Cited by 1,059Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

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Zhou, Qiao, Anderson, David J.·2002·Cell

DOI 10.1016/s0092-8674(02)00677-3

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Abstract

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest that Olig1(-/-)2(-/-) pMN progenitors instead generate V2 interneurons and then astrocytes. This apparent conversion likely reflects independent roles for OLIG1/2 in specifying motoneuron and oligodendrocyte fates. Olig genes therefore couple neuronal and glial subtype specification, unlike proneural bHLH factors that control the neuron versus glia decision. Our results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes, the three fundamental cell types of the central nervous system.

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“Olig1 has roles in the development and maturation of oligodendrocytes, while Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, a conclusion based on the study of targeted disruption of each gene (Zhou and Anderson, 2002).”
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“It has been suggested that OLIG2 is involved in initiation of differentiation to oligodendrocytes and OLIG1 in oligodendrocyte maturation (Zhou and Anderson 2002).”
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“Factors OLIG1/2, SOX10, MYRF [7, 8]; signals NRG1–ERBB, IGF1.”
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“…the Olig1 gene, which operates in concert with its homologue Olig2, plays a vital role in the differentiation and myelination processes of oligodendrocytes (Dai et al., 2015), essential for synaptic regulation and neural circuitry, and crucial for remyelination in mice (Zhou and Anderson, 2002).”
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“30 : Rowitch et al. ( 2002 ), Lu et al. ( 2002 ) for the disappearance of Hb9 + motoneurons in the hindbrain, Zhou and Anderson ( 2002 ) for Mo12 and sympathetics, Espinosa-Medina et al. ( 2016 ) for sympathetics, Zannino and Appel ( 2009 ) for Mo6 in zebrafish ; 31 : (Thaler et al. 1999 ),…”
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“In pMNs, Olig2 has been shown to repress Hes 1/5, leading to a derepression of Neurog2 and initiation of motor neurogenesis (Novitch et al. 2001; Lu et al. 2002; Zhou and Anderson 2002; Sagner et al. 2018).”
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“Interestingly, Ddx20 interacts with Olig2 (Bizen et al., 2022), a transcription factor essential for the development of oligodendrocytes (Lu et al., 2002; Takebayashi et al., 2002 ; Zhou & Anderson, 2002), and spinal motor neurons.”
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“…sip1 mRNAs were unaltered in both FCD types in line with a constant need of these transcription factors for the maturation and preservation of OLs (Zhou and Anderson, 2002, Lu et al., 2002) and by unaltered binding capacities of OLIG2 to genes encoding structural myelin proteins as shown in our…”
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BackgroundMethodInfluential
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“…basic helix-loop-helix transcription factor Olig2, is one of the pivotal intrinsic determinants for oligodendrocyte specification (Liu et al., 2007; Q. R. Lu et al., 2002; Q. R. Lu et al., 2000; Maire, Wegener, Kerninon, & Nait Oumesmar, 2010; Zhou & Anderson, 2002; Zhou, Wang, & Anderson, 2000).”
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“In Olig2 null spinal cords, pMN cells fail to generate both MNs and OPCs (Lu et al., 2002; Takebayashi et al., 2002; Zhou and Anderson, 2002).”
Background
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“Des études de perte et gain de fonction ont permis d’identifier les facteurs Olig1 et Olig2 comme centraux dans le déterminisme, la maturation et la myélinisation des oligodendrocytes (Lu et al. 2002; Zhou and Anderson 2002).”
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Etude des conséquences fonctionnelles des mutations du facteur eIF2B sur la maturation gliale
Huyghe, A. (2011) · theses.fr (ABES) · doi:10.70675/9d457db4zdf63z4e9ez9f8dzb0949a38698b
“KEY WORDS : eIF2B-related disorders, GEF activity, stress, transcriptomic analysis, mRNA splicing, glial cells, embryonic stem cells. te l-0 08 55 79 4, v er si on 1 - 30 A ug 2 01 3 LISTE DES ABBREVATIONS 4OHT 4-Hydroxy-Tamoxifène A2RE hnRNPA2 Response Element ABC transporteurs ATP-Binding Cassette ABCD1 ATP-Binding…”
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“For example, the identification of the basic helix-loop-helix (bHLH) transcription factor has allowed us to further understand the molecular regulation of vertebrate neurogenesis and gliogenesis (Bertrand et al., 2002; Kageyama et al., 2005; Lu et al., 2000; Zhou and Anderson, 2002).”
Background

Authors: Zhou, Q., & Anderson, D. J.
Affiliations: California Institute of Technology (US)
Corresponding author: Anderson, David J.
ORCID: Zhou, Qiao
Anderson, David J.
Venue: Cell
Publisher: Elsevier BV
Published: 2002-04
Volume: 109
Issue: 1
Pages: 61-73
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/s0092-8674(02)00677-3
OpenAlex: W2125920059
Cited by: 1,059
References: 70
Citations by year: 2026: 16 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 45 · 2021: 46 · 2020: 26 · 2019: 36 · 2018: 36 · 2017: 36 · 2016: 33 · 2015: 41 · 2014: 52 · 2013: 48 · 2012: 52
FWCI: 14.68
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4125 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01-NS23476, R01NS023476)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: Olig2, Olig1, bHLH transcription factors, motor neurons, oligodendrocytes, astrocytes, proneural genes, lineage tracing
MeSH terms: Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cell Differentiation, DNA-Binding Proteins, Female, Interneurons, Male, Motor Neurons, Mutation, Nerve Tissue Proteins, Neuroglia, Neurons, Oligodendroglia, Rhombencephalon, Spinal Cord, Stem Cells, Transcription Factors, Helix-Loop-Helix Motifs, Mice, Knockout, Homeodomain Proteins, Cell Lineage, Mice, Basic Helix-Loop-Helix Proteins

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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

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