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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Open accessAbstract
OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then astrocytes. This apparent conversion likely reflects independent roles for OLIG1/2 in specifying motoneuron and oligodendrocyte fates. Olig genes therefore couple neuronal and glial subtype specification, unlike proneural bHLH factors that control the neuron versus glia decision. Our results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes, the three fundamental cell types of the central nervous system.
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“Cell type-specific transcription factor expression is important for cell fate determination and cell differentiation (e.g., Neu-roD for specification of neuron cell fate, Olig2 for specification of oligodendrocyte fate, and GM98/Myrf for oligodendrocyte differentiation; Lee et al., 1995;Zhou and Anderson, 2002;Emery et al., 2009).”
From An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014) · cites this paper as Zhou and Anderson, 2002
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Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089 · cited 5×
“Anderson1,2,3 Division of Biology 216-76 2 Howard Hughes Medical Institute California Institute of Technology V3 interneurons are generated from the p0, p1, p2, and Pasadena, California 91125 p3 domains, respectively (Briscoe et al., 2000; Jessell, 2000).”
BackgroundInfluentialLu, Q. R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C. D., & Rowitch, D. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,087
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Kanda, T., Sullivan, K., & Wahl, G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70156-3 · Cited by 1,040
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
Lu, Q. R., Yuk, D.-I., Alberta, J., Zhu, Z.-M., Pawlitzky, I., Chan, J., McMahon, A., Stiles, C., & Rowitch, D. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80897-1 · Cited by 883 · cited 1×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
Identification of neurogenin, a vertebrate neuronal determination gene.
Ma, Q.-F., Kintner, C., & Anderson, D. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81321-5 · Cited by 874 · cited 1×
“These data sug-sophila proneural genes, such as the Neurogenins gest that Olig genes couple neuronal and glial subtype (Ngns) (Gradwohl et al., 1996; Ma et al., 1996; McCor-specification. mick et al., 1996) and Mash1 (Johnson et al., 1990 .”
BackgroundSelf-citationHomeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
Briscoe, J., Sussel, L., Serup, P., Hartigan-O'Connor, D., Jessell, T., Rubenstein, J., & Ericson, J. (1999) · Nature · doi:10.1038/19315 · Cited by 807
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789 · cited 13×
“In heterozygotes, Olig2-hGFP -derived precursors gave is restricted to oligodendrocyte precursors (Lu et al., 2000; Zhou et al., 2000), nearly all OLIG2-positive cells rise to Islet1/2 (cid:2) motoneurons (Figure 3A, yellow cells) but not Chx10 (cid:2) V2 interneurons (Figure 3B).”
InfluentialSelf-citation
Research works printed but not linked: 7
- Briscoe, 2000, A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube, Cell, 101, 435, 10.1016/S0092-8674(00)80853-3 · DOI
- Dubreuil, 2000, The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity, Development, 127, 5191, 10.1242/dev.127.23.5191 · DOI
- Farah, 2000, Generation of neurons by transient expression of neural bHLH proteins in mammalian cells, Development, 127, 693, 10.1242/dev.127.4.693 · DOI
- Hall, 1996, Spinal cord oligodendrocytes develop from ventrally derived progenitor cells that express PDGF alpha-receptors, Development, 122, 4085, 10.1242/dev.122.12.4085 · DOI
- Hojo, 2000, Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina, Development, 127, 2515, 10.1242/dev.127.12.2515 · DOI
- Lo, 2002, Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells, Development, in press
- Vetter, 2001, A turn of the helix, Neuron, 29, 559, 10.1016/S0896-6273(01)00231-8 · DOI
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Sussman, C., Davies, J. E., & Miller, R. (2002) · Glia · doi:10.1002/glia.10114 · Cited by 34
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Baydyuk, M., Morrison, V. E., Gross, P. S., & Huang, J. K. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02967-7 · Cited by 42
Biswas, S., Chung, S.-H., Jiang, P., Dehghan, S., & Deng, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-45247-3 · Cited by 33
Chirivella, L., Kirstein, M., Ferrón, S. R., Domingo-Muelas, A., Durupt, F. C., Umanzor, C. A., Cano‐Jaimez, M., Pérez‐Sánchez, F., Barbacid, M., Ortega, S., et al. (2017) · Stem Cells · doi:10.1002/stem.2694 · Cited by 35
New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development
de Faria, J. P., Kessaris, N., Andrew, P., Richardson, W., & Li, H. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-12 · Cited by 33
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BackgroundMethodInfluentialAdult neurogenesis without germinal layers: the "atypical" cerebellum of rabbits.
