Cited by 131Genomics and Chromatin DynamicsHemoglobinopathies and Related DisordersGenetic Associations and Epidemiology

The DOI matches its Crossref record; 179 of the 180 references it cites were found in a registry or an index.

Chapter 4 β‐Globin Regulation and Long‐Range Interactions

Palstra, Robert‐Jan, de Laat, Wouter, Grosveld, Frank·2008·Advances in genetics

DOI 10.1016/s0065-2660(07)00004-1

Open this paper in CoChat — free account

Abstract

Transcriptional activation in higher eukaryotes frequently involves the long-range action of a number of regulatory DNA elements. One of the main questions in transcriptional regulation is how cis-regulatory elements communicate with the promoter of a gene over large distances. There has been a lively debate in recent years whether this communication takes place via a noncontact mechanism (linking, tracking) or via a contact mechanism (looping). The demonstration that the major regulatory element of the beta-globin locus, the locus control region (LCR), is in close proximity to the active beta-globin genes validates the contact model for long-range activation. Here, we will review the beta-globin locus as a model system to study long-range activation, briefly describe the different models for long-range activation, and summarize the recent findings that the LCR of the beta-globin locus is in close proximity to the active promoters. Although it is now firmly established that looping takes place within the beta-globin locus (and other loci), it is not clear how these long-range contacts are established and what the precise role is of the LCR. We will argue that the main action of the LCR takes place at the promoter and open reading frame of the gene itself and we will discuss key rate-limiting steps in transcriptional activation and the possible mechanisms by which they are influenced by the LCR.

Integrity signals

Registry

Crossref · 10.1016/s0065-2660(07)00004-1

Cites

179 of 179 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Capturing Chromosome Conformation
Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908
Chromosomal Subunits in Active Genes Have an Altered Conformation: Globin genes are digested by deoxyribonuclease I in red blood cell nuclei but not in fibroblast nuclei.
Weintraub, H., & Groudine, M. (1976) · Science · doi:10.1126/science.948749 · Cited by 1,809
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344
Self-citation
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory
Berg, O. G., Winter, R. B., & von Hippel, P. H. (1981) · Biochemistry · doi:10.1021/bi00527a028 · Cited by 1,299
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Chan, H. M., & La Thangue, N. B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2363 · Cited by 1,092
Active genes dynamically colocalize to shared sites of ongoing transcription
Osborne, C. S., Chakalova, L., Brown, K. E., Carter, D., Horton, A., Debrand, E., Goyenechea, B., Mitchell, J. A., Lopes, S. M. C. D. S., Reik, W., et al. (2004) · Nature Genetics · doi:10.1038/ng1423 · Cited by 1,080
Development of hematopoietic stem cell activity in the mouse embryo
Müller, A. M., Medvinsky, A., Strouboulis, J., Grosveld, F. G., & Dzierzakt, E. (1994) · Immunity · doi:10.1016/1074-7613(94)90081-7 · Cited by 901

