CoChat
Sign Up
Cited by 518Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationRenal and related cancers

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Open access
Wang, Shouwen, Krinks, Marie, Lin, Keming, Luyten, Frank P, Moos, Malcolm·1997·Cell
DOI 10.1016/s0092-8674(00)81922-4
Open this paper in CoChat — free accountOpen PDF

Abstract

We isolated a Xenopus homolog of Frzb, a newly described protein containing an amino-terminal Frizzled motif. It dorsalized Xenopus embryos and was expressed in the Spemann organizer during early gastrulation. Unlike Frizzled proteins, endogenous Frzb was soluble. Frzb was secretable and could act across cell boundaries. In several functional assays, Frzb antagonized Xwnt-8, a proposed ventralizing factor with an expression pattern complementary to that of Frzb. Furthermore, Frzb blocked induction of MyoD, an action reported recently for a dominant-negative Xwnt-8. Frzb coimmunoprecipitated with Wnt proteins, providing direct biochemical evidence for Frzb-Wnt interactions. These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0092-8674(00)81922-4

Cites

70 of 70 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 70 references

Research works printed but not linked: 3

  1. Evans, 1991, Biochemical fractionation of oocytes, Meth. Cell Biol., 36, 117
  2. Kay, 1991, Injection of oocytes and embryos, Meth. Cell Biol., 36, 657
  3. Saunders, 1968

Cited by

Sorted by citations

  • The Wnt Signaling Pathway in Development and Disease

    Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

    “In general, both SFRPs and WIFs are thought to function as extracellular Wnt inhibitors (Bafico et al. 1999, Dennis et al. 1999, Hsieh et al. 1999a, Leyns et al. 1997, Salic et al. 1997, Uren et al. 2000, Wang et al. 1997).”
    Background

  • Wnt signaling and cancer

    Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183

    “The so-called secreted frizzled-related proteins (sFRP) bind to the wnt ligands, thereby exerting antagonistic activity when overexpressed in wnt signaling assays (Leyns et al. 1997; Wang et al. 1997).”
    Background

  • Wnt signaling: a common theme in animal development

    Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567

    “tein does not uniquely bind to cells expressing Dfz2; a variety of other Fz family members (Wang et al. 1996; Y.K. Wang et al. 1997), including the original Fz, also enable cells to interact with Wg (Table 3; Bhanot et al. 1996).”
    Background

  • MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

    Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030

    “…of Xwnt-5A to induce a secondary axis can be overcome by coinjection of human Frizzled 5, suggesting that the availability of a specific receptor rather than a fundamental difference in its signal transduction P1: APR/ary P2: ARS/dat QC: ARS/APM T1: ARS August 29, 1998 9:42 Annual Reviews AR066-03”
    Background

  • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

    Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608

    “Consistent with our two-inhibitor model for head formation, the organizer secretes at least one Wnt-antagonist, Frzb, which blocks muscle formation and anteriorizes embryo”
    Method

See all 518

Related

Metadata

Authors
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M.
Affiliations
  • United States Food and Drug Administration (US)
  • Center for Biologics Evaluation and Research (US)
  • National Institutes of Health (US)
Corresponding author
Moos, Malcolm
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
1997-03
Volume
88
Issue
6
Pages
757-766
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/s0092-8674(00)81922-4
OpenAlex
W1988350691
Cited by
518
References
70
Citations by year
2026: 3 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 13 · 2017: 17 · 2016: 6 · 2015: 12 · 2014: 15 · 2013: 9 · 2012: 14
FWCI
17.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • George Washington University
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Oncology › Renal and related cancers
Keywords
FRZB, Spemann organizer, dorsalization, ventralization, gastrulation, axial patterning, MyoD, Wnt signaling inhibition, secreted proteins, Xenopus embryo
MeSH terms
Frizzled-Related Proteins, Animals, Biological Transport, Cell Communication, Dogs, Embryonic Induction, Female, Glycoproteins, Male, Mesoderm, Microsomes, Protein Binding, Proteins, Rabbits, RNA, Messenger, Solubility, Transcription, Genetic, Xenopus, Zygote, MyoD Protein, Gene Expression Regulation, Developmental, COS Cells, Zebrafish Proteins, Intracellular Signaling Peptides and Proteins, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review