The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Open accessAbstract
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival. Akt phosphorylates BAD in vitro and in vivo, and blocks the BAD-induced death of primary neurons in a site-specific manner. These findings define a mechanism by which growth factors directly inactivate a critical component of the cell-intrinsic death machinery.
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“which is a critical mediator of neuronal survival (Datta et al., 1997; Dudek et al., 1997).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Datta et al., 1997
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Self-citationInhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874
Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578
Mechanisms and Genes of Cellular Suicide
Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,469
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Self-citationBad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Yang, E., Zha, J., Jockel, J., Boise, L., Thompson, C. B., & Korsmeyer, S. J. (1995) · Cell · doi:10.1016/0092-8674(95)90411-5 · Cited by 2,125
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,076
Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,001
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“Furthermore, in IGF1-positive brain areas, the increased phosphorylation of Akt, enhanced levels of the apoptosis-suppressing protein Bcl-2 as well as the inactivation of the apoptosis-mediator Bad were detected (Datta et al., 1997).”
BackgroundBichet, M. C., Adderley, J., Avellaneda-Franco, L., Magnin-Bougma, I., Torriero-Smith, N., Gearing, L. J., Deffrasnes, C., David, C., Pepin, G., Gantier, M. P., et al. (2023) · PLOS Biology · doi:10.1371/journal.pbio.3002341 · Cited by 47
Gama, V, Gomez, J. A., Mayo, L. D., Jackson, M. W., Danielpour, D., Song, K., Haas, A. L., Laughlin, M. J., & Matsuyama, S. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.6 · Cited by 46
Cavasin, M. A. (2006) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200606050-00003 · Cited by 46
Renner, O., Blanco-Aparicio, C., Grassow, M., Cañamero, M., Leal, J. F. M., & Carnero, A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1539 · Cited by 44
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Soeda, Y., Tsuneki, H., Muranaka, H., Mori, N., Hosoh, S., Ichihara, Y., Kagawa, S., Wang, X., Toyooka, N., Takamura, Y., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0163 · Cited by 38
Jiang, S.-L., Guan, Y.-D., Chen, X.-S., Ge, P., Wang, X.-L., Lao, Y.-Z., Xiao, S.-S., Zhang, Y., Yang, J.-M., Xu, X.-J., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0165-9 · Cited by 37
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Imai, S., Okayama, N., Shimizu, M., & Itoh, M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00092-4 · Cited by 32
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Shen, C.-Y., Chen, L.-H., Lin, Y.-F., Lai, L.-C., Chuang, E. Y., & Tsai, M.-H. (2016) · Oncotarget · doi:10.18632/oncotarget.13237 · Cited by 8
Metadata
- Authors
- Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E.
- Affiliations
- Boston Children's Hospital (US)
- Emory University (US)
- Corresponding author
- Greenberg, Michael E
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 91
- Issue
- 2
- Pages
- 231-241
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2097767970
- Cited by
- 5,689
- References
- 57
- Citations by year
- 2026: 58 · 2025: 65 · 2024: 70 · 2023: 82 · 2022: 60 · 2021: 88 · 2020: 101 · 2019: 113 · 2018: 110 · 2017: 140 · 2016: 143 · 2015: 163 · 2014: 185 · 2013: 237 · 2012: 242
- FWCI
- 80.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM 53165)
- National Institute of Neurological Disorders and Stroke (NS 28829)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655, P30HD-18655)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Akt phosphorylation, Bad, Bcl-2 family proteins, PI3K/Akt signaling, apoptosis, cell survival, growth factor signaling, primary neurons, site-specific phosphorylation
- MeSH terms
- Amino Acid Sequence, Animals, Carrier Proteins, Cell Survival, Insulin-Like Growth Factor I, Mice, Inbred BALB C, Molecular Sequence Data, Neurons, Phosphorylation, Proto-Oncogene Proteins, Serine, Signal Transduction, 3T3 Cells, Cell Death, Protein Serine-Threonine Kinases, bcl-Associated Death Protein, Proto-Oncogene Proteins c-akt, Mice
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