Cited by 171Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsStress Responses and Cortisol

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Early-life handling stimulation and environmental enrichment

Fernández-Teruel, Alberto, Giménez-Llort, Lydia, Escorihuela, Rosa M., Gil, Luis, Aguilar, Raúl, Steimer, Thierry, Tobeña, Adolf·2002·Pharmacology Biochemistry and Behavior

DOI 10.1016/s0091-3057(02)00787-6

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Abstract

Neonatal (early) handling (EH) and environmental enrichment (EE) of laboratory rodents have been the two most commonly used methods of providing supplementary environmental stimulation in order to study behavioral and neurobiological plasticity. A large body of research has been generated since the 1950s, unequivocally showing that both treatments induce profound and long-lasting behavioral and neural consequences while also inducing plastic brain effects and being "protective" against some age-related deficits. The present work is aimed at reviewing the main neurobehavioral effects of both manipulations, with the final purpose of comparing them and trying to find out to what extent the effects of both treatments may share (or not) possible neural mechanisms.

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See all 171

Authors: Fernández-Teruel, A., Giménez-Llort, L., Escorihuela, R. M., Gil, L., Aguilar, R., Steimer, T., & Tobeña, A.
Affiliations: Universitat Autònoma de Barcelona (ES)
ORCID: Escorihuela, Rosa M.
Aguilar, Raúl
Tobeña, Adolf
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2002-08
Volume: 73
Issue: 1
Pages: 233-245
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/s0091-3057(02)00787-6
OpenAlex: W80710638
Cited by: 171
References: 137
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 7
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: neonatal handling, environmental enrichment, laboratory rodents, neuroplasticity, behavioral plasticity, neurobehavioral effects, brain development, age-related deficits, neural mechanisms
MeSH terms: Animals, Animals, Newborn, Environment, Exploratory Behavior, Handling, Psychological, Learning, Rats

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Early-life handling stimulation and environmental enrichment

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