Opposing Effects of Ras on p53

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018

ras oncogenes in human cancer: a review.

Bos, J. L. (1989) · PubMed · Cited by 5,061

Lessons from hereditary colorectal cancer

Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506

The p53 tumour suppressor gene

Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803

A cell cycle regulator potentially involved in genesis of many tumor types

Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751

Proliferation, cell cycle and apoptosis in cancer

Evan, G. I., & Vousden, K. H. (2001) · Nature · doi:10.1038/35077213 · Cited by 3,417

The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690

Control of apoptosis by p53

Fridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.022 · Cited by 1,265

The INK4a/ARF network in tumour suppression

Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 1,003

APC, Signal transduction and genetic instability in colorectal cancer

Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876

p53

Vousden, K. H. (2000) · Cell · doi:10.1016/s0092-8674(00)00171-9 · Cited by 785

The MDM2-p53 interaction.

Moll, U. M., & Petrenko, O. (2003) · PubMed · Cited by 778

Regulation and function of the p53 tumor suppressor protein

Ryan, K. M., Phillips, A. C., & Vousden, K. H. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00216-7 · Cited by 721

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

Yang, J.-Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J.-Y., Lai, C., Chang, C. J., Huang, W., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1676 · Cited by 720

Tumor suppression by Ink4a-Arf: progress and puzzles.

Lowe, S. W., & Sherr, C. J. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00013-8 · Cited by 699

Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

Ogawara, Y., Kishishita, S., Obata, T., Isazawa, Y., Suzuki, T., Tanaka, K., Masuyama, N., & Gotoh, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109745200 · Cited by 617

Trk receptor tyrosine kinases: A bridge between cancer and neural development

Nakagawara, A. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00530-4 · Cited by 499

Raf proteins and cancer: B-Raf is identified as a mutational target

Mercer, K., & Pritchard, C. A. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00016-7 · Cited by 455

The dark side of Ras: regulation of apoptosis

Cox, A. D., & Der, C. J. (2003) · Oncogene · doi:10.1038/sj.onc.1207111 · Cited by 443

The MDM2-p53 pathway revisited

Nag, S. A., Jiangjiang, Q., Kalkunte, S. S., Ming-hai, W., & Zhang, R. (2013) · Journal of Biomedical Research · doi:10.7555/jbr.27.20130030 · Cited by 438

The evolution of diverse biological responses to DNA damage: insights from yeast and p53

Wahl, G. M., & Carr, A. M. (2001) · Nature Cell Biology · doi:10.1038/ncb1201-e277 · Cited by 376

PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy

Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., & Donner, D. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108302200 · Cited by 351

The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

Manfredi, J. J. (2010) · Genes & Development · doi:10.1101/gad.1941710 · Cited by 344

Activation of the p53 tumor suppressor protein

Vousden, K. H. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00035-5 · Cited by 337

Radiation-induced cell signaling: inside-out and outside-in

Valerie, K. C., Yacoub, A., Hagan, M. P., Curiel, D. T., Fisher, P. B., Grant, S., & Dent, P. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0596 · Cited by 335

Regulation of p53 Function

Woods, D. B., & Vousden, K. H. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5141 · Cited by 323

Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1

Asher, G., Lotem, J., Cohen, B., Sachs, L., & Shaul, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1188 · Cited by 317

p53 stabilization is decreased upon NFκB activation

Tergaonkar, V., Pando, M. P., Vafa, O., Wahl, G. M., & Verma, I. M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00068-5 · Cited by 319

MDM2 is a Central Node in the p53 Pathway: 12 Years and Counting

Bond, G. L., Hu, W., & Levine, A. J. (2005) · Current Cancer Drug Targets · doi:10.2174/1568009053332627 · Cited by 310

Raf kinases in cancer–roles and therapeutic opportunities

Maurer, G., Tarkowski, B., & Baccarini, M. (2011) · Oncogene · doi:10.1038/onc.2011.160 · Cited by 311

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

Ferbeyre, G., de Stanchina, E., Lin, A. W., Querido, E., McCurrach, M. E., Hannon, G. J., & Lowe, S. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3497-3508.2002 · Cited by 290

The p53 and Mdm2 families in cancer

Michael, D. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00264-7 · Cited by 288

Multiple roles of the tumor suppressor p53

Bargonetti, J., & Manfredi, J. J. (2002) · Current Opinion in Oncology · doi:10.1097/00001622-200201000-00015 · Cited by 332

Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway

Li, M., Zhang, Z., Hill, D. L., Wang, H., & Zhang, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3066 · Cited by 278

The Ras radiation resistance pathway.

