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Cited by 95Neurogenesis and neuroplasticity mechanismsMedical and Biological SciencesNeonatal and fetal brain pathology

Myelination in the human hippocampal formation from midgestation to adulthood

Ábrahám, Hajnalka, Vincze, András, Jewgenow, Ilja, Veszprémi, Béla, Kravják, András, Gömöri, Éva, Seress, László·2010·International Journal of Developmental Neuroscience
DOI 10.1016/j.ijdevneu.2010.03.004
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Abstract

Myelination, one of the last steps of neuronal development, was examined in the human fetal and postnatal hippocampal formation using immunohistochemistry to detect a protein component of the myelin sheath, the myelin basic protein synthesized by oligodendroglial cells. Myelin basic protein‐immunoreactive oligodendroglial cells were first seen at the 20th gestational week in the fimbria fornicis and in the alveus. Between the 21st and 35th weeks, myelinated axons also appeared in the fimbria fornicis. At the age of 39 gestational weeks, short and thin myelinated fibers were present in the fimbria, in the alveus, and less so in the stratum oriens of the hippocampus, while the first oligodendroglial cells appeared in the stratum lacunosum‐moleculare and in the hilus. By the 2nd postnatal week myelinated fibers appeared in the stratum lacunosum‐moleculare of Ammon's horn. At the 3rd month, myelination was strong in the alveus, moderate in the strata oriens, lacunosum‐moleculare and radiatum of Ammon's horn, while only a small number of myelinated fibers were detected in the hilus. By the 5th month, the first oligodendroglial cells were detected in the molecular layer of the dentate gyrus. Myelination continued in the following years, particularly in the dentate gyrus, where even at the age of 11 years the density of myelinated fibers did not reach the adult level. It appears that the first myelinated axons belong to the long‐projecting large hippocampal pyramidal cells and/or to their subcortical and cortical afferents. The sequence of myelination follows the known developmental pattern of hippocampal afferent and efferent pathways, and the prolonged myelination might be a factor in the prolonged functional maturation of hippocampal circuitry.

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  • In the human hippocampus, myelination begins at 20 weeks gestational age; by age two many regions reach adult levels, although some areas continue to myelinate into adulthood.

    “In the human hippocampus, myelination begins at 20 weeks gestational age, and by age 2 years, many regions have attained adult levels of myelination — although some areas, such as the hilus of the dentate, continue to myelinate throughout childhood into adulthood212–214.”

    From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [212]

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Authors
Ábrahám, H., Vincze, A., Jewgenow, I., Veszprémi, B., Kravják, A., Gömöri, É., & Seress, L.
Affiliations
University of Pecs (HU)
Corresponding author
Ábrahám, Hajnalka
ORCID
Ábrahám, Hajnalka
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
2010-04-22
Volume
28
Issue
5
Pages
401-410
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
DOI
10.1016/j.ijdevneu.2010.03.004
OpenAlex
W2090578392
Cited by
94
References
48
Citations by year
2026: 5 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 6 · 2013: 10 · 2012: 4
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hungarian Scientific Research Fund (#K 047109, #A 234)
  • Magyar Tudományos Akadémia
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
myelination, hippocampal formation, myelin basic protein, oligodendrocytes, human fetal development, postnatal development, fimbria, alveus, dentate gyrus, Ammon's horn, hippocampal pyramidal neurons
MeSH terms
Adult, Child, Child, Preschool, Myelin Basic Protein, Female, Gestational Age, Hippocampus, Humans, Infant, Male, Middle Aged, Myelin Sheath, Nerve Fibers, Myelinated, Dentate Gyrus, Neurogenesis

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