Chapter 1 Folate‐Mediated One‐Carbon Metabolism

Homocysteine and Cardiovascular Disease

Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., & Rozen, R. R. (1996) · Circulation · doi:10.1161/01.cir.93.1.7 · Cited by 1,380

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3290 · Cited by 1,139

Folate and Carcinogenesis: An Integrated Scheme

Choi, S., & Mason, J. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.129 · Cited by 954

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

Klerk, M., Verhoef, P., Clarke, R., Blom, H. J., Kok, F. J., & Schouten, E. G. (2002) · JAMA · doi:10.1001/jama.288.16.2023 · Cited by 932

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

van der Put, N. M. J., Trijbels, F. J. M., van den Heuvel, L. P., Blom, H. J., Steegers‐Theunissen, R. P. M., Eskes, T. K. A. B., Mariman, E. C. M., den Heyer, M., Frosst, P. D., & Rozen, R. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91743-8 · Cited by 862

THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

Carreras, C. W., & Santi, D. V. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003445 · Cited by 789

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Ma, J., Stampfer, M. J., Giovannucci, E. L., Artigas, C., Hunter, D. J., Fuchs, C. S., Willett, W. C., Selhub, J., Hennekens, C. H., & Rozen, R. R. (1997) · PubMed · Cited by 774

DNA methylation: The nuts and bolts of repression

Miranda, T. B., & Jones, P. A. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21224 · Cited by 701

MRP 1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

Rijpma, S. R., van der Velden, M., Bilos, A., Jansen, R. S., Mahakena, S., Rüssel, F. G. M., Sauerwein, R. W., van de Wetering, K., & Koenderink, J. B. (2016) · FEBS Letters · doi:10.1002/1873-3468.12079 · Cited by 17

Evaluating LINE-1 Methylation in Cleft Lip Tissues and its Association with Early Pregnancy Exposures

Khan, M. F. J., Little, J., Mossey, P. A., Steegers‐Theunissen, R. P. M., Autelitano, L., Lombardo, I., Andreasi, R. B., & Rubini, M. (2017) · Epigenomics · doi:10.2217/epi-2017-0081 · Cited by 17

Folic acid-mediated mitochondrial activation for protection against oxidative stress in human dental pulp stem cells derived from deciduous teeth

Zhang, Y., Kato, H., Sato, H., Yamaza, H., Hirofuji, Y., Han, X., Masuda, K., & Nonaka, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.169 · Cited by 17

Phosphoserine Phosphatase Is Required for Serine and One-Carbon Unit Synthesis in Hydrogenobacter thermophilus

Kim, K., Chiba, Y., Kobayashi, A., Arai, H., & Ishii, M. (2017) · Journal of Bacteriology · doi:10.1128/jb.00409-17 · Cited by 14

Knowledge, attitude and practice of physicians regarding periconceptional folic acid for women at low risk of a neural tube defect affected pregnancy

Mida, L. A., Zazzera, V. D., & Fontaine‐Bisson, B. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101327 · Cited by 16

Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort

Alampi, J. D., Lanphear, B. P., MacFarlane, A. J., Oulhote, Y., Braun, J. M., Muckle, G., Arbuckle, T. E., Ashley‐Martin, J., Hu, J. M. Y., Chen, A., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14479 · Cited by 18

Folate Network Genetic Variation Predicts Cardiovascular Disease Risk in Non-Hispanic White Males

Wernimont, S. M., Clark, A. G., Stover, P. J., Wells, M. T., Litonjua, A. A., Weiss, S. T., Gaziano, J. M., Vokonas, P., Tucker, K. L., & Cassano, P. A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.157180 · Cited by 16

Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance

Matone, A., Scott‐Boyer, M., Carayol, J., Fazelzadeh, P., Lefebvre, G. C., Valsesia, A., Charon, C., Vervoort, J. J. M., Astrup, A. V., Saris, W. H. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150495 · Cited by 16

Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization

Krupenko, N. I., Holmes, R. S., Tsybovsky, Y., & Krupenko, S. A. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.12.022 · Cited by 16

Insights into the role of methionine synthase in the universal 13 C depletion in O - and N -methyl groups of natural products

Romek, K. M., Krzemińska, A., Remaud, G. S., Julien, M., Paneth, P., & Robins, R. J. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.10.012 · Cited by 16

Role of homocysteine metabolism in animal reproduction: A review

Rizzo, A., & Sciorsci, R. L. (2018) · Research in Veterinary Science · doi:10.1016/j.rvsc.2018.11.011 · Cited by 16

Mechanisms of genome instability from cellular folate stress

Mellor, C., Larson, E. A., & Wang, M. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202502205 · Cited by 17

The Role of Brain Barriers in Maintaining Brain Vitamin Levels

Tiani, K. A., Stover, P. J., & Field, M. S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124235 · Cited by 14

Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish

Tu, H.-C., Lin, M.-Y., Lin, C.-Y., Hsiao, T., Wen, Z., Chen, B., & Fu, T.-F. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109380 · Cited by 14

Neurodevelopment of Autism: Critical Periods, Stress and Nutrition

Ayoub, G. (2024) · Cells · doi:10.3390/cells13231968 · Cited by 14

Encyclopedia of bacterial gene circuits whose presence or absence correlate with pathogenicity – a large-scale system analysis of decoded bacterial genomes

Shestov, M., Ontañón, S., & Tözeren, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1957-7 · Cited by 14

Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells

Bae, S., Chon, J., Field, M. S., & Stover, P. J. (2017) · Journal of Nutrition · doi:10.3945/jn.116.244467 · Cited by 14

Evaluating sub-lethal stress from Roundup® exposure in Artemia franciscana using 1H NMR and GC–MS

Morgan, M. A., Griffith, C. M., Dinges, M. M., Lyon, Y. A., Julian, R. R., & Larive, C. K. (2019) · Aquatic Toxicology · doi:10.1016/j.aquatox.2019.04.023 · Cited by 14

Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways

Zaitsev, A. V., Martinov, M. V., Vitvitsky, V., & Атауллаханов, Ф. И. (2019) · Scientific Reports · doi:10.1038/s41598-019-44009-5 · Cited by 15

Methionine dependence in tumor cells: The potential role of cobalamin and MMACHC

Sorin, M., Watkins, D., Gilfix, B. M., & Rosenblatt, D. S. (2021) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2021.01.006 · Cited by 14

Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability

Higa, R., Rosario, F. J., Powell, T. L., Jansson, T., & Jawerbaum, A. (2021) · Reproduction · doi:10.1530/rep-20-0603 · Cited by 14

TMEFF2 modulates the AKT and ERK signaling pathways.

Chen, X., & Ruiz-Echevarría, M. J. (2013) · Europe PMC (PubMed Central) · Cited by 14

Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

García-Calderón, C. B., Bejarano-García, J. A., Tinoco-Gago, I., Castro, M. J., Moreno-Gordillo, P., Piruat, J. I., Caballero‐Velázquez, T., Pérez‐Simón, J. A., & Rosado, I. V. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0089-4 · Cited by 15

Expression Levels of the γ-Glutamyl Hydrolase I Gene Predict Vitamin B9 Content in Potato Tubers

Robinson, B. R., Salinas, C. G., Ramos‐Parra, P. A., Bamberg, J. B., de la Garza, R. I. D., & Goyer, A. (2019) · Agronomy · doi:10.3390/agronomy9110734 · Cited by 14

Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains

Lian, T., Wang, X., Li, S., Jiang, H., Zhang, C., Wang, H., & Jiang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031708 · Cited by 14

Association of development quotient with nutritional status of vitamins B6, B12, and folate in 6–59-month-old children: Results from the Brazilian National Survey on Child Nutrition (ENANI-2019)

de Freitas-Costa, N. C., Andrade, P. G., Normando, P., Salvatte, K., Raymundo, C. E., de Castro, I. R. R., Lacerda, E. M. D. A., Farias, D. R., & Kac, G. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.04.026 · Cited by 14

Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility

Jackson, R. A., Nguyen, M. L., Barrett, A. N., Tan, Y. Y., Choolani, M. A., & Chen, E. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2276-0 · Cited by 13

Methylation capacity in children with severe cerebral palsy

Schoendorfer, N. C., Obeid, R., Moxon‐Lester, L., Sharp, N., Vitetta, L., Boyd, R. N., & Davies, P. S. W. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02644.x · Cited by 13

Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women

Silva, N. N. T., Sabino, A. D. P., Tafuri, A., & Lima, A. A. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0831-x · Cited by 13

Metastable epialleles in humans

Derakhshan, M., Kessler, N. J., Hellenthal, G., & Silver, M. J. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.09.007 · Cited by 12

Nature's hydrides: rapid reduction of halocarbons by folate model compounds

Denk, M. K., Milutinović, N. S., Marczenko, K. M., Sadowski, N. M., & Paschos, A. (2016) · Chemical Science · doi:10.1039/c6sc04314c · Cited by 12

Reconstruction of amino acid biosynthetic pathways increases the productivity of 2-keto- l -gulonic acid in Ketogulonicigenium vulgare-Bacillus endophyticus consortium via genes screening

Pan, C., Wang, E., Jia, N., Dong, X., Liu, Y., Ding, M., & Yuan, Y. (2017) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-017-1928-x · Cited by 12

Functional elucidation of hypothetical proteins for their indispensable roles toward drug designing targets from Helicobacter pylori strain HPAG1

Singh, G., & Singh, V. (2017) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2017.1302361 · Cited by 12

Development of a Sensitive Chemiluminescence Immunoassay for the Quantification of Folic Acid in Human Serum

Chen, X., Zhou, Q., Zhang, T., Wang, C., Yu, Z., Ahamada, H., Bai, Z., & Huang, X. Y. (2019) · Journal of Analytical Methods in Chemistry · doi:10.1155/2019/5402903 · Cited by 12

Effect of processing on cereal folates

Boz, H. (2021) · Journal of Cereal Science · doi:10.1016/j.jcs.2021.103202 · Cited by 12

Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells

Moussa, C., Ross, N., Jolette, P., & MacFarlane, A. J. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002688 · Cited by 12

Measurement of Histone Methylation Dynamics by One-Carbon Metabolic Isotope Labeling and High-energy Collisional Dissociation Methylation Signature Ion Detection

Tang, H. R., Tian, B., Brasier, A. R., Sowers, L. C., & Zhang, K. (2016) · Scientific Reports · doi:10.1038/srep31537 · Cited by 12

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Coleman, M. F., O’Flanagan, C. H., Pfeil, A. J., Chen, X., Pearce, J. B., Sumner, S., Krupenko, S. A., & Hursting, S. D. (2021) · Nutrients · doi:10.3390/nu13051637 · Cited by 12

Polymorphisms in Serine Hydroxymethyltransferase 1 and Methylenetetrahydrofolate Reductase Interact to Increase Cardiovascular Disease Risk in Humans

Wernimont, S. M., Raiszadeh, F., Stover, P. J., Rimm, E. B., Hunter, D. J., Tang, W., & Cassano, P. A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.132506 · Cited by 12

Folate and Vitamin B12 Function

Shane, B. (2013) · Encyclopedia of Biological Chemistry · doi:10.1016/b978-0-12-378630-2.00039-6 · Cited by 12

Using logic programming for modeling the one-carbon metabolism network to study the impact of folate deficiency on methylation processes

Gnimpiéba, E. Z., Eveillard, D., Guéant, J., & Chango, A. (2011) · Molecular BioSystems · doi:10.1039/c1mb05102d · Cited by 11

NAC Pre-Administration Prevents Cardiac Mitochondrial Bioenergetics, Dynamics, Biogenesis, and Redox Alteration in Folic Acid-AKI-Induced Cardio-Renal Syndrome Type 3

