The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Open accessAbstract
The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene silencing as well as aging in yeast. Here, we show that mammalian Sir2alpha physically interacts with p53 and attenuates p53-mediated functions. Nicotinamide (Vitamin B3) inhibits an NAD-dependent p53 deacetylation induced by Sir2alpha, and also enhances the p53 acetylation levels in vivo. Furthermore, Sir2alpha represses p53-dependent apoptosis in response to DNA damage and oxidative stress, whereas expression of a Sir2alpha point mutant increases the sensitivity of cells in the stress response. Thus, our findings implicate a p53 regulatory pathway mediated by mammalian Sir2alpha. These results have significant implications regarding an important role for Sir2alpha in modulating the sensitivity of cells in p53-dependent apoptotic response and the possible effect in cancer therapy.
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“analysis of p53 acetylation, a known Sirtuin target40,41, revealed that nicotinamide was effective in our assays”
From Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining (2010) · cites this paper as [40]
Citations
Cites
p53, the cellular gatekeeper for growth and division
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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Self-citationhSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Self-citationActivation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
Self-citationPUMA, a Novel Proapoptotic Gene, Is Induced by p53
Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
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Acetylation of Histones and Transcription-Related Factors
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Self-citationAtmospheric carbon dioxide concentrations over the past 60 million years
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Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185
Metadata
- Authors
- Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W.
- Affiliations
- Columbia University (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Gu, Wei
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 107
- Issue
- 2
- Pages
- 137-148
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2012753961
- Cited by
- 2,081
- References
- 54
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 30 · 2023: 37 · 2022: 54 · 2021: 71 · 2020: 62 · 2019: 62 · 2018: 71 · 2017: 84 · 2016: 97 · 2015: 105 · 2014: 134 · 2013: 127 · 2012: 121
- FWCI
- 39.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01ca085533-16)
- National Cancer Institute (R01CA85533)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- p53, histone deacetylation, nicotinamide, p53 acetylation, apoptosis, DNA damage response, oxidative stress, stress response, cell survival, NAD+-dependent deacetylation, cancer therapy
- MeSH terms
- Animals, Cell Line, Cell Survival, DNA Damage, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Histone Deacetylases, Humans, NAD, Neoplasms, Niacinamide, Poly(ADP-ribose) Polymerases, Protein Binding, Blotting, Western, Transcriptional Activation, Trans-Activators, Polymerase Chain Reaction, Tumor Suppressor Protein p53, Mutagenesis, Site-Directed, Cell Death, Apoptosis, Point Mutation, Protein Structure, Tertiary, DNA, Complementary, Oxidative Stress, fas Receptor, Sirtuins, Mice, Sirtuin 1
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