Cited by 1,059Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

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Zhou, Qiao, Anderson, David J.·2002·Cell

DOI 10.1016/s0092-8674(02)00677-3

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Abstract

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then astrocytes. This apparent conversion likely reflects independent roles for OLIG1/2 in specifying motoneuron and oligodendrocyte fates. Olig genes therefore couple neuronal and glial subtype specification, unlike proneural bHLH factors that control the neuron versus glia decision. Our results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes, the three fundamental cell types of the central nervous system.

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Mammalian neural stem cells.
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · cited 5×
“Anderson1,2,3 Division of Biology 216-76 2 Howard Hughes Medical Institute California Institute of Technology V3 interneurons are generated from the p0, p1, p2, and Pasadena, California 91125 p3 domains, respectively (Briscoe et al., 2000; Jessell, 2000).”
BackgroundInfluential
Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection
Lu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells.
Kanda, T., Sullivan, K., & Wahl, G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70156-3 · Cited by 1,040
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.
Lu, Q. R., Yuk, D.-I., Alberta, J., Zhu, Z.-M., Pawlitzky, I., Chan, J., McMahon, A., Stiles, C., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 883 · cited 1×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
Identification of neurogenin, a vertebrate neuronal determination gene.
Ma, Q.-F., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 874 · cited 1×
“These data sug-sophila proneural genes, such as the Neurogenins gest that Olig genes couple neuronal and glial subtype (Ngns) (Gradwohl et al., 1996; Ma et al., 1996; McCor-specification. mick et al., 1996) and Mash1 (Johnson et al., 1990 .”
BackgroundSelf-citation
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807
Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789 · cited 13×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
InfluentialSelf-citation

Show all 70 references

Research works printed but not linked: 7

Briscoe, 2000, A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube, Cell, 101, 435, 10.1016/S0092-8674(00)80853-3 · DOI
Dubreuil, 2000, The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity, Development, 127, 5191, 10.1242/dev.127.23.5191 · DOI
Farah, 2000, Generation of neurons by transient expression of neural bHLH proteins in mammalian cells, Development, 127, 693, 10.1242/dev.127.4.693 · DOI
Hall, 1996, Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors, Development, 122, 4085, 10.1242/dev.122.12.4085 · DOI
Hojo, 2000, Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina, Development, 127, 2515, 10.1242/dev.127.12.2515 · DOI
Lo, 2002, Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells, Development, in press
Vetter, 2001, A turn of the helix, Neuron, 29, 559, 10.1016/S0896-6273(01)00231-8 · DOI

