Cited by 295Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 343 of the 343 references it cites were found in a registry or an index.

The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy

Russell, John A, Leng, Gareth, Douglas, Alison J·2003·Frontiers in Neuroendocrinology

DOI 10.1016/s0091-3022(02)00104-8

Open this paper in CoChat — free account

Abstract

Oxytocin secretion from the posterior pituitary gland is increased during parturition, stimulated by the uterine contractions that forcefully expel the fetuses. Since oxytocin stimulates further contractions of the uterus, which is exquisitely sensitive to oxytocin at the end of pregnancy, a positive feedback loop is activated. The neural pathway that drives oxytocin neurons via a brainstem relay has been partially characterised, and involves A2 noradrenergic cells in the brainstem. Until close to term the responsiveness of oxytocin neurons is restrained by neuroactive steroid metabolites of progesterone that potentiate GABA inhibitory mechanisms. As parturition approaches, and this inhibition fades as progesterone secretion collapses, a central opioid inhibitory mechanism is activated that restrains the excitation of oxytocin cells by brainstem inputs. This opioid restraint is the predominant damper of oxytocin cells before and during parturition, limiting stimulation by extraneous stimuli, and perhaps facilitating optimal spacing of births and economical use of the store of oxytocin accumulated during pregnancy. During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases. In addition, the oxytocin cells discharge a burst of action potentials as each fetus passes through the birth canal. Each burst causes the secretion of a pulse of oxytocin, which sharply increases uterine tone; these bursts depend upon auto-stimulation by oxytocin released from the dendrites of the magnocellular neurons in the supraoptic and paraventricular nuclei. With the exception of the opioid mechanism that emerges to restrain oxytocin cell responsiveness, the behavior of oxytocin cells and their inputs in pregnancy and parturition is explicable from the effects of hormones of pregnancy (relaxin, estrogen, progesterone) on pre-existing mechanisms, leading through relative quiescence at term inter alia to net increase in oxytocin storage, and reduced auto-inhibition by nitric oxide generation. Cyto-architectonic changes in parturition, involving evident retraction of glial processes between oxytocin cells so they get closer together, are probably a response to oxytocin neuron activation rather than being essential for their patterns of firing in parturition.