Ponti, G., Crociara, P., Armentano, M., & Bonfanti, L. (2010) · Archives Italiennes de Biologie · doi:10.4449/aib.v148i2.1135 · Cited by 33
Chang, L. W., & Spitzer, N. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4264-08.2009 · Cited by 29
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BackgroundDevelopmental neurobiology and the origin of brain tumors
Shih, A., & Holland, E. (2004) · Journal of Neuro-Oncology · doi:10.1007/s11060-004-2746-3 · Cited by 33
“Mice with disrupted Olig1 and Olig2 genes have a complete loss of oligodendrocytes demonstrating that these transcription factors are essential for oligodendrocyte specification [34].”
Newton, K., Dugger, D. L., Sengupta-Ghosh, A., Ferrando, R. E., Chu, F., Tao, J., Lam, W., Haller, S., Chan, S. M., Sa, S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805033115 · Cited by 32
Danesin, C., & Soula, C. (2017) · Journal of Developmental Biology · doi:10.3390/jdb5020004 · Cited by 36
Havrda, M., Paolella, B. R., Ran, C., Jering, K., Wray, C. M., Sullivan, J., Nailor, A., Hitoshi, Y., & Israel, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1839 · Cited by 32
“18 oligodendrocyte lineage (35), and proliferative expansion of neuronal precursors and glioma cells (36).”
BackgroundKim, H. M., Hwang, D. H., Choi, J. Y., Park, C., Suh‐Kim, H., Kim, S. U., & Kim, B. G. (2011) · Glia · doi:10.1002/glia.21182 · Cited by 29
Multiple Sclerosis and Demyelinating Diseases
Leary, S. M., Giovannoni, G., Howard, R. S., Miller, D. H., & Thompson, A. J. (2007) · doi:10.1002/9781444311709.ch10 · Cited by 32
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Bradley, C. K., Takano, E. A., Hall, M. A., Göthert, J. R., Harvey, A. R., Begley, C. G., & van Eekelen, J. A. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04712.x · Cited by 30
The Cortical Ancestry of Oligodendrocytes: Common Principles and Novel Features
Noble, M., Arhin, A., Gass, D. A., & Mayer‐Pröschel, M. (2003) · Developmental Neuroscience · doi:10.1159/000072270 · Cited by 32
“…progenitor cell [Lu et al., 2000, 2002; Mekki-Dauriac et al., 2002; Nery et al., 2001a; Orentas et al., 1999; Pringle et al., 1996; Richardson et al., 1997, 2000; Rowitch et al., 2002; Sauvageot and Stiles, 2002; Takebayashi et al., 2002; Tekki-Kessaris et al., 2001; Zhou and Anderson, 2002].”
BackgroundThe Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage
Nguyen, L., Borgs, L., Vandenbosch, R., Mangin, J., Beukelaers, P., Moonen, G., Gallo, V., Malgrange, B., & Belachew, S. M. (2006) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20103 · Cited by 25
Tong, L., Deng, Y.-B., Du, W., Zhou, W., Liao, X.-Y., & Jiang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.914153 · Cited by 31
“Olig2, a member of the basic helix-loophelix (b-HLH) family (Li and Richardson, 2016), regulates the formation and generation of oligodendrocyte lineage cells (Zhou and Anderson, 2002; Tan et al., 2017).”
BackgroundMartins‐Macedo, J., Lepore, A. C., Domingues, H. S., Salgado, A. J., Gomes, E. D., & Pinto, L. (2020) · Glia · doi:10.1002/glia.23922 · Cited by 31
Memory functions reveal structural properties of gene regulatory networks
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Tan, C., Mazzoni, E. O., & Wichterle, H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.067 · Cited by 31
Deregulated proliferation and differentiation in brain tumors
Swartling, F. J., Čančer, M., Frantz, A., Weishaupt, H., & Persson, A. I. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-2046-y · Cited by 32
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Roberts, N. A., Woolf, A. S., Stuart, H. M., Thuret, R., McKenzie, E. A., Newman, W. G., & Hilton, E. N. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu147 · Cited by 31
Allodi, I., & Hedlund, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00109 · Cited by 31
Klempin, F., Marr, R. A., & Peterson, D. A. (2012) · Stem Cells · doi:10.1002/stem.1005 · Cited by 31
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Balabanov, R., & Popko, B. (2005) · Nature Neuroscience · doi:10.1038/nn0305-262 · Cited by 31
Zhang, W., Wu, Q., Hao, S., & Chen, S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1117999 · Cited by 30
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BackgroundBarbashina, V., Salazar, P., Ladanyi, M., Rosenblum, M., & Edgar, M. (2007) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3180335f65 · Cited by 30
Liu, C., Apuzzo, M., & Tirrell, D. (2003) · Neurosurgery · doi:10.1227/01.neu.0000057747.93237.8f · Cited by 30
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“During development, Olig2 inactivation leads to a reduced production of OPCs in most CNS regions (Lu et al., 2002; Zhou and Anderson, 2002), while SOX10 loss has no effect during determination but results in failure in terminal cell differentiation (Stolt et al.”
