The DOI matches its Crossref record; 343 of the 343 references it cites were found in a registry or an index.
The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy
Abstract
Oxytocin secretion from the posterior pituitary gland is increased during parturition, stimulated by the uterine contractions that forcefully expel the fetuses. Since oxytocin stimulates further contractions of the uterus, which is exquisitely sensitive to oxytocin at the end of pregnancy, a positive feedback loop is activated. The neural pathway that drives oxytocin neurons via a brainstem relay has been partially characterised, and involves A2 noradrenergic cells in the brainstem. Until close to term the responsiveness of oxytocin neurons is restrained by neuroactive steroid metabolites of progesterone that potentiate GABA inhibitory mechanisms. As parturition approaches, and this inhibition fades as progesterone secretion collapses, a central opioid inhibitory mechanism is activated that restrains the excitation of oxytocin cells by brainstem inputs. This opioid restraint is the predominant damper of oxytocin cells before and during parturition, limiting stimulation by extraneous stimuli, and perhaps facilitating optimal spacing of births and economical use of the store of oxytocin accumulated during pregnancy. During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases. In addition, the oxytocin cells discharge a burst of action potentials as each fetus passes through the birth canal. Each burst causes the secretion of a pulse of oxytocin, which sharply increases uterine tone; these bursts depend upon auto-stimulation by oxytocin released from the dendrites of the magnocellular neurons in the supraoptic and paraventricular nuclei. With the exception of the opioid mechanism that emerges to restrain oxytocin cell responsiveness, the behavior of oxytocin cells and their inputs in pregnancy and parturition is explicable from the effects of hormones of pregnancy (relaxin, estrogen, progesterone) on pre-existing mechanisms, leading through relative quiescence at term inter alia to net increase in oxytocin storage, and reduced auto-inhibition by nitric oxide generation. Cyto-architectonic changes in parturition, involving evident retraction of glial processes between oxytocin cells so they get closer together, are probably a response to oxytocin neuron activation rather than being essential for their patterns of firing in parturition.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In lactating rats, suckling evokes bursts of action potentials in oxytocin cells that result in pulsatile oxytocin secretion, and this bursting is facilitated by 1-2ng oxytocin i.c.v.(26).Effects on maternal behavior in the rat need much higher doses (~400ng) (4).Partner preference effects in voles require infusions of oxytocin at 10-100ng/h (5), and, to stimulate maternal behavior in sheep, it”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [26]
In the citing paper
“Finally, Carter et al. 119 claimed a biological validation for the ELISA in reporting that breastfeeding in women lowered salivary concentrations of oxytocin. Because suckling‐induced oxytocin release is indispensable for milk let‐down in mammals 123, it is difficult to understand how such an anomalous observation qualifies as a validation.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [123]
In the citing paper
“There are indications for this in the context of labor during child birth (Russell et al., 2003), and this is hypothesized, for example, in the context of affiliation (Uvnäs-Moberg, 1998) and cooperation (see De Dreu, 2012).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Russell et al., 2003
Citations
Cites
The structure of evolutionary theory
Gould, S. J. (2002) · Choice Reviews Online · doi:10.5860/choice.39-6411 · Cited by 2,764
Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80086-0 · Cited by 2,534
Simerly, R. B., Swanson, L. W., Chang, C., & Muramatsu, M. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902940107 · Cited by 2,118
Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Ericsson, A. B., Kovacs, K., & Sawchenko, P. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00897.1994 · Cited by 679
Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons
Oliet, S. H. R., Piet, R., & Poulain, D. A. (2001) · Science · doi:10.1126/science.1059162 · Cited by 623
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., et al. (1997) · Science · doi:10.1126/science.277.5326.681 · Cited by 608