Integrity signals

Registry

Crossref · 10.1016/s0091-3022(02)00104-8

Cites

343 of 343 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–343 of 343

Hypothalamic opioid mechanisms controlling oxytocin neurones during parturition
Bicknell, R. J., Leng, G., Russell, J. A., Dyer, R. G., Mansfield, S., & Zhao, B.-G. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90086-x · Cited by 59
Self-citation
Uterine Contractile Activity Stimulates Supraoptic Neurons in Term Pregnant Rats Via a Noradrenergic Pathway**This work was supported by The Wellcome Trust (Project Grant 047318/Z/96/Z) and the Biotechnology and Biological Sciences Research Council.
Douglas, A. J., Scullion, S., Antonijevic, I. A., Brown, D., Russell, J. A., & Leng, G. (2001) · Endocrinology · doi:10.1210/endo.142.2.7962 · Cited by 59
Self-citation
Stress-induced disruption of parturition in the rat may be mediated by endogenous opioids
Leng, G., Mansfield, S., Bicknell, R. J., Brown, D., Chapman, C., Hollingsworth, S., Ingram, C. D., Marsh, M., Yates, J. O., & Dyer, R. G. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1140247 · Cited by 58
Self-citation
Brain opioid systems in reproduction
Crowley, W. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90190-l · Cited by 56
Expression of the oxytocin gene in rat placenta
Lefebvre, D. L., Giaid, A., & Zingg, H. H. (1992) · Endocrinology · doi:10.1210/endo.130.3.1537285 · Cited by 56
Effect of gonadal steroids upon hypothalamic oxytocin expression.
Amico, J. A., Crowley, R. S., Insel, T. R., Thomas, A., & O’Keefe, J. A. (1995) · PubMed · Cited by 56
Rapid morphological changes in supraoptic nucleus and posterior pituitary induced by a single hypertonie saline injection
Beagley, G. H., & Hatton, G. I. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90111-a · Cited by 55
Fos expression within regions of the preoptic area, hypothalamus and brainstem during pregnancy and parturition
Luckman, S. M. (1995) · Brain Research · doi:10.1016/0006-8993(94)01271-i · Cited by 55
Nuclear Progestin Receptors in Rat Brain and Pituitary
Rainbow, T. C., McGinnis, M. Y., Krey, L. C., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000123340 · Cited by 54
Dendritic secretion of peptides from hypothalamic magnocellular neurosecretory neurones: a local dynamic control system and its functions
Morris, J. F., Christian, H., Ma, D., & Wang, H. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00016.x · Cited by 54
Involvement of cholecystokinin receptor types in pathways controlling oxytocin secretion
Luckman, S. M., Hamamura, M., Antonijevic, I. A., Dye, S., & Leng, G. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13820.x · Cited by 54
Self-citation
Superfluous neurotransmitters?
Bowers, C. W. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90168-6 · Cited by 54
Electrical properties of oxytocin neurons in organotypic cultures from postnatal rat hypothalamus
Jourdain, P., Poulain, D. A., Theodosis, D. T., & Israël, J.-M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.4.2772 · Cited by 53
Central opioids: a possible role in parturition?
Leng, G., Mansfield, S., Bicknell, R. J., Dean, A. D. P., Ingram, C. D., Marsh, M., Yates, J. O., & Dyer, R. G. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1060219 · Cited by 52
Self-citation
Effects of Tetrodotoxin on Osmotically Stimulated Central and Peripheral Vasopressin and Oxytocin Release
Ludwig, M., Callahan, M. F., & Morris, M. (2008) · Neuroendocrinology · doi:10.1159/000127058 · Cited by 52
Neuronal histamine and expression of corticotropin-releasing hormone, vasopressin and oxytocin in the hypothalamus: relative importance of H1 and H2 receptors
Kjær, A., Larsen, P., Knigge, U., Jorgensen, H., & Warberg, J. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390238 · Cited by 52
Activation of excitatory amino acid inputs to supraoptic neurons. I. Induced increases in dye-coupling in lactating, but not virgin or male rats
Hatton, G. I., & Yang, Q. Z. (1990) · Brain Research · doi:10.1016/0006-8993(90)90465-n · Cited by 51
Pre‐ and postsynaptic modulation of the electrical activity of rat supraoptic neurones
Shibuya, I., Kabashima, N., Ibrahim, N., Setiadji, S., Ueta, Y., & Yamashita, H. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00018.x · Cited by 51
Up-regulation of nitric oxide synthase messenger RNA in an integrated forebrain circuit involved in oxytocin secretion
Luckman, S. M., Huckett, L., Bicknell, R. J., Voisin, D. L., & Herbison, A. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00498-8 · Cited by 51
Modulation of Multiple Potassium Currents by Metabotropic Glutamate Receptors in Neurons of the Hypothalamic Supraoptic Nucleus
Schrader, L. A., & Tasker, J. G. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.6.3428 · Cited by 51
Mice without a Functional Relaxin Gene Are Unable to Deliver Milk to Their Pups
Zhao, L. (1999) · Endocrinology · doi:10.1210/en.140.1.445 · Cited by 51
Functional Consequences of Morphological Neuroglial Changes in the Magnocellular Nuclei of the Hypothalamus
Oliet, S. H. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2001.00766.x · Cited by 50
Visualization of local afferent inputs to magnocellular oxytocin neurons in vitro
Jourdain, P., Dupouy, B., Bonhomme, R., Poulain, D. A., Israël, J.-M., & Theodosis, D. T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00620.x · Cited by 50
Chronic stress elevates enkephalin expression in the rat paraventricular and supraoptic nuclei
Young, W. S., & Lightman, S. L. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90050-l · Cited by 50
NMDA and non-NMDA receptors on rat supraoptic nucleus neurons activated monosynaptically by olfactory afferents
Yang, Q. Z., Smithson, K. G., & Hatton, G. I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00153-h · Cited by 50
Extracellular K+ in the supraoptic nucleus of the rat during reflex bursting activity by oxytocin neurones.
Coles, J. A., & Poulain, D. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018672 · Cited by 50
Sex‐Steroid Induction of Endogenous Opioid Inhibition on Oxytocin Secretory Responses to Stress
Douglas, Johnstone, Brunton, P. J., & Russell (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00460.x · Cited by 50
Distribution and synaptic release of oxytocin in the central nervous system
Buijs, R. M., Vries, G. J. D., & van Leeuwen, F. W. (1985) · Data Archiving and Networked Services (DANS) · Cited by 50
Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N‐ and P/Q‐type calcium channels
Hirasawa, M., Kombian, S. B., & Pittman, Q. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0595e.x · Cited by 49
Inhibition of spontaneous inhibitory postsynaptic currents (IPSC) by noradrenaline in rat supraoptic neurons through presynaptic α2-adrenoceptors
Wang, Y., Shibuya, I., Kabashima, N., Setiadji, V. S., Isse, T., Ueta, Y., & Yamashita, H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00732-x · Cited by 48
Central oxytocin potentiates excitatory responses of oxytocin neurones to stimulation of the dorsomedial hypothalamic nucleus in the suckled rat
Cosgrave, A. S., & Wakerley, J. B. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02402-8 · Cited by 48
κ‐Opioid Receptor Activation Inhibits Post‐Spike Depolarizing After‐Potentials in Rat Supraoptic Nucleus Neurones In Vitro
Brown, C. H., Ghamari‐Langroudi, Leng, & Bourque (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00419.x · Cited by 47
Caesium blocks depolarizing after‐potentials and phasic firing in rat supraoptic neurones
Ghamari‐Langroudi, M., & Bourque, C. W. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.165bz.x · Cited by 47
Identification of Efferent Neural Pathways from the Lamina Terminalis Activated by Blood‐Borne Relaxin
Sunn, N., McKinley, M. J., & Oldfield, B. J. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00650.x · Cited by 45
The Affinity and Activity of the Multiple Hormone Response Element in the Proximal Promoter of the Human Oxytocin Gene
Stedronsky, K., Telgmann, R., Tillmann, G., Walther, N., & Ivell, R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00799.x · Cited by 44
Supraoptic nucleus afferents from the main olfactory bulb—II. Intracellularly recorded responses to lateral olfactory tract stimulation in rat brain slices
Hatton, G. I., & Yang, Q. Z. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90374-6 · Cited by 44
Effects of Relaxin on Blood Pressure and the Release of Vasopressin and Oxytocin in Anesthetized Rats during Pregnancy and Lactation1
Parry, L. J., Poterski, R. S., & Summerlee, A. J. S. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.3.622 · Cited by 44
Density of transient K+ current influences excitability in acutely isolated vasopressin and oxytocin neurones of rat hypothalamus
Fisher, T. E., Voisin, D. L., & Bourque, C. W. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.423bh.x · Cited by 43
Induction of members of the Fos/Jun family of immediate-early genes in identified hypothalamic neurons: in vivo evidence for differential regulation
Luckman, S. M., Dye, S., & Cox, H. J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00076-0 · Cited by 43
Changes in NADPH‐d Staining in the Paraventricular and Supraoptic Nuclei During Pregnancy and Lactation in Rats: Role of Ovarian Steroids and Oxytocin
Popeski, Amir, & Woodside (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00291.x · Cited by 42
Influence of oxytocin on sodium excretion in the anaesthetized Brattleboro rat
Brimble, M. J., BALMENT, R. J., Smith, C. P., Windle, R. J., & Forsling, M. L. (1991) · Journal of Endocrinology · doi:10.1677/joe.0.1290049 · Cited by 42
Analysis of bursting responses of oxytocin neurones in the rat in late pregnancy, lactation and after weaning.
Jiang, Q. B., & Wakerley, J. B. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020806 · Cited by 42
Osmoregulation of the magnocellular system during pregnancy and lactation
Koehler, E., McLemore, G. L., Tang, W., & Summy‐Long, J. Y. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.3.r555 · Cited by 42
Brain opioid systems in reproduction
(1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90345-7 · Cited by 41
Stimulation of Central and Systemic Oxytocin Release by Histamine in the Paraventricular Hypothalamic Nucleus: Evidence for an Interaction with Norepinephrine*
Bealer, S. L., & Crowley, W. R. (1999) · Endocrinology · doi:10.1210/endo.140.3.6601 · Cited by 41
Oxytocin modulates the onset of murine parturition by competing ovarian and uterine effects
Imamura, T., Luedke, C. E., Vogt, S. K., & Muglia, L. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r1061 · Cited by 40
Control of posterior pituitary vasopressin content: implications for the regulation of the vasopressin gene.