Gupta, A. K., Bakanauskas, V. J., Cerniglia, G. J., Cheng, Y., Bernhard, E. J., Muschel, R. J., & McKenna, W. G. (2001) · PubMed · Cited by 238

STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis

Townsend, P. A., Scarabelli, T. M., Davidson, S. M., Knight, R. A., Latchman, D. S., & Stephanou, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m302637200 · Cited by 233

p53-Mdm2--the affair that never ends

Alarcon-Vargas, D. (2002) · Carcinogenesis · doi:10.1093/carcin/23.4.541 · Cited by 234

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

Zhang, J., Sun, Q., Zhang, Z., Ge, S., Han, Z.-G., & Chen, W.-T. (2012) · Oncogene · doi:10.1038/onc.2012.28 · Cited by 226

INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence

Brookes, S., Rowe, J., Ruas, M., Llanos, S., Clark, P. A., Lomax, M., James, M. C., Vatcheva, R., Bates, S., Vousden, K. H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf289 · Cited by 220

Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

Wei, W., Hemmer, R. M., & Sedivy, J. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6748-6757.2001 · Cited by 217

BCR/ABL activates mdm2 mRNA translation via the La antigen

Trotta, R., Vignudelli, T., Candini, O., Intine, R. V. A., Pecorari, L., Guerzoni, C., Santilli, G., Byrom, M., Goldoni, S., Ford, L. P., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00020-5 · Cited by 222

Deregulated β‐catenin induces a p53‐ and ARF‐dependent growth arrest and cooperates with Ras in transformation

Damalas, A., Kahan, S., Shtutman, M. S., Ben‐Ze'ev, A., & Oren, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4912 · Cited by 208

p53 induction and activation of DDR1 kinase counteract p53‐mediated apoptosis and influence p53 regulation through a positive feedback loop

Ongusaha, P. P., Kim, J., Fang, L., Wong, T. W., Yancopoulos, G. D., Aaronson, S. A., & Lee, S. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg129 · Cited by 198

Phosphorylation of HDM2 by Akt

Ashcroft, M., Ludwig, R. L., Woods, D. B., Copeland, T. D., Weber, H. O., MacRae, E. J., & Vousden, K. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205276 · Cited by 197

Inhibition of MDM2 by hsp90 Contributes to Mutant p53 Stabilization

Peng, Y., Chen, L., Li, C., Lu, W., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102817200 · Cited by 180

Calmodulin Binds to K-Ras, but Not to H- or N-Ras, and Modulates Its Downstream Signaling

Villalonga, P., López-Alcalá, C., Bosch, M., Chiloeches, A., Rocamora, N., Gil, J., Marais, R., Marshall, C. J., Bachs, O., & Agell, N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7345-7354.2001 · Cited by 181

A Single Nucleotide Polymorphism in the MDM2 Gene: From a Molecular and Cellular Explanation to Clinical Effect

Bond, G. L., Hu, W., & Levine, A. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0825 · Cited by 176

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Wade, M., & Wahl, G. M. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0423 · Cited by 170

Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers

Dillon, M., Lopez, A. R., Lin, E., Sales, D., Perets, R., & Jain, P. (2021) · Cancers · doi:10.3390/cancers13205059 · Cited by 175

The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNAHOTAIRvia a novel intronic enhancer

Zhang, X., Zhou, L., Fu, G., Sun, F. Y., Shi, J., Wei, J., Lu, C. T., Zhou, C., Yuan, Q., & Yang, M. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu103 · Cited by 156

Specificity in the activation and control of transcription factor E2F-dependent apoptosis

Hallstrom, T. C., & Nevins, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831408100 · Cited by 152

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152

Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?

Nag, S. A., Zhang, X., Srivenugopal, K. S., Wang, M.-H., Wang, W., & Zhang, R. (2014) · Current Medicinal Chemistry · doi:10.2174/09298673113206660325 · Cited by 156

Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy

Zhang, X., Qi, Z., Yin, H., & Yang, G. S. (2019) · Theranostics · doi:10.7150/thno.29673 · Cited by 148

Untitled work

(2003) · PubMed · Cited by 147

The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators

Fuller-Pace, F. V. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.03.004 · Cited by 150

Apoptosis in cancer—implications for therapy

Schulze‐Bergkamen, H., & Krammer, P. H. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2003.11.006 · Cited by 146

Genistein, a Dietary Isoflavone, Down-Regulates the MDM2 Oncogene at Both Transcriptional and Posttranslational Levels

Li, M., Zhang, Z., Hill, D. L., Chen, X., Wang, H., & Zhang, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1302 · Cited by 138

Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformationPreprint

Suzuki, T., Kawamura-Tsuzuku, J., Ajima, R., Nakamura, T., Yoshida, Y., & Yamamoto, T. S. (2002) · Genes & Development · doi:10.1101/gad.962802 · Cited by 136

TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X.-J., Danielpour, D., Pollok, K. E., Boothman, D. A., & Mayo, L. D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39194 · Cited by 133

p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.