Distribution of estrogen receptor β immunoreactivity in the rat central nervous system
Shughrue, P. J., & Merchenthaler, I. J. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1054 · Cited by 490
Research works printed but not linked: 5
- Brunton, 2001, Endogenous opioids and attenuated neuroendocrine responses to immune challenge in pregnant rats, Soc. Neurosci. Abstracts, 27, 412.13
- Brunton, 2002, Reduced neuroendocrine stress responses to immune signals in pregnant rats, Stress, 5S
- A.J. Douglas, T. Birch, J.A. Russell, A role for noradrenaline in the supraoptic nucleus (SON) in parturition, WCNH 1999 Edinburgh Proceedings, Mon24, p. 86
- S.L. Langle, D.A. Poulain, D.T. Theodosis, Oxytocin induces rapid neuronal-glial and synaptic remodelling in the adult supraoptic nucleus in vitro, WCNH 2001 Bordeaux Proceedings, P2-2, P74
- K. Nishimori, Y. Takayanagi, Y. Sugimoto, M. Kawamata, K. Takeda, M. Matzuk, T. Kimura, Molecular-genetic analysis of oxytocin/oxytocin receptor/PGF2a receptor genes system in mice, WCNH 2001 Bordeaux Proceedings, S8-2
Cited by
Sorted by citations
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
Self-citationFeldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02010.x · Cited by 787
CD38 is critical for social behaviour by regulating oxytocin secretion
Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., et al. (2007) · Nature · doi:10.1038/nature05526 · Cited by 665
Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., Bartz, J. A., Yee, J. R., & van Zuiden, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.019 · Cited by 620
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 616
Self-citationThe Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407
Self-citationBaskerville, T. A., & Douglas, A. J. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00154.x · Cited by 377
Self-citationSkrundz, M., Bolten, M., Nast, I., Hellhammer, D. H., & Meinlschmidt, G. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.74 · Cited by 349
Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment
Levine, A., Zagoory-Sharon, O., Feldman, R., & Weller, A. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.016 · Cited by 315
Environmental and sow-related factors affecting the duration of farrowing
Oliviero, C., Heinonen, M., Valros, A., & Peltoniemi, O. A. T. (2009) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2009.12.009 · Cited by 280
Sex differences in psychopathology: of gonads, adrenals and mental illness
Solomon, M. B., & Herman, J. P. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.033 · Cited by 272
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0674-y · Cited by 249
Self-citationMeasuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers
Leng, G., & Sabatier, N. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12413 · Cited by 237
“Because suckling-induced oxytocin release is indispensable for milk let-down in mammals (123), it is difficult to understand how such an anomalous observation quali-fies as a validation.”
BackgroundSelf-citationLow sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235
Neuroendocrine Mechanisms in Pregnancy and Parturition
Petraglia, F., Imperatore, A., & Challis, J. R. G. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0019 · Cited by 224
An Allostatic Theory of Oxytocin
Quintana, D. S., & Guastella, A. J. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.008 · Cited by 223
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212
Emergent Synchronous Bursting of Oxytocin Neuronal Network
Rossoni, E., Feng, J., Tirozzi, B., Brown, D., Leng, G., & Moos, F. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000123 · Cited by 207
Self-citationOxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis
Elabd, C., Basillais, A., Beaupied, H., Breuil, V., Wagner, N., Scheideler, M., Zaragosi, L.-E., Massiéra, F., Lemichez, E., Trajanoski, Z., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0127 · Cited by 202
Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain
Meddle, S. L., Bishop, V. R., Gkoumassi, E., van Leeuwen, F. W., & Douglas, A. J. (2007) · Endocrinology · doi:10.1210/en.2007-0615 · Cited by 195
Self-citationOliviero, C., Heinonen, M., Valros, A., Hälli, O., & Peltoniemi, O. A. T. (2007) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2007.03.015 · Cited by 192
Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00068 · Cited by 187
Oxytocin--anatomy and functional assignments: a minireview.