Fitzsimmons, M. D., Roberts, M., & ROBINSON, A. G. (1994) · Endocrinology · doi:10.1210/endo.134.4.8137755 · Cited by 40
Kappa-Opioid Restraint of Oxytocin Secretion: Plasticity through Pregnancy
Leng, G., Dye, S., & Bicknell, R. J. (2008) · Neuroendocrinology · doi:10.1159/000127263 · Cited by 40
Self-citation
Progesterone regulation of GABAA receptor plasticity in adult rat supraoptic nucleus
Fénelon, V. S., & Herbison, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00053.x · Cited by 40
Rat Amnion: A Novel Site of Oxytocin Production1
Lefebvre, D. L., Larivière, R., & Zingg, H. H. (1993) · Biology of Reproduction · doi:10.1095/biolreprod48.3.632 · Cited by 40
Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats.
Geddes, B. J., Parry, L. J., & Summerlee, A. J. S. (1994) · Endocrinology · doi:10.1210/endo.134.3.8119158 · Cited by 40
Direct hypertonic stimulation of the rat supraoptic nucleus increases c-fos expressionin glial cells rather than magnocellular neurones
Ludwig, M., Johnstone, L. E., Neumann, I. D., Landgraf, R., & Russell, J. A. (1996) · Cell and Tissue Research · doi:10.1007/s004410050733 · Cited by 39
Self-citation
Local opioid inhibition and morphine dependence of supraoptic nucleus oxytocin neurones in the rat in vivo
Ludwig, M., Brown, C. H., Russell, J. A., & Leng, G. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.145bc.x · Cited by 39
Self-citation
The neurosteroid allopregnanolone modulates oxytocin expression in the hypothalamic paraventricular nucleus
Blyth, B. J., Hauger, R. L., Purdy, R. H., & Amico, J. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.3.r684 · Cited by 39
Chapter 25 Nucleus tractus solitarius innervation of supraoptic nucleus: anatomical and electrophysiological studies in the rat suggest differential innervation of oxytocin and vasopressin neurons
Raby, W. N., & Renaud, L. P. (1989) · Progress in brain research · doi:10.1016/s0079-6123(08)62020-8 · Cited by 38
Induction of uterine activity with oxytocin in late pregnant rats replicates the expression of c-fos in neuroendocrine and brain stem neurons as seen during parturition
Antonijevic, I. A., Leng, G., Luckman, S. M., Douglas, A. J., Bicknell, R. J., & Russell, J. A. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828526 · Cited by 38
Self-citation
Relaxin acts centrally to inhibit oxytocin release during parturition: an effect that is reversed by naloxone
Jones, S. A., & Summerlee, A. J. S. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1110099 · Cited by 38
DNA Binding of Hypothalamic Nuclear Proteins on Estrogen Response Element and Preproenkephalin Promoter: Modification by Estrogen
Zhu, Y., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000127035 · Cited by 38
In Vivo Modulation of Post‐Spike Excitability in Vasopressin Cells by κ‐Opioid Receptor Activation
Brown, C. H., & Leng, G. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00547.x · Cited by 37
Self-citation
Stimulation of expression of the oxytocin gene in rat supraoptic neurons at parturition
Douglas, A. J., Meeren, H. K. M., Johnstone, L. E., Pfaff, D. W., Russell, J. A., & Brooks, P. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01275-4 · Cited by 37
Self-citation
Incidence of neuronal coupling in supraoptic nuclei of virgin and lactating rats: estimation by neurobiotin and Lucifer yellow
Hatton, G. I., & Yang, Q. Z. (1994) · Brain Research · doi:10.1016/0006-8993(94)90207-0 · Cited by 37
Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro
Doi, N., Brown, C. H., Cohen, H. D., Leng, G., & Russell, J. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703911 · Cited by 36
Self-citation
Release of Oxytocin into Blood and into Cerebrospinal Fluid Induced by Naloxone in Anaesthetized Morphine‐Dependent Rats: The Role of the Paraventricular Nucleus
Coombes, J. E., Robinson, I. C. A. F., Antoni, F. A., & Russell, J. A. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00316.x · Cited by 36
Self-citation
Oxytocin release during parturition in the pelvic-neurectomized rat
Higuchi, T., Uchide, K., Honda, K., & Negoro, H. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1090149 · Cited by 35
Effect of progesterone on the activation of neurones of the supraoptic nucleus during parturition
Antonijevic, I. A., Russell, J. A., Bicknell, R., Leng, G., & Douglas, A. J. (2000) · Reproduction · doi:10.1530/jrf.0.1200367 · Cited by 35
Self-citation
Extrinsic Modulation of Spike Afterpotentials in Rat Hypothalamoneurohypophysial Neurons
Bourque, C. W., Kirkpatrick, K., & Jarvis, C. R. (1998) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022566924921 · Cited by 34
Oxytocin Released from Magnocellular Dendrites
Sabatier, N., Caquineau, C., Douglas, A. J., & Leng, G. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03183.x · Cited by 34
Self-citation
Comparison of the expression of two immediate early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brainstem during pregnancy, parturition and lactation
Lin, S., Miyata, S., Weng, W., Matsunaga, W., Ichikawa, J., Furuya, K., Nakashima, T., & Kiyohara, T. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)00100-x · Cited by 34
Evidence for the involvement of histaminergic neurones in the regulation of the rat oxytocinergic system during pregnancy and parturition
Luckman, S. M., & Larsen, P. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.649bm.x · Cited by 34