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Background
Relevance of combinatorial profiles of intermediate filaments and transcription factors for glioma histogenesis
Colin, C., Virard, I., Baeza, N., Tchoghandjian, A., Fernandez, C., Bouvier, C., Calisti, A., Tong, S., Durbec, P., & Figarella-Branger, D. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00829.x · Cited by 39
The 36K protein of zebrafish CNS myelin is a short‐chain dehydrogenase
Morris, J. K., Willard, B., Yin, X., Jeserich, G., Kinter, M., & Trapp, B. D. (2004) · Glia · doi:10.1002/glia.10338 · Cited by 39
The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity
Noble, M., & Dietrich, J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.12.007 · Cited by 39
Molecular Conservation and Novelties in Vertebrate Ear Development
Fritzsch, B., & Beisel, K. W. (2003) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)57001-6 · Cited by 39
“In general, the bHLH genes can be divided into three functional groups: true proneural bHLH genes that generate a neural lineage, bHLH genes that drive neural differentiation, and bHLH genes that drive the switch from neural to glial cell lineage (Bertrand et al., 2002, Zhou and Anderson, 2002).”
Background
MicroRNAs in oligodendrocyte development and remyelination
Ngo, C., & Kothary, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15618 · Cited by 44
“These transcription factors influence the production of OPCs, as inhibiting their expression inhibits OPC specification from NPCs (Liu et al., 2003; Zhou & Anderson, 2002).”
Background
The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis
de Jong, C. G. H. M., Gabius, H., & Baron, W. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03327-7 · Cited by 44
A role for ErbB signaling in the induction of reactive astrogliosis
Chen, J., He, W., Hu, X., Shen, Y., Cao, J., Wei, Z., Luan, Y., He, L., Jiang, F., & Tao, Y. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.44 · Cited by 42
Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury
Piltti, K. M., Funes, G. M., Avakian, S. N., Salibian, A. A., Huang, K. I., Carta, K., Kamei, N., Flanagan, L. A., Monuki, E. S., Uchida, N., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.04.009 · Cited by 44
Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum
Ju, J., Liu, Q., Zhang, Y., Liu, Y., Jiang, M., Zhang, L., He, X.-L., Peng, C.-C., Zheng, T., Lu, Q. R., et al. (2016) · Scientific Reports · doi:10.1038/srep30711 · Cited by 38
Polarized Macrophages Have Distinct Roles in the Differentiation and Migration of Embryonic Spinal-cord-derived Neural Stem Cells After Grafting to Injured Sites of Spinal Cord
Zhang, K., Zheng, J., Bian, G., Liu, L., Xue, Q., Liu, F., Yu, C., Zhang, H., Song, B., Chung, S. K., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.46 · Cited by 38
Neural differentiation on synthetic scaffold materials
Mammadov, B., Sever, M., Guler, M. O., & Tekinay, A. B. (2013) · Biomaterials Science · doi:10.1039/c3bm60150a · Cited by 42
SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis
Moll, N. M., Hong, E., Fauveau, M., Naruse, M., Kerninon, C., Tepavčević, V., Klopstein, A., Seilhean, D., Chew, L., Gallo, V., et al. (2013) · Glia · doi:10.1002/glia.22547 · Cited by 40
Autotaxin/ENPP2 Regulates Oligodendrocyte Differentiation in vivo in the Developing Zebrafish Hindbrain
Yuelling, L. W., Waggener, C. T., Afshari, F. S., Lister, J., & Fuss, B. (2012) · Glia · doi:10.1002/glia.22381 · Cited by 38
New mouse oligodendrocyte precursor (mOP) cells for studies on oligodendrocyte maturation and function.
Lin, T., Xiang, Z.-M., Cui, L.-B., Stallcup, W., & Reeves, S. A. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.04.014 · Cited by 38
Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease
Chen, K., & Chen, J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00628-z · Cited by 41
The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas
Anderson, J. L., Muraleedharan, R., Oatman, N., Klotter, A., Sengupta, S., Waclaw, R. R., Wu, J., Drissi, R., Miles, L., Raabe, E. H., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now299 · Cited by 44
Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9
Hashimoto, R., Hori, K., Owa, T., Miyashita, S., Dewa, K., Masuyama, N., Sakai, K., Hayase, Y., Seto, Y., Inoue, Y., et al. (2016) · Mechanisms of Development · doi:10.1016/j.mod.2016.02.004 · Cited by 56
Oligodendrocyte generation during mouse development
Takebayashi, H., & Ikenaka, K. (2015) · Glia · doi:10.1002/glia.22863 · Cited by 44
Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage
Hernandez, M., & Casaccia, P. (2015) · Glia · doi:10.1002/glia.22818 · Cited by 42
Deciphering the Oligodendrogenic Program of Neural Progenitors: Cell Intrinsic and Extrinsic Regulators
Rivera, F. J., Steffenhagen, C., Kremer, D., Kandasamy, M., Sandner, B., Couillard‐Després, S., Weidner, N., Küry, P., & Aigner, L. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0293 · Cited by 33
Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
Stock, K., Nolden, L., Edenhofer, F., Quandel, T., & Brüstle, O. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0347-1 · Cited by 42
“Several studies have demonstrated that expression of the basic helix-loop-helix transcription factors Olig1 and Olig2 is required for oligodendrocyte lineage determination in vivo [33–35].”
Background
Olig2 Transcription Factor in the Developing and Injured Forebrain; Cell Lineage and Glial Development
Ono, K., Takebayashi, H., & Ikenaka, K. (2009) · Molecules and Cells · doi:10.1007/s10059-009-0067-2 · Cited by 40
“1A-1C). Loss-of-function studies by independent groups have elucidated that Olig2 is essential not only for oligodendrocyte development but also for motoneuron development, as Olig2-deficient mice and caaOO-knockdown zebrafish are devoid of both cell types in the spinal cord and hindbrain (Lu et al., 2002; Park et al.…”
Background
The differential diagnosis of central nervous system tumors: a critical examination of some recent immunohistochemical applications.
Edgar, M., & Rosenblum, M. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.1043/1543-2165(2008)132[500:tddocn]2.0.co;2 · Cited by 37
