Chapter 1 Folate‐Mediated One‐Carbon Metabolism

Homocysteine and Cardiovascular Disease

Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., & Rozen, R. R. (1996) · Circulation · doi:10.1161/01.cir.93.1.7 · Cited by 1,380

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3290 · Cited by 1,139

Folate and Carcinogenesis: An Integrated Scheme

Choi, S., & Mason, J. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.129 · Cited by 954

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

Klerk, M., Verhoef, P., Clarke, R., Blom, H. J., Kok, F. J., & Schouten, E. G. (2002) · JAMA · doi:10.1001/jama.288.16.2023 · Cited by 932

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

van der Put, N. M. J., Trijbels, F. J. M., van den Heuvel, L. P., Blom, H. J., Steegers‐Theunissen, R. P. M., Eskes, T. K. A. B., Mariman, E. C. M., den Heyer, M., Frosst, P. D., & Rozen, R. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91743-8 · Cited by 862

THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

Carreras, C. W., & Santi, D. V. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003445 · Cited by 789

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Ma, J., Stampfer, M. J., Giovannucci, E. L., Artigas, C., Hunter, D. J., Fuchs, C. S., Willett, W. C., Selhub, J., Hennekens, C. H., & Rozen, R. R. (1997) · PubMed · Cited by 774

DNA methylation: The nuts and bolts of repression

Miranda, T. B., & Jones, P. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21224 · Cited by 701

Identifying the Safe and Adequate Folic Acid Intake Range Using Biomarkers in 2 Mouse Models

Munezero, E., Hopperton, K. E., Behan, N. A., Matias, F. M. G., Gaudet, J., Wang, G. S., Field, M. S., & MacFarlane, A. J. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.10.042 · Cited by 4

Effect of Low Dietary Folate on Mouse Spermatogenesis and Spindle Assembly Checkpoint Dysfunction May Contribute to Folate Deficiency-Induced Chromosomal Instability in Cultured Mouse Spermatogonia

Ren, H., Wang, K., Liu, Z., Zhong, X., Liang, M., & Liao, Y. (2023) · DNA and Cell Biology · doi:10.1089/dna.2023.0035 · Cited by 4

Dynamic evolution of the mTHF gene family associated with primary metabolism across life

Rork, A. M., Bala, A. S., & Renner, T. (2024) · BMC Genomics · doi:10.1186/s12864-024-10159-8 · Cited by 4

Folate-Mediated One-Carbon Metabolism in the Crustacean Copepod Calanus finmarchicus: Identification of Transcripts and Relative Expression across Development

Ascione, D., Carotenuto, Y., Lauritano, C., & Roncalli, V. (2024) · Journal of Marine Science and Engineering · doi:10.3390/jmse12050786 · Cited by 4

Integrated transcriptomic and proteomic analysis identified key folate biosynthesis gene in waxy maize

Jiao, Y., Shi, Y., Dong, H., Pan, Y., Liu, H., Li, Z., Wang, X., Li, C., Wang, T., Wang, S., et al. (2025) · The Crop Journal · doi:10.1016/j.cj.2025.02.008 · Cited by 4

Epigenetic Epidemiology of Type 1 Diabetes

MacFarlane, A. J. (2011) · Springer eBooks · doi:10.1007/978-94-007-2495-2_19 · Cited by 4

Whole blood propionylcarnitine in newborns with orofacial cleft

Hozyasz, K. K., Ołtarzewski, M., Lugowska, I. A., Szymanski, M., & Surowiec, Z. (2010) · Maternal and Child Nutrition · doi:10.1111/j.1740-8709.2010.00240.x · Cited by 4

Quantitation of Whole-Blood Total Folate within Defined MTHFR C677T Genotype Groups by Isotope Dilution–Liquid Chromatography–Tandem Mass Spectrometry Differs from Microbiologic Assay3

Stamm, R. A., Harper, M. J., & Houghton, L. A. (2012) · Journal of Nutrition · doi:10.3945/jn.112.165035 · Cited by 4

