited by 151

C/EBPβ cooperates with RB:E2F to implement RasV12‐induced cellular senescence

Sebastian, T. B., Malı́k, R., Thomas, S., Sage, J., & Johnson, P. F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600789 · Cited by 151

Loss of FBP function arrests cellular proliferation and extinguishes c‐myc expression

He, L., Liu, J., Collins, I. J., Sanford, S., O'Connell, B. C., Benham, C. J., & Levens, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1034 · Cited by 150

c-Myc Is Required for the Formation of Intestinal Crypts but Dispensable for Homeostasis of the Adult Intestinal Epithelium

Bettess, M. D., Dubois, N. C., Murphy, M., Dubey, C., Roger, C., Robine, S., & Trumpp, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7868-7878.2005 · Cited by 149

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a

Giraud, S., Bienvenu, F., Avril, S., Gascan, H., Heery, D. M., & Coqueret, O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111486200 · Cited by 149

BLIMP-1: trigger for differentiation of myeloid lineage

Chang, D., Angelin‐Duclos, C., & Calame, K. L. (2000) · Nature Immunology · doi:10.1038/77861 · Cited by 149

Transcription and Promoter Usage of the myc Gene tn Normal Somatic and Spermatogenic Cells

Stewart, T. A., Bellvé, A. R., & Leder, P. (1984) · Science · doi:10.1126/science.6494906 · Cited by 149

A Nuclease Hypersensitive Element in the Human c-myc Promoter Adopts Several Distinct i-Tetraplex Structures

Simonsson, T., Pribylova, M., & Vorlı́čková, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3783 · Cited by 149

Regulated subset of G 1 growth-control genes in response to derepression by the Wnt pathway

Baek, S. H., Kioussi, C., Briata, P., Wang, D., Nguyen, H., Ohgi, K. A., Glass, C. K., Wynshaw-Boris, A. J., Rose, D. W., & Rosenfeld, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0330217100 · Cited by 148

Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein.

Bergemann, A. D., Ma, Z. W., & Johnson, E. M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5673 · Cited by 147

Recruitment of Distinct Chromatin-modifying Complexes by Tamoxifen-complexed Estrogen Receptor at Natural Target Gene Promoters in Vivo*

Liu, X.-F., & Bagchi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311932200 · Cited by 147

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesisPreprint

Park, J. H., Kunjibettu, S., McMahon, S. B., & Cole, M. D. (2001) · Genes & Development · doi:10.1101/gad.900101 · Cited by 147

Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases

Hindley, A. D., & Kölch, W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1575 · Cited by 147

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

Grumont, R. J., Strasser, A., & Gerondakis, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00779-7 · Cited by 147

A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor.

Postel, E. H., Mango, S. E., & Flint, S. J. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5123 · Cited by 147

p70s6k Integrates Phosphatidylinositol 3-Kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes

Brennan, P., Babbage, J., Thomas, G., & Cantrell, D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4729 · Cited by 147

Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

Langer, S. J., Bortner, D. M., Roussel, M. F., Sherr, C. J., & Ostrowski, M. C. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5355-5362.1992 · Cited by 146

STAM, Signal Transducing Adaptor Molecule, Is Associated with Janus Kinases and Involved in Signaling for Cell Growth and c-myc Induction

Takeshita, T., Arita, T., Higuchi, M., Asao, H., Endo, K., Kuroda, H., Tanaka, N., Murata, K., Ishii, N., & Sugamura, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80288-5 · Cited by 146

Mel-18, a Polycomb Group Protein, Regulates Cell Proliferation and Senescence via Transcriptional Repression of Bmi-1 and c-Myc Oncoproteins

Guo, W., Datta, S., Band, V., & Dimri, G. P. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0447 · Cited by 146

Biophysical Studies of the c-MYC NHE III1 Promoter: Model Quadruplex Interactions with a Cationic Porphyrin