Uterine Contractile Activity Stimulates Supraoptic Neurons in Term Pregnant Rats Via a Noradrenergic Pathway
Douglas, A. J. (2001) · Endocrinology · doi:10.1210/en.142.2.633 · Cited by 34
Self-citation
Expression of inducible cAMP early repressor (ICER) in hypothalamic magnocellular neurons
Luckman, S. M., & Cox, H. J. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00167-q · Cited by 32
Stimulation of oxytocin release in the lactating rat by central excitatory amino acid mechanisms: evidence for specific involvement of R,S-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-sensitive glutamate receptors
Parker, S. L. (1993) · Endocrinology · doi:10.1210/en.133.6.2847 · Cited by 32
Release of classical transmitters and nitric oxide in the rat olfactory bulb, evoked by vaginocervical stimulation and potassium, varies with the oestrus cycle
Guevara‐Guzmán, R., Barrera‐Mera, B., de la Riva, C., & Kendrick, K. M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00882.x · Cited by 31
Histaminergic Control of Oxytocin Release in the Paraventricular Nucleus during Lactation in Rats
Bealer, S. L., & Crowley, W. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7770 · Cited by 31
Expression of the endothelin-1 and oxytocin genes in the hypothalamus of the pregnant rat
Horwitz, M. J., Bloch, K. D., Kim, N. B., & Amico, J. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)91905-4 · Cited by 31
The Effects of Progesterone on Oxytocin mRNA Levels in the Paraventricular Nucleus of the Female Rat Can Be Altered by the Administration of Diazepam or RU4861
Thomas, Shughrue, Merchenthaler, & Amico (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00294.x · Cited by 30
GABAergic projection from the arcuate nucleus to the supraoptic nucleus in the rat
Ludwig, M., & Leng, G. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00846-6 · Cited by 30
Self-citation
Down-regulation of endogenous nitric oxide synthase in late-pregnancy and parturition in the rat hypothalamic magnocellular neurons and neurohypophysis
Okere, C. O., & Higuchi, T. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13248-1 · Cited by 29
Corticotrophin-releasing hormone, proenkephalin A and oxytocin mRNA's in the paraventricular nucleus during pregnancy and parturition in the rat.
Douglas, A. J., & Russell, J. A. (1994) · PubMed · Cited by 29
Self-citation
Chapter 2.1.3 Phenotypic and state-dependent expression of the electrical and morphological properties of oxytocin and vasopressin neurones
Armstrong, W. E., & Stern, J. E. (1999) · Progress in brain research · doi:10.1016/s0079-6123(08)61564-2 · Cited by 28
Circumventricular Organs: Gateways to the Brain Role Of Circumventricular Organs (CVO) In Neuroendocrine Responses: Interactions Of Cvo And The Magnocellular Neuroendocrine System In Different Reproductive States
Summy‐Long, J. Y., & Kadekaro, M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03491.x · Cited by 28
Neutralization of Relaxin within the Brain Affects the Timing of Birth in Rats*
Summerlee, A. J. S., Ramsey, D. G., & Poterski, R. S. (1998) · Endocrinology · doi:10.1210/endo.139.2.5741 · Cited by 28
Membrane Excitability and Secretion from Peptidergic Nerve Terminals
Branchaw, J. L., Hsu, S., & Jackson, M. B. (1998) · Cellular and Molecular Neurobiology · doi:10.1023/a:1022523109900 · Cited by 27
The Variability of Basal Action Potential Firing Is Positively Correlated with Bursting in Hypothalamic Oxytocin Neurones
Brown, D., Fontanaud, P., & Moos, F. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00478.x · Cited by 27
Vaginocervical stimulation-induced release of classical neurotransmitters and nitric oxide in the nucleus of the solitary tract varies as a function of the oestrus cycle
Guevara‐Guzmán, R., Buzo, E., Larrazolo, A., de la Riva, C., da Costa, A. P., & Kendrick, K. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02207-7 · Cited by 27
Relaxin-lnduced Expression of Fos in the Forebrain of the Late Pregnant Rat
Heine, P. A., Di, S., Ross, L. R., Anderson, L. L., & Jacobson, C. D. (2008) · Neuroendocrinology · doi:10.1159/000127217 · Cited by 26
Vasopressin and Oxytocin Decrease Excitatory Amino Acid Release in Adult Rat Supraoptic Nucleus
Currás‐Collazo, M., Gillard, E. R., Jin, J., & Pandika, J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00976.x · Cited by 26
The Posterior Pituitary and Labour
GUNTHER, M. (1948) · BMJ · doi:10.1136/bmj.1.4550.567-b · Cited by 24
Reproductive state changes NADPH-diaphorase staining in the paraventricular and supraoptic nuclei of female rats
Woodside, B. C., & Amir, S. (1996) · Brain Research · doi:10.1016/s0006-8993(96)01072-4 · Cited by 24
Characteristics of early‐ and late‐recruited oxytocin bursting cells at the beginning of suckling in rats.
Moos, F., & Richard, P. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017064 · Cited by 23
Effects of the κ‐opioid agonist U50,488 on parturition in rats
Douglas, A. J., Clarke, G., MacMillan, S. J. A., Bull, P. M., Neumann, I. D., Way, S. A., Wright, D. M., McGrory, B. G., & Russell, J. A. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13561.x · Cited by 23
Self-citation
Nitric oxide prolongs parturition and inhibits maternal behavior in rats
Okere, C. O., Higuchi, T., Kaba, H., Russell, J. A., Takahashi, S., & Murata, T. (1996) · Neuroreport · doi:10.1097/00001756-199607080-00034 · Cited by 23