Synthesis and physicochemical characterization of the one-carbon carrier 10-formyltetrahydrofolate; a reference standard for metabolomics

Lewin, A. H., Silinski, P., Hayes, J. P., Gilbert, A., Mascarella, S. W., & Seltzman, H. H. (2017) · Metabolomics · doi:10.1007/s11306-017-1256-1 · Cited by 4

Ischemia from Retinal Vascular Hypertension in Normal Tension Glaucoma: Neuroprotective Role of Folate

Ayoub, G. (2023) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2023.20.002786 · Cited by 4

Atlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Williams, J., Kim, W. S., Danner, R., Cho, J., Silva, B. F., Harris, D. A., Rey, F. E., & Chaudhari, S. N. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01489-w · Cited by 4

One-carbon metabolic enzymes are regulated during cell division and make distinct contributions to the metabolome and cell cycle progression in Saccharomyces cerevisiae

Hammer, S. E., & Polymenis, M. (2023) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkad005 · Cited by 3

Exome sequencing identified novel variants in three Chinese patients with 5,10-methenyltetrahydrofolate synthetase deficiency

Xu, X., Zhu, J., Fang, L., Zou, Z., Yuan, J., Peng, M., Yu, G., Wu, D., Liu, Y., & Tang, J. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1236849 · Cited by 3

NMR-Based Structural Insights on Folic Acid and Its Interactions with Copper(II) Ions

Kola, A., & Valensin, D. (2024) · Inorganics · doi:10.3390/inorganics12090248 · Cited by 3

Folates, bacteria and ageing: insights from the model organism C. elegans in the study of nutrition and ageing

Weinkove, D. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124004890 · Cited by 3

Folic acid supplementation on congenital heart disease and its dual character

Wang, Y., Cheng, Z., He, M., Gu, R., & Gu, H. F. (2025) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2025.100222 · Cited by 5

Ecological risks under combined pollution: Toxicological effects of clothianidin and microplastics on Penaeus vannamei

Luo, Z., Lin, Z., Li, Z.-F., Fu, Z.-Q., Han, F.-L., & Li, E. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107417 · Cited by 3

Primary Metabolism co-Opted for Defensive Chemical Production in the Carabid Beetle, Harpalus pensylvanicus

Rork, A. M., Xu, S., Attygalle, A. B., & Renner, T. (2021) · Journal of Chemical Ecology · doi:10.1007/s10886-021-01253-2 · Cited by 3

The Differential Translation Capabilities of the Human DHFR2 Gene Indicates a Developmental and Tissue-Specific Endogenous Protein of Low Abundance

Bookey, N., Drago, P., Leung, K., Hughes, L., MacCooey, A., Ozaki, M., Henry, M. A., de Castro, S. C., Doykov, I., Heywood, W., et al. (2024) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2024.100718 · Cited by 3

Diet, DNA methylation, and cardiovascular disease

Liu, Y.-W., Westerman, K. E., Ordovás, J. M., & Lai, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18979-1.00009-5 · Cited by 3

Vitamins and dietary supplements in cancer treatment: is there a need for increased usage?

Esposito, T., Pentimalli, F., Giordano, A., & Cortellino, S. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2501077 · Cited by 4

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, B. R., & Ganapathy, V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00035-6 · Cited by 3

Maternal Nutrition and Epigenetic Perturbation: Modeling Trends to Translation

Oakes, J., & Ideraabdullah, F. (2013) · Current Pediatrics Reports · doi:10.1007/s40124-013-0025-5 · Cited by 3

Reproductive technologies for the future: a role for epigenetics

Walker, C. G., & Mitchell, M. D. (2013) · Animal Production Science · doi:10.1071/an12267 · Cited by 3

Tetrahydrofolate increases suspension growth of dihydrofolate reductase‐deficient chinese hamster ovary DG44 cells in chemically defined media

Kim, B. G., & Park, H. W. (2016) · Biotechnology Progress · doi:10.1002/btpr.2351 · Cited by 3