Freyer, M. W., Buscaglia, R., Kaplan, K. A., Cashman, D. J., Hurley, L. H., & Lewis, E. A. S. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.097246 · Cited by 146

An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence.Preprint

Benvenisty, N., Leder, A., Kuo, A. F., et al. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2513 · Cited by 145

The p270 (ARID1A/SMARCF1) Subunit of Mammalian SWI/SNF-Related Complexes Is Essential for Normal Cell Cycle Arrest

Nagl, N. G., Patsialou, A., Haines, D. S., Dallas, P. B., Beck, G. R., & Morán, E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1225 · Cited by 145

Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells

Calonge, M. J., & Massagué, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33637 · Cited by 144

Regulation of c-myc expression by Ras/Raf signalling

Kerkhoff, E., Houben, R., Löffler, S., Troppmair, J., Lee, J., & Rapp, U. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201520 · Cited by 144

The Abd-B-like Hox Homeodomain Proteins Can Be Subdivided by the Ability to Form Complexes with Pbx1a on a Novel DNA Target

Shen, W.-F., Rozenfeld, S. B., Lawrence, H. J., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8198 · Cited by 143

Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation.

Kirillova, I., Chaisson, M. L., & Fausto, N. (1999) · PubMed · Cited by 143

Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis.

Hurlin, P. J., Foley, K., Ayer, D. E., Eisenman, R. N., Hanahan, D., & Arbeit, J. M. (1995) · PubMed · Cited by 143

Regulation of c-myc expression by PDGF through Rho GTPases

Chiariello, M., Marinissen, M. J., & Gutkind, J. S. (2001) · Nature Cell Biology · doi:10.1038/35078555 · Cited by 142

PuF/NM23-H2/NDPK-B transactivates a human c-myc promoter-CAT gene via a functional nuclease hypersensitive element.

Berberich, S. J., & Eh, P. (1995) · PubMed · Cited by 142

HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.Preprint

Tevosian, S. G., Shih, H. H., Mendelson, K., Sheppard, K.-A., Paulson, K. E., & Yee, A. S. (1997) · Genes & Development · doi:10.1101/gad.11.3.383 · Cited by 141

Effects of c-myc Expression on Cell Cycle Progression

Hanson, K. D., Shichiri, M., Follansbee, M. R., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5748-5755.1994 · Cited by 141

A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts

Neal, J. W., & Clipstone, N. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300528200 · Cited by 140

Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation

Kondo, Y., Shen, L., Yan, P. S., Huang, T. H. ‐., & Issa, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306641101 · Cited by 140

Unfolding of G-Quadruplexes: Energetic, and Ion and Water Contributions of G-Quartet Stacking

Olsen, C. M., Gmeiner, W. H., & Marky, L. A. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp0574697 · Cited by 140

Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene.

Davis, T. L., Firulli, A. B., & Kinniburgh, A. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9682 · Cited by 140

Interaction of c‐Myc with the pRb‐related protein p107 results in inhibition of c‐Myc‐mediated transactivation.

Beijersbergen, R. L., Hijmans, E. M., Zhu, L., & Bernards, R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06725.x · Cited by 139

Gene-target recognition among members of the Myc superfamily and implications for oncogenesis

O’Hagan, R. C., Schreiber‐Agus, N., Chen, K., et al. (2000) · Nature Genetics · doi:10.1038/72761 · Cited by 137

Requirement for c-Src Catalytic Activity and the SH3 Domain in Platelet-derived Growth Factor BB and Epidermal Growth Factor Mitogenic Signaling

Broome, M. A., & Hunter, T. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16798 · Cited by 137

Armadillo/β-catenin signals in the nucleus – proof beyond a reasonable doubt?