Kiss, A., & Mikkelsen, J. D. (2005) · PubMed · Cited by 185
Unternaehrer, E., Meyer, A. H., Burkhardt, S. C. A., Dempster, E., Staehli, S., Theill, N., Lieb, R., & Meinlschmidt, G. (2015) · Stress · doi:10.3109/10253890.2015.1038992 · Cited by 181
The vasopressin system — From antidiuresis to psychopathology
Frank, E., & Landgraf, R. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.063 · Cited by 162
Oxytocin and the maternal brain
LENG, G., MEDDLE, S., & DOUGLAS, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.001 · Cited by 158
Self-citationYamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
ERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145
Endocrine induced changes in brain function during pregnancy
Brunton, P. J., & Russell, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.062 · Cited by 138
Self-citationInteraction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01525.x · Cited by 133
Neural Pathways Controlling Central and Peripheral Oxytocin Release During Stress
Onaka, T. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01186.x · Cited by 130
Martins, D., Mazibuko, N., Zelaya, F. O., Vasilakopoulou, S., Loveridge, J., Oates, A. E., Maltezos, S., Mehta, M. A., Wastling, S. J., Howard, M. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14845-5 · Cited by 131
Newborn Analgesia Mediated by Oxytocin during Delivery
Mazzuca, M., Minlebaev, M., Shakirzyanova, A., Tyzio, R., Taccola, G., Janáčková, S., Gataullina, S., Ben‐Ari, Y., Giniatullin, R. A., & Khazipov, R. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00003 · Cited by 127
Allopregnanolone in the brain: Protecting pregnancy and birth outcomes
Brunton, P. J., Russell, J. A., & Hirst, J. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.005 · Cited by 122
Self-citationThe physiology and pharmacology of oxytocin in labor and in the peripartum period
Uvnäs-Moberg, K. (2024) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2023.04.011 · Cited by 118
Eapen, V., Dadds, M. R., Barnett, B. E. W., Kohlhoff, J. R., Khan, F., Radom, N., & Silove, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107745 · Cited by 123
Neuroendocrine Regulation of Lactation and Milk Production
Crowley, W. R. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140029 · Cited by 135
OxytocinSynthesis, Secretion, and Reproductive Functions
BURBACH, J., YOUNG, L., & RUSSELL, J. (2006) · Knobil and Neill's Physiology of Reproduction · doi:10.1016/b978-012515400-0/50063-4 · Cited by 113
Self-citationHormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care
Buckley, S. J. (2015) · Issue Lab (Candid) · Cited by 113
LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00413-5 · Cited by 112
Self-citationNonsocial Functions of Hypothalamic Oxytocin
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013) · ISRN Neuroscience · doi:10.1155/2013/179272 · Cited by 116
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108
Self-citationOxytocin Involvement in SSRI-Induced Delayed Ejaculation: A Review of Animal Studies
A, T. R. D. J., Veening, J. G., Olivier, B., & Waldinger, M. D. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00394.x · Cited by 108
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 106
Walker, C., Deschamps, S., Proulx, K., Tu, M. T., Salzman, C., Woodside, B. C., LUPIEN, S. J., Gallo‐Payet, N., & Richard, D. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0436 · Cited by 99
CD38 and its role in oxytocin secretion and social behavior
Higashida, H., Yokoyama, S., Kikuchi, M., & Munesue, T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.011 · Cited by 98
Interactions between dopamine and oxytocin in the control of sexual behaviour
Baskerville, T., & Douglas, A. S. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00423-8 · Cited by 93
Self-citationNeuroendocrine control of maternal stress responses and fetal programming by stress in pregnancy
Brunton, P. J., & Russell, J. A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.023 · Cited by 91
