Cited by 310Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 260 of the 264 references it cites were found in a registry or an index.

Neurobiology of the nicotine withdrawal syndrome

Kenny, Paul J., Markou, Athina·2001·Pharmacology Biochemistry and Behavior

DOI 10.1016/s0091-3057(01)00651-7

Open this paper in CoChat — free account

Abstract

The aversive aspects of withdrawal from chronic nicotine exposure are thought to be an important motivational factor contributing to the maintenance of the tobacco habit in human smokers. Much emphasis has been placed on delineating the underlying neurobiological mechanisms mediating different components of the nicotine withdrawal syndrome. Recent studies have shown that both central and peripheral populations of nicotinic acetylcholine receptors (nAChRs) are involved in mediating somatic signs of nicotine withdrawal as measured by the rodent nicotine abstinence scale. However, only central populations of nAChRs are involved in mediating affective aspects of nicotine withdrawal, as measured by elevations in brain-stimulation reward thresholds and conditioned place aversion. Nicotine interacts with several neurotransmitter systems, including acetylcholine, dopamine, opioid peptides, serotonin, and glutamate systems. Evidence so far suggests that these neurotransmitters play a role in nicotine dependence and withdrawal processes. The available evidence also suggests that different underlying neurochemical deficits mediate somatic and affective components of nicotine withdrawal. The aim of the present review is to discuss preclinical findings concerning the neuroanatomical and neurochemical substrates involved in these different aspects of nicotine withdrawal.