Show all 180 references

Sorted by citations

Reactivation of developmentally silenced globin genes by forced chromatin looping
Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.050 · Cited by 443
Thalassaemia
Higgs, D. R., Engel, J. D., & Stamatoyannopoulos, G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60283-3 · Cited by 455
Noncoding Transcription at Enhancers: General Principles and Functional Models
Natoli, G., & Andrau, J. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155459 · Cited by 418
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
Traxler, E. A., Yao, Y., Wang, Y.-D., Woodard, K. J., Kurita, R., Nakamura, Y., Hughes, J. R., Hardison, R. C., Blobel, G. A., Li, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4170 · Cited by 366
Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6
Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes & Development · doi:10.1101/gad.1897310 · Cited by 361
Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Dos Santos, M., Backer, S., Saintpierre, B., Izac, B., Andrieu, M., Letourneur, F., Relaix, F., Sotiropoulos, A., & Maire, P. (2020) · Nature Communications · doi:10.1038/s41467-020-18789-8 · Cited by 259
A model for all genomes: the role of transcription factories
Cook, P. R. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.10.031 · Cited by 247
Nfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle
Messina, G., Biressi, S., Monteverde, S., Magli, A., Cassano, M., Perani, L., Roncaglia, E., Tagliafico, E., Starnes, L., Campbell, C. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.027 · Cited by 210
Molecular basis of β thalassemia and potential therapeutic targets
Thein, S. L. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.06.001 · Cited by 219
Erythropoiesis: Model systems, molecular regulators, and developmental programs
Tsiftsoglou, A. S., Vizirianakis, I. S., & Strouboulis, J. (2009) · IUBMB Life · doi:10.1002/iub.226 · Cited by 217
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression
Pop, R., Shearstone, J. R., Shen, Q., Liu, Y., Hallstrom, K., Koulnis, M., Gribnau, J., & Socolovsky, M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000484 · Cited by 179
Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?
Nora, E. P., Dekker, J., & Heard, É. (2013) · BioEssays · doi:10.1002/bies.201300040 · Cited by 187
In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of β-thalassemia
Miccio, A., Cesari, R., Lotti, F., Rossi, C., Sanvito, F., Ponzoni, M., Routledge, S. J. E., Chow, C.-M., Antoniou, M. N., & Ferrari, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711666105 · Cited by 154
An Integrated Holo-Enhancer Unit Defines Tissue and Gene Specificity of the Fgf8 Regulatory Landscape
Marinić, M., Aktaş, T., Ruf, S., & Spitz, F. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.025 · Cited by 149
Tissue- and Expression Level–Specific Chromatin Looping at Maizeb1Epialleles
Louwers, M., Bader, R., Haring, M., DRIEL, R. V., de Laat, W. L., & Stam, M. E. (2009) · The Plant Cell · doi:10.1105/tpc.108.064329 · Cited by 151
Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress
Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Müller, M., & Kersten, S. (2010) · Circulation Research · doi:10.1161/circresaha.110.217380 · Cited by 133
Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR
Ganis, J. J., Hsia, N., Trompouki, E., de Jong, J. L. O., DiBiase, A., Lambert, J. S., Jia, Z., Sabo, P. J., Weaver, M., Sandstrom, R. S., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.021 · Cited by 139
A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber
Comet, I. V., Schuettengruber, B., Sexton, T., & Cavalli, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002059108 · Cited by 126
A condensin-like dosage compensation complex acts at a distance to control expression throughout the genomePreprint
Jans, J. J. M., Gladden, J. M., Ralston, E. J., Pickle, C. S., Michel, A. H., Pferdehirt, R. R., Eisen, M. B., & Meyer, B. J. (2009) · Genes & Development · doi:10.1101/gad.1751109 · Cited by 111
