Impaired myelination of the human hippocampal formation in Down syndrome
Abstract
Myelination is considered as one of the last steps of neuronal development and is essential to the physiologically matured function of afferent and efferent pathways. In the present study, myelin formation was examined in the human fetal, postnatal and adult hippocampal formation in Down syndrome and in age-matched controls with immunohistochemistry detecting a protein component of the myelin sheath, the myelin basic protein synthesized by oligodendroglial cells. Myelination is mainly a postnatal event in the hippocampal formation of both healthy controls and in patients with Down syndrome. In patients with Down syndrome the sequence of myelination of the hippocampal formation followed a similar developmental pattern to that in controls. However, myelin formation was generally delayed in Down syndrome compared to age-matched controls. In addition, in the hilus of the dentate gyrus a decreased density of myelinated axons was detected from the start of myelination until adulthood. The majority of local axons (mossy fibers) are not myelinated in the hilar region and myelinated fibers arriving in the hilus come mainly from the subcortical septal nuclei. Since intact septo-hippocampal connections are necessary for memory formation, we hypothesize that decreased myelination in the hilus may contribute to the mental retardation of Down syndrome patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Post-mortem studies show reduced myelin content and fewer oligodendrocytes in DS striatum.
“This is in agreement both with previous studies showing that DS children manifest learning and memory problems in late infancy which often worsen in adolescence (Koo et al., 1992; Lanfranchi et al., 2010) and with post-mortem studies that show reduced myelin content (Abraham et al., 2012; Wisniewski, 1990; Wisniewski and Schmidt-Sidor, 1989) and fewer oligodendrocytes in DS striatum (Karlsen and P”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Abraham et al., 2012
The density of the final myelinated axons is decreased in Down syndrome.
“In addition to the developmental delay, the density of the final myelinated axons is decreased in DS (Ábrahám et al., 2012; Olmos-Serrano et al., 2016a).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Ábrahám et al., 2012
Myelination is also delayed in the hippocampus in Down syndrome.
“Myelination is also delayed in the hippocampus in DS (Ábrahám et al., 2012).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Ábrahám et al., 2012
Cites
ROACH, A., TAKAHASHI, N., PRAVTCHEVA, D., RUDDLE, F., & HOOD, L. (1985) · Cell · doi:10.1016/s0092-8674(85)80110-0 · Cited by 336 · see citing works
Executive function in adolescents with Down Syndrome
Lanfranchi, S., Jerman, O., Dal Pont, E., Alberti, A., & Vianello, R. (2010) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2010.01262.x · Cited by 308 · see citing works
Dendritic atrophy in children with down’s syndrome.
Becker, L. E., Armstrong, D. L., & Chan, F. (1986) · Annals of Neurology · doi:10.1002/ana.410200413 · Cited by 279 · see citing works
Carlesimo, G. A., Marotta, L., & Vicari, S. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(96)00055-3 · Cited by 211 · see citing works
Down's syndrome: Is there a decreased population of neurons?
Ross, M. H., Galaburda, A. M., & Kemper, T. L. (1984) · Neurology · doi:10.1212/wnl.34.7.909 · Cited by 191 · see citing works
Myelination in the human hippocampal formation from midgestation to adulthood
Ábrahám, H., Vincze, A., Jewgenow, I., Veszprémi, B., Kravják, A., Gömöri, É., & Seress, L. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.03.004 · Cited by 94 · see citing works
Self-citationReduced cell number in the neocortical part of the human fetal brain in Down syndrome
Larsen, K. B., Laursen, H., Græm, N., Samuelsen, G. B., Bogdanovic, N., & Pakkenberg, B. (2008) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2008.05.007 · Cited by 87 · cited 1× · see citing works
“In 19-week-old DS fetuses, reduction of 34% in the number of neocortical cells was detected despite the lack of morphological and cell density differences compared with controls (Larsen et al., 2008).”
ResultVincze, A., Mázló, M., Seress, L., Komoly, S., & Ábrahám, H. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2008.05.003 · Cited by 85 · see citing works
Self-citationEvidence of Arrest of Neurogenesis and Synaptogenesis in Brains of Patients with Down's Syndrome
(1984) · New England Journal of Medicine · doi:10.1056/nejm198411013111819 · Cited by 82 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Olmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239 · see citing works
“…which often worsen in adolescence (Koo et al., 1992; Lanfranchi et al., 2010), and with postmortem studies that show reduced myelin content (Ábrahám et al., 2012; Wisniewski, 1990; Wisniewski and Schmidt-Sidor, 1989) and fewer oligodendrocytes in DS striatum (Karlsen and…”
Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“Myelination is also delayed in the hippocampus in DS (Ábrahám et al., 2012).”
BackgroundShaw, P. R., Klein, J. A., Aziz, N. M., & Haydar, T. F. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.046243 · Cited by 45 · see citing works
Postnatal Cytoarchitecture and neurochemical hippocampal dysfunction in Down Syndrome
Moreno, D. G., Utagawa, E. C., Arva, N. C., Schafernak, K. T., Mufson, E. J., & Perez, S. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153414 · Cited by 7 · see citing works
- Authors
- Ábrahám, H., Vincze, A., Veszprémi, B., Kravják, A., Gömöri, É., Kovács, G. G., & Seress, L.
- Affiliations
- University of Pecs (HU)
- Medical University of Vienna (AT)
- Corresponding author
- Ábrahám, Hajnalka
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2011-12-06
- Volume
- 30
- Issue
- 2
- Pages
- 147-158
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W1988585329
- Cited by
- 85
- References
- 9
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 9 · 2012: 2
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hungarian Scientific Research Fund (K 047109)
- Bolyai Scholarship of the Hungarian Academy of Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Down syndrome, myelination, hippocampal formation, myelin basic protein, oligodendrocytes, dentate gyrus hilus, mossy fibers, septohippocampal pathway, delayed myelination, intellectual disability, human brain development
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Down Syndrome, Female, Hippocampus, Humans, Infant, Infant, Newborn, Male, Middle Aged, Myelin Sheath, Nerve Fibers, Myelinated, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
