The illusion of cell immortality
Open accessAbstract
Normal cultured cell populations are mortal but cells that are immortal are abnormal and most have properties of cancer cells. Nevertheless, this distinction becomes blurred because the terms 'mortality' and 'immortality' are subject to enormous variations in understanding. Forty years ago we showed that cell mortality and immortality are inextricably linked to longevity determination, ageing and cancer. We suggested that a counting mechanism existed in normal cells and that has now been identified as telomere attrition. This replicometer, in combination with the discovery of the enzyme telomerase, has gone very far in explaining why most normal somatic cells have a finite capacity to replicate both in vivo and in vitro and how immortal cancer cells circumvent this inevitability. It is suggested that telomere attrition may be better understood as a direct measure of longevity determination and to only have an indirect association with age changes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Attrition of telomeres is a protective mechanism against cancer, as each round of proliferation is likely to introduce mutations.
“Attrition of telomeres is a protective mechanism against cancer, as each round of proliferation is likely to introduce mutations [100].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Continuous cultures of fused cells secreting antibody of predefined specificity
Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
Self-citationThe limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Self-citationTelomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · see citing works
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · see citing works
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200 · see citing works
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1× · see citing works
“Telomerase was later found to occur in extracts of immo human cell lines (Morin, 1989; Counter et al, 1992) and in ab 90% of all human tumours studied (Chiu and Harley, 199 Subsequently, the telomerase RNA component (Feng et al, 1 and the catalytic portion of the enzyme were cloned (Nakamu al,…”
BackgroundOlovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works
Smith, J. M., Smith, N. H., O'Rourke, M., & Spratt, B. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4384 · Cited by 1,802 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632 · see citing works
THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
McClintock, B. (1941) · Genetics · doi:10.1093/genetics/26.2.234 · Cited by 1,610 · see citing works
Morin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495 · see citing works
Telomere end-replication problem and cell aging
Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90096-3 · Cited by 1,069 · see citing works
Blackburn, E. H., & Gall, J. G. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90294-2 · Cited by 1,023 · see citing works
Structure and variability of human chromosome ends.
de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
Zhang, X., Mar, V., Zhou, W., Harrington, L., & Robinson, M. O. (1999) · Genes & Development · doi:10.1101/gad.13.18.2388 · Cited by 698 · see citing works
[Principle of marginotomy in template synthesis of polynucleotides].
Olovnikov, A. M. (1971) · PubMed · Cited by 567 · see citing works
Hayflick, L. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00023-0 · Cited by 469 · see citing works
Self-citationTelomeres, telomerase, and aging: Origin of the theory
Olovnikov, A. M. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(96)00005-8 · Cited by 431 · see citing works
Muller, H. J. (1938) · Medical Entomology and Zoology · Cited by 405 · see citing works
GENETIC DISEASES AND GENE KNOCKOUTS REVEAL DIVERSE CONNEXIN FUNCTIONS
White, T. W., & Paul, D. L. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.283 · Cited by 398 · see citing works
Functional Evidence for an RNA Template in Telomerase
Shippen-Lentz, D., & Blackburn, E. H. (1990) · Science · doi:10.1126/science.1689074 · Cited by 379 · see citing works
A Functional Biology of Clonal Animals
Harrington, R., & Hughes, R. N. (1990) · Journal of Animal Ecology · doi:10.2307/4898 · Cited by 349 · see citing works
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS
Hayflick, L., & Moorhead, P. S. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3075-7.50017-7 · Cited by 317 · see citing works
Self-citationTelomere positional effects and the regulation of cellular senescence
Wright, W. E., & Shay, J. W. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90232-s · Cited by 246 · see citing works
Variability at the Telomeres of the Human X/Y Pseudoautosomal Region
Cooke, H. J., & Smith, B. A. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.026 · Cited by 233 · see citing works
CREOSOTE BUSH: LONG‐LIVED CLONES IN THE MOJAVE DESERT
Vasek, F. C. (1980) · American Journal of Botany · doi:10.1002/j.1537-2197.1980.tb07648.x · Cited by 229 · see citing works
Replicative Senescence and Cell Immortality: The Role of Telomeres and Telomerase
Chiu, C. P., & Harley, C. B. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-214-44075 · Cited by 214 · see citing works
Mortality and immortality at the cellular level. A review.