Integrity signals

Registry

Crossref · 10.1016/s0091-3057(01)00651-7

Cites

260 of 260 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study
Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Psychopharmacology: The Fourth Generation of Progress
Brophy, J. J. (1995) · JAMA · doi:10.1001/jama.1995.03530220079046 · Cited by 1,582
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308
Smoking, smoking cessation, and major depression
Glassman, A. H. (1990) · JAMA · doi:10.1001/jama.1990.03450120058029 · Cited by 1,207
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Kramer, M. S., Cutler, N. R., Feighner, J. P., Shrivastava, R. K., Carman, J. S., Sramek, J. J., Reines, S. A., Liu, G. F., Snavely, D. B., Wyatt-Knowles, E. S., et al. (1998) · Science · doi:10.1126/science.281.5383.1640 · Cited by 1,071
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
The Diversity of Neuronal Nicotinic Acetylcholine Receptors
Sargent, P. B. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002155 · Cited by 1,052
Selective activation of the mesocortical DA system by stress
Thierry, A. M., Tassin, J., BLANC, G., & Glowinski, J. (1976) · Nature · doi:10.1038/263242a0 · Cited by 1,033
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022
Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats
Moghaddam, B., & Adams, B. W. (1998) · Science · doi:10.1126/science.281.5381.1349 · Cited by 1,006
Requirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947
Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
Cartmell, J., & Schoepp, D. D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750889.x · Cited by 883
A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.
Flores, C. M., Rogers, S. W., Pabreza, L. A., Wolfe, B. B., & Kellar, K. J. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08832-7 · Cited by 880
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767
Self-citation
Nicotinic Receptors in the Development and Modulation of CNS Synapses
Role, L. W., & Berg, D. K. (1996) · Neuron · doi:10.1016/s0896-6273(00)80134-8 · Cited by 762
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720
Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
Imperato, A., Mulas, A., & Di Chiara, G. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90629-1 · Cited by 693
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674
Self-citation
Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei
Klink, R., d'Exaerde, A. D. K., Zoli, M., & Changeux, J.-P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01452.2001 · Cited by 674
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
Elgoyhen, A. B., Vetter, D. E., Katz, E., Rothlin, C. V., Heinemann, S. F., & Boulter, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051622798 · Cited by 673
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668
The scientific case that nicotine is addictive
Stolerman, I. P., & Jarvis, M. J. (1995) · Psychopharmacology · doi:10.1007/bf02245088 · Cited by 646
Molecular and cellular aspects of nicotine abuse
Dani, J. A., & Heinemann, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80112-9 · Cited by 605
Nicotine maintains robust self-administration in rats on a limited-access schedule
Corrigall, W. A., & Coen, K. M. (1989) · Psychopharmacology · doi:10.1007/bf00589894 · Cited by 578
Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis
Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565
Smoking withdrawal symptoms in two weeks of abstinence
Shiffman, S. M., & Jarvik, M. E. (1976) · Psychopharmacology · doi:10.1007/bf00634151 · Cited by 542
Neurotrophins and depression
Altar, C. A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01309-7 · Cited by 535
Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity
Albensi, B. C., & Mattson, M. P. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2 · Cited by 527
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
Nisell, M., Nomikos, G. G., & Svensson, T. H. (1994) · Synapse · doi:10.1002/syn.890160105 · Cited by 521
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505
Self-citation
Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal
Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F. (1997) · Science · doi:10.1126/science.276.5321.2050 · Cited by 499
Role of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 474
Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston-Jones, G. (2000) · Nature · doi:10.1038/35000212 · Cited by 462
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats
Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457
Symptoms of Tobacco Withdrawal: A Replication and Extension
Hughes, J. R. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810250054007 · Cited by 449
Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery
Holladay, M. W., Dart, M. J., & Lynch, J. K. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970377o · Cited by 442
Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function,
Albuquerque, E. X., Alkondon, M., Pereira, E. F. R., Castro, N. G., Schrattenholz, A. S., Barbosa, C. T. F., Bonfante-Cabarcas, R. A., Aracava, Y., Eisenberg, H. M., & Maelicke, A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36503-6 · Cited by 437
The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity
Benwell, M. E. M., & Balfour, D. J. K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09067.x · Cited by 426
Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal
S. Watkins, G. F. K. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050011277 · Cited by 424
Overview of nicotinic receptors and their roles in the central nervous system
Dani, J. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01011-8 · Cited by 421
Human neuronal nicotinic receptors
Gotti, C., Fornasari, D., & Clementi, F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00034-8 · Cited by 417