BackgroundThe function of contactin‐2/TAG‐1 in oligodendrocytes in health and demyelinating pathology
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“1, Sox10, Olig1, Olig2, Ascl1/Mash1, and YY1 have been implicated in promoting OPC specification and oligodendrocyte differentiation which morphologically coincides with the extension of thin processes (Cai et al., 2010; Fu et al., 2002; He et al., 2007; K€uspert et al., 2011; Lu et al., 2001; Qi et al., 2001; Stolt e…”
BackgroundLovrics, A., Gao, Y., Juhász, B., Bock, I., Byrne, H. M., Dinnyés, A., & Kovács, K. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111430 · Cited by 31
Maire, C. L., Ramkissoon, S. H., Hayashi, M., Haidar, S., Ramkissoon, L. A., DiTomaso, E., & Ligon, K. L. (2013) · Stem Cells · doi:10.1002/stem.1590 · Cited by 30
Czekaj, M. W., Haas, J., Gebhardt, M., Müller-Reichert, T., Humphries, P., Farrar, J., Bartsch, U., & Ader, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041798 · Cited by 29
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BackgroundBithell, A., Finch, S. E., Hornby, M. F., & Williams, B. P. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0832 · Cited by 29
Liang, Y., Bollen, A., Nicholas, M., & Gupta, N. (2005) · BMC Clinical Pathology · doi:10.1186/1472-6890-5-6 · Cited by 29
“OLIG1 and OLIG2 play a central role in oligodendrocyte development, as illustrated by their expression in fully differentiated oligodendrocytes [21], the failure of oligodendrocyte differentiation in Olig1/Olig2-knockout mice [12], and the expansion of oligodendroglial cells in vivo following overexpression of OLIG1 a…”
BackgroundScott, K., O'Rourke, R., Winkler, C. C., Kearns, C. A., & Appel, B. (2021) · bioRxiv · doi:10.1101/2021.04.28.441874 · Cited by 28
“A second group of sox10+ cells expressed sox5, sox9a, sox9b and olig1, them as OPCs (Baroti et al., 2016; Schebesta and Serluca, 2009; Stolt et al., 2006; Zhou and Anderson, 2002) (Fig.”
BackgroundSamudyata, S., Castelo‐Branco, G., & Liu, J. (2020) · Glia · doi:10.1002/glia.23820 · Cited by 34
“This led to the identification of an OPC-specific lncRNA, lnc-OPC, which presented binding of Olig2, a transcription factor with a role in OPC specification and differentiation (Q. Zhou & Anderson, 2002; Q. Zhou, Choi, & Anderson, 2001), in its upstream regulatory region.”
BackgroundLiu, W. C., Zhou, H., Liu, L., Zhao, C., Deng, Y., Chen, L., Wu, L.-M. N., Mandrycky, N., McNabb, C. T., Peng, Y.-B., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.021 · Cited by 31
“Olig2 is required for oligodendrocyte fate specification and motor neuron formation from neural progenitor cells during embryogenesis (Lu et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002), and critical for glial development in postnatal stages (Cai et al.”
Piotrowska-Nitsche, K., & Caspary, T. (2012) · Cilia · doi:10.1186/2046-2530-1-6 · Cited by 29
“One domain, the progenitors of motor neuron cells, expresses the Shhresponsive transcription factor Olig2 [18-20].”
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Peru, R. L., Mandrycky, N., Nait-Oumesmar, B., & Lu, Q. R. (2008) · Stem Cell Reviews · doi:10.1007/s12015-008-9043-z · Cited by 28
“These studies suggest that the functions of Olig1/2 are partially redundant in oligodendrocyte development in the brain [105, 107 ].”