Bienz, M., & Clevers, H. (2003) · Nature Cell Biology · doi:10.1038/ncb0303-179 · Cited by 137

TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins

Nikiforov, M. A., Chandriani, S. J., Park, J. H., Kotenko, I., Matheos, D. P., Johnsson, A., McMahon, S. B., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5054-5063.2002 · Cited by 137

Inhibition of c-myc Expression Induces Apoptosis of WEHI 231 Murine B Cells

Wu, M., Arsura, M., Bellas, R. E., Fitzgerald, M. J., Lee, H., Schauer, S. L., Sherr, D. H., & Sonenshein, G. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5015 · Cited by 136

A far upstream element stimulates c-myc expression in undifferentiated leukemia cells.

Avigan, M., Strober, B. J., & Levens, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44785-5 · Cited by 135

The Myc trilogy: lord of RNA polymerases

Óskarsson, T., & Trumpp, A. (2005) · Nature Cell Biology · doi:10.1038/ncb0305-215 · Cited by 135

Identifying Genes Regulated in a Myc-dependent Manner

Watson, J. D., Oster, S. K., Shago, M., Khosravi, F., & Penn, L. Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201493200 · Cited by 135

A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif

Kolluri, R., Torrey, T. A., & Kinniburgh, A. J. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.111 · Cited by 135

Human NM23/Nucleoside Diphosphate Kinase Regulates Gene Expression through DNA Binding to Nuclease-Hypersensitive Transcriptional Elements

Postel, E. H., Berberich, S. J., Rooney, J. W., & Kaetzel, D. M. (2000) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005541114029 · Cited by 134

The pRB‐related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

Zhu, L., Enders, G. H., Lees, J. A., Beijersbergen, R. L., Bernards, R., & Harlow, E. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07182.x · Cited by 134

The MYC Oncogene as a Cancer Drug Target

Hermeking, H. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481949 · Cited by 133

Oncogene addiction

Jonkers, J., & Berns, A. J. M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.12.002 · Cited by 133

RNA trafficking in myelinating cells

Carson, J. H., Kwon, S., & Barbarese, E. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80088-3 · Cited by 132

Negative Protein 1, Which Is Required for Function of the Chicken Lysozyme Gene Silencer in Conjunction with Hormone Receptors, Is Identical to the Multivalent Zinc Finger Repressor CTCF

Burcin, M. M., Arnold, R., Lutz, M., Kaiser, B., Runge, D., Lottspeich, F., Filippova, G. N., Lobanenkov, V. V., & Renkawitz, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1281 · Cited by 132

Stop and Go: Anti-Proliferative and Mitogenic Functions of the Transcription Factor C/EBPβ

Sebastian, T. B., & Johnson, P. F. (2006) · Cell Cycle · doi:10.4161/cc.5.9.2733 · Cited by 132

Hitting their targets: an emerging picture of E2F and cell cycle control

Blais, A., & Dynlacht, B. D. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.003 · Cited by 131

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells

Watanabe, S., Itoh, T., & Arai, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12681 · Cited by 131

Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5

Rascle, A., Johnston, J. A., & Amati, B. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4162-4173.2003 · Cited by 131

Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer

Zajac‐Kaye, M. (2001) · Lung Cancer · doi:10.1016/s0169-5002(01)00343-9 · Cited by 131

Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes

Macaluso, M., Montanari, M., & Giordano, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209680 · Cited by 130

Identification of a Functionally Impaired Positive Regulatory Domain I Binding Factor 1 Transcription Repressor in Myeloma Cell Lines

Győry, I., Fejér, G., Ghosh, N., Seto, E., & Wright, K. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3125 · Cited by 130

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

Alexandrow, M. G., Kawabata, M., Aakre, M. E., & Moses, H. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3239 · Cited by 130

Tyrosine Kinase Oncogenes Abrogate Interleukin-3 Dependence of Murine Myeloid Cells through Signaling Pathways Involving c-myc: Conditional Regulation of c-myc Transcription by Temperature-Sensitive v -abl

Cleveland, J. L., Dean, M. C., Rosenberg, N. E., Wang, J. Y. J., & Rapp, U. R. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.12.5685 · Cited by 129

mel‐18, a Polycomb group‐related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.