Tobacco withdrawal in self-quitters
Hughes, J. R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.60.5.689 · Cited by 412
Tobacco withdrawal in self-quitters.
Hughes, J. R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.5.689 · Cited by 409
Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal
Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407
Nicotinic effects on the firing pattern of midbrain dopamine neurons
GRENHOFF, J., ASTON‐JONES, G., & SVENSSON, T. H. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07988.x · Cited by 399
The Role of Corticotropin-Releasing Factor in Drug Addiction
Sarnyai, Z., Shaham, Y., & Heinrichs, S. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01492-3 · Cited by 381
Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex
Kawasaki, H., Adolphs, R., Kaufman, O., Damásio, H., Damásio, A. R., Granner, M. A., Bakken, H. E., Hori, T., & Howard, M. A. (2001) · Nature Neuroscience · doi:10.1038/82850 · Cited by 367
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364
Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function
Buisson, B., & Bertrand, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01819.2001 · Cited by 361
CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat
Baldwin, H. A., Rassnick, S., Rivier, J., Koob, G. F., & Britton, K. T. (1991) · Psychopharmacology · doi:10.1007/bf02244208 · Cited by 353
Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine
Goldberg, S. R., Spealman, R. D., & Goldberg, D. M. (1981) · Science · doi:10.1126/science.7291998 · Cited by 347
Decreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345
Self-citation
Rodent model of nicotine abstinence syndrome
Malin, D. H., Lake, J. R., Newlin-Maultsby, P., Roberts, L. K., Lanier, J. G., Carter, V. A., Cunningham, J. S., & Wilson, O. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90408-8 · Cited by 334
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332
Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices.
Alkondon, M., Pereira, E. F. R., Barbosa, C. T. F., & Albuquerque, E. X. (1997) · PubMed · Cited by 326
Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors
Taber, M. T., & Fibiger, H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03896.1995 · Cited by 318
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318
Self-citation
Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors
Deneris, E. S., Connolly, J. G., Rogers, S. W., & Duvoisin, R. M. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90486-c · Cited by 318
Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal
Stinus, L., Le Moal, M., & Koob, G. F. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90106-e · Cited by 317
Dopaminergic Innervation of the Amygdala Is Highly Responsive to Stress
Inglis, F., & Moghaddam, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721088.x · Cited by 310
Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area
Suaud-Chagny, M. F., Chergui, K., Chouvet, G., & Gonon, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90076-e · Cited by 307
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
Santarelli, L., Gobbi, G., Debs, P. C., Sibille, E. L., Blier, P., Hen, R., & Heath, M. J. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1912 · Cited by 303
Cigarette smoking and major depression
Covey, L. S., Glassman, A. H., & Stetner, F. (1998) · Journal of Addictive Diseases · doi:10.1300/j069v17n01_04 · Cited by 302
α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release
Luo, S., Kulak, J. M., Cartier, G. E., Jacobsen, R. B., Yoshikami, D., Olivera, B. M., & McIntosh, J. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08571.1998 · Cited by 290
Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions
Conroy, W. G., & Berg, D. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4424 · Cited by 288
Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.
Schulteis, G., Markou, A., Gold, L. H., Stinus, L., & Koob, G. F. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24024-1 · Cited by 285
Self-citation
Selective dopamine antagonists reduce nicotine self-administration
Corrigall, W. A., & Coen, K. M. (1991) · Psychopharmacology · doi:10.1007/bf02244174 · Cited by 282
Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding
Donny, E. C., Caggiula, A. R., Rowell, P. P., Gharib, M. A., Maldovan, V., Booth, S., Mielke, M. M., Hoffman, A., & McCallum, S. E. (2000) · Psychopharmacology · doi:10.1007/s002130000497 · Cited by 265
Smoking withdrawal dynamics in unaided quitters.
Piasecki, T. M., Niaura, R., Shadel, W. G., Abrams, D., Goldstein, M., Fiore, M. C., & Baker, T. B. (2000) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.109.1.74 · Cited by 262
Smoking, smoking cessation, and major depression
Glassman, A. H. (1990) · JAMA · doi:10.1001/jama.264.12.1546 · Cited by 251
Major depression following smoking cessation
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.2.263 · Cited by 250
Clonidine for smoking cessation
Gourlay, S. G., Stead, L. F., & Benowitz, N. L. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000058.pub2 · Cited by 248
Nicotine self-administration in rats
Donny, E. C., Caggiula, A. R., Knopf, S., & Brown, C. (1995) · Psychopharmacology · doi:10.1007/bf02246272 · Cited by 233
The Role of Corticotropin‐Releasing Factor in Behavioural Responses to Stress
Koob, G. F., Heinrichs, S. C., Pich, E. M., Menzaghi, F., Baldwin, H. A., Miczek, K. A., & Britton, K. T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch14 · Cited by 232
Blockade of Nicotine Self-Administration with Nicotinic Antagonists in Rats
Watkins, S. S., Epping-Jordan, M. P., Koob, G. F., & Markou, A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00226-3 · Cited by 229
Self-citation
Depression of Mesolimbic Dopamine Transmission and Sensitization to Morphine During Opiate Abstinence