Self-citationVasopressin and Oxytocin in Control of the Cardiovascular System
Japundžić‐Žigon, N. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311020008 · Cited by 89
Lu, W., Dow, L., Gümüsgöz, S., Brierley, M. J., Warne, J. M., McCrohan, C. R., BALMENT, R. J., & Riccardi, D. (2004) · Endocrinology · doi:10.1210/en.2004-0144 · Cited by 88
Leng, G., Pineda, R., Sabatier, N., & Ludwig, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0087 · Cited by 85
Self-citationChanges in cerebrospinal fluid neurochemistry during pregnancy
Altemus, M., Fong, J., Yang, R., Damast, S., Luine, V., & Ferguson, D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.002 · Cited by 83
Wakerley, J. B. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50064-6 · Cited by 84
Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice
Okabe, S., Tsuneoka, Y., Takahashi, A., Ooyama, R., Watarai, A., Maeda, S., Honda, Y., Nagasawa, M., Mogi, K., Nishimori, K., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.036 · Cited by 82
Fernández, I. O., Gabriel, M. Á. M., Gil-Sánchez, A., García‐Segura, L. M., & Arévalo, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.007 · Cited by 85
Effects of oxytocin on GABA signalling in the foetal brain during delivery
KHAZIPOV, R., TYZIO, R., & BENARI, Y. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00421-4 · Cited by 77
Neuroendocrine control of maternal behavior in non-human and human mammals
Lévy, F. (2016) · Annales d Endocrinologie · doi:10.1016/j.ando.2016.04.002 · Cited by 77
Bealer, S. L., Armstrong, W. E., & Crowley, W. R. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00217.2010 · Cited by 76
A, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 76
Oxytocin receptors in brain cortical regions are reduced in haploinsufficient (+/−) reeler mice
Liu, W., Pappas, G. D., & Carter, C. S. (2005) · Neurological Research · doi:10.1179/016164105x35602 · Cited by 73
Higashida, H., Yokoyama, S., Huang, J., Liu, L., Ma, W., Akther, S., Higashida, C., Kikuchi, M., Minabe, Y., & Munesue, T. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.030 · Cited by 74
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
Douglas, A. J. (2005) · Stress · doi:10.1080/10253890500044380 · Cited by 68
Self-citationLu, W., Greenwood, M. P., Dow, L., Yuill, J., Worthington, J., Brierley, M. J., McCrohan, C. R., Riccardi, D., & BALMENT, R. J. (2006) · Endocrinology · doi:10.1210/en.2005-1457 · Cited by 69
Henderson, L. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.022 · Cited by 67
Bonapace, J., Gagné, G., Chaillet, N., Gagnon, R. F., Hébert, E., & Buckley, S. J. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.08.003 · Cited by 66
Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
Dobolyi, A., Cservenák, M., & Young, L. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.002 · Cited by 64
Numan, M. J., FLEMING, A., & Lévy, F. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50040-3 · Cited by 63
Regulation of Oxytocin Secretion
Leng, G., Caquineau, C., & Sabatier, N. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71002-5 · Cited by 68
Self-citationRay, S., Tzeng, R.-Y., DiCarlo, L. M., Bundy, J. L., Vied, C., Tyson, G., Nowakowski, R. S., & Arbeitman, M. N. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.020982 · Cited by 67
Dendritic Release of Neurotransmitters
Ludwig, M., Apps, D. K., Menzies, J. R. W., Patel, J. C., & Rice, M. E. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160007 · Cited by 75
Paris, J. J., Brunton, P. J., Russell, J. A., & Frye, C. A. (2011) · Stress · doi:10.3109/10253890.2011.628719 · Cited by 61
Self-citationMetabolic and feeding adjustments during pregnancy
Haddad-Tóvolli, R., & Claret, M. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00871-y · Cited by 67
Are There Different Types of Female Orgasm?
King, R., Belsky, J., Mah, K., & Binik, Y. M. (2010) · Archives of Sexual Behavior · doi:10.1007/s10508-010-9639-7 · Cited by 58
Oxytocin and love: myths, metaphors and mysteries.