Hayflick, L. (1997) · PubMed · Cited by 202 · see citing works
Self-citationTelomeres and senescence: The history, the experiment, the future
Greider, C. W. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70105-8 · Cited by 191 · see citing works
Telomerase activity in ‘immortal’ fish1
Klapper, W., Heidorn, K., Kühne, K., Parwaresch, R. M., & Krupp, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01020-5 · Cited by 148 · see citing works
Human cell transformation by simian virus 40—A review
Sack, G. H. (1981) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02618025 · Cited by 136 · see citing works
Ish‐Horowicz, D., & Pinchin, S. M. (1987) · Cell · doi:10.1016/0092-8674(87)90636-2 · Cited by 124 · see citing works
For Better or Worse? Telomerase Inhibition and Cancer
de Lange, T., & Jacks, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81955-8 · Cited by 119 · see citing works
Oinonen, E. (1967) · Acta Forestalia Fennica · doi:10.14214/aff.7180 · Cited by 104 · see citing works
Wright, W. E., & Hayflick, L. (1975) · Experimental Cell Research · doi:10.1016/s0014-4827(75)80043-7 · Cited by 96 · see citing works
Self-citationWITKOWSKI, J. A. (1980) · Medical History · doi:10.1017/s0025727300040126 · Cited by 92 · see citing works
Sex and death in protozoa (the History of an obsession)
Ammermann, D. (1989) · Trends in Genetics · doi:10.1016/0168-9525(89)90202-3 · Cited by 91 · see citing works
Sex and death in protozoa: the history of an obsession
(1990) · Choice Reviews Online · doi:10.5860/choice.27-4502 · Cited by 89 · see citing works
Alexis Carrel and the mysticism of tissue culture
WITKOWSKI, J. A. (1979) · Medical History · doi:10.1017/s0025727300051760 · Cited by 85 · see citing works
Muggleton-Harris, A. L., & Hayflick, L. (1976) · Experimental Cell Research · doi:10.1016/0014-4827(76)90269-x · Cited by 75 · see citing works
Self-citationPartridge, L., & Bell, G. (1991) · Journal of Animal Ecology · doi:10.2307/5466 · Cited by 72 · see citing works
Spontaneous Immortalization Rate of Cultured Chinese Hamster Cells2
Kraemer, P. M., Ray, F. A., Brothman, A. R., Barthoidi, M. F., & Cram, L. S. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/76.4.703 · Cited by 58 · see citing works
Growth and Development in Clonal Plant Populations
Cook, R. E. (2018) · Yale University Press eBooks · doi:10.2307/j.ctt2250w9n.11 · Cited by 49 · see citing works
Weismann, A., Poulton, E. B., Schönland, S., & Shipley, A. E. (1891) · Clarendon Press eBooks · doi:10.5962/bhl.title.87921 · Cited by 40 · see citing works
Human cell transformation by Simian Virus 40
Sack, G. H., & Obie, C. (1981) · Experimental Cell Research · doi:10.1016/0014-4827(81)90442-0 · Cited by 24 · see citing works
Genetic approaches to the study of replicative senescence
Ran, Q. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00080-7 · Cited by 24 · see citing works
WITKOWSKI, J. A. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90076-3 · Cited by 21 · see citing works
Hayflick, L. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00115-0 · Cited by 13 · see citing works
Self-citationComparative Biology of Cell Immortalization
Macieira‐Coelho, A. (1999) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-06227-2_3 · Cited by 10 · see citing works
2 Telomere DNA StructurePreprint
Henderson, E. R. (1995) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969457.29.11 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796 · see citing works
Neurovascular mechanisms of Alzheimer's neurodegeneration
Zloković, B. V. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.02.001 · Cited by 921 · see citing works
The molecular biology of cancer
Bertram, J. S. (2000) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(00)00007-8 · Cited by 592 · see citing works
Kippin, T. E., Martens, D. J., & van der Kooy, D. (2005) · Genes & Development · doi:10.1101/gad.1272305 · Cited by 442 · see citing works
Human cell senescence as a DNA damage response
Zglinicki, T. V., Saretzki, G., Ladhoff, J., Fagagna, F. D. D., & Jackson, S. P. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.034 · Cited by 419 · see citing works
Biological Aging Is No Longer an Unsolved Problem
HAYFLICK, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.001 · Cited by 418 · see citing works
Self-citationHayflick, L. (2000) · Nature · doi:10.1038/35041709 · Cited by 360 · see citing works
Self-citationDNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm893 · Cited by 344 · see citing works
Telomeres and Telomere Length: A General Overview