Esteller, M., Cordon‐Cardo, C., Corn, P. G., Meltzer, S. J., Pohar, K. S., Watkins, D. N., Capellá, G., Peinado, M. A., Matías‐Guiu, X., Prat, J., et al. (2001) · PubMed · Cited by 132

A Novel eIF5A Complex Functions As a Regulator of p53 and p53-dependent Apoptosis

Li, A.-L., Li, H., Jin, B.-F., Ye, Q.-N., Zhou, T., Yu, X.-D., Pan, X., Man, J.-H., He, K., Yu, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407165200 · Cited by 131

Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

Janssen, K., Marjou, F. E., Pinto, D., Sastre‐Garau, X., Rouillard, D., Fouquet, C., Soussi, T., Louvard, D., & Robine, S. (2002) · Gastroenterology · doi:10.1053/gast.2002.34786 · Cited by 137

Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling Pathway

Woods, D. B., Cherwinski, H. M., Venetsanakos, E., Bhat, A., Gysin, S., Humbert, M., Bray, P. F., Saylor, V., & McMahon, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.9.3192-3205.2001 · Cited by 132

IFITM1 plays an essential role in the antiproliferative action of interferon-γ

Yang, G., Xu, Y., Chen, X., & Hu, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209807 · Cited by 129

MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

Satō, A., Sunayama, J., Matsuda, K., Seino, S., Suzuki, K., Watanabe, E., Tachibana, K., Tomiyama, A., Kayama, T., & Kitanaka, C. (2011) · Stem Cells · doi:10.1002/stem.753 · Cited by 125

DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repair

O’Reilly, M. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.2.l291 · Cited by 122

Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor

Sreeramaneni, R., Chaudhry, A., McMahon, M., Sherr, C. J., & Inoue, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.220-232.2005 · Cited by 123

HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.

Polsky, D., Bastian, B. C., Hazan, C., Melzer, K., Pack, J., Houghton, A., BUSAM, K. J., Cordon‐Cardo, C., & Osman, I. (2001) · PubMed · Cited by 120

Oncogenes in melanoma

Polsky, D., & Cordon‐Cardo, C. (2003) · Oncogene · doi:10.1038/sj.onc.1206449 · Cited by 119

Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival

Cartlidge, R. A., Thomas, G. R., Cagnol, S., Jong, K. A., Molton, S. A., Finch, A. J., & McMahon, M. (2008) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2008.00491.x · Cited by 119

The MDM2 promoter polymorphism SNP309T→G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

Alhopuro, P., Ylisaukko‐oja, S. K., Koskinen, W. J., Bono, P., Arola, J., Järvinen, H. J., Mecklin, J., Atula, T. S., Kontio, R., Mäkitie, A. A., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.031260 · Cited by 114

Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc

Datta, A., Nag, A., Pan, W., Hay, N., Gartel, A. L., Colamonici, O. R., Mori, Y., & Raychaudhuri, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312305200 · Cited by 113

Sumoylation of p68 and p72 RNA Helicases Affects Protein Stability and Transactivation Potential

Mooney, S. M., Grande, J. P., Salisbury, J. L., & Janknecht, R. (2009) · Biochemistry · doi:10.1021/bi901263m · Cited by 111

Regulation of p53

Oren, M., Damalas, A., Gottlieb, T. M., Michael, D., Taplick, J., Martínez-Leal, J. F., Maya, R. B.-Y., Moas, M., Seger, R., Taya, Y., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04669.x · Cited by 113

The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network

Boominathan, L. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9257-9 · Cited by 112

MDM2 SNP309 and cancer risk: a combined analysis

Wilkening, S., Bermejo, J. L., & Hemminki, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm191 · Cited by 109

Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.038 · Cited by 108

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

Phelps, M., Darley, M., Primrose, J. N., & Blaydes, J. P. (2003) · PubMed · Cited by 109

Mdm2 overexpression and p14ARF inactivation are two mutually exclusive events in primary human lung tumors

Eymin, B., Gazzéri, S., Brambilla, C., & Brambilla, E. M. (2002) · Oncogene · doi:10.1038/sj.onc.1205359 · Cited by 104

An update on molecular genetics of gastrointestinal stromal tumours

Tornillo, L., & Terracciano, L. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.031112 · Cited by 105

Hypoxia Enhances Metastatic Efficiency by Up-Regulating Mdm2 in KHT Cells and Increasing Resistance to Apoptosis

Zhang, L., & Hill, R. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3038 · Cited by 108

Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis

Wu, W. K. K., Wang, X., Cheng, A. S. L., Luo, M. X. M., Ng, S. S. M., To, K. F., Chan, F. K. L., Cho, C. H., Sung, J. J. �., & Yu, J. Q. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.11.009 · Cited by 111

MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.