Molecular basis of bacterial formaldehyde sensing

Law, J. (2012) · Research Explorer (The University of Manchester) · Cited by 3

Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactionsPreprint

Romoli, O., Schönbeck, J. C., Hapfelmeier, S., & Gendrin, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.31.891671 · Cited by 3

Metabolic Reprogramming As a Prostate Cancer Hallmark

Zeković, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-51712-9_6 · Cited by 2

Additive CHARMM Force Field for Pterins and Folates

Balduzzi, E., Yin, W., Lambry, J., Myllykallio, H., & Aleksandrov, A. V. (2024) · Journal of Computational Chemistry · doi:10.1002/jcc.27548 · Cited by 2

The apicoplast transportome of the malaria parasite

Akkerman, L. J., Kooij, T. W. A., & de Vries, L. E. (2025) · Trends in Parasitology · doi:10.1016/j.pt.2025.06.011 · Cited by 2

Prevalent low Mediterranean diet adherence and low folate status in a Spanish Km 0 Mediterranean coast population

Eigbefoh-Addeh, A., Salas‐Huetos, A., Ramos-Rodríguez, C., Ceruelo, S., Ríos, L., Ueland, P. M., Meyer, K., Fernandez-Ballart, J. D., & Murphy, M. M. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.101217 · Cited by 2

Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study

Eigbefoh-Addeh, A., Salas‐Huetos, A., Ramos-Rodríguez, C., Santos-Calderón, L. A., Agarwal, R., Salas‐Salvadó, J., Babió, N., McCann, A., Ueland, P. M., & Murphy, M. M. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101385 · Cited by 2

From Embryo to Adult: One Carbon Metabolism in Stem Cells

Altundag‐Erdogan, Ö., & Çelebi‐Saltik, B. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200712191308 · Cited by 2

Carboxypeptidase G and pterin deaminase metabolic pathways degrade folic acid in Variovorax sp. F1

You, Y., Doi, Y., Maeda, N., Masuo, S., Takeshita, N., & Takaya, N. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02643-6 · Cited by 2

Does folate deficiency alter sperm parameters in infertile males?

Alamdari, S. S., Derakhshan, M., Derakhshan, M., & Mahzouni, P. (2023) · Immunopathologia Persa · doi:10.34172/ipp.2023.39480 · Cited by 2

Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevityPreprint

Maitra, N., He, C. Z., Blank, H. M., Tsuchiya, M., Schilling, B., Kaeberlein, M. R., Aramayo, R., Kennedy, B. K., & Polymenis, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.05.935726 · Cited by 2

Antioxidants and Male Infertility

Cutini, M., Bruno, C., Mancini, A., & Balercia, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-32300-4_43 · Cited by 1

RNA-Seq-Based Transcriptome Analysis of Chinese Cordyceps Aqueous Extracts Protective Effect against Adriamycin-Induced mpc5 Cell Injury

Long, H., Liu, M., Rao, Z., Guan, S., Chen, X., Huang, X., Cao, L., & Han, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910352 · Cited by 1

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

Rork, A. M., Xu, S., Attygalle, A. B., & Renner, T. (2025) · Insect Molecular Biology · doi:10.1111/imb.12984 · Cited by 1

Construction of a Cofactor Self-Sufficient Enzyme Cascade System Coupled with Microenvironmental Engineering for Efficient Biosynthesis of Tetrahydrofolate and Its Derivative of L-5-Methyltetrahydrofolate

Yan, Z., Qin, L., Qin, R., Wang, X., & Chen, K. (2025) · Catalysts · doi:10.3390/catal15030235 · Cited by 1

Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions

Pan, M., & O’Flaherty, C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104482 · Cited by 1

Retinal Biomarkers of Folate and Vitamin B12 Metabolic Dysfunction: A Framework for Machine Learning-Assisted Detection of Cerebral Folate Deficiency

Ayoub, G., & Brown, C. J. (2026) · Cells · doi:10.3390/cells15161453 · Cited by 1

