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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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Cellular Senescence: Aging, Cancer, and Injury

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SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

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SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

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Histone deacetylases and cancer

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

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Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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Awakening guardian angels: drugging the p53 pathway

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

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Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

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Calorie restriction–the SIR2 connection

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SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

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SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B

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Stressing the role of FoxO proteins in lifespan and disease

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Sirt1 and the Mitochondria

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SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

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Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

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Sirtuins in aging and age-related disease

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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

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SIRT1 Controls Endothelial Angiogenic Functions During Vascular Growth

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Tissue-specific regulation of SIRT1 by calorie restriction

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Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

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SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

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Cellular and molecular biology of aging endothelial cells

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Acetylation of p53 inhibits its ubiquitination by Mdm2

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Redox regulation of SIRT1 in inflammation and cellular senescence

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Sirtuin Functions in Health and Disease

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Sirtuins as potential targets for metabolic syndrome

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Cancer as a robust system: implications for anticancer therapy

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Genetics and the Specificity of the Aging Process

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Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

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Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase

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AMP-activated protein kinase and its downstream transcriptional pathways

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p53 modifications: exquisite decorations of the powerful guardian

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Epigenetic control of rDNA loci in response to intracellular energy status

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Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

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Nuclear DNA damage signalling to mitochondria in ageing

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Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

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Sirtuin functions and modulation: from chemistry to the clinic

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

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Mammalian Sirt1: insights on its biological functions

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A local mechanism mediates NAD-dependent protection of axon degeneration

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Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

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FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

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USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development

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