Opposing Effects of Ras on p53

p53 Mutations in Human Cancers

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Mdm2 promotes the rapid degradation of p53

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The p53 tumour suppressor gene

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer.

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Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX

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HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies

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Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy

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HIF1α and p53 Regulated MED30, a Mediator Complex Subunit, is Involved in Regulation of Glioblastoma Pathogenesis and Temozolomide Resistance

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Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects

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Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines

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Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies

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Therapeutic considerations for Mdm2: not just a one trick pony

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Decoding the Central Dogma: Quantitative Insights into Transcription and Translation Dynamics in the p53-Mediated DNA Damage Response

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Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor

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MageC2 protein is upregulated by oncogenic activation of MAPK pathway and causes impairment of the p53 transactivation function

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A Novel E1B-55kD-Deleted Oncolytic Adenovirus Carrying Mutant KRAS-Regulated hdm2 Transgene Exerts Specific Antitumor Efficacy on Colorectal Cancer Cells

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Proteomics analyses of ovarian caner using genetically defined human ovarian cancer models

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Associations of KRAS Point Mutations with Survival of Patients Who Underwent Curative-Intent Resection of Colorectal Liver Metastases

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The ID genotype of MDM2 40 bp insertion/deletion polymorphism was associated with lower risk of SLE

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The Regulation of Tumor Suppressor Genes by Oncogenes

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Cellular senescence and its pathogenic and therapeutic implications in autoimmune hepatitis

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Cooperation between MDM2 and MDMX in the Regulation of p53

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Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention

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Role of cell cycle regulator p19ARF in regulating T cell responses

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The p53-Mdm2 Loop: A Critical Juncture of Stress Response

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Cellular lifespan and senescence: a complex balance between multiple cellular pathways

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Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner

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Combination of AURKA inhibitor and MEK inhibitor strongly enhances G1 arrest and induces synergistic antitumor effect on KRAS or BRAF mutant colon cancer cells

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MDM2 and MDMX Regulators of p53 Activity

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Systems Theory for Pharmaceutical Drug Discovery

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Impact of MDM2 Single Nucleotide Polymorphism on Oral Squamous Cell Carcinoma Risk

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Association of Murine Double Minute 2 Genotypes and Lung Cancer Risk

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Activation of the Snail transcription factor induces Mdm2 gene expression

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Biologia molecular dos glioblastomas: perspectivas terapêuticas do monoterpeno álcool perílico

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The Impact of Oncogenes on Tumor Maintenance

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Regulation of the Tumor Suppresser p53 and Survivin by Ras and Ral GTPases:Implications for Malignant Transformation

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20 Years of DNA Damage Signaling to p53

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Mdm2 and ARF

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Disruptive changes in tissue microenvironment prime oncogenic processes at different stages of carcinogenesis in lungPreprint

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Regulation of the p53 Response by Cellular Growth and Survival Factors

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Multiple modes of Mdmx regulation affect p53 activation

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Expression levels of MDM2 and MDMX proteins and their associated effects on P53 in human liposarcomas

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B cell signalling in mechanisms of central and peripheral tolerance

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Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7

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IKKalpha mediated NOTCH1 Activation Promotes Tumorigenesis via FOXA2 Suppression

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Effects of overexpressingp14 ARF on the apoptosis in human melanoma cells irradiated with γ-ray

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TRANSCRIPTOME STUDIES OF CELL-FATE AND AGING

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Title New druggable targets in the Ras pathway

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and Function in Maintaining Nucleolar Structure ARF p19Suppressor Role for Basal

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Role of hnRNP A1 in the Regulation of HDM2 Gene Expression

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Impact of MDM2 Single Nucleotide Polymorphism on Oral Squamous Cell Carcinoma Risk

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Development of an Inhibitor of raf Kinase

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MALAT1 overexpression contributes to choriocarcinoma by binding with RBM10 and promoting p53 degradation

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The interaction of the adenovirus E1B-55K protein with a histone deacetylase complex : its importance in regulation of p53 protein functions.

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Role of MDM2 In Cell Growth Regulation

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Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

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p19ARF links the tumour suppressor p53 to Ras

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