Gene regulation at a distance: From remote enhancers to 3D regulatory ensembles
Spitz, F. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.017 · Cited by 99
Interchromosomal association and gene regulation in trans
Williams, A., Spilianakis, C. G., & Flavell, R. A. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.01.007 · Cited by 100
Chromosome looping at the human α-globin locus is mediated via the major upstream regulatory element (HS −40)
Vernimmen, D., Marques-Kranc, F., Sharpe, J. A., Sloane-Stanley, J. A., Wood, W. G., Wallace, H. A. C., Smith, A. J. H., & Higgs, D. R. (2009) · Blood · doi:10.1182/blood-2009-03-213439 · Cited by 89
Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub
Gavrilov, A. A., Gushchanskaya, E. S., Strelkova, O., Zhironkina, O., Kireev, I. I., Iarovaia, O. V., & Razin, S. V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt067 · Cited by 87
A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
Santos, M. D., Backer, S., Aurade, F., Wong, M. M.-K., Wurmser, M., Pierre, R., Vives, F. L., Cruzeiro, M. D., Schmitt, A., Concordet, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28666-1 · Cited by 75
Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
Sakakibara, I., Santolini, M., Ferry, A., Hakim, V., & Maire, P. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004386 · Cited by 70
Activation of γ-globin expression by hypoxia-inducible factor 1α
Feng, R., Mayuranathan, T., Huang, P., Doerfler, P. A., Li, Y., Yao, Y., Zhang, J., Palmer, L. E., Mayberry, K. D., Christakopoulos, G. E., et al. (2022) · Nature · doi:10.1038/s41586-022-05312-w · Cited by 69
Transcription factories in the context of the nuclear and genome organization
Razin, S. V., Gavrilov, A. A., Pichugin, A., Lipinski, M., Iarovaia, O. V., & Vassetzky, Y. S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr683 · Cited by 73
Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
Doerfler, P. A., Feng, R., Li, Y., Palmer, L. E., Porter, S. N., Bell, H. W., Crossley, M., Pruett‐Miller, S. M., Cheng, Y., & Weiss, M. J. (2021) · Nature Genetics · doi:10.1038/s41588-021-00904-0 · Cited by 67
Chromatin Conformation in Development and Disease
Boltsis, I., Grosveld, F. G., Giraud, G., & Kolovos, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723859 · Cited by 59
Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease
Thein, S. L. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-7299-9_2 · Cited by 60
Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation
Alter, J., & Bengal, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029498 · Cited by 53
A Conserved Noncoding Sequence Can Function as a Spermatocyte-Specific Enhancer and a Bidirectional Promoter for a Ubiquitously Expressed Gene and a Testis-Specific Long Noncoding RNA
Kurihara, M., Shiraishi, A., Satake, H., & Kimura, A. P. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.06.018 · Cited by 48
KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation
Campbell, M., Watanabe, T., Nakano, K., Davis, R. R., Lyu, Y., Tepper, C. G., Durbin-Johnson, B. P., Fujimuro, M., & Izumiya, Y. (2017) · Nature Communications · doi:10.1038/s41467-017-02089-9 · Cited by 44
Optimizing Retroviral Gene Expression for Effective Therapies
Antoniou, M. N., Skipper, K. A., & Anakök, Ö. F. (2013) · Human Gene Therapy · doi:10.1089/hum.2013.062 · Cited by 48
Landscapes and archipelagos: spatial organization of gene regulation in vertebrates
Montavon, T., & Duboule, D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.04.003 · Cited by 50
A view of the chromatin landscape
Rapkin, L. M., Anchel, D., Li, R., & Bazett‐Jones, D. P. (2011) · Micron · doi:10.1016/j.micron.2011.11.007 · Cited by 43
Long-range DNA interactions at the IL-1/IL-36/IL-37 gene cluster (2q13) are induced by activation of monocytes
Sharaf, N., Nicklin, M. J. H., & di Giovine, F. S. (2014) · Cytokine · doi:10.1016/j.cyto.2014.03.002 · Cited by 42
