Cited by 310Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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Neurobiology of the nicotine withdrawal syndrome

Kenny, Paul J., Markou, Athina·2001·Pharmacology Biochemistry and Behavior

DOI 10.1016/s0091-3057(01)00651-7

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Abstract

The aversive aspects of withdrawal from chronic nicotine exposure are thought to be an important motivational factor contributing to the maintenance of the tobacco habit in human smokers. Much emphasis has been placed on delineating the underlying neurobiological mechanisms mediating different components of the nicotine withdrawal syndrome. Recent studies have shown that both central and peripheral populations of nicotinic acetylcholine receptors (nAChRs) are involved in mediating somatic signs of nicotine withdrawal as measured by the rodent nicotine abstinence scale. However, only central populations of nAChRs are involved in mediating affective aspects of nicotine withdrawal, as measured by elevations in brain-stimulation reward thresholds and conditioned place aversion. Nicotine interacts with several neurotransmitter systems, including acetylcholine, dopamine, opioid peptides, serotonin, and glutamate systems. Evidence so far suggests that these neurotransmitters play a role in nicotine dependence and withdrawal processes. The available evidence also suggests that different underlying neurochemical deficits mediate somatic and affective components of nicotine withdrawal. The aim of the present review is to discuss preclinical findings concerning the neuroanatomical and neurochemical substrates involved in these different aspects of nicotine withdrawal.

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Authors: Kenny, P. J., & Markou, A.
Affiliations: Scripps Research Institute (US)
Corresponding author: Markou, Athina
ORCID: Kenny, Paul J.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2001-12
Volume: 70
Issue: 4
Pages: 531-549
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/s0091-3057(01)00651-7
OpenAlex: W2020567468
Cited by: 310
References: 264
Citations by year: 2025: 9 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 17 · 2014: 12 · 2013: 19 · 2012: 18
FWCI: 0.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA 11946, R56DA011946)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine withdrawal, nicotine dependence, nicotinic acetylcholine receptors, somatic withdrawal signs, conditioned place aversion, dopamine, opioid peptides, serotonin, glutamate, acetylcholine, neuroanatomical substrates
MeSH terms: Animals, Humans, Nicotine, Substance Withdrawal Syndrome, Nicotinic Agonists

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