Mechanisms of glial development
Colognato, H., & ffrench‐Constant, C. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.009 · Cited by 37
Impact of the Olig Family on Neurodevelopmental Disorders
Szu, J. I., Wojcinski, A., Jiang, P., & Kesari, S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.659601 · Cited by 39
PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway
Wang, W., Cho, H., Kim, D., Park, Y., Moon, J., Lim, S. J., Yoon, S. M., McCane, M., Aicher, S., Kim, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108147 · Cited by 36
A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2
Zhou, J., Tien, A., Alberta, J., Ficarro, S. B., Griveau, A., Sun, Y., Deshpande, J., Card, J. D., Morgan-Smith, M., Michowski, W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.003 · Cited by 36
“Olig2-null mouse embryos develop to term but die within minutes following birth, due to a total deficit of motor neurons (Lu et al., 2002; Zhou and Anderson, 2002).”
Non‐neuronal cell responses differ between normal and Down syndrome developing brains
Kanaumi, T., Milenkovic, I., Adle-Biassette, H., Aronica, E., & Kovács, G. G. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.09.011 · Cited by 36
“Olig2 is an excellent marker for the specification and maturation of oligodendrocytes, which make myelin sheaths (Lu et al., 2002; Maire et al., 2010; Takebayashi et al., 2002; Yue et al., 2006; Zhou and Anderson, 2002).”
Background
Minocycline protects oligodendroglial precursor cells against injury caused by oxygen‐glucose deprivation
Schmitz, T., Endesfelder, S., Chew, L., Zaak, I., & Bührer, C. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22824 · Cited by 35
Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation
Usui, N., Watanabe, K., Ono, K., Tomita, K., Tamamaki, N., Ikenaka, K., & Takebayashi, H. (2012) · Development · doi:10.1242/dev.069997 · Cited by 40
Endothelial cell‐derived bone morphogenetic proteins regulate glial differentiation of cortical progenitors
Imura, T., Tane, K., Toyoda, N., & Fushiki, S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06134.x · Cited by 36
“The development of oligodendrocytes requires the expression of the basic helix-loop-helix transcription factors Olig1 and Olig2 (Lu et al., 2002; Zhou & Anderson, 2002).”
Background
Molecular pathogenesis of adult brain tumors and the role of stem cells.
Sauvageot, C., Kesari, S., & Stiles, C. (2007) · Neurologic clinics · doi:10.1016/j.ncl.2007.07.014 · Cited by 36
Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells.
Shibasaki, K., Takebayashi, H., Ikenaka, K., Feng, L., & Gan, L. (2007) · Gene Expression Patterns · doi:10.1016/j.modgep.2006.05.008 · Cited by 36
Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
Kim, J., Choi, T.-I., Park, S., Kim, M., Kim, C.-H., & Lee, S. (2018) · Development · doi:10.1242/dev.165340 · Cited by 35
“The bHLH factor Olig2 pMN progenitors generate motor neurons (MNs) and, later, oligodendrocytes (Lee et al., 2005; Ravanelli and Appel, 2015; Zhou and Anderson, 2002).”
Background
Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine.
Abbaszadeh, H.-A., Tiraihi, T., Delshad, A., Saghedizadeh, M., Taheri, T., Kazemi, H., & Hassoun, H. (2014) · Tissue & Cell · doi:10.1016/j.tice.2014.08.003 · Cited by 35
Generating spinal motor neuron diversity: a long quest for neuronal identity
Francius, C., & Clotman, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1398-x · Cited by 35
“2 or Irx3 to become strictly restricted to the MN progenitor domain [25, 30].”
Expression and function of myelin-associated proteins and their common receptor NgR on oligodendrocyte progenitor cells
Huang, J., Wang, Y.-X., Gu, W.-L., Fu, S., Li, Y., Huang, L., Zhao, Z., Hang, Q., Zhu, H., & Lu, P. (2011) · Brain Research · doi:10.1016/j.brainres.2011.12.008 · Cited by 31
Effects of Olig2-Overexpressing Neural Stem Cells and Myelin Basic Protein-Activated T Cells on Recovery from Spinal Cord Injury
Hu, J.-G., Shen, L., Wang, R., Wang, Q.-Y., Zhang, C., Xi, J., Ma, S.-F., Zhou, J.-S., & Lu, H.-Z. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0090-9 · Cited by 35
Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain
Wang, H., Xu, H., Niu, J., Mei, F., Li, X., Kong, J., Cai, W., & Xiao, L. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.02.1068 · Cited by 42
“In addition to NG2, OPCs also express the basic helix– loop–helix (bHLH) transcription factors Olig1 and Olig2, which are required for OLs specification and maturation (Ligon et al., 2006; Lu et al., 2002; Zhou and Anderson, 2002).”
Radial glial cells as neuronal precursors: The next generation?
Gregg, C., Chojnacki, A., & Weiss, S. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10340 · Cited by 35
Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
Chen, T., & Chen, J. (2019) · eLife · doi:10.7554/elife.50848 · Cited by 43
Decoding cell signalling and regulation of oligodendrocyte differentiation
Santos, A. K., Vieira, M. S., Vasconcellos, R., Goulart, V. A. M., Kihara, A. H., & Resende, R. R. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.020 · Cited by 43
Subependymomas Are Low-Grade Heterogeneous Glial Neoplasms Defined by Subventricular Zone Lineage Markers.
D'Amico, R. S., Praver, M., Zanazzi, G., Englander, Z. K., Sims, J. S., Samanamud, J., Ogden, A. T., Mccormick, P., Feldstein, N., McKhann, G., et al. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.08.009 · Cited by 34
“2 (3-11) Mean follow-up in months (range) 35 (1-171) 39 (3-171) 33 (1-78) 29 (7-57) Mean tumor size in cm (range) 2.”
Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury
Panayiotou, E., & Malas, S. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00340 · Cited by 34
“Consequently, loss of OLIG2 leads to the conversion of prospective OLPs to Astrocyte progenitors suggesting that, at least in the embryonic spinal cord, OLIG2 regulates the fate of otherwise bi-potent glial progenitors (Lu et al., 2002; Zhou and Anderson, 2002; Liu et al., 2007).”
Background
Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons
Rebelo, S., Reguenga, C., Lopes, C., & Lima, D. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22305 · Cited by 34