Jones, C. L., Gearheart, C. M., Fosmire, S., Delgado-Martín, C., Evensen, N. A., Bride, K. L., Waanders, A., Pais, F. M., Wang, J.-H., Bhatla, T., et al. (2015) · Blood · doi:10.1182/blood-2015-04-639138 · Cited by 110

PTEN Regulates Mdm2 Expression through the P1 Promoter

Chang, C.-J., Freeman, D. J., & Wu, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401488200 · Cited by 100

ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

Wolvetang, E. J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg015 · Cited by 98

Integrins regulate the apoptotic response to DNA damage through modulation of p53

Lewis, J. M., Truong, T., & Schwartz, M. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062698499 · Cited by 100

MDM2: life without p53

Daujat, S., NEEL, H., & PIETTE, J. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02369-1 · Cited by 97

Cell cycle regulatory functions of the human oncoprotein MDM2.

Deb, S. P. (2003) · PubMed · Cited by 96

Blocking of p53-Snail Binding, Promoted by Oncogenic K-Ras, Recovers p53 Expression and function

Lee, S.-H., Lee, S.-J., Jung, Y. S., Xu, Y., Kang, H. S., Ha, N., & Park, B.-J. (2009) · Neoplasia · doi:10.1593/neo.81006 · Cited by 100

Met acts on Mdm2 via mTOR to signal cell survival during development

Moumen, A., Patané, S., Porras, A., Dono, R., & Maina, F. (2007) · Development · doi:10.1242/dev.02820 · Cited by 95

Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

Quinlan, M. P., Quatela, S. E., Philips, M. R., & Settleman, J. E. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01661-07 · Cited by 96

TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Cipriano, R., Kan, C. E., Graham, J., Danielpour, D., Stampfer, M., & Jackson, M. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015022108 · Cited by 92

Role of Apoptosis in Low-Dose Hyper-radiosensitivity

Krueger, S. A., Joiner, M. C., Weinfeld, M., Piasentin, E., & Marples, B. (2007) · Radiation Research · doi:10.1667/rr0776.1 · Cited by 92

Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1α and Hdm2

LaRusch, G. A., Jackson, M. W., Dunbar, J. D., Warren, R. S., Donner, D. B., & Mayo, L. D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2710 · Cited by 89

Killing time for cancer cells

Klein, S., McCormick, F. P., & Levitzki, A. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1651 · Cited by 89

Growth Factor-Mediated Induction of HDM2 Positively Regulates Hypoxia-Inducible Factor 1α Expression

Bárdos, J. I., Chau, N.-M., & Ashcroft, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2905-2914.2004 · Cited by 87

Nucleolar Adaptation in Human Cancer

Maggi, L. B., & Weber, J. D. (2005) · Cancer Investigation · doi:10.1080/07357900500283085 · Cited by 87

The RING domain of Mdm2 can inhibit cell proliferation.

Dang, J., Kuo, M.-L., Eischen, C. M., Stepanova, L., Sherr, C. J., & Roussel, M. F. (2002) · PubMed · Cited by 86

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival

Carón, R. W., Yacoub, A., Li, M., Zhu, X., Mitchell, C., Hong, Y. K., Hawkins, W., Sasazuki, T., Shirasawa, S., Kozikowski, A. P., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.257.4.2 · Cited by 85

Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells

Lu, T., Huang, G., Lu, T., Wu, J.-B., Wu, C., Yang, T., Iizuka, A., & Chen, Y.-F. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.05.023 · Cited by 83

Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells

Halaschek-Wiener, J., Wacheck, V., Kloog, Y., & Jansen, B. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.003 · Cited by 45

p19ARF links the tumour suppressor p53 to Ras

Palmero, I., Pantoja, C., & Serrano, M. (1998) · Nature · doi:10.1038/25870 · Cited by 619

p19ARF‐independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

Roper, E. A., Weinberg, W. C., Watt, F. M., & Land, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve020 · Cited by 59

Divorcing ARF and p53: an unsettled case

Sherr, C. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1954 · Cited by 595

In Vivo Discoveries in MDM2-Mediated p53 Regulation

Tackmann, N. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/z7ta-7m83