Srinivas, N., Rachakonda, P. S., & Kumar, R. (2020) · Cancers · doi:10.3390/cancers12030558 · Cited by 313 · see citing works
Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
Gewirtz, D. A., Holt, S. E., & Elmore, L. W. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.06.024 · Cited by 281 · see citing works
Hayflick, L. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030220 · Cited by 260 · see citing works
Self-citationHattiangady, B., & Shetty, A. K. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.015 · Cited by 247 · see citing works
Duan, J., Duan, J., Zhang, Z., & Tong, T. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.01.010 · Cited by 229 · see citing works
TERT promoter mutations in telomere biology
Heidenreich, B., & Kumar, R. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.11.002 · Cited by 198 · see citing works
Oxidative stress induces senescence in human mesenchymal stem cells
Brandl, A., Meyer, M., Bechmann, V., Nerlich, M. N., & Angele, P. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.02.015 · Cited by 181 · see citing works
O’Donoghue, K., & Fisk, N. M. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.06.010 · Cited by 179 · see citing works
Senescence Regulation by the p53 Protein Family
Qian, Y., & Chen, X. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_3 · Cited by 170 · see citing works
Telomere Attrition Due to Infection
Ilmonen, P., Kotrschal, A., & Penn, D. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002143 · Cited by 170 · see citing works
McMurray, H. R., & McCance, D. J. (2003) · Journal of Virology · doi:10.1128/jvi.77.18.9852-9861.2003 · Cited by 165 · see citing works
Oxidative stress induces senescence in chondrocytes
Brandl, A., Hartmann, A. J., Bechmann, V., Graf, B. M., Nerlich, M. N., & Angele, P. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21348 · Cited by 135 · see citing works
Cellular Senescence - its role in cancer and the response to ionizing radiation
Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 116 · see citing works
Jedrzejczak-Silicka, M. (2017) · New Insights into Cell Culture Technology · doi:10.5772/66905 · Cited by 87 · see citing works
Yang, Z., Tu, Y., Xia, H., Jie, G., Chen, X., & He, P. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.05.006 · Cited by 85 · see citing works
Jie, G., Lin, Z., Zhang, L., Lv, H., He, P., & Zhao, B. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061663o · Cited by 85 · see citing works
Aging: The Reality: "Anti-Aging" Is an Oxymoron
Hayflick, L. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.6.b573 · Cited by 85 · see citing works
Self-citationImmortalization and Transformation of Human Cells
Hahn, W. C. (2002) · Molecules and Cells · doi:10.1016/s1016-8478(23)15045-x · Cited by 84 · see citing works
Living forever and dying in the attempt
Hayflick, L. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.003 · Cited by 82 · see citing works
Self-citationHayflick, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.6.b547 · Cited by 77 · see citing works
Self-citationLuan, J., Sun, X., Fei, Z., & Douglas, A. E. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.041 · Cited by 77 · see citing works
Molecular defects in the pathogenesis of pituitary tumours
Levy, A., & Lightman, S. L. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(03)00012-8 · Cited by 77 · see citing works
Replicative senescence and the art of counting
von Zglinicki, T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.015 · Cited by 68 · see citing works
New Insights into Cell Culture Technology
Gowder, S. J. (2017) · InTech eBooks · doi:10.5772/62590 · Cited by 67 · see citing works
Cellular senescence: unravelling complexity
Passos, J. F., Simillion, C., Hallinan, J. S., Wipat, A., & von Zglinicki, T. (2009) · AGE · doi:10.1007/s11357-009-9108-1 · Cited by 61 · see citing works
The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses
Suram, A., & Herbig, U. (2014) · Aging Cell · doi:10.1111/acel.12246 · Cited by 54 · see citing works
Functional Dye-Doped Silica Nanoparticles for Bioimaging, Diagnostics and Therapeutics
Santra, S., Dutta, D., & Moudgil, B. M. (2005) · Food and Bioproducts Processing · doi:10.1205/fbp.04400 · Cited by 55 · see citing works
A mathematical model of cellular apoptosis and senescence through the dynamics of telomere loss
Arkus, N. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.12.016 · Cited by 53 · see citing works
Cellular longevity: role of apoptosis and replicative senescence
Bree, R. T., Stenson-Cox, C., Grealy, M., Byrnes, L., Gorman, A. M., & Afshin Samali, A. (2002) · Biogerontology · doi:10.1023/a:1016299812327 · Cited by 53 · see citing works