Handling and Analysis of 5-Formyl-, 5,10-Methenyl-, 10-Formyl-, 5-Formimno-, and 5,10-Methylenetetrahydrofolates

Lewin, A. H., & Silinski, P. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9488-5_8 · Cited by 1

NMR‐based metabolomic investigation of dogs with acute flaccid paralysis due to tick paralysis

Gülersoy, E., Balıkçı, C., Şahan, A., Günal, İ., & Atlı, M. O. (2024) · Veterinary Medicine and Science · doi:10.1002/vms3.1528 · Cited by 1

Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Group

d’Annunzio, G., Accogli, A., Tallone, R., Bolloli, S., & Lorini, R. (2013) · InTech eBooks · doi:10.5772/53267 · Cited by 2

Nutritional modulation of the transcriptome in adipose, liver, and polymorphonuclear leukocytes in peripartal dairy cows

Agrawal, A. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1

Molecular recognition, selective targeting, and overcoming gastrointestinal digestion by folic acid–functionalized oral delivery systems in colon cancer

Borah, P. K., & Duary, R. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819363-1.00014-4 · Cited by 1

A low-cost mass spectrometry-based approach for quantifying purines in placental explants

Rodriguez, R., Konovets, I. M., Ralchenko, S., Kharkhota, M. А., Kostyuk, A., Kosach, V., Voronina, I., Filimonova, N. B., & Obolenskaya, M. Y. (2020) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2020.116490 · Cited by 1

Relação do hábito alimentar e polimorfismos da MTHFR C677T com a instabilidade genômica em fumicultores gaúchos

Fernandes, S. P. (2012) · Americanae (AECID Library) · Cited by 1

COMBATING β-CATENIN DRIVEN HEPATOCELLULAR CARCINOMA

Delgado, E. R. (2014) · D-Scholarship@Pitt (University of Pittsburgh)

Exercise prevents hyperhomocysteinemia in a folate-deficient mouse model

Neuman, J. C. (2010) · doi:10.31274/etd-180810-484

EFEITOS DA CLONAGEM NA INATIVAÇÃO DO CROMOSSOMO X E DA REGULAÇÃO NUTRICIONAL DO METABOLISMO DA METIONINA NA QUALIDADE OVOCITÁRIA EM BOVINOS

Ferreira, A. R. (2013) · Americanae (AECID Library)

Chronic arsenic exposure: mitigation with nutritional interventions and effects on inflammation and renal function

Peters, B. A. (2015) · doi:10.7916/d8bp01z0

Serine Hydroxymethyltransferase Anchorsde Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA

Anderson, D. D., Woeller, C. F., Chiang, E. I., Shane, B., & Stover, P. J. (2012)

Molecular Genetics of Hereditary Folate Malabsorption

Watkins, D. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0024325

A Novel Molecular Mechanistic Hypothesis to Validate the Therapeutic Effects of Tribulus terrestris (Gokshur) to Ameliorate Pathophysiology and Improve Pregnancy and Fetal Outcome in Preeclampsia

Deshpande, M. (2014) · Gynecology & Obstetrics · doi:10.4172/2161-0932.1000195

Einfluss der Homocystein-, Folsäure- und Vitamin B12- Konzentration im Serum und in der Follikelflüssigkeit bei Patientinnen mit kontrollierter ovarieller Hyperstimulation auf das ICSI-Ergebnis

Solomayer, E. (2013)

Universidade Federal do Rio Grande do Sul Programa de Pós Graduação em Genética e Biologia Molecular

Giongo, A. (2007)

Kultivierung von Caenorhabditis elegans über Flüssigmedium zur Untersuchung des molekularen Folsäuremetabolismus

der Diplomarbeit, T. (2009)

Folic Acid and Pathogenesis of Cardiovascular Disease

House, J. D., Jing, M.-Y., Hwang, S., & Karmin, O. (2012) · CRC Press eBooks · doi:10.1201/b11562-6

Genetic or nutritional disturbances in folate‐related pathways and epigenetic interactions

Leclerc, D., & Rozen, R. R. (2017) · Wiley eBooks · doi:10.1002/9781119101277.ch2

The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]pyrimidine Antifolates"

Mitchell-Ryan, S. K. (2015) · Human Biology

A High Multivitamin Diet Fed To Wistar Rat Dams During Pregnancy Increases Later Life Maternal Weight Gain and Alters Homeostatic, Hedonic and Peripheral Regulatory Systems of Energy Balance.