Role of Helix-Loop-Helix Proteins during Differentiation of Erythroid Cells
Anantharaman, A., Lin, I., Barrow, J. J., Liang, S. Y., Masannat, J., Strouboulis, J., Huang, S., & Bungert, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01186-10 · Cited by 43
Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22
Jones, E. A., Brewer, M. H., Srinivasan, R., Krueger, C., Sun, G., Charney, K. N., Keleş, S., Antonellis, A., & Svaren, J. P. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr595 · Cited by 40
H b A 2 levels in normal adults are influenced by two distinct genetic mechanisms
Menzel, S., Garner, C. P., Rooks, H., Spector, T. D., & Thein, S. L. (2012) · British Journal of Haematology · doi:10.1111/bjh.12084 · Cited by 40
Development of Gene Therapy for Thalassemia
Nienhuis, A. W., & Persons, D. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011833 · Cited by 38
Transcription in the context of the 3D nucleus
Wendt, K. S., & Grosveld, F. G. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.020 · Cited by 43
Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle
Sakakibara, I., Wurmser, M., Santos, M. D., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, K., & Maire, P. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0102-x · Cited by 41
A long-range cis-regulatory element for class I odorant receptor genes
Iwata, T., Niimura, Y., Kobayashi, C., Shirakawa, D., Suzuki, H., Enomoto, T., Touhara, K., Yoshihara, Y., & Hirota, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00870-4 · Cited by 37
Kaposi's Sarcoma-Associated Herpesvirus Hijacks RNA Polymerase II To Create a Viral Transcriptional Factory
Chen, C. P., Lyu, Y., Chuang, F. Y. S., Nakano, K., Izumiya, C., Jin, D., Campbell, M., & Izumiya, Y. (2017) · Journal of Virology · doi:10.1128/jvi.02491-16 · Cited by 37
Chromatin accessibility maps provide evidence of multilineage gene priming in hematopoietic stem cells
Martin, E. W., Krietsch, J., Reggiardo, R. E., Sousae, R., Kim, D. H., & Forsberg, E. C. (2021) · Epigenetics & Chromatin · doi:10.1186/s13072-020-00377-1 · Cited by 36
The β-Globin Locus Control Region in Combination With the EF1α Short Promoter Allows Enhanced Lentiviral Vector-mediated Erythroid Gene Expression With Conserved Multilineage Activity
Montiel-Equihua, C., Zhang, L., Knight, S., Saadeh, H., Scholz, S., Carmo, M., Alonso-Ferrero, M. E., Blundell, M. P., Monkeviciute, A., Schulz, R., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2012.50 · Cited by 36
Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding
Silicheva, M., Golovnin, A. K., Pomerantseva, E. A., Паршиков, А. Ф., Georgiev, P. G., & Maksimenko, O. G. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp877 · Cited by 33
Massively parallel sequencing: the new frontier of hematologic genomics
Johnsen, J. M., Nickerson, D. A., & Reiner, A. P. (2013) · Blood · doi:10.1182/blood-2013-07-460287 · Cited by 34
DNA-binding factor CTCF and long-range gene interactions in V(D)J recombination and oncogene activation
de Almeida, C. R., Stadhouders, R., Thongjuea, S., Soler, É., & Hendriks, R. W. (2012) · Blood · doi:10.1182/blood-2012-03-402586 · Cited by 31
Gene expression in time and space: additive vs hierarchical organization of cis-regulatory regions
Maeda, R. K., & Karch, F. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.01.021 · Cited by 31
Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus
Eun, B., Sampley, M. L., Good, A. L., Gebert, C. M., & Pfeifer, K. E. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1182 · Cited by 31
Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages
Dabitao, D., Hedrich, C. M., Wang, F., Vacharathit, V., & Bream, J. H. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701340 · Cited by 30
Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies
Paschoudi, K., Yannaki, E., & Psatha, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119527 · Cited by 30
