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Cited by 43Circadian rhythm and melatoninSleep and Wakefulness ResearchHypothalamic control of reproductive hormones

Chapter 9 Pre-natal development of a hypothalamic biological clock

Reppert, Steven M.·1992·Progress in Brain Research
DOI 10.1016/s0079-6123(08)64568-9
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Abstract

The available evidence indicates that a biological clock oscillates in the mammalian fetus and that the fetal clock is entrained by redundant circadian signals from the mother. An entrainable biological clock during fetal life helps the developing mammal more readily prepare for life in the outside world. In humans, the early establishment of maternal-infant synchrony may help the infant maximize its responsiveness to the outside world.

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Crossref · 10.1016/s0079-6123(08)64568-9

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53 of 53 references verified0 citation errors · 0 not checkable

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  • In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus.

    “In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN26–28, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus29,30.”

    From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [26]

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Authors
Reppert, S. M.
Affiliations
Harvard University (US)
Corresponding author
Reppert, Steven M.
ORCID
Reppert, Steven M.
Venue
Progress in Brain Research
Publisher
Elsevier
Published
1992
Volume
93
Pages
119-132
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/s0079-6123(08)64568-9
OpenAlex
W2198479210
Cited by
43
References
54
Citations by year
2026: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2016: 3 · 2012: 1
FWCI
2.35
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
biological clock, circadian rhythm, fetal development, hypothalamus, entrainment, infant development
MeSH terms
Animals, Circadian Rhythm, Female, Embryonic and Fetal Development, Gestational Age, Hormones, Humans, Hypothalamus, Pregnancy

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