Kanno, M., Hasegawa, M., Ishida, A., Isono, K., & Taniguchi, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00254.x · Cited by 129

Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius

Neiman, P. E., Ruddell, A., Jasoni, C. L., Loring, G., Thomas, S., Brandvold, K. A., Lee, R.-M., Burnside, J., & Delrow, J. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111144898 · Cited by 129

Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase

Wells, J. M., Yan, P. S., Cechvala, M. M., Huang, T. H. ‐., & Farnham, P. (2003) · Oncogene · doi:10.1038/sj.onc.1206264 · Cited by 129

c‐Abl is an effector of Src for growth factor‐induced c‐myc expression and DNA synthesis

Furstoss, O., Dorey, K., Simon, V., Barilà, D., Superti‐Furga, G., & Roche, S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.514 · Cited by 128

Opposite Effects of the Acute Promyelocytic Leukemia PML-Retinoic Acid Receptor α (RARα) and PLZF-RARα Fusion Proteins on Retinoic Acid Signalling

Ruthardt, M., Testa, U., Nervi, C., Ferrucci, P. F., Grignani, F., Puccetti, E., Grignani, F., Peschle, C., & Pelicci, P. G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4859 · Cited by 127

Myc-mediated transformation: the repression connection

Claassen, G. F., & Hann, S. (1999) · Oncogene · doi:10.1038/sj.onc.1202747 · Cited by 127

A downstream initiation element required for efficient TATA box binding and in vitro function of TFIID

Nakatani, Y., Horikoshi, M., Brenner, M., et al. (1990) · Nature · doi:10.1038/348086a0 · Cited by 126

Identification and Characterization of ERK MAP Kinase Phosphorylation Sites in Smad3

Matsuura, I., Wang, G., He, D., & Liu, F. (2005) · Biochemistry · doi:10.1021/bi050560g · Cited by 126

hnRNP K Binds a Core Polypyrimidine Element in the Eukaryotic Translation Initiation Factor 4E (eIF4E) Promoter, and Its Regulation of eIF4E Contributes to Neoplastic Transformation

Lynch, M. C., Chen, L., Ravitz, M. J., Mehtani, S., Korenblat, K., Pazin, M. J., & Schmidt, E. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6436-6453.2005 · Cited by 126

A transcriptional repressor of c-myc

Kakkis, E., Riggs, K. J., Gillespie, W., et al. (1989) · Nature · doi:10.1038/339718a0 · Cited by 125

Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription

Nair, M., Teng, A., Bilanchone, V., Agrawal, A., Li, B., & Dai, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508196 · Cited by 125

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

Duncan, J. S., Whittle, M. C., Nakamura, K., Abell, A. N., Midland, A. A., Zawistowski, J. S., Johnson, N. L., Granger, D. A., Jordan, N. V., Darr, D. B., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.053 · Cited by 732

MYC: Connecting selective transcriptional control to global RNA production

Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521

An Overview of MYC and Its Interactome

Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172

Molecular Basis of Transient Repression of β-Galactosidase in Escherichia coli

Tyler, B., & Magasanik, B. (1969) · Journal of Bacteriology · doi:10.1128/jb.97.2.550-556.1969 · Cited by 34

Mechanism of Temperature Regulator and Application of Home Produced Regulator

Wang, Y.-Y., & Shanghai, S. (2006) · Pharmaceutical & Engineering Design

Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae.

Flick, J. S., & Johnston, M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.9.4757 · Cited by 179

Su(z)2 Antagonizes Auto-Repression of Myc in Drosophila, Increasing Myc Levels and Subsequent Trans-Activation

Khan, A. A., Shover, W., & Goodliffe, J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005076 · Cited by 12

Multiple mechanisms mediate glucose repression of the yeast GAL1 gene.

Lamphier, M. S., & Ptashne, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5922 · Cited by 55