Self-citation
Endogenous opioid regulation of oxytocin release during parturition is reduced in ovariectomized rats
Way, S. A., Douglas, A. J., Dye, S., Bicknell, R. J., Leng, G., & Russell, J. A. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1380013 · Cited by 22
Self-citation
Effects of ovariectomy and estrogen replacement on dye coupling among rat supraoptic nucleus neurons
Hatton, G. I., Yang, Q. Z., & Koran, L. (1992) · Brain Research · doi:10.1016/0006-8993(92)90487-t · Cited by 22
Regulation of cardiac oxytocin system and natriuretic peptide during rat gestation and postpartum
Mukaddam‐Daher, S., Jankowski, M., Wang, D., Ménaouar, A., & Gutkowska, J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750211 · Cited by 22
Reduced Oxytocin Release from the Neural Lobe of Lactating Rats is Associated with Reduced Pituitary Content and does not Reflect Reduced Excitability of Oxytocin Neurons
Higuchi, T., Bicknell, R. J., & Leng, G. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00278.x · Cited by 21
Self-citation
Peripartum interneuronal coupling in the supraoptic nucleus
Hatton, G. I., & Yang, Q. Z. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02279-5 · Cited by 21
HYPOTHALAMIC PARAVENTRICULAR UNIT ACTIVITY DURING LABOUR IN THE RAT
Boer, K., & Nolten, J. W. L. (1978) · Journal of Endocrinology · doi:10.1677/joe.0.0760155 · Cited by 21
Pethidine (meperidine) inhibition of oxytocin secretion and action in parturient rats
Russell, J. A., Leng, G., Coombes, J. E., Crockett, S. A., Douglas, A. J., Murray, I., & Way, S. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.2.r358 · Cited by 21
Self-citation
Opioids and Coupling of the Anterior Peri‐Third Ventricular Input to Oxytocin Neurones in Anaesthetized Pregnant Rats
Bull, P. M., Douglas, A. J., & Russell, J. A. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00582.x · Cited by 20
Self-citation
Control of posterior pituitary vasopressin content: implications for the regulation of the vasopressin gene
Fitzsimmons, M. D. (1994) · Endocrinology · doi:10.1210/en.134.4.1874 · Cited by 20
Ablation of the region anterior and ventral to the third ventricle (AV3V region) does not impede parturition in rats
Russell, J. A., Blackburn, R. E., & Leng, G. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1210109 · Cited by 19
Self-citation
Quantitative Analysis of Oxytocin and Vasopressin Messenger Ribonucleic Acids in Single Magnocellular Neurons Isolated from Supraoptic Nucleus of Rat Hypothalamus
Xi, D. (1999) · Endocrinology · doi:10.1210/en.140.10.4677 · Cited by 19
Chapter 16 Relaxin and drinking in pregnant rats
Hornsby, D., Wilson, B. C., & Summerlee, A. J. S. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33017-0 · Cited by 18
Functional development of the oxytocin release mechanism and its role in the initiation of parturition in the rat
Higuchi, T., Uchide, K., Honda, K., & Negoro, H. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1060311 · Cited by 18
The Milk‐Ejection Reflex in the Peri‐Partum Rat: Effects of Oestradiol and Progesterone on Basal Milk‐Ejection Frequency and the Facilitatory Response to Central Oxytocin
Jiang, D. Q. Y., & Wakerley, J. B. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00602.x · Cited by 18
Effects of porcine relaxin on the length of gestation and duration of parturition in the rat
Jones, S. A., & Summerlee, A. J. S. (1986) · Journal of Endocrinology · doi:10.1677/joe.0.1090085 · Cited by 18
Role of the subfornical organ in the relaxin-induced prolongation of gestation in the rat.
Summerlee, A. J. S., & Wilson, B. C. (1994) · Endocrinology · doi:10.1210/endo.134.5.8156911 · Cited by 18
The Regulation of Oxytocin mRNA Levels in the Medial Preoptic Area
Brooks, P. J. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34361.x · Cited by 18
Effect of progesterone on the activation of neurones of the supraoptic nucleus during parturition
Antonijevic, I., Russell, J. A., Bicknell, R., et al. (2000) · Reproduction · doi:10.1530/reprod/120.2.367 · Cited by 18
Self-citation
Stimulation of Central and Systemic Oxytocin Release by Histamine in the Paraventricular Hypothalamic Nucleus: Evidence for an Interaction with Norepinephrine
Bealer, S. L. (1999) · Endocrinology · doi:10.1210/en.140.3.1158 · Cited by 18
Electrophysiological Studies of Oxytocin Neurons in Organotypic Slice Cultures
Jourdain, P., Dupouy, B., Bonhomme, R., Theodosis, D. T., Poulain, D. A., & Israël, J.-M. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_16 · Cited by 17
Catecholamines are not linked to myometrial phospholipase C and uterine contraction in late pregnant and parturient mouse
Mhaouty‐Kodja, S., Houdeau, É., Cohen-Tannoudji, J., & Legrand, C. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00123.x · Cited by 17
Nitric oxide, interleukin and prostaglandin interactions affecting the magnocellular system
Summy‐Long, J. Y., Bui, V., Gestl, S. A., & Kadekaro, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02556-8 · Cited by 17
Diethylstilbesterol- and Pregnancy-Induced Changes in Rat Neurointermediate Lobe Oxytocin, Arginine Vasopressin, Methionine Enkephalin and Dynorphin
Schriefer, J. A. (2008) · Neuroendocrinology · doi:10.1159/000125874 · Cited by 17
Afferent Stimulation Regulates Oxytocin Messenger Ribonucleic Acid During Early Lactation in Rats