Carter, C. S. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100107 · Cited by 57
Region Specific Up-Regulation of Oxytocin Receptors in the Opioid Oprm1−/− Mouse Model of Autism
Gigliucci, V., Leonzino, M., Busnelli, M., Luchetti, A., Palladino, V. S., D’Amato, F. R., & Chini, B. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00091 · Cited by 56
Bell, A. F., White‐Traut, R. C., & Rankin, K. (2012) · Early Human Development · doi:10.1016/j.earlhumdev.2012.09.017 · Cited by 55
Pulsatility in Neuroendocrine Systems
Leng, G., Sabatier, N., & Caquineau, C. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01198-0 · Cited by 55
Self-citationGlycemia Regulation: From Feedback Loops to Organizational Closure
Bich, L., Mossio, M., & Soto, A. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00069 · Cited by 65
Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms
Liu, C. M., Spaulding, M. O., Rea, J. J., Noble, E. E., & Kanoski, S. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910859 · Cited by 60
Oxytocin in health and disease
Tom, N., & Assinder, S. J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.008 · Cited by 53
The interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54
Control of neurohypophysial hormone secretion, blood osmolality and volume in pregnancy.
Brunton, P. J., Velmurugan, S., & Ja, R. (2008) · PubMed · Cited by 51
Stern, J. E., & Zhang, W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077735 · Cited by 52
Hypnosis, Attachment, and Oxytocin:An Integrative Perspective1
Zelinka, V., Cojan, Y., & Desseilles, M. (2013) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/00207144.2013.841473 · Cited by 49
Endogenous opiates and behavior: 2003
Bodnar, R. J., & Klein, G. E. (2004) · Peptides · doi:10.1016/j.peptides.2004.09.005 · Cited by 49
Oxytocin—a social peptide? Deconstructing the evidence
Leng, G., Leng, R., & Ludwig, M. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0055 · Cited by 51
Self-citationKisspeptin Activation of Supraoptic Nucleus Neurons in Vivo
Scott, V., & Brown, C. H. (2011) · Endocrinology · doi:10.1210/en.2011-1181 · Cited by 48
Lonstein, J. S., Pereira, M., Morrell, J. I., & Marler, C. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00051-x · Cited by 46
Oxytocin and Maternal Brain Plasticity
Kim, S., & Strathearn, L. (2016) · New Directions for Child and Adolescent Development · doi:10.1002/cad.20170 · Cited by 52
The osmoresponsiveness of oxytocin and vasopressin neurones: Mechanisms, allostasis and evolution
Leng, G., & Russell, J. A. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12662 · Cited by 48
Self-citationLopatina, O. L., Ивановна, И. А., Пичугина, Ю. А., Okamoto, H., Salmina, A. B., & Higashida, H. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02136.x · Cited by 48
Fish caudal neurosecretory system: A model for the study of neuroendocrine secretion
McCrohan, C. R., Lu, W., Brierley, M. J., Dow, L., & BALMENT, R. J. (2007) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.12.027 · Cited by 44
Brunton, P. J., Bales, J., & Russell, J. A. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02295.x · Cited by 43
Self-citationRagnauth, A. K., Goodwillie, A., Brewer, C., Muglia, L. J., Pfaff, D. W., & Kow, L.-M. (2004) · Neuroendocrinology · doi:10.1159/000081844 · Cited by 41
Nabb, M. T. M., Kimber, L., Haines, A., & McCourt, C. (2006) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2005.12.006 · Cited by 42
Metadata
- Authors
- Russell, J. A., Leng, G., & Douglas, A. J.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Russell, John A
- ORCID
- Leng, Gareth
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 24
- Issue
- 1
- Pages
- 27-61
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W1972511187
- Cited by
- 295
- References
- 335
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 9 · 2020: 28 · 2019: 10 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 13 · 2014: 12 · 2013: 15 · 2012: 9
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, magnocellular neurons, childbirth, pregnancy, neurohypophysis, uterine contraction, positive feedback loop, brainstem, GABAergic inhibition, opioid inhibition, supraoptic nucleus, paraventricular nucleus, nitric oxide, relaxin, estrogen, birth spacing
- MeSH terms
- Action Potentials, Adaptation, Physiological, Animals, Female, Gene Expression Regulation, Humans, Mice, Transgenic, Neurons, Nitric Oxide, Olfactory Bulb, Oxytocin, Pituitary Gland, Posterior, Pregnancy, Uterus, Opioid Peptides, Feedback, Physiological, Parturition, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