Senescence and functional failure in hematopoietic stem cells
Chen, J. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.08.001 · Cited by 53 · see citing works
Age Distribution of Cancer: The Incidence Turnover at Old Age
Pompei, F., & Wilson, R. (2001) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/20018091095267 · Cited by 52 · see citing works
Activation-induced and damage-induced cell death in aging human T cells
Sikora, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.011 · Cited by 51 · see citing works
Vogt, S., Iking‐Konert, C., Hug, F., Andrássy, K., & Hänsch, G. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00037.x · Cited by 48 · see citing works
Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas
Wu, T. (2003) · Lung Cancer · doi:10.1016/s0169-5002(03)00195-8 · Cited by 44 · see citing works
Matrix and Backstage: Cellular Substrates for Viral Vaccines
Jordan, I., & Sandig, V. (2014) · Viruses · doi:10.3390/v6041672 · Cited by 43 · see citing works
Estrogen reduces cellular aging in human mesenchymal stem cells and chondrocytes
Breu, A., Sprinzing, B., Merkl, K., Bechmann, V., Kujat, R., Jenei‐Lanzl, Z., Prantl, L., & Angele, P. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21424 · Cited by 41 · see citing works
Identification of cultivation-independent markers of human endothelial cell senescence in vitro
Unterluggauer, H., Hütter, E., Voglauer, R., Grillari, J., Vöth, M., Bereiter-Hahn, J., Jansen-Dürr, P., & Jendrach, M. (2007) · Biogerontology (Dordrecht) · doi:10.1007/s10522-007-9082-x · Cited by 44 · see citing works
Artificial human telomeres from DNA nanocircle templates
Lindström, U. M., Chandrasekaran, R. A., Orbai, L., Helquist, S. A., Miller, G. P., Oroudjev, E., Hansma, H. G., & Kool, E. T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252396199 · Cited by 40 · see citing works
Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner
Zeng, X., Hernandez-Sanchez, W. M., Xu, M., Whited, T. L., Baus, D., Zhang, J., Berdis, A. J., & Taylor, D. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.020 · Cited by 39 · see citing works
Ré, R. N., & Cook, J. L. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00414.2009 · Cited by 35 · see citing works
Makpol, S., Abidin, A. Z., Sairin, K., Mazlan, M., Top, G. M., & Ngah, W. Z. W. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.1.9940 · Cited by 34 · see citing works
Molecular and cellular processes underlying the hallmarks of head and neck cancer
Bernstein, J. M., Bernstein, C. R., West, C., & Homer, J. J. (2012) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-012-2323-x · Cited by 34 · see citing works
Human fibroblasts in vitro senesce with a donor‐specific telomere length
Serra, V., & von Zglinicki, T. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02504-8 · Cited by 31 · see citing works
Role of angiotensin II in aging
Yi, W., Chen, F., Zhang, H., Tang, P., Yuan, M., Wen, J., Wang, S., & Cai, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1002138 · Cited by 30 · see citing works
Telomerase inhibitors: a patent review (2010–2015)
Man, R., Chen, L., & Zhu, H. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1181172 · Cited by 29 · see citing works
Association of exposure to air pollution and telomere length in preschool children
Moslem, A., Rad, A., de Prado-Bert, P., Alahabadi, A., Aval, H. E., Miri, M., Gholizadeh, A., Ehrampoush, M. H., Sunyer, J., Nawrot, T. S., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137933 · Cited by 29 · see citing works
Talari, F. S., Bagherzadeh, K., Golestanian, S., Jarstfer, M. B., & Amanlou, M. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00336 · Cited by 28 · see citing works
Folini, M., Bandiera, R., Millo, E., Gandellini, P., Sozzi, G., Gasparini, P., Longoni, N., Binda, M., Daidone, M. G., Berg, K., et al. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00470.x · Cited by 28 · see citing works
Barlow, P. W. (2015) · Communicative & Integrative Biology · doi:10.1080/19420889.2015.1041696 · Cited by 27 · see citing works
Kulić, A., Plavetić, N. D., Gamulin, S., Jakić‐Razumović, J., Vrbanec, D., & Sirotković-Skerlev, M. (2016) · Medical Oncology · doi:10.1007/s12032-016-0736-x · Cited by 27 · see citing works
Occurrence, functionality and abundance of the TERT promoter mutations
Rachakonda, S. P., Hoheisel, J. D., & Kumar, R. (2021) · International Journal of Cancer · doi:10.1002/ijc.33750 · Cited by 26 · see citing works
Is the ischemic blood–brain barrier insufficiency responsible for full-blown Alzheimer's disease?