Cuevas-López, B., Romero-Ramirez, E. I., García‐Arroyo, F. E., Tapia, E., León‐Contreras, J. C., Silva‐Palacios, A., Roldán, F., Medina‐Campos, O. N., Hernández‐Esquivel, L., Marín‐Hernández, Á., et al. (2023) · Antioxidants · doi:10.3390/antiox12081592 · Cited by 11

LINE‐1 methylation in cleft lip tissues: Influence of infant MTHFR c.677C>T genotype

Khan, M. F. J., Little, J., Aleotti, V., Mossey, P. A., Steegers‐Theunissen, R. P. M., Autelitano, L., Meazzini, M. C., Ravaei, A., & Rubini, M. (2019) · Oral Diseases · doi:10.1111/odi.13136 · Cited by 12

Maternal plasma folate concentration is positively associated with serum total cholesterol and low-density lipoprotein across the three trimesters of pregnancy

da Silva, M. T., Mujica-Coopman, M. F., Figueiredo, A. C. C., Hampel, D., Vieira, L. S., Farias, D. R., Shahab‐Ferdows, S., Allen, L. H., Alex Brito, O., Lamers, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77231-7 · Cited by 11

Endocrine Disruptor Exposure Causes Infochemical Dysregulation and an Ecological Cascade from Zooplankton to Algae

Jeong, T., & Simpson, M. J. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c07847 · Cited by 11

Approaches for the Identification of Genetic Modifiers of Nutrient Dependent Phenotypes: Examples from Folate

Zinck, J. W. R., & MacFarlane, A. J. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00008 · Cited by 11

Macromolecular Conjugate and Biological Carrier Approaches for the Targeted Delivery of Antibiotics

Tram, N. D. T., & Ee, P. L. R. (2017) · Antibiotics · doi:10.3390/antibiotics6030014 · Cited by 11

The cooperative interplay among inflammation, necroptosis and YAP pathway contributes to the folate deficiency-induced liver cells enlargement

Chi, W., Hsiao, T., Lee, G., Su, I.-H., Chen, B., Tang, M., & Fu, T.-F. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04425-9 · Cited by 10

Non-linear association between serum folate concentrations and dyslipidemia: Korea National Health and Nutrition Examination Survey 2016-2018

Jin, T., Park, E. Y., Kim, B., & Oh, J. (2022) · Epidemiology and Health · doi:10.4178/epih.e2022046 · Cited by 10

A narrative review on the role of folate-mediated one-carbon metabolism and its associated gene polymorphisms in posing risk to preeclampsia

Mahmood, S., Younas, H., Younus, A., & Nathaniel, S. (2021) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2021.1916942 · Cited by 10

Significant association of MTHFD1 1958G A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population

Murthy, J., Gurramkonda, V. B., & Bhaskar, L. V. (2014) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.19796 · Cited by 10

The Inescapable Effects of Ribosomes on In-Cell NMR Spectroscopy and the Implications for Regulation of Biological Activity

Burz, D. S., Breindel, L., & Shekhtman, A. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061297 · Cited by 10

Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model

Salamoun, Y. M., Polireddy, K., Cho, Y. K., Medcalf, M. R., & Funk, R. S. (2021) · Metabolites · doi:10.3390/metabo12010024 · Cited by 9

The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

Eadsforth, T. C., Cameron, S., & Hunter, W. N. (2011) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2011.11.004 · Cited by 9

Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice

Pjetri, E., & Zeisel, S. H. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.051 · Cited by 9

Effects of the Methyl Donors Supplementation on Hippocampal Oxidative Stress, Depression and Anxiety in Chronically High Fructose-treated Rats

Coulibaly, S. M., Mesfioui, A., Berkiks, I., Ennaciri, A., Chahirou, Y., Diagana, Y., Ouichou, A., Midaoui, A. E., & Hessni, A. E. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.008 · Cited by 9

In Utero One‐Carbon Metabolism Interplay and Metabolic Syndrome in Cardiovascular Disease Risk Reduction

Mabasa, L., Samodien, E., Sangweni, N. F., Pheiffer, C., Louw, J., & Johnson, R. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900377 · Cited by 9

A gene‐nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila

Pilesi, E., Angioli, C., Graziani, C., Parroni, A., Contestabile, R., Tramonti, A., & Vernı̀, F. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31033 · Cited by 8

Effects of Guava (Psidium guajava L.) Leaf Extract on the Metabolomics of Serum and Feces in Weaned Piglets Challenged by Escherichia coli

Wang, D., Zhou, L., Zhou, H., & Hou, G. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.656179 · Cited by 9

Serum metabolomic analysis of the dose-response effect of dietary choline in overweight male cats fed at maintenance energy requirements

Rankovic, A., Godfrey, H., Grant, C., Shoveller, A. K. K., Bakovic, M., Kirby, G. M., & Verbrugghe, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280734 · Cited by 8

Characteristic effects of methylglyoxal and its degraded product formate on viability of human histiocytes: A possible detoxification pathway of methylglyoxal

Koizumi, K., Nakayama, M., Zhu, W.-J., & Ito, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.041 · Cited by 8

One crisis, diverse impacts—Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae

Tu, H.-C., Lee, G., Hsiao, T., Kao, T.-T., Wang, T.-Y., Tsai, J., & Fu, T.-F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188585 · Cited by 8

Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization

Naglah, A. M., Refat, M. S. E.-D., Al-Omar, M. A., Bhat, M. A., Alkahtani, H. M., & Al‐Wasidi, A. S. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s190310 · Cited by 8

Mutation of mpv17 results in loss of iridophores due to mitochondrial dysfunction in tilapia

Xu, J., Li, P., Xu, M., Wang, C., Kocher, T. D., & Wang, D. (2024) · Journal of Heredity · doi:10.1093/jhered/esae034 · Cited by 8

Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion

Stark, M., Levin, M., Ulitsky, I., & Assaraf, Y. G. (2023) · BMC Biology · doi:10.1186/s12915-023-01525-1 · Cited by 7

Poly-γ-glutamylation of biomolecules

Bashiri, G., Bulloch, E. M. M., Bramley, W. R., Davidson, M., Stuteley, S. M., Young, P. G., Harris, P. W. R., Naqvi, M. S. H., Middleditch, M., Schmitz, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45632-1 · Cited by 7

Whole blood citrulline concentrations in newborns with non-syndromic oral clefts--a preliminary report.

Hozyasz, K. K., Ołtarzewski, M., & Lugowska, I. A. (2010) · PubMed · Cited by 7

Enzymatic and Mutational Analysis of the PruA Pteridine Reductase Required for Pterin-Dependent Control of Biofilm Formation in Agrobacterium tumefaciens

Labine, M., DePledge, L., Feirer, N., Greenwich, J. L., Fuqua, C., & Allen, K. D. (2020) · Journal of Bacteriology · doi:10.1128/jb.00098-20 · Cited by 6

One-Carbon Metabolism in Nepalese Infant–Mother Pairs and Child Cognition at 5 Years Old

Kvestad, I., McCann, A., Chandyo, R. K., Giil, L. M., Shrestha, M., Ulak, M., Hysing, M., Ueland, P. M., & Strand, T. A. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa403 · Cited by 7

Cancer Metabolism

Reid, M. A., Sanderson, S. M., & Locasale, J. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-47674-4.00009-8 · Cited by 9

Conformational Changes in the BSA-LT4 Complex Induced by the Presence of Vitamins: Spectroscopic Approach and Molecular Docking

Cazacu, N., Chilom, C. G., David, M., & Florescu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084215 · Cited by 7

Association between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and risk of ischemic stroke in North Indian population: A hospital based case–control study

Kumar, A., Misra, S., Hazarika, A., Kumar, P., Sagar, R., Pathak, A., Chakravarty, K., & Prasad, K. (2016) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2016.01.001 · Cited by 7

Excited State Electronic Structures of 5,10-Methenyltetrahydrofolate and 5,10-Methylenetetrahydrofolate Determined by Stark Spectroscopy

Pauszek, R. F., Kodali, G., & Stanley, R. J. (2014) · The Journal of Physical Chemistry A · doi:10.1021/jp501143u · Cited by 7

Phytochemicals With Antileishmanial Activity

Hazra, S. K., Ghosh, S., & Hazra, B. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63931-8.00008-4 · Cited by 7

Physical activity, body mass index and arsenic metabolism among Mexican women

Gamboa-Loira, B., Cebrián, M. E., & López‐Carrillo, L. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110869 · Cited by 7

Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms Modify the Associations of Plasma Glycine and Serine With Risk of Acute Myocardial Infarction in Patients With Stable Angina Pectoris in WENBIT (Western Norway B Vitamin Intervention Trial)

Ding, Y., Pedersen, E. R., Svingen, G. F. T., Helgeland, Ø., Gregory, J. F., Løland, K. H., Meyer, K., Tell, G. S., Ueland, P. M., & Nygard, O. K. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001483 · Cited by 7

Folate, Vitamin B12, and Vitamin B6

Stover, P. J. (2011) · doi:10.1002/9780470959824.ch12 · Cited by 7

Improved methyl supply for 5-methyltetrahydrofolate production in E. coli through a novel C1 transfer pathway

Liu, W., Guo, J., Lu, W. D., Cheng, T., Li, Y., Xian, M., & Zhang, R. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02707-y · Cited by 6

Folate from probiotic bacteria and its therapeutic applications

Megala, G., & Kavitha, M. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04327-x · Cited by 6

Scoping review of micronutrient imbalances, clinical manifestations, and interventions

English, K. J., Uwibambe, C., Daniels, P., & Dzukey, E. (2025) · World Journal of Methodology · doi:10.5662/wjm.v15.i4.107664 · Cited by 7

Folates: An Introduction

Shams, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102349 · Cited by 6

Genetics, vitamins, and Spaceflight Associated Neuro-Ocular Syndrome

Zwart, S. R., & Smith, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91524-3.00017-x · Cited by 6

Comprehensive Evaluation of (+)-Usnic Acid–induced Cardiotoxicity in Rats by Sequential Cross-omics Analysis

Yokouchi, Y., Imaoka, M., Niino, N., Kiyosawa, N., & Kai, K. (2017) · Toxicologic Pathology · doi:10.1177/0192623317707074 · Cited by 6

Gene expression levels of gamma-glutamyl hydrolase in tumor tissues may be a useful biomarker for the proper use of S-1 and tegafur-uracil/leucovorin in preoperative chemoradiotherapy for patients with rectal cancer

Sadahiro, S., Suzuki, T., Tanaka, A., Okada, K., Saito, G., Miyakita, H., Ogimi, T., & Nagase, H. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3295-8 · Cited by 6

DHFR2 RNA directly regulates dihydrofolate reductase and its expression level impacts folate one carbon metabolism

Drago, P., Bookey, N., Leung, K., Henry, M. A., Meleady, P., Greene, N. D. E., & Parle‐McDermott, A. (2025) · The FASEB Journal · doi:10.1096/fj.202401039rr · Cited by 5

GWAS of Folate Metabolism With Gene–environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study

Tsukamoto, M., Hishida, A., Tamura, T., Nagayoshi, M., Okada, R., Kubo, Y., Kato, Y., Hamajima, N., Nishida, Y., Shimanoe, C., et al. (2023) · Journal of Epidemiology · doi:10.2188/jea.je20220341 · Cited by 5

Quantification of S-adenosylmethionine and S-adenosylhomocysteine in human placenta and placental explants under homocysteine treatment

Rodriguez, R., Vakulenko, O., Ralchenko, S., Kostiuk, A., Porublyova, L., Konovets, I. M., Voronina, I., & Obolenskaya, M. Y. (2017) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2017.08.002 · Cited by 5

Chemoenzymatic Assembly of Isotopically Labeled Folates

Angelastro, A., Dawson, W., Luk, L. Y. P., Loveridge, E. J., & Allemann, R. K. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06358 · Cited by 5

Interaction Between Nutrition and Metabolism

Barrouin‐Melo, S. M., Morejón-Terán, Y. A., Anturaniemi, J., & Hielm-Björkman, A. K. (2018) · Experientia supplementum · doi:10.1007/978-3-319-74932-7_2 · Cited by 5

Molecular structure of a 5,10‐methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori

Haque, M. R., Higashiura, A., Nakagawa, A., Hirowatari, A., Furuya, S., & Yamamoto, K. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12595 · Cited by 5

Protective effect of folic acid on vulnerability to oxidative stress in dental pulp stem cells of deciduous teeth from children with orofacial clefts

Zhang, Y., Sun, X., Han, X., Sato, H., Hirofuji, Y., & Masuda, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.031 · Cited by 5

Mass spectrometric analysis of PTM dynamics using stable isotope labeled metabolic precursors in cell culture

van Pijkeren, A., Bischoff, R., & Kwiatkowski, M. (2019) · The Analyst · doi:10.1039/c9an01258c · Cited by 5

Folate contents in insects as promising food components quantified by stable isotope dilution

Weber, N., Kouřimská, L., Kulma, M., Petříčková, D., Seufert, F., & Rychlik, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.970255 · Cited by 5

Folate-responsive birth defects: of mice and womens

Shane, B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.029595 · Cited by 5

Bioavailability of vitamins C, B2 and B9 (Folate) in nutrition and health claims: a critical appraisal

Beltramo, B., Urlings, M. J. E., Padilla‐Díaz, C. M., Bast, A., Diliën, H., & de Boer, A. (2025) · Food Production Processing and Nutrition · doi:10.1186/s43014-025-00330-3 · Cited by 4

Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice

Blank, H. M., Hammer, S. E., Boatright, L., Roberts, C., Heyden, K. E., Nagarajan, A., Tsuchiya, M., Brun, M., Johnson, C. D., Stover, P. J., et al. (2024) · Life Science Alliance · doi:10.26508/lsa.202402868 · Cited by 5

Human organoids potentially boost research into environmental factors of neural tube defects

Li, H., Zhang, J., & Niswander, L. A. (2025) · Reproductive Toxicology · doi:10.1016/j.reprotox.2025.108936 · Cited by 4

Effects of Dietary Garlic Skin Based on Metabolomics Analysis in the Meat Quality of Black Goats

Zeng, W., & Shen, X. (2025) · Foods · doi:10.3390/foods14111911 · Cited by 4

Folic Acid Supplementation and Risk of Gestational Diabetes Mellitus: A Systematic Review of the Literature

Gómez‐Cabrera, A. S., Santiago, A. E. G., Castañeda‐Arellano, R., Corona-Meraz, F.-I., Baptista-Rosas, R. C., & Parada, M. G. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167977 · Cited by 6

The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision

Wang, Y., Labapuchi, L., Liu, M., & Chen, L. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.026 · Cited by 4

The association-dissociation of formyltetrahydrofolate synthetase and its relation to monovalent cation activation of catalytic activity

Scott, J. M., & Rabinowitz, J. C. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90473-1 · Cited by 40

One-Carbon Metabolism in Health and Disease

Ducker, G. S., & Rabinowitz, J. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.009 · Cited by 2,239

The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

Xiu, Y., & Field, M. S. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa153 · Cited by 75

In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.

Barlowe, C. K., & Appling, D. R. (1988) · PubMed · Cited by 110

Compartmentation of folate‐mediated one‐carbon metabolism in eukaryotes

Appling, D. R. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.12.1916088 · Cited by 350