Cold feet and prolonged sleep-onset latency in vasospastic syndrome
Abstract
People with vasospastic syndrome have cold hands and feet and abnormal vasoconstriction after local cold exposure. Normally there is a circadian rhythm of distal vasodilation, with onset in the early evening, which directly influences ability to fall asleep. We gave a sleep questionnaire to 32 patients with primary vasospastic syndrome and 31 healthy controls. People with vasospasticity had significantly prolonged sleep-onset latency both at onset of night-time sleep and after nocturnal disturbance. This prolonged latency could be associated with impaired capacity for distal vasodilation.
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People with vasospastic syndrome have a lower temperature of their hands and tend to have difficulties falling asleep, and the same association between higher skin temperature and easier sleep onset was shown for them.
“The same association was shown for people with a vasospastic syndrome, who have a lower temperature of their hands and tend to have difficulties falling asleep [64]”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [64]
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Chokroverty, S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-7506-7584-0.00007-0
- Authors
- Pache, M., Kräuchi, K., Cajochen, C., Wirz-Justice, A., Dubler, B., Flammer, J., & Kaiser, H. J.
- Affiliations
- Universitäre Psychiatrische Kliniken Basel (CH)
- Corresponding author
- Pache, Mona
- ORCID
- Cajochen, Christian
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 358
- Issue
- 9276
- Pages
- 125-126
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1992460259
- Cited by
- 104
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Keywords
- cold hands and feet, sleep latency, circadian rhythm, vasoconstriction, nocturnal sleep disturbance
- MeSH terms
- Adult, Aged, Constriction, Pathologic, Female, Foot, Humans, Hypothermia, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Predictive Value of Tests, Surveys and Questionnaires, Risk Factors, Syndrome, Vasodilation, Case-Control Studies, Sleep Disorders, Circadian Rhythm
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