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Renal dysfunction accompanying oral creatine supplements
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In the citing paper
“With regard to the question of whether creatine has effect on renal function, a few case studies [249–252] reported that individuals purportedly taking creatine with or without other supplements presented with high creatinine levels and/or renal dysfunction [249–251].”
From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [251]
In the citing paper
“Based on increased blood levels of creatinine and subsequent estimate of calculated creatinine clearance, his kidney health was presumed to be deteriorating, although he was otherwise in good health.”
From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [51]
In the citing paper
“In 1998, a case study of a young male with focal segmental glomerulosclerosis and relapsing nephrotic syndrome was reported [51]. The young male, who had kidney disease for 8 years and was treated with cyclosporine (i.e., immunosuppressant) for 5 years, had recently begun ingesting creatine supplementation (15 g/day for 7 days; followed by 2 g/day for 7 weeks).”
From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [51]
In the citing paper
“A few case study reports also appeared in the literature suggesting adverse events despite other mitigating factors unrelated to creatine supplementation [52–54] which subsequently have been debunked [15,55,56].”
From Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports (2025) · cites this paper as [52]
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Metadata
- Authors
- Pritchard, N., & Kalra, P.
- Affiliations
- Salford Royal NHS Foundation Trust (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 351
- Issue
- 9111
- Pages
- 1252-1253
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1973648573
- Cited by
- 213
- References
- 4
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 1 · 2012: 8
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- creatine supplementation, renal dysfunction, creatine loading, serum creatinine, exercise performance, dietary supplements, drug safety
- MeSH terms
- Administration, Oral, Adult, Creatine, Glomerular Filtration Rate, Humans, Male, Nephrotic Syndrome, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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