Spinolo, L. H., Raghow, R., & Crowley, W. R. (1992) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00157.x · Cited by 15
Fos expression in the hypothalamic magnocellular neurons of rats during pregnancy, parturition and lactation
Lin, S., Miyata, S., Itoh, T., Kawarabayashi, T., Nakashima, T., & Kiyohara, T. (1995) · Neuroscience Research · doi:10.1016/0168-0102(95)90007-1 · Cited by 15
Ultrastructural localization of inhibin β- and somatostatin-28-immunoreactivities in the paraventricular and supraoptic nuclei
Sawchenko, P. E., & Pfeiffer, S. W. (1995) · Brain Research · doi:10.1016/0006-8993(95)00760-n · Cited by 15
Differential regulation of oxytocin and vasopressin messenger ribonucleic acid levels by gonadal steroids in postpartum rats
Thomas, A., Kim, N. B., & Amico, J. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00760-3 · Cited by 14
Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats
Geddes, B. J. (1994) · Endocrinology · doi:10.1210/en.134.3.1188 · Cited by 13
Permissive Effect of Centrally Administered Oxytocin on the Excitatory Response of Oxytocin Neurones to Ventral Tegmental Stimulation in the Suckled Lactating Rat
Cosgrave, A. S., Richardson, C. M., & Wakerley, J. B. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00531.x · Cited by 12
Porcine Relaxin Affects the Release of Luteinizing Hormone in Rats
Summerlee, A. J. S., Mumford, A. D., & Smith, M. S. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00254.x · Cited by 12
Oxytocin suppresses the GABAergic synaptic input in supraoptic neurones from the rat.
Brussaard, A. B. (1995) · PubMed · Cited by 12
Neutralization of Relaxin within the Brain Affects the Timing of Birth in Rats
Summerlee, A. J. S. (1998) · Endocrinology · doi:10.1210/en.139.2.479 · Cited by 12
Electrophysiological responses of neurones in the rat nucleus tractus solitarius to oxytocin-releasing stimuli
Bailey, A. R. T., & Wakerley, J. B. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00788-x · Cited by 11
HYPOTHALAMIC NEURONE ACTIVITY: HORMONE RELEASE AND BEHAVIOUR IN FREELY MOVING RATS
Summerlee, A. J. S. (1983) · Quarterly Journal of Experimental Physiology · doi:10.1113/expphysiol.1983.sp002743 · Cited by 11
An ovarian steroid hormone regimen that increases hypothalamic oxytocin expression alters [3H] muscimol binding in the hypothalamic supraoptic nucleus of the female rat
Amico, J. A., Davis, A. M., & McCarthy, M. M. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02373-2 · Cited by 11
Influence of reproductive state and ovarian steroids on facilitation of the milk-ejection reflex by central oxytocin.
Wakerley, J. B., Qb, J., Sj, H., Terenzi, M. G., & Ingram, C. D. (1995) · PubMed · Cited by 11
Veni, vidi, vici: the neurohypophysis in the twentieth century
Russell, J. A., & Leng, G. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00002.x · Cited by 10
Self-citation
Progesterone-Inhibition of Oxytocin Release during Vaginal Distention: Evidence for a Central Site of Action1
ROBERTS, J. S. (1971) · Endocrinology · doi:10.1210/endo-89-5-1137 · Cited by 10
Oxytocin transgenic mice.
Murphy, D., & Ho, M.-Y. (1995) · PubMed · Cited by 10
Oxytocin does not act locally in the hypothalamus to elicit norepinephrine release
Etgen, A. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)01193-5 · Cited by 9
Does a stretch-inactivated cation channel integrate osmotic and peptidergic signals?
Bourque, C. W., & Chakfe, Y. (2000) · Nature Neuroscience · doi:10.1038/78732 · Cited by 8
Rhythms and Parturition
Ducsay, C. A. (1996) · The Endocrinologist · doi:10.1097/00019616-199601000-00006 · Cited by 8
Oxytocin antagonists in the treatment of preterm labour
Åkerlund, M. (2002) · Fetal and Maternal Medicine Review · doi:10.1017/s0965539502000128 · Cited by 8
Role of the subfornical organ in the relaxin-induced prolongation of gestation in the rat
Summerlee, A. J. S. (1994) · Endocrinology · doi:10.1210/en.134.5.2115 · Cited by 8
Intrauterine oxytocin system
Morel, G., Péchoux, C., Raccurt, M., & Zingg, H. H. (2001) · Cell and Tissue Research · doi:10.1007/s004410100382 · Cited by 7
[Dual noradrenergic control of oxytocin release during the milk ejection reflex in the rat].
Moos, F., & Richard, P. (1980) · PubMed · Cited by 5
Upregulation of synapsin IIa and IIb mRNAs in the paraventricular and supraoptic nuclei in chronic salt loaded and lactating rats
Nomura, M. J., Ueta, Y., Serino, R., Yamamoto, Y., Shibuya, I., & Yamashita, H. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00117-6 · Cited by 4
The effect of adrenergic, cholinergic and peptidergic salivary stimulants on gastric mucosal integrity in the rat.
Soper, B. D., & Tepperman, B. L. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016288 · Cited by 4
Central Somatostatin Inhibits Cholecystokinin‐lnduced Oxytocin Secretion in Conscious Rats
Blackburn, R. E., Frederick, S. E., Strieker, E. M., & Verbalis, J. G. (1992) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00188.x · Cited by 3
Effects of pregnancy, parturition and lactation on somatostatin, proenkephalin A and μ-opioid receptor mRNA expression in the rat brainstem.
Meddle, S., Frances, K., Bishop, V. R., & Russell, J. P. (2001) · Cited by 2
Self-citation
Progesterone Regulates Hypothalamic Oxytocin mRNA Levels Through Gamma Aminobutyric Acid
Thomas, A., & Amico, J. A. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_12 · Cited by 1

