Mapping neuroreceptors at work: on the definition and interpretation of binding potentials after 20 years of progress
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[11C]Raclopride measures are influenced by extracellular DA, so decreased binding could reflect low D2/D3 receptor levels or increased DA release.
“[ 11 C]Raclopride measures are influenced by extracellular DA, so decreased binding could reflect low D2/D3 receptor levels or increased DA release 32 .”
From Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway (2011) · cites this paper as [32]
We were not able to assess whether dynamics such as receptor internalization or changes in the affinity of D2/D3 receptors for dopamine and/or fallypride were implicated.
“Consequently, we were not able to assess whether dynamics such as receptor internalization (Laruelle, 2000) or changes in the affinity of D2/D3 receptors for dopamine and/or fallypride were implicated (Laruelle, 2000; Gjedde et al., 2005).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Gjedde et al., 2005
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“[(11)C]Raclopridemeasuresare influenced byextracellulardopamine(thehigherthe extracellulardopamine, theless thebindingof[(11)C]raclopridetoD2/D3 receptors), andthus low-bindingpotential couldreflectlowD2/D3receptorlevelsorincreased dopamine release.(54) However, the latter is unlikely since we had previously reported…”
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- Authors
- Gjedde, A., Wong, D. F., Rosa-Neto, P., & Cumming, P.
- Affiliations
- Johns Hopkins University (US)
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2005
- Volume
- 63
- Pages
- 1-20
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W1493538977
- Cited by
- 50
- References
- 22
- Citations by year
- 2022: 4 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 16.64
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- binding potential, positron emission tomography, radioligands, radiolabeled substrates, neurotransmission
- MeSH terms
- Animals, Brain, Humans, Ligands, Radioligand Assay, Sensory Receptor Cells, Imaging, Three-Dimensional
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