Pluta, R. M. (2006) · Neurological Research · doi:10.1179/016164106x130399 · Cited by 25 · see citing works
The contribution of oxidative stress to platelet senescence during storage
Wang, L., Xie, R., Fan, Z., Yang, J., Liang, W. H., Wu, Q., Wu, M. X., Wang, Z., & Lu, Y. (2019) · Transfusion · doi:10.1111/trf.15291 · Cited by 24 · see citing works
Cellular senescence induces replication stress with almost no affect on DNA replication timing
Rivera‐Mulia, J. C., Schwerer, H., Besnard, E., Desprat, R., Trevilla‐García, C., Sima, J., Bensadoun, P., Zouaoui, A., Gilbert, D. M., & Lemaı̂tre, J.-M. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1491235 · Cited by 21 · see citing works
Pluta, R. M., Miziak, B., & Czuczwar, S. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310739 · Cited by 22 · see citing works
Babizhayev, M. A., & Yegorov, Y. E. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35515 · Cited by 19 · see citing works
Darekar, S. D., Mushtaq, M., Gurrapu, S., Kovalevska, L. M., Drummond, C. J., Petruchek, M., Tirinato, L., Fabrizio, E. M. D., Carbone, E., & Kashuba, E. (2015) · Oncotarget · doi:10.18632/oncotarget.4123 · Cited by 17 · see citing works
A structural basis for cellular senescence
Aranda‐Anzaldo, A. (2009) · Aging · doi:10.18632/aging.100074 · Cited by 17 · see citing works
A glance at … telomeres, oxidative stress, antioxidants, and biological aging
Glade, M. J., & Meguid, M. M. (2015) · Nutrition · doi:10.1016/j.nut.2015.05.018 · Cited by 17 · see citing works
Mori, T. (2022) · Pathology International · doi:10.1111/pin.13279 · Cited by 16 · see citing works
The Sun determines human longevity: teratogenic effects of chaotic solar radiation
Davis, G. E., & Lowell, W. E. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.010 · Cited by 16 · see citing works
High-Fidelity Sensitive Tracing Circulating Tumor Cell Telomerase Activity
Wang, Z., Chen, X., Qiu, X., Chen, Y., Wang, T., Lv, L., Guo, X., Yang, F., Tang, M., Gu, W., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c05749 · Cited by 13 · see citing works
Senescence of Hematopoietic Stem Cells and Bone Marrow Failure
Chen, J. (2005) · International Journal of Hematology · doi:10.1532/ijh97.05094 · Cited by 13 · see citing works
Influence of telomere length on short-term recovery after allogeneic stem cell transplantation
Widmann, T., Willmann, B., Pfreundschuh, M. G., & Beelen, D. W. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.05.019 · Cited by 13 · see citing works
Vadlakonda, L., Indracanti, M., Kalangi, S. K., Gayatri, B. M., Gajula, N. N., & Reddy, A. B. M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00566-5 · Cited by 11 · see citing works
A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis
Wang, S., Liu, H., Yang, P., Wang, Z., Ye, P., Xia, J., & Chen, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1260688 · Cited by 10 · see citing works
Liu, X., Yin, M., Liu, X., Da, J., Zhang, K., Zhang, X., Liu, L., Wang, J., Jin, H. Y., Liu, Z., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.573877 · Cited by 9 · see citing works
Sucharitha, A. (2023) · doi:10.23880/accp-16000102 · Cited by 7 · see citing works
Aquarium: Marbled Crayfi sh Gaining Ground in Europe: the Role of the Pet Trade as Invasion Pathway
Kawai, T., Faulkes, Z., & Scholtz, G. (2015) · CRC Press eBooks · doi:10.1201/b18723-9 · Cited by 7 · see citing works
Pompei, F., Lee, E., & Wilson, R. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1073-c2 · Cited by 7 · see citing works
Mattarocci, S., D’Ambrosio, E., Tafaro, L., Somma, V., Zannino, G., Marigliano, V., Ascenzioni, F., & Cimino-Reale, G. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.11.002 · Cited by 6 · see citing works
Mangosh, T. L., Awadallah, W. N., Grabowska, M. M., & Taylor, D. J. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0314 · Cited by 6 · see citing works
Ten Years of CRISPRing Cancers In Vitro
Capoferri, D., Filiberti, S., Faletti, J., Tavani, C., & Ronca, R. (2022) · Cancers · doi:10.3390/cancers14235746 · Cited by 6 · see citing works
Telomere in Aging and Age-Related Diseases