Quantitative analysis of genomic element interactions by molecular colony technique
Gavrilov, A. A., Chetverina, H. V., Chermnykh, E. S., Razin, S. V., & Chetverin, A. B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1322 · Cited by 25
Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny
Martin, E. W., y Baena, A. R., Reggiardo, R. E., Worthington, A. K., Mattingly, C. S., Poscablo, D. M., Krietsch, J., McManus, M. T., Carpenter, S. B., Kim, D. H., et al. (2023) · Stem Cells · doi:10.1093/stmcls/sxad022 · Cited by 24
Haemoglobin and the Inherited Disorders of Globin Synthesis
Thein, S. L., & Rees, D. C. (2015) · Wiley eBooks · doi:10.1002/9781118853771.ch6 · Cited by 22
Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation
Li, Y., Ding, L., Li, W., Story, M. D., & Pace, B. S. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-153 · Cited by 23
Phosphorproteome Changes of Myofibrillar Proteins at Early Post-mortem Time in Relation to Pork Quality As Affected by Season
Li, X., Fang, T., Zong, M., Shi, X., Xu, X., Dai, C., Li, C., & Zhou, G. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03997 · Cited by 23
Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites
Liu, C. F., Brandt, G. S., Hoang, Q. Q., Naumova, N., Lazarevic, V., Hwang, E. S., Dekker, J., Glimcher, L. H., Ringe, D., & Petsko, G. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613914113 · Cited by 23
Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle
Long, K., Su, D., Li, X., Li, H., Zeng, S., Zhang, Y., Zhong, Z., Lin, Y., Li, X., Lu, L., et al. (2022) · BMC Genomics · doi:10.1186/s12864-022-08737-9 · Cited by 24
Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression
Stratigi, K., Kapsetaki, M., Aivaliotis, M., Town, T., Flavell, R. A., & Spilianakis, C. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502182112 · Cited by 22
An Electronic Infrastructure for Research and Treatment of the Thalassemias and Other Hemoglobinopathies: The Euro-Mediterranean Ithanet Project
Lederer, C. W., Başak, A. N., Aydınok, Y., Christou, S., El-Beshlawy, A. M., Eleftheriou, A., Fattoum, S., Felice, A. E., Fibach, E., Galanello, R., et al. (2009) · Hemoglobin · doi:10.1080/03630260903089177 · Cited by 21
Memories of lost enhancers: Figure 1.Preprint
Sen, R., & Grosschedl, R. (2010) · Genes & Development · doi:10.1101/gad.1930610 · Cited by 20
Cooperative insulation of regulatory domains by CTCF-dependent physical insulation and promoter competition
Ealo, T., Sánchez-Gaya, V., Respuela, P., Martín, M. M., Martín-Batista, E., Haro, E., & Rada-Iglesias, Á. (2024) · Nature Communications · doi:10.1038/s41467-024-51602-4 · Cited by 24
TMEM8 – a non-globin gene entrapped in the globin web
Philonenko, E. S., Klochkov, D. B., Borunova, V. V., Gavrilov, A. A., Razin, S. V., & Iarovaia, O. V. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp838 · Cited by 19
Spatial organization of genes as a component of regulated expression
Pai, D. A., & Engelke, D. R. (2009) · Chromosoma · doi:10.1007/s00412-009-0236-2 · Cited by 18
Developmental Silencing of Human ζ-Globin Gene Expression Is Mediated by the Transcriptional Repressor RREB1
Chen, R.-L., Chou, Y., Lan, Y., Huang, T.-S., & Shen, C. ‐. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049130 · Cited by 18
Genetic and Epigenetic Mechanisms of β-Globin Gene Switching
Iarovaia, O. V., Kovina, A. P., Petrova, N. V., Razin, S. V., Ioudinkova, E. S., Vassetzky, Y. S., & Ulianov, S. V. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918040090 · Cited by 19
Haemoglobin and the Inherited Disorders of Globin Synthesis
Thein, S. L., & Rees, D. C. (2010) · Wiley eBooks · doi:10.1002/9781444323160.ch6 · Cited by 19
An Evolutionarily Conserved TNF-α–Responsive Enhancer in the Far Upstream Region of Human CCL2 Locus Influences Its Gene Expression
Bonello, G. B., Pham, M.-H., Begum, K., Sigala, J. A., Sataranatarajan, K., & Mummidi, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0900643 · Cited by 18