Acquas, E., & Chiara, G. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10033.x · Cited by 223
Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.
Kalivas, P. W., Duffy, P., & Barrow, J. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20732-7 · Cited by 215
Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects
Watkins, S. S., Stinus, L., Koob, G. F., & Markou, A. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35389-3 · Cited by 214
Self-citation
Nicotine as a reinforcer in human subjects and laboratory animals
Henningfield, J. E., & Goldberg, S. R. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(83)90405-7 · Cited by 214
Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome
Harris, G. C., & Aston‐Jones, G. (1994) · Nature · doi:10.1038/371155a0 · Cited by 214
Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence
MALDONADO, R. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00061-5 · Cited by 213
Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: Studies on the involvement of dopamine
Reid, M. S., Hsu, K., & Berger, S. P. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199710)27:2 · Cited by 212
In vivo CRF release in rat amygdala is increased during cocaine withdrawal in self-administering rats
Richter, R. M., & Weiss, F. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990615)32:4 · Cited by 210
Rewarding effects of opiates are absent in mice lacking the receptor for substance P
Murtra, P., Sheasby, A. M., Hunt, S. P., & Felipe, C. D. (2000) · Nature · doi:10.1038/35012069 · Cited by 208
N-methyl-d-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens
Schilström, B., Nomikos, G. G., Nisell, M., Hertel, P., & Svensson, T. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00243-1 · Cited by 207
Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine
Fenster, C. P., Whitworth, T. L., Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04804.1999 · Cited by 204
Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
Nisell, M., Nomikos, G. G., & Svensson, T. H. (1994) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1994.tb00373.x · Cited by 204
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome
Hildebrand, B. E., Nomikos, G. G., Hertel, P., Schilström, B., & Svensson, T. H. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01135-9 · Cited by 200
Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons
Sudweeks, S. N., & Yakel, J. L. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00515.x · Cited by 197
Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo‐cortical transmission
Gioanni, Y., Rougeot, C., Clarke, P. B. S., Lepousé, C., Thierry, A. M., & Vidal, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00403.x · Cited by 191
Pharmacologic characterization of nicotine-induced conditioned place preference
Fudala, P. J., Teoh, K., & Iwamoto, E. T. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90384-3 · Cited by 190
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats
Basso, A. M., Spina, M. G., Rivier, J., Vale, W., & Koob, G. F. (1999) · Psychopharmacology · doi:10.1007/s002130051028 · Cited by 190
Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.
Piasecki, T. M., Fiore, M. C., & Baker, T. B. (1998) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.107.2.238 · Cited by 189
Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice
Sparks, J. A., & Pauly, J. R. (1999) · Psychopharmacology · doi:10.1007/s002130050818 · Cited by 188
Effects of mecamylamine on human cigarette smoking and subjective ratings
Nemeth-Coslett, R., Henningfield, J., O'Keeffe, M., & Griffiths, R. R. (1986) · Psychopharmacology · doi:10.1007/bf00178502 · Cited by 186
Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors
Lindstrom, J. M., Anand, R., Gerzanich, V., Peng, X.-D., Wang, F., & Wells, G. B. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62094-4 · Cited by 179
Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms
Fagerström, K. O., Schneider, N. G., & Lunell, E. (1993) · Psychopharmacology · doi:10.1007/bf02244941 · Cited by 176
Determinants of Competitive Antagonist Sensitivity on Neuronal Nicotinic Receptor β Subunits
Harvey, S. C., & Luetje, C. W. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03798.1996 · Cited by 175
Guidance for commissioners on the cost effectiveness of smoking cessation interventions
Parrott, S., Godfrey, C., Raw, M., West, R., & McNeill, A. D. (1998) · PubMed Central · Cited by 170
Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars, and pipes.
Jacob, P., Yu, L., Shulgin, A. T., & Benowitz, N. L. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.5.731 · Cited by 169
Multiple Determinants of Dihydro‐β‐Erythroidine Sensitivity on Rat Neuronal Nicotinic Receptor α Subunits
Harvey, S. C., Maddox, F. N., & Luetje, C. W. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67051953.x · Cited by 168
A comparison of nicotine and cocaine self-administration in the dog: fixed-ratio and progressive-ratio schedules of intravenous drug infusion.
Risner, M. E., & Goldberg, S. R. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33473-7 · Cited by 168
Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats
Harrison, A. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00237-2 · Cited by 167
The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat
Malin, D. H., Ronald Lake, J., Carter, V. A., Scott Cunningham, J., Hebert, K. M., Conrad, D. L., & Wilson, O. B. (1994) · Psychopharmacology · doi:10.1007/bf02244770 · Cited by 165
Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
Kenny, P. J., File, S. E., & Rattray, M. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00246-1 · Cited by 165
Self-citation
UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes
Sharples, C. G. V., Kaiser, S., Soliakov, L. S., Marks, M. J., Collins, A. C., Washburn, M. S., Wright, E., Spencer, J. A., Gallagher, T., Whiteaker, P., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02783.2000 · Cited by 164
The Role of CRF in Behavioral Aspects of Stress
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Britton, K. T., & Koob, G. F. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44673.x · Cited by 160
Differential Inhibition by α‐Conotoxin‐MII of the Nicotinic Stimulation of [3H]Dopamine Release from Rat Striatal Synaptosomes and Slices
Kaiser, S., Soliakov, L. S., Harvey, S. C., Luetje, C. W., & Wonnacott, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70031069.x · Cited by 160
Comparing the reinforcing efficacy of nicotine containing and de-nicotinized cigarettes: a behavioral economic analysis
Shahan, T. A., Bickel, W. K., Madden, G. J., & Badger, G. J. (1999) · Psychopharmacology · doi:10.1007/s002130051162 · Cited by 159
Nicotine self-administration in rats on a progressive ratio schedule of reinforcement
Donny, E. C., Caggiula, A. R., Mielke, M. M., Booth, S., Gharib, M. A., Hoffman, A., Maldovan, V., Shupenko, C., & McCallum, S. E. (1999) · Psychopharmacology · doi:10.1007/s002130051153 · Cited by 158
Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum
Grady, S. R., Meinerz, N. M., Cao, J., Reynolds, A. M., Picciotto, M. R., Changeux, J., McIntosh, J. M., Marks, M. J., & Collins, A. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00019.x · Cited by 156
Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal
Manzoni, O. J., & Williams, J. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06629.1999 · Cited by 156
Nicotine self-administration in animals as a dependence model
Corrigall, W. A. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011121 · Cited by 155
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat
Markou, A., & Paterson, N. E. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110073380 · Cited by 154
Self-citation
A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.
Gellert, V. F., & Sparber, S. B. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30826-8 · Cited by 149
Naloxone precipitates nicotine abstinence syndrome in the rat
Malin, D. H., Lake, J. R., Carter, V. A., Cunningham, J. S., & Wilson, O. B. (1993) · Psychopharmacology · doi:10.1007/bf02244930 · Cited by 147
Naloxone reduces cigarette smoking
Karras, A., & Kane, J. M. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90562-7 · Cited by 144
Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.
Grottick, A. J., Trube, G., Corrigall, W., Huwyler, J., Malherbe, P., Wyler, R., & Higgins, G. A. (2000) · PubMed · Cited by 142
Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal
Koob, G. F., Wall, T. L., & Bloom, F. E. (1989) · Psychopharmacology · doi:10.1007/bf00441954 · Cited by 142
Differential Regulation of Neuronal Nicotinic Receptor Binding Sites Following Chronic Nicotine Administration
Flores, C. M., Dávila‐García, M. I., Ulrich‐Lai, Y. M., & Kellar, K. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052216.x · Cited by 142
Participation of the Central Amygdaloid Nucleus in the Response of Adrenocorticotropin Secretion to Immobilization Stress: Opposing Roles of the Noradrenergic and Dopaminergic Systems
Beaulieu, S., Paolo, T. D., Côté, J., & Barden, N. (2008) · Neuroendocrinology · doi:10.1159/000124701 · Cited by 140
Both Nicotinic and Muscarinic Receptors in Ventral Tegmental Area Contribute to Brain-Stimulation Reward
Yeomans, J. S., & Baptista, M. A. S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00467-4 · Cited by 139
Systemic Nicotine Stimulates Dopamine Release in Nucleus Accumbens: Re-evaluation of the Role ofN-Methyl-d-aspartate Receptors in the Ventral Tegmental Area
Fu, Y., Matta, S. G., Gao, W., Brower, V. G., & Sharp, B. M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39093-7 · Cited by 139
Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus
Sershen, H. W., Balla, A., Lajtha, Á., & Vizi, E. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00425-3 · Cited by 136
Hippocampal neurotrophin and trk receptor mRNA levels are altered by local administration of nicotine, carbachol and pilocarpine
French, S. J., Humby, T., Horner, C. H., Sofroniew, M. V., & Rattray, M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00048-0 · Cited by 134
The fall and rise of neuronal α-bungarotoxin binding proteins
Clarke, P. B. S. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90125-p · Cited by 133
Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles
Benwell, M. E. M., & Balfour, D. J. K. (1979) · Psychopharmacology · doi:10.1007/bf00426913 · Cited by 132
Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal
Diana, M., Muntoni, A. L., Pistis, M., Melis, M., & Gessa, G. L. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00488.x · Cited by 132
Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus
Alkondon, M., Pereira, E. F. R., Almeida, L. E. F., Randall, W. R., & Albuquerque, E. X. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00156-8 · Cited by 129
Nornicotine is self-administered intravenously by rats
Bardo, M. T., Green, T. A., Crooks, P. A., & Dwoskin, L. P. (1999) · Psychopharmacology · doi:10.1007/s002130051119 · Cited by 128
Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms
Hildebrand, B. E., Nomikos, G. G., Bondjers, C., Nisell, M., & Svensson, T. H. (1997) · Psychopharmacology · doi:10.1007/s002130050200 · Cited by 122
Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists
Shoaib, M., Benwell, M. E. M., Akbar, M., Stolerman, I. P., & Balfour, D. J. K. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14854.x · Cited by 121
Characterization of N‐[3H]Methylcarbamylcholine Binding Sites and Effect of N‐Methylcarbamylcholine on Acetylcholine Release in Rat Brain