Meiliana, A., Dewi, N. M., & Wijaya, A. (2017) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v9i3.361 · Cited by 5 · see citing works
DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy
Ana, M., Ferreira, L. M. R., Joana, F., Carlos, F., & Maria, C. (2011) · InTech eBooks · doi:10.5772/23190 · Cited by 5 · see citing works
Modulating Aging, Longevity Determination and the Diseases of Old Age
Hayflick, L. (2003) · Springer eBooks · doi:10.1007/978-94-017-0283-6_1 · Cited by 5 · see citing works
Self-citationFeldhaeusser, B., Turek, M., Lawrence, J., Cornell, K. K., & Gogal, R. M. (2013) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2012.722577 · Cited by 4 · see citing works
Oxidative Telomere Attrition, Nutritional Antioxidants and Biological Aging
Glade, M. J. (2015) · International Journal Of Nutrition · doi:10.14302/issn.2379-7835.ijn-14-606 · Cited by 3 · see citing works
Evolution of Cancer Stem Cells
Shostak, S. (2011) · doi:10.5772/17359 · Cited by 4 · see citing works
Effects of Exercise-Induced Fatigue and Blocked Vision on Postural Control during Upright Stance
Oh, H.-J., Youm, C., & Kim, T.-H. (2011) · Korean Journal of Sport Biomechanics · doi:10.5103/kjsb.2011.21.3.353 · Cited by 3 · see citing works
Molecular and therapeutic bases of cancer
Fajardo-Orduña, G. R., & Chamorro-Plata, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819828-5.00002-4 · Cited by 3 · see citing works
The Evolutionary Origins of Cancer and of Its Control by Immune Policing and Genetic Suppression
Nunney, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804310-3.00001-6 · Cited by 3 · see citing works
The role of telomeres and telomerase in aging and longevity determination
Hayflick, L. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08010-5 · Cited by 2 · see citing works
Self-citationStatistical Analysis of Different Cancers in Kermanshah Province
Mirmomeni, M. H., Mohammadi, F., Sisakhtnez, S., Hashemi, R., & Nazari, G. (2009) · Journal of Biological Sciences · doi:10.3923/jbs.2009.200.216 · Cited by 1 · see citing works
The Biology of Human Longevity, Aging and Age-Associated Diseases
Hayflick, L. (2008) · Cited by 1 · see citing works
Self-citationPhysiological and Pathological Vascular Aging
Pitrez, P. R., Aires, H. I. R., Tomé, I., Ferreira, R. S., & Ferreira, L. (2018) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-319-99319-5_3 · Cited by 1 · see citing works
Mangosh, T. L., Grabowska, M. M., & Taylor, D. J. (2021) · The Prostate · doi:10.1002/pros.24225 · Cited by 1 · see citing works
Ranhem, C., Larsson, G. L., Lindqvist, D., Sorbe, B., Karlsson, M. G., Farnebo, M., Hellman, K., Kovaleska, L., Kashuba, E., & Andersson, S. (2021) · Oncology Letters · doi:10.3892/ol.2021.13148 · Cited by 1 · see citing works
Regulation of Cell Cycle and Apoptosis
Miele, L. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-401-6_5 · Cited by 1 · see citing works
HUMANS, ANIMALS, AND PETRI DISHES: BIOMEDICAL MODELING BETWEEN EXPERIMENTATION AND REPRESENTATION
Germain, P. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/germain-pierre-luc_phd2014-03-25 · Cited by 1 · see citing works
Microfluidic studies on flow manipulation to assist metastasis research
Tran, D. Q. (2017) · doi:10.32657/10356/69578 · Cited by 1 · see citing works
Vitamin D and the Menopause: A Focus on Apoptosis in Cancer
Franke, H. R. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-373-2_23
- Authors
- Hayflick, L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Hayflick, L
- ORCID
- Hayflick, L
- Venue
- British Journal of Cancer
- Published
- 2000-10
- Volume
- 83
- Issue
- 7
- Pages
- 841-846
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2374692
- OpenAlex
- W1510708869
- Cited by
- 124
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- cell immortalization, cell death, telomere shortening, telomerase, replicative capacity, cellular aging, cancer cells
- MeSH terms
- Animals, Cell Survival, Cells, Cultured, Humans, Neoplasms, Telomere, Cellular Senescence, Cell Death
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