BackgroundInfluentialActivation of subventricular zone stem cells after neuronal injury
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Asakawa, K., & Kawakami, K. (2018) · bioRxiv · doi:10.1101/283473 · Cited by 27
Fritzsch, B., Elliott, K. L., & Glover, J. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2676-y · Cited by 27
Pooley, J. R., Flynn, B. P., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R. L., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1929 · Cited by 27
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BackgroundProx1 Regulates Olig2 Expression to Modulate Binary Fate Decisions in Spinal Cord Neurons
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“…Olig2 is a key regulator for the specification of motor neurons (MNs) and other neural subtypes (Mizuguchi et al., 2001; Novitch et al., 2001; Zhou et al., 2001; Lu et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002; Li et al., 2011; Hafler et al., 2012), as well as cancer…”
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“Downstream to Shh signaling, two bHLH transcription factors, Olig1 and Olig2, are particularly important for oligodendrocyte development (Lu et al., 2001, 2002; Zhou et al., 2001; Zhou and Anderson, 2002).”
BackgroundAll the embryo's a stage, and Olig2 in its time plays many parts.
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“Later in development, Olig2 directs the formation of oligodendrocyte precursors and mature oligodendrocytes (Lu et al., 2002; Park et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002; Zhou et al., 2001).”
BackgroundFujimoto, M., Takagi, Y., Muraki, K., Nozaki, K., Yamamoto, N., Tsuji, M., Hashimoto, N., Honjo, T., & Tanigaki, K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.06.001 · Cited by 25
“Olig2 is required for oligodendroglial cell generation (Lu et al., 2002; Zhou and Anderson, 2002), and overexpression of Olig2 in SVZ neural progenitor cells leads to preferential differentiation to oligodendroglial cells and inhibition of neuronal differentiation (Buffo et al., 2005; Hack et al.,…”
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Kim, H., Jeon, H.-M., Batara, D. C., Lee, S., Lee, S. J., Yin, J., Park, S., Park, M., Seo, J. B., Hwang, J., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01873-z · Cited by 24
Dermitzakis, I., Μanthou, M. E., Meditskou, S., Miliaras, D., Kesidou, E., Boziki, M. K., Petratos, S., Grigoriadis, N., & Theotokis, P. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44070222 · Cited by 26
“2 2 ′,3′-cyclic nucleotide 3′ phosphodiesterase Migration; Differentiation [52,153] CNTF 11q12.”
BackgroundInfluentialCheng, T.-F., Xue, X.-D., & Fu, J.-H. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.3028 · Cited by 26
“The expression of the OL transcription factor OLIG1 was detected in immature oligodendrocyte precursor cells (OPCs) of the nervous system (6).”
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Oyallon, J., Apitz, H., Miguel-Aliaga, I., Timofeev, K., Ferreira, L., & Salecker, I. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.027 · Cited by 26
Shh and Gli3 activities are required for timely generation of motor neuron progenitors
Oh, S., Huang, X., Liu, J., Litingtung, Y., & Chiang, C. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.539 · Cited by 26
“Abrogating Olig2 function not only led to lack of motor neuron generation but also prolonged ventral neural progenitor cell proliferation (Lu et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002).”
BackgroundAbematsu, M., Kagawa, T., Fukuda, S., Inoue, T., Takebayashi, H., Komiya, S., & Taga, T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20762 · Cited by 26
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Raghavan, S., Mooney, K. L., Folpe, A., & Charville, G. W. (2019) · Human Pathology · doi:10.1016/j.humpath.2019.07.003 · Cited by 25
Yuan, T., York, J. R., & McCauley, D. W. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.07.002 · Cited by 26
Meijer, D. H., Sun, Y., Liu, T., Kane, M., Alberta, J. A., Adelmant, G., Kupp, R., Marto, J. A., Rowitch, D. H., Nakatani, Y., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0309-14.2014 · Cited by 23
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“…role Reference OLIG1/OLIG2 Implicated in neurogenesis and oligodendrogenesis Causes GABAergic excitatory-inhibitory imbalance Lu et al., 2002; Zhou & Anderson, 2002; Chakrabarti et al., 2010 KCNJ6 Effector protein for GABAB receptors; modulates potassium channel current and…”
BackgroundEvidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.
Sun, T., Hafler, B., Kaing, S., Kitada, M., Ligon, K., Widlund, H., Yuk, D.-I., Stiles, C., & Rowitch, D. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.12.047 · Cited by 25
“(B) Consistent with previously described patterning abnormalities in Olig2 embryos (Lu et al., 2002; Zhou and Anderson, 2002), there is a marked increase in Chx10 V2 (red) and (C) GATA3 V2b interneuron cell production, reflecting ventral expansion of the p2 domain (white brackets).”