Pannia, E. (2014) · TSpace (University of Toronto)

Women and Reproduction: An Exploration of Factors Affecting Folate Status and Other Select Micronutrients Involved in One Carbon Metabolism

Hartman, B. (2015) · TSpace (University of Toronto)

Early Environmental and Epigenetic Influences on Respiratory Health

deDekker, H. T. (2017)

An evaluation of the accuracy of the folate microbiologic assay and comparison with liquid chromatography-tandem mass spectrometry

Stamm, R. A. (2012) · Otago University Research Archive (University of Otago)

Development of a Pediatric Model of Nafld in Neonatal Iberian Pigs

Hernandez, G. V. (2019) · DigitalCommons - CalPoly (California State Polytechnic University) · doi:10.15368/theses.2019.107

Methionine synthase supports tumor tetrahydrofolate poolsPreprint

Wang, J. Z., Ghergurovich, J. M., Yang, L., & Rabinowitz, J. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.05.284521

Enhancing Folic Acid Dietary Intervention Research in Mouse Models

Munezero, E. (2021) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2021-14593

Effects of Guava (Psidium Guajava L.) Leaf Extract on Growth Performance and Metabolomics in Weaned Piglets Challenged by Escherichia ColiPreprint

Wang, D., Zhou, L., Zhou, H., & Hou, G. (2021) · Research Square · doi:10.21203/rs.3.rs-148723/v1

Circadian Signatures in Rat Liver: From Gene Expression to Pathways

Ovacik, M., Sukumaran, S., Almon, R. R., DuBois, D. C., Jusko, W. J., & Androulakis, I. P. (2014) · Apple Academic Press eBooks · doi:10.1201/b17253-4

Metabolic reprogramming by folate restriction leads to a less aggressive cancer phenotype

Ashkavand, Z., O'Flanagan, C., Hennig, M., Du, X., Hursting, S., & Krupenko, S. A. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0317-t

The Roles of SUMO in Metabolic Regulation

Anderson, D. D., & Stover, P. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-2649-1_8

Vitamins | Folate and Vitamin B12 Function

Shane, B. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-819460-7.00640-x

Genetic Polymorphism in Homocysteine Metabolism

Ojha, R. P., Dubey, G. P., Shahi, U. P., Mishra, V. N., Jain, D., & Upadhyay, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-6867-8_7

Metabolic mapping of high-fit and low-fit individuals for human physiological health

Janssen, J. J. E. (2022) · doi:10.18174/573397

Metabolomic Profiling of Red Blood Cells to Identify Molecular Markers of Methotrexate Response in the Collagen Induced Arthritis Mouse Model

Salamoun, Y. M., Polireddy, K., Cho, Y. K., & Funk, R. S. (2022) · Future Pharmacology · doi:10.3390/futurepharmacol2040038

DEFICIENCY AND TOXICITY OF VITAMINS

MIHĂESCU, V.-M., Dascălu, R.-I., Andra Ioana, N. U. T. A., & GROSU, L.-B. (2023) · Annals of the Academy of Romanian Scientists Series of Medicine · doi:10.56082/annalsarscimed.2023.1.38

Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in micePreprint

Blank, H. M., Hammer, S. E., Boatright, L., Roberts, C., Heyden, K. E., Nagarajan, A., Tsuchiya, M., Marcel Brun, A., Johnson, C. D., Stover, P. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.12.575290

Vitamins: cobalamin and folate

Watkins, D., Manoli, I., Venditti, C. P., & Rosenblatt, D. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19176-3.00060-1