Authors: Zhou, Q., & Anderson, D. J.
Affiliations: California Institute of Technology (US)
Corresponding author: Anderson, David J.
ORCID: Zhou, Qiao
Anderson, David J.
Venue: Cell
Publisher: Elsevier BV
Published: 2002-04
Volume: 109
Issue: 1
Pages: 61-73
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00677-3
OpenAlex: W2125920059
Cited by: 1,059
References: 70
Citations by year: 2026: 16 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 45 · 2021: 46 · 2020: 26 · 2019: 36 · 2018: 36 · 2017: 36 · 2016: 33 · 2015: 41 · 2014: 52 · 2013: 48 · 2012: 52
FWCI: 14.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4125 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01-NS23476, R01NS023476)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: Olig2, Olig1, bHLH transcription factors, motor neurons, oligodendrocytes, astrocytes, proneural genes, lineage tracing
MeSH terms: Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cell Differentiation, DNA-Binding Proteins, Female, Interneurons, Male, Motor Neurons, Mutation, Nerve Tissue Proteins, Neuroglia, Neurons, Oligodendroglia, Rhombencephalon, Spinal Cord, Stem Cells, Transcription Factors, Helix-Loop-Helix Motifs, Mice, Knockout, Homeodomain Proteins, Cell Lineage, Mice, Basic Helix-Loop-Helix Proteins

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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

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