Research works printed but not linked: 5

Brunton, 2001, Endogenous opioids and attenuated neuroendocrine responses to immune challenge in pregnant rats, Soc. Neurosci. Abstracts, 27, 412.13
Brunton, 2002, Reduced neuroendocrine stress responses to immune signals in pregnant rats, Stress, 5S
A.J. Douglas, T. Birch, J.A. Russell, A role for noradrenaline in the supraoptic nucleus (SON) in parturition, WCNH 1999 Edinburgh Proceedings, Mon24, p. 86
S.L. Langle, D.A. Poulain, D.T. Theodosis, Oxytocin induces rapid neuronal-glial and synaptic remodelling in the adult supraoptic nucleus in vitro, WCNH 2001 Bordeaux Proceedings, P2-2, P74
K. Nishimori, Y. Takayanagi, Y. Sugimoto, M. Kawamata, K. Takeda, M. Matzuk, T. Kimura, Molecular-genetic analysis of oxytocin/oxytocin receptor/PGF2a receptor genes system in mice, WCNH 2001 Bordeaux Proceedings, S8-2

Sorted by citations

Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Self-citation
Evidence for a Neuroendocrinological Foundation of Human Affiliation: Plasma Oxytocin Levels Across Pregnancy and the Postpartum Period Predict Mother-Infant Bonding
Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02010.x · Cited by 787
CD38 is critical for social behaviour by regulating oxytocin secretion
Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., et al. (2007) · Nature · doi:10.1038/nature05526 · Cited by 665
The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620

See all 295

Authors: Russell, J. A., Leng, G., & Douglas, A. J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Russell, John A
ORCID: Leng, Gareth
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2003-01
Volume: 24
Issue: 1
Pages: 27-61
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/s0091-3022(02)00104-8
OpenAlex: W1972511187
Cited by: 295
References: 335
Citations by year: 2026: 8 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 9 · 2020: 28 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 15 · 2012: 9
FWCI: 2.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, magnocellular neurons, childbirth, pregnancy, neurohypophysis, uterine contraction, positive feedback loop, brainstem, GABAergic inhibition, opioid inhibition, supraoptic nucleus, paraventricular nucleus, nitric oxide, relaxin, estrogen, birth spacing
MeSH terms: Action Potentials, Adaptation, Physiological, Animals, Female, Gene Expression Regulation, Humans, Mice, Transgenic, Neurons, Nitric Oxide, Olfactory Bulb, Oxytocin, Pituitary Gland, Posterior, Pregnancy, Uterus, Opioid Peptides, Feedback, Physiological, Parturition, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks