Failure of the ubiquitin-proteasome system in Parkinson’s disease
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Reduction of proteasomal activity in PD supports the accumulation of pSer40-TH to form inclusion bodies in PD patients.
“Insight into the reduction of proteasomal activity in PD [94,95,96] further supports the evidence of the accumulation of pSer40-TH to form inclusion bodies in PD patients [71].”
From Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia (2020) · cites this paper as [95]
Failure of the ubiquitin-proteasome system is implicated in the pathogenesis of both sporadic and familial PD.
“Failure of the ubiquitin-proteasome system is implicated in the pathogenesis of both sporadic and familial PD [22,23,24,94,95,96].”
From Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia (2020) · cites this paper as [95]
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- Authors
- McNaught, K. S. P., Olanow, C. W., Halliwell, B., Isacson, O., & Jenner, P.
- Affiliations
- Harvard University (US)
- Icahn School of Medicine at Mount Sinai (US)
- National University of Singapore (SG)
- King's College London (GB)
- Venue
- Nature Reviews Neuroscience
- Published
- 2001-08
- Volume
- 2
- Issue
- 8
- Pages
- 589-594
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2067340670
- Cited by
- 519
- References
- 66
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 6 · 2023: 17 · 2022: 15 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 8 · 2017: 20 · 2016: 9 · 2015: 16 · 2014: 13 · 2013: 18 · 2012: 18
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- Parkinson's disease, ubiquitin-proteasome system, neurodegeneration, dopaminergic neurons, familial Parkinson's disease, sporadic Parkinson's disease, protein degradation, genetic mutations
- MeSH terms
- Animals, Cysteine Endopeptidases, Humans, Multienzyme Complexes, Nerve Tissue Proteins, Parkinson Disease, Peptide Hydrolases, Substantia Nigra, Ubiquitins, Lewy Bodies, Proteasome Endopeptidase Complex
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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