Chromosomal organization at the level of gene complexes
Chopra, V. S. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0585-2 · Cited by 16
Sickle cell disease caused by heterozygosity for Hb S and novel LCR deletion: Report of two patients
Koenig, S. C., Becirevic, E., Hellberg, M. S. C., Li, M. Y., So, J. C. C., Hankins, J. S., Ware, R. E., McMahon, L. C., Steinberg, M. H., Luo, H., et al. (2009) · American Journal of Hematology · doi:10.1002/ajh.21480 · Cited by 15
Adaptations to environmental change: Globin superfamily evolution in Antarctic fishes
Daane, J. M., Giordano, D., Coppola, D., di Prisco, G., Detrich, H. W., & Verde, C. (2019) · Marine Genomics · doi:10.1016/j.margen.2019.100724 · Cited by 11
Targeting HIF-1α in sickle cell disease and cancer: unraveling therapeutic opportunities and risks
Ubaid, S., Kashif, M., Laiq, Y., Nayak, A., Kumar, V., & Singh, V. K. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2367640 · Cited by 13
A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter
Yocum, A. O., Steiner, L. A., Seidel, N. E., Cline, A. P., Rout, E. D., Lin, J. Y., Wong, C., Garrett, L. J., Gallagher, P. G., & Bodine, D. M. (2012) · Blood · doi:10.1182/blood-2012-08-450262 · Cited by 11
Towards a genome-wide reconstruction of cis-regulatory networks in the human genome
Cecchini, K. R., Banerjee, A. R., & Kim, T. H. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.06.005 · Cited by 11
Transcriptional Repressors of Fetal Globin Genes as Novel Therapeutic Targets in Beta-Thalassemia
Martino, M. D., Sessa, R., Storino, M. R., Giuliano, M., Trombetti, S., Catapano, R., Bianco, A. L., Izzo, P., & Grosso, M. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90762 · Cited by 10
Tissue specific CTCF occupancy and boundary function at the human growth hormone locus
Tsai, Y., Cooke, N. E., & Liebhaber, S. A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku139 · Cited by 10
Concise Review: Advanced Cell Culture Models for Diamond Blackfan Anemia and Other Erythroid Disorders
Migliaccio, A. R., & Varricchio, L. (2017) · Stem Cells · doi:10.1002/stem.2735 · Cited by 9
Control of Vertebrate Hox Clusters by Remote and Global Cis-Acting Regulatory Sequences
Spitz, F. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5_4 · Cited by 9
Globin vector regulatory elements are active in early hematopoietic progenitor cells
Cabriolu, A., Odak, A., Zamparo, L., Yuan, H., Leslie, C. S., & Sadelain, M. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.028 · Cited by 9
Keys to Open Chromatin for Transcription Activation: FACT and Asf1
Krebs, A. R., & Tora, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.004 · Cited by 8
The inactivation of the π gene in chicken erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the α-globin gene domain into a repressive heterochromatin-like structure
Ioudinkova, E. S., Ulianov, S. V., Bunina, D., Iarovaia, O. V., Gavrilov, A. A., & Razin, S. V. (2011) · Epigenetics · doi:10.4161/epi.6.12.18215 · Cited by 8
Transcriptome Analyses of β-Thalassemia −28(A>G) Mutation Using Isogenic Cell Models Generated by CRISPR/Cas9 and Asymmetric Single-Stranded Oligodeoxynucleotides (assODNs)
Li, J., Zhou, Z., Sun, H., Ouyang, W., Dong, G., Liu, T., Ge, L., Zhang, X., Liu, C., & Gu, Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.577053 · Cited by 7
Integrated Gene Regulatory Circuits: Celebrating the 50th Anniversary of the Operon Model
Tajbakhsh, S., Cavalli, G., & Richet, E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.003 · Cited by 8
Transcriptional Regulation in Plants
Macrae, R. K., & Long, J. A. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0023755 · Cited by 8
A Novel Deletion/Insertion Caused by a Replication Error in the β-Globin Gene Locus Control Region
Joly, P., Lacan, P., Garcia, C., Meley, R., Pondarré, C., & Francina, A. (2011) · Hemoglobin · doi:10.3109/03630269.2011.571331 · Cited by 7
Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I
Manchinu, M. F., Simbula, M., Caria, C. A., Musu, E., Perseu, L., Porcu, S., Steri, M., Poddie, D., Frau, J., Cocco, E. E., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00163 · Cited by 6
Comparison of Two Known Chromosomal Rearrangements in the δβ-Globin Complex with Identical DNA Breakpoints but Causing Different Hb A2Levels
Saller, E., Moradkhani, K., Dutly, F., Vinatier, I., Préhu, C., Frischknecht, H., & Goossens, M. (2012) · Hemoglobin · doi:10.3109/03630269.2011.644651 · Cited by 5
Detection of Hb Anti-Lepore Hong Kong (NG_000007.3: g.63154_70565dup) in Chinese Individuals
Lou, J., He, Y., Liu, Y., Zhong, B., Zhao, Y. J., He, X., & Li, D. (2014) · Hemoglobin · doi:10.3109/03630269.2013.875477 · Cited by 5
Interaction between Erythropoiesis and Iron Metabolism in Human β-thalassemia - Recent Advances and New Therapeutic Approaches
Sposi, N. M. (2015) · InTech eBooks · doi:10.5772/61716 · Cited by 5
1kbp 5′ upstream sequence enables developmental stage-specific expressions of globin genes in the fish, medaka Oryzias latipes
Maruyama, K., Wang, B., Ishikawa, Y., Yasumasu, S., & Iuchi, I. (2011) · Gene · doi:10.1016/j.gene.2011.10.026 · Cited by 5
Hypermethylation of the gene LARP2 for noninvasive prenatal diagnosis of β-thalassemia based on DNA methylation profile
Gao, T., Nie, Y., & Guo, J. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1489-z · Cited by 5
Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress
Chauhan, W., & Zennadi, R. (2026) · Antioxidants · doi:10.3390/antiox15030324 · Cited by 5
Haemoglobin switching modulator SNPs rs5006884 is associated with increased HbA2 in β-thalassaemia carriers
Cyrus, C., Vatte, C., Chathoth, S., Sayed, A. A., Borgio, J. F., Alrubaish, M. A., Alfalah, R. M., Alsaikhan, J., & Al‐Ali, A. K. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.86705 · Cited by 4
Analyzing 5′HS3 and 5′HS4 LCR core regions and NF-E2 in Iranian thalassemia intermedia patients with normal or carrier status for beta-globin mutations
Neishabury, M., Azarkeivan, A., Oberkanins, C., Abedini, S. S., Zamani, S., & Najmabadi, H. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.12.007 · Cited by 3
Chromosomal Distribution of Disease Genes in the Human Genome
Cooper, D. N., Ball, E. V., & Mort, M. E. (2010) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2010.0081 · Cited by 3
Synergistic insulation of regulatory domains by developmental genes and clusters of CTCF sitesPreprint
Ealo, T., Sánchez-Gaya, V., Respuela, P., Martín, M. M., Martín-Batista, E., Haro, E., & Rada-Iglesias, Á. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.15.571760 · Cited by 3
Modulation of the Murine CD8 Gene Complex Following the Targeted Integration of Human CD2-Locus Control Region Sequences
Menzel, U., Kosteas, T., Tolaini, M., Killeen, N. P., Roderick, K., & Kioussis, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100709 · Cited by 2

Authors: Palstra, R., de Laat, W., & Grosveld, F.
Affiliations: Erasmus MC (NL)
ORCID: Palstra, Robert‐Jan
Grosveld, Frank
Venue: Advances in genetics
Publisher: Elsevier
Published: 2008
Volume: 61
Pages: 107-142
ISSN: 0065-2660 (ISSN-L)
DOI: 10.1016/s0065-2660(07)00004-1
OpenAlex: W1564263074
Cited by: 131
References: 180
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 15
FWCI: 23.68
Type: book chapter
Language: en
Open access: closed
Locations: Advances in genetics (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: beta-globin locus, locus control region, chromatin looping, cis-regulatory elements, transcriptional regulation, gene expression regulation
MeSH terms: Animals, Chromatin, Epistasis, Genetic, Gene Expression Regulation, Globins, Humans, Models, Biological, Promoter Regions, Genetic, Transcription, Genetic, Locus Control Region, Gene Order

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chapter 4 β‐Globin Regulation and Long‐Range Interactions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks