Cited by 265Bladder and Urothelial Cancer TreatmentsPhotodynamic Therapy Research StudiesPorphyrin Metabolism and Disorders

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Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid

Kriegmair, M., Ehsan, A., Baumgartner, R., Lumper, W., Knuechel, R., Hofstädter, F., Steinbach, P., Hofstetter, A.·1994·Urology

DOI 10.1016/s0090-4295(94)80167-3

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Abstract

Objectives Tiny papillary tumors and flat urothelial lesions such as dysplasia or carcinoma in situ can easily be missed during routine cystoscopy. Various methods for in vivo detection of fluorescing agents (preferentially localized in malignant tissue) have been developed. Most of them are based on systemically administered synthetic porphyrin compounds and require sensitive detection devices and image processing units for fluorescence visualization. The usefulness of intracellularly accumulated endogenous protoporphyrin IX (PPIX), induced by 5-aminolevulinic acid (ALA), for diagnosis of early bladder cancer and the correlation with cystoscopic, microscopic, and fluorescence findings was investigated. Methods ALA was instilled intravesically in 68 patients, followed by fluorescence cystoscopy with violet light from a krypton ion laser that produced fluorescence excitation. There were 299 biopsies obtained from fluorescing and nonfluorescing areas of the bladder. Results ALA-induced fluorescence could be easily observed with the naked eye during cystoscopy under violet light illumination. All tumor lesions were sharply marked with brightly shining red fluorescence. Correlation of fluorescence and microscopic findings gave a sensitivity of 100% and a specificity of 68.5%. There were 26 malignant or precancerous lesions that were missed during routine cystoscopy but were detected only by ALA-induced fluorescence. Conclusions Labeling of urothelial lesions by PPIX fluorescence induced by intravesically instilled ALA seems to be a promising diagnostic procedure for malignant lesions that are difficult to visualize with standard cystoscopy.

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Heney, N. M., Ahmed, S., Flanagan, M. J., Frable, W. J., Corder, M. P., Hafermann, M. D., & Hawkins, I. R. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)51695-x · Cited by 922
Non-Invasive Papillary Carcinoma of the Bladder Associated with Carcinoma in Situ
Althausen, A. F., Prout, G. R., & Daly, J. J. (1976) · The Journal of Urology · doi:10.1016/s0022-5347(17)58916-8 · Cited by 445
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Wj, C., & Catàlona, W. J. (1992) · Cited by 373
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Kiemeney, L. A. L. M., Witjes, J. A., Heijbroek, R. P., Verbeek, A. L. M., & Debruyne, F. M. J. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35397-1 · Cited by 210
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Monnier, P., Savary, M., Fontolliet, C., Wagnières, G., Châtelain, A., Cornaz, P. F., Depeursinge, C., & van den Bergh, H. (1990) · Lasers in Medical Science · doi:10.1007/bf02031377 · Cited by 146
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Lam, S. C., Palcic, B., McLean, D. I., Hung, J. Y., Korbelik, M., & Profio, A. E. (1990) · CHEST Journal · doi:10.1378/chest.97.2.333 · Cited by 103
Prognostic Significance of Biopsy Results of Normal‐looking Mucosa in Cases of Superficial Bladder Cancer
Smith, G., Elton, R. A., BEYNON, L. L., NEWSAM, J. E., CHISHOLM, G. D., & Hargreave, T. B. (1983) · British Journal of Urology · doi:10.1111/j.1464-410x.1983.tb03400.x · Cited by 103

Show all 19 references

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Kriegmair, 1993, Fluorescence cystoscopy following intravesical instillation of aminolevulinic acid (ALA), J Urol, 149, 240A
Kriegmair, 1992, Intravesikale Instillation von Delta-Aminolävulinsaure (ALA)—Eine neue Methode zur photodynamischen Diagnostik and Therapie, Lasermedizin, 8, 83

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Muschter, R. (2003) · Current Urology Reports · doi:10.1007/s11934-003-0073-4 · Cited by 32
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Authors: Kriegmair, M., Ehsan, A., Baumgartner, R., Lumper, W., Knuechel, R., Hofstädter, F., Steinbach, P., & Hofstetter, A.
Affiliations: University of Regensburg (DE)
Venue: Urology
Publisher: Elsevier BV
Published: 1994-12
Volume: 44
Issue: 6
Pages: 836-841
ISSN: 0090-4295 (ISSN-L)
DOI: 10.1016/s0090-4295(94)80167-3
OpenAlex: W2034798789
Cited by: 265
References: 19
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 11 · 2014: 4 · 2013: 10 · 2012: 8
FWCI: 12.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Urology (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Bladder and Urothelial Cancer Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords: 5-aminolevulinic acid, fluorescence cystoscopy, protoporphyrin IX, urothelial tumors, bladder cancer, carcinoma in situ, dysplasia, intravesical instillation, early cancer detection, sensitivity and specificity
MeSH terms: Administration, Intravesical, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Urinary Bladder, Urinary Bladder Neoplasms, Cystoscopy, Female, Fluorescence, Humans, Male, Middle Aged, Predictive Value of Tests, Protoporphyrins, Sensitivity and Specificity

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Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid

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