Araujo, D. M., Lapchak, P. A., Collier, B., & Quirion, R. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb04869.x · Cited by 121
The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study
Lança, A. J., Adamson, K. L., Coen, K. M., Chow, B. L., & Corrigall, W. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00607-7 · Cited by 120
The acetylcholine receptor of the neuromuscular junction recognizes mecamylamine as a noncompetitive antagonist.
Varanda, W. A., Aracava, Y., Sherby, S. M., VanMeter, W. G., Eldefrawi, M. E., & Albuquerque, E. X. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13493-7 · Cited by 120
Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats
Hand, T. H., Koob, G. F., Stinus, L., & Moal, M. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)90452-0 · Cited by 119
Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking
Crooks, P. A., & Dwoskin, L. P. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00117-2 · Cited by 118
Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers
Butschky, M. F., Bailey, D., Henningfield, J. E., & Pickworth, W. B. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00269-o · Cited by 118
Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds
Wise, R. A., & Munn, E. M. (1995) · Psychopharmacology · doi:10.1007/bf02245178 · Cited by 115
The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses
Cheeta, S., Irvine, E. E., Kenny, P. J., & File, S. E. (2001) · Psychopharmacology · doi:10.1007/s002130100681 · Cited by 113
Self-citation
Nicotinic receptor function determined by stimulation of rubidium efflux from mouse brain synaptosomes.
Marks, M. J., Farnham, D. A., Grady, S. R., & Collins, A. C. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10175-4 · Cited by 112
Differential effects of acute and chronic nicotine on dopamine output in the core and shell of the rat nucleus accumbens
Nisell, M., Marcus, M. M., Nomikos, G. G., & Svensson, T. H. (1997) · Journal of Neural Transmission · doi:10.1007/bf01271290 · Cited by 112
Naltrexone Effects on Short-Term and Long-Term Smoking Cessation
Covey, L. S., Glassman, A. H., & Stetner, F. (1999) · Journal of Addictive Diseases · doi:10.1300/j069v18n01_04 · Cited by 111
Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam
Coco, M. L., Kuhn, C. M., Ely, T. D., & Kilts, C. D. (1992) · Brain Research · doi:10.1016/0006-8993(92)91079-t · Cited by 110
Endogenous κ-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release
Spanagel, R., Almeida, O. F. X., Bartl, C., & Shippenberg, T. S. (1994) · Psychopharmacology · doi:10.1007/bf02244761 · Cited by 110
Associations between tobacco smoking and illicit drug use among methadone-maintained opiate-dependent individuals.
Frosch, D. L., SHOPTAW, S. J., Nahom, D., & Jarvik, M. E. (2000) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.8.1.97 · Cited by 110
Effects of nicotine on the threshold for rewarding brain stimulation in rats
Huston-Lyons, D., & Kornetsky, C. H. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90223-3 · Cited by 109
The Role of Corticotropin‐Releasing Factor in the Anxiogenic Effects of Ethanol Withdrawal
Menzaghi, F., Rassnick, S., Heinrichs, S. C., Baldwin, H. A., Pich, E. M., Weiss, F., & Koob, G. F. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb19819.x · Cited by 109
Effects of chronic bupropion on interstitial concentrations of dopamine in rat nucleus accumbens and striatum.
Nomikos, G. G., Damsma, G., Wenkstern, D., & Fibiger, H. C. (1992) · PubMed · Cited by 109
Anxiolytic Action of a Neurokinin1 Receptor Antagonist in the Social Interaction Test
File, S. E. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)90002-2 · Cited by 108
Effects of chronic 17?-estradiol treatment on the serotonin 5-HT1A receptor mRNA and binding levels in the rat brain
�sterlund, M. K., Halldin, C., & Hurd, Y. L. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200001)35:1 · Cited by 108
Development of Major Depressive Disorder During Smoking-Cessation Treatment
Murphy, C., & Abrams, D. B. (1996) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v57n1106 · Cited by 105
Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
Dani, J. A., Radcliffe, K. A., & Pidoplichko, V. I. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00003-0 · Cited by 103
Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats
Paterson, N. E., Myers, C., & Markou, A. (2000) · Psychopharmacology · doi:10.1007/s002130000559 · Cited by 103
Self-citation
LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats
Helton, D. R., Tizzano, J. P., Monn, J. A., Schoepp, D. D., & Kallman, M. J. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00170-6 · Cited by 103
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes
Wilkie, G., Hutson, P. H., Sullivan, J. P., & Wonnacott, S. (1996) · Neurochemical Research · doi:10.1007/bf02532425 · Cited by 103
Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat Role of Nicotinic Receptors in the Ventral Tegmental Area
Hildebrand, B. E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00055-x · Cited by 103
Decrease of tolerance to, and physical dependence on morphine by glutamate receptor antagonists
Gonzalez, P. G., Cabello, P., Germany, A., Norris, B., & Contreras, E. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01099-6 · Cited by 102
Target‐Specific Glutamatergic Regulation of Dopamine Neurons in the Ventral Tegmental Area
Takahata, R., & Moghaddam, B. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751775.x · Cited by 101
Diazepam dependence prevented by glutamate antagonists.
Steppuhn, K. G., & Turski, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6889 · Cited by 101
Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release
Kenny, P. J., File, S. E., & Neal, M. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752409.x · Cited by 100