InfluentialAnalysis of the bHLH Transcription Factors Olig1 and Olig2 in Brain Tumors
Aguirre-Cruz, L., Mokhtari, K., Hoang-Xuan, K., Marie, Y., Crinière, E., Taillibert, S., Lopes, M., Delattre, J., & Sanson, M. (2004) · Journal of Neuro-Oncology · doi:10.1023/b:neon.0000024190.56750.81 · Cited by 25
“Olig genes are crucial for oligodendroglial specification and their ectopic expression results in oligodendroglial differenciation [15,16] while their invalidation leads to the absence of oligodendrocytes [17,18].”
BackgroundBiology and Clinical Application of Neural Stem Cells
Shimazaki, T. (2003) · Hormone Research in Paediatrics · doi:10.1159/000074492 · Cited by 25
Molecular Organization and Patterning of the Medulla Oblongata in Health and Disease
Diek, D., Smidt, M., & Mesman, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169260 · Cited by 24
Oligodendrocyte Development and Regenerative Therapeutics in Multiple Sclerosis
Gacem, N., & Nait‐Oumesmar, B. (2021) · Life · doi:10.3390/life11040327 · Cited by 27
“Indeed, Olig2 inactivation lead to a depletion of oligodendrocytes [26,27], while Olig2 overexpression promotes the generation of OPCs [28].”
BackgroundMorrison, V. E., Smith, V. N., & Huang, J. K. (2019) · eNeuro · doi:10.1523/eneuro.0270-19.2019 · Cited by 27
“…and OL numbers To determine whether RA synthesis by Ng2-Crerecombined cells is required for normal OL development in vivo, we quantified the number of OL lineage cells, comprising OPCs and OLs, using the lineage marker OL transcription factor 2 (OLIG2; Zhou et al., 2000; Zhou and Anderson, 2002).”
MethodExpression of Oligodendrocyte Precursor Cell Markers in Canine Oligodendrogliomas
Kishimoto, T. E., Uchida, K., Thongtharb, A., Shibato, T., CHAMBERS, J. K., Nibe, K., Kagawa, Y., & Nakayama, H. (2018) · Veterinary Pathology · doi:10.1177/0300985818777794 · Cited by 28
Motavaf, M., Sadeghizadeh, M., & Javan, M. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0472-6 · Cited by 25
prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements
Zannino, D., Downes, G., & Sagerström, C. G. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.02.025 · Cited by 24
“For example, loss of olig2 function causes the pMN domain to give rise to V2 interneurons and astrocytes instead of motor neurons and oligodendrocytes (Zhou and Anderson, 2002).”
The identification of transcriptional targets of Ascl1 in oligodendrocyte development
Ueno, T., Ito, J., Hoshikawa, S., Ohori, Y., Fujiwara, S., Yamamoto, S., Ohtsuka, T., Kageyama, R., Akai, M., Nakamura, K., et al. (2012) · Glia · doi:10.1002/glia.22369 · Cited by 17
Naruse, M., Ishino, Y., Kumar, A., Ono, K., Takebayashi, H., Yamaguchi, M., Ishizaki, Y., Ikenaka, K., & Hitoshi, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhv141 · Cited by 24
Hayakawa‐Yano, Y., Nishida, K., Fukami, S., Gotoh, Y., Hirano, T., Nakagawa, T., Shimazaki, T., & Okano, H. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0584 · Cited by 23
Oligodendrocytes Are a Major Target of the Toxicity of Spongiogenic Murine Retroviruses
Clase, A. C., Dimcheff, D. E., Favara, C., Dorward, D. W., McAtee, F. J., Parrie, L. E., Ron, D., & Portis, J. L. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051357 · Cited by 21
“39 In the embryo, the expression of Olig2 is detectable in common multipotential progenitors of oligodendrocytes and neurons 40 as well as in a common progenitor of oligodendrocytes and astrocytes.”
BackgroundRegulation of iro3 expression in the zebrafish spinal cord
Lewis, K. E., Bates, J., & Eisen, J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20215 · Cited by 24
Diller, K., Gilbert, W., & Kocher, T. (2002) · Molecular biology and evolution · doi:10.1093/oxfordjournals.molbev.a004061 · Cited by 24
“It is required for motor neuron development and contributes to neural patterning (Zhou and Anderson 2002).”