Clinical implications of 10-formyltetrahydrofolate dehydrogenase expression in hormone receptor-positive breast cancer

Ryu, H., Kim, D. S., Abdellatef, A. A., Nikas, I. P., & Krupenko, S. A. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1838093

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes

Ong, H. B., Wyllie, S., & Fairlamb, A. H. (2025) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0013332

Binge drinking as a potential cardiometabolic risk factor during adolescence in rats: novel protective antinitrosative mechanism of folic acid via caveolin-1

Gallego‐López, M. D. C., Nogales, F., Herrera, I. R., Carreras, O., & Ojeda, M. L. (2025) · Hypertension Research · doi:10.1038/s41440-025-02455-x

The relationship of dietary folate, folic acid, and childhood cancer

Xiang, Y., Wiemels, J. L., & Nickels, E. M. (2025) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2025.101820

Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive DisorderPreprint

Maes, M. H. J., Almulla, A. F., Vasupanrajit, A., Jirakran, K., Tunvirachaisakul, C., Maes, A., Chanchaem, P., Klomkliew, P., Payungporn, S., & Zhang, Y. (2025) · medRxiv · doi:10.64898/2025.12.10.25342027

Serine Hydroxymethyltransferase in Cancer Cells

Гаврилюк, Л. А. (2025) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750824601371

The role of abnormal amino acid metabolism in the occurrence and development of tumors

Zhang, Y., & Chen, H. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1759991

FgGCV1, a glycine cleavage system T protein, regulates glycine metabolism and sexual reproduction in Fusarium graminearum

Wang, J., Yang, L., Bai, E., Ruan, B., Chen, F., Zhang, Y., Wu, L., & Yu, Y. (2026) · Frontiers in Plant Science · doi:10.3389/fpls.2026.1771151

Association Between Folic Acid Use and Serum One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women

Kubo, Y., Fukuoka, H., Shoji, K., Mori, C., Sakurai, K., Yamamoto, M., Nishikawa, M., Oshida, K., & Kawabata, T. (2026) · Metabolites · doi:10.3390/metabo16040215

Tumor suppressor function of SHMT in a Drosophila RasV12DlgRNAi model: DNA damage and synergistic gene-nutrient interaction with PLP

Angioli, C., Ferriero, A., Pilesi, E., Tesoriere, G., Agostini, B., Tramonti, A., Contestabile, R., & Vernı̀, F. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08602-7

La résistance du colza à la hernie peut-elle être modulée par la fertilisation azotée ?

Aigu, Y. (2017) · doi:10.70675/c8818383z3dfdz4208zb25cz9f89501e8de8

Maternal Betaine and Methylation Potential during Pregnancy Are Associated with Child Growth at Birth and Early Childhood: Results of the Chilean Maternal & Infant Cohort Study-II

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Tetrodotoxin (TTX) reshapes the functional potential of the gut microbiome in juvenile tiger pufferfish (Takifugu rubripes) across salinity gradients

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Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons

Gu, J., Fan, C., Xiang, S., Yang, L., Liu, J., Si, Y., Zhu, B., Sun, Y., Ding, C., Cao, S., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014335

Oxidative stress induces nucleus pulposus cell senescence and metabolic substrate depletion-driven reprogramming: a multi-omics study

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Compound Enzyme Supplementation Improves Intestinal Health, Immunity, and Antioxidant Capacity in Pigeons via Gut Microbiota and Metabolome Modulation

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Serine: From Metabolic Intermediate to Signaling Entity

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Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans

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Targeting the Selectivity Barrier in One-Carbon Metabolism: Rutaecarpine Preferentially Inhibits MTHFD2 over MTHFD1

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Integrated Transcriptomic and Metabolomic Analyses Reveal Acyl-CoA Dehydrogenase-Mediated Primordium Formation and Metabolite Synthesis in Cordyceps militaris

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The association-dissociation of formyltetrahydrofolate synthetase and its relation to monovalent cation activation of catalytic activity

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One-Carbon Metabolism in Health and Disease

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The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

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In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.

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Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes

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