Self-citation
Naltrexone, smoking behaviour and cigarette withdrawal
Sutherland, G., Stapleton, J., Russell, M. A., & Feyerabend, C. (1995) · Psychopharmacology · doi:10.1007/bf02245813 · Cited by 98
Nicotine abstinence in the mouse
Isola, R., Vogelsberg, V., Wemlinger, T. A., Neff, N. H., & Hadjiconstantinou, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02131-9 · Cited by 96
Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats
Carboni, E., Bortone, L., Giua, C., & Di Chiara, G. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00064-2 · Cited by 96
Nicotine vs. placebo gum in the alleviation of withdrawal during smoking cessation
Schneider, N. G., Jarvik, M. E., & Forsythe, A. B. (1984) · Addictive Behaviors · doi:10.1016/0306-4603(84)90052-2 · Cited by 96
Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study
Davidson, M., Shanley, B., & Wilce, P. (1995) · Brain Research · doi:10.1016/0006-8993(94)01440-s · Cited by 94
Allosteric nicotinic receptors, human pathologies
Léna, C., & Changeux, J. (1998) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(98)80140-x · Cited by 93
Mecamylamine-precipitated nicotine-withdrawal aversion in rats
Suzuki, T., Ise, Y., Tsuda, M., Maeda, J., & Misawa, M. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00723-6 · Cited by 93
Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs
Lin, D. C.-H., Koob, G. F., & Markou, A. (1999) · Psychopharmacology · doi:10.1007/s002130051060 · Cited by 92
Self-citation
Smoking-associated changes in the serotonergic systems of discrete regions of human brain
Benwell, M. E. M., Balfour, D. J. K., & ANDERSON, J. M. (1990) · Psychopharmacology · doi:10.1007/bf02245746 · Cited by 90
Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence
Lü, L. T., Liu, D., Ceng, X., & Ma, L. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01310.x · Cited by 89
The Anxiogenic β‐Carboline FG 7142 Selectively Increases Dopamine Release in Rat Prefrontal Cortex as Measured by Microdialysis
Bradberry, C. W., Lory, J. D., & Roth, R. H. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb01987.x · Cited by 88
Nicotinic acetylcholine receptor subunit mRNA expression and channel function in medial habenula neurons
Sheffield, E. B., Quick, M. W., & Lester, R. A. J. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00138-6 · Cited by 87
Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection
Goldberg, S. R., & Henningfield, J. E. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90450-9 · Cited by 87
Naloxone does not affect cigarette smoking
Nemeth-Coslett, R., & Griffiths, R. R. (1986) · Psychopharmacology · doi:10.1007/bf00174355 · Cited by 86
Antagonist-precipitated opioid withdrawal in rats: Evidence for dissociations between physical and motivational signs
Higgins, G. A., & Sellers, E. M. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90489-8 · Cited by 85
Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat
Belluardo, N., Blum, M., Mudò, G., Andbjer, B., & Fuxé, K. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00323-0 · Cited by 83
Dramatic Depletion of Mesolimbic Extracellular Dopamine after Withdrawal from Morphine, Alcohol or Cocaine: A Common Neurochemical Substrate for Drug Dependence
Rossetti, Z. L., Melis, F., Carboni, S., & Gessa, G. L. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb26016.x · Cited by 82
Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity
Helton, D. R., Modlin, D. L., Tizzano, J. P., & Rasmussen, K. (1993) · Psychopharmacology · doi:10.1007/bf02245698 · Cited by 81
Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin
Dw, S., Loring, R., Aizenman, E., & Zigmond, R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00287.1991 · Cited by 78
Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes
East, S. J., Hill, M. P., & Brotchie, J. M. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00119-6 · Cited by 77
Amphetamine withdrawal: A behavioral evaluation
Kokkinidis, L., Zacharko, R. M., & Anisman, H. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90501-1 · Cited by 77
Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking
Rose, J. E., Behm, F. M., & Westman, E. C. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00465-2 · Cited by 76
Naltrexone administration affects ad libitum smoking behavior
Wewers, M. E., Dhatt, R., & Tejwani, G. A. (1998) · Psychopharmacology · doi:10.1007/s002130050756 · Cited by 76
Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal
Heinrichs, S. C., Lapsansky, J., Behan, D. P., Chan, R. K. W., Sawchenko, P. E., Lorang, M. T., LING, N. C., Vale, W., & Souza, E. B. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15475 · Cited by 76
Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat brain
Pandey, S. C., Roy, A., Xu, T., & Mittal, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00309.x · Cited by 75
Nicotine attenuates naloxone-induced jumping behaviour in morphine-dependent mice
Zarrindast, M., & Farzin, D. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00761-x · Cited by 75
Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation
Grillner, P., & Svensson, T. H. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 75
Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis
Toide, K., & Arima, T. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90510-4 · Cited by 74
Nicotine self-administration and withdrawal: modulation of anxiety in the social interaction test in rats
Irvine, E. E., Bagnalasta, M., Marcon, C., Motta, C., Tessari, M., File, S. E., & Chiamulera, C. (2000) · Psychopharmacology · doi:10.1007/s002130000586 · Cited by 73
MK801 attenuates behavioural adaptation to chronic nicotine administration in rats
Shoaib, M. C., & Stolerman, I. P. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09010.x · Cited by 72