BackgroundRepressive interactions in gene regulatory networks: When you have no other choice
Delàs, M. J., & Briscoe, J. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.03.003 · Cited by 25
A Glance at the Molecules That Regulate Oligodendrocyte Myelination
Wang, S., Wang, Y., & Zou, S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44050149 · Cited by 24
Many roles for oligodendrocyte precursor cells in physiology and pathology
Nishiyama, A., Serwanski, D. R., & Pfeiffer, F. (2021) · Neuropathology · doi:10.1111/neup.12732 · Cited by 31
Kasuga, Y., Fudge, A. D., Zhang, Y., & Li, H. (2019) · Glia · doi:10.1002/glia.23684 · Cited by 23
Huang, S., O’Donovan, K. J., Turner, E. E., Zhong, J., & Ginty, D. D. (2015) · eLife · doi:10.7554/elife.10874 · Cited by 23
Purification and Culture of Oligodendrocyte Lineage CellsPreprint
Dugas, J. C., & Emery, B. (2013) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top074898 · Cited by 25
Piens, M., Müller, M., Bodson, M., Baudouin, G., & Plumier, J.-C. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-64 · Cited by 23
“Neuronal differentiation is a tightly orchestrated timeand location-dependent process in which many extracellular and intrinsic factors are involved [15-17].”
Liu, H., Jia, D., Fu, J., Zhao, S., He, G., Ling, E., Gao, J., & Hao, A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.045 · Cited by 23
Megalin deficiency induces critical changes in mouse spinal cord development
Wicher, G., & Aldskogius, H. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282f94267 · Cited by 20
“2Aa) in agreement with previous studies [9].”
Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain
Li, J., Liu, Z., Pan, Y.-C., Liu, Q., Fu, X., Cooper, N., Li, Y.-X., Qiu, M.-S., & Shi, T.-L. (2007) · Genome Biology · doi:10.1186/gb-2007-8-11-r244 · Cited by 23
“Experimental tests Recent studies in the spinal cord showed that Olig1 comprises the combinatorial code for the subtype specification of neurons and glial cells (astrocytes or oligodendrocytes) together with Olig2 [32], which is a target gene of Olig1 in the largest module of the network.”
BackgroundDividing Olig2‐expressing progenitor cells derived from ES cells
Xian, H.-Q., & Gottlieb, D. I. (2004) · Glia · doi:10.1002/glia.20010 · Cited by 23
Lee, D. G., Kim, Y.-K., & Baek, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213936 · Cited by 25
“Olig2 single and Olig1/2 double knockout mice lack the oligodendrocyte lineage cells [57,63,64].”
BackgroundmiR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M. T. N., Yang, H. H., Beffagna, G., Campanaro, S., Tam, W. L., Argenton, F., et al. (2020) · Cells · doi:10.3390/cells9030711 · Cited by 26
Paola, E. D., Verdile, V., & Paronetto, M. P. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.12.001 · Cited by 24
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution
Kim, N., Park, C., Jeong, Y., & Song, M.-R. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005560 · Cited by 22
Felton, C. M., & Johnson, C. M. (2014) · G3: Genes, Genomes, Genetics · doi:10.1534/g3.114.010819 · Cited by 22
“Yoshimura, S., J. I. Murray, Y. Lu, R. H. Waterston, and S. Shaham, 2008 mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans.”
BackgroundInfluentialWu, Y., Richard, J., Wang, S. D., Rath, P., Laterra, J., & Xia, S. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02260.x · Cited by 23
Metadata
- Authors
- Zhou, Q., & Anderson, D. J.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Anderson, David J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 109
- Issue
- 1
- Pages
- 61-73
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2125920059
- Cited by
- 1,059
- References
- 70
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 45 · 2021: 46 · 2020: 26 · 2019: 36 · 2018: 36 · 2017: 36 · 2016: 33 · 2015: 41 · 2014: 52 · 2013: 48 · 2012: 52
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01-NS23476, R01NS023476)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Olig2, Olig1, bHLH transcription factors, motor neurons, oligodendrocytes, astrocytes, proneural genes, lineage tracing
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cell Differentiation, DNA-Binding Proteins, Female, Interneurons, Male, Motor Neurons, Mutation, Nerve Tissue Proteins, Neuroglia, Neurons, Oligodendroglia, Rhombencephalon, Spinal Cord, Stem Cells, Transcription Factors, Helix-Loop-Helix Motifs, Mice, Knockout, Homeodomain Proteins, Cell Lineage, Mice, Basic Helix-Loop-Helix Proteins
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