Research works printed but not linked: 3

Paterson, 2001, Nicotine self-administration in rats: short-term abstinence, progressive ratio schedule, and extinction with or without conditioned stimuli, Drug Alcohol Depend, 63, S120
Ridley, 1997, The influence of nicotine on 5-HT overflow in the dorsal hippocampus of the rat, Br J Pharmacol, 112, 301P
Wonnacott, 1993, Methyllycaconitine: a new probe that discriminates between nicotinic acetylcholine receptor subclasses, Methods Neurosci, 12, 263

Sorted by citations

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559
Cue dependency of nicotine self-administration and smoking
Caggiula, A. R., Donny, E. C., White, A. R., Chaudhri, N., Booth, S., Gharib, M. A., Hoffman, A., Perkins, K. A., & Sved, A. F. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00676-1 · Cited by 425
Reward, addiction, withdrawal to nicotine
De Biasi, M., & Dani, J. A. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113734 · Cited by 366
“In the conditioned place-aversion paradigm, the animal learns to avoid the compartment in which nicotine withdrawal is experienced (Jackson et al. 2009, Kenny & Markou 2001).”
Background
What Keeps Us Awake: the Neuropharmacology of Stimulants and Wakefulness Promoting Medications
Boutrel, B., & Koob, G. F. (2004) · SLEEP · doi:10.1093/sleep/27.6.1181 · Cited by 310

See all 310

Authors: Kenny, P. J., & Markou, A.
Affiliations: Scripps Research Institute (US)
Corresponding author: Markou, Athina
ORCID: Kenny, Paul J.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2001-12
Volume: 70
Issue: 4
Pages: 531-549
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/s0091-3057(01)00651-7
OpenAlex: W2020567468
Cited by: 310
References: 264
Citations by year: 2025: 9 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 17 · 2014: 12 · 2013: 19 · 2012: 18
FWCI: 0.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA 11946, R56DA011946)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine withdrawal, nicotine dependence, nicotinic acetylcholine receptors, somatic withdrawal signs, conditioned place aversion, dopamine, opioid peptides, serotonin, glutamate, acetylcholine, neuroanatomical substrates
MeSH terms: Animals, Humans, Nicotine, Substance Withdrawal Syndrome, Nicotinic Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurobiology of the nicotine withdrawal syndrome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks