The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial
Open accessAbstract
Background Trial findings show cognitive behaviour therapy (CBT) and graded exercise therapy (GET) can be effective treatments for chronic fatigue syndrome, but patients' organisations have reported that these treatments can be harmful and favour pacing and specialist health care. We aimed to assess effectiveness and safety of all four treatments.Methods In our parallel-group randomised trial, patients meeting Oxford criteria for chronic fatigue syndrome were recruited from six secondary-care clinics in the UK and randomly allocated by computer-generated sequence to receive specialist medical care (SMC) alone or with adaptive pacing therapy (APT), CBT, or GET. Primary outcomes were fatigue (measured by Chalder fatigue questionnaire score) and physical function (measured by short form-36 subscale score) up to 52 weeks after randomisation, and safety was assessed primarily by recording all serious adverse events, including serious adverse reactions to trial treatments. Primary outcomes were rated by participants, who were necessarily unmasked to treatment assignment; the statistician was masked to treatment assignment for the analysis of primary outcomes. We used longitudinal regression models to compare SMC alone with other treatments, APT with CBT, and APT with GET. The final analysis included all participants for whom we had data for primary outcomes. This trial is registered at http://isrctn.org, number ISRCTN54285094.Findings We recruited 641 eligible patients, of whom 160 were assigned to the APT group, 161 to the CBT group, 160 to the GET group, and 160 to the SMC-alone group. Compared with SMC alone, mean fatigue scores at 52 weeks were 3·4 (95% CI 1·8 to 5·0) points lower for CBT (p = 0·0001) and 3·2 (1·7 to 4·8) points lower for GET (p = 0·0003), but did not differ for APT (0·7 [-0·9 to 2·3] points lower; p = 0·38). Compared with SMC alone, mean physical function scores were 7·1 (2·0 to 12·1) points higher for CBT (p = 0·0068) and 9·4 (4·4 to 14·4) points higher for GET (p = 0·0005), but did not differ for APT (3·4 [-1·6 to 8·4] points lower; p=0·18). Compared with APT, CBT and GET were associated with less fatigue (CBT p = 0·0027; GET p = 0·0059) and better physical function (CBT p=0·0002; GET p<0·0001). Subgroup analysis of 427 participants meeting international criteria for chronic fatigue syndrome and 329 participants meeting London criteria for myalgic encephalomyelitis yielded equivalent results. Serious adverse reactions were recorded in two (1%) of 159 participants in the APT group, three (2%) of 161 in the CBT group, two (1%) of 160 in the GET group, and two (1%) of 160 in the SMC-alone group.Interpretation CBT and GET can safely be added to SMC to moderately improve outcomes for chronic fatigue syndrome, but APT is not an effective addition.Funding UK Medical Research Council, Department of Health for England, Scottish Chief Scientist Office, Department for Work and Pensions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cognitive–behavioural therapy (CBT) has been shown to reduce symptoms and increase functioning in adults with FSS,27–30”
From Comparing group-based acceptance and commitment therapy (ACT) with enhanced usual care for adolescents with functional somatic syndromes: A study protocol for a randomised trial (2016) · cites this paper as [28]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Research has shown that CBT improves physical functioning and fatigue reduction immediately and some time after treatment [9,10].”
From Cognitive behavior therapy in patients with chronic fatigue syndrome: The role of illness acceptance and neuroticism. (2013) · cites this paper as [9]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“CBT aimed at increasing functioning, and its objective and content are comparable with manuals of other CBT trials [9,12].”
From Cognitive behavior therapy in patients with chronic fatigue syndrome: The role of illness acceptance and neuroticism. (2013) · cites this paper as [9]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The introduction to graded exercise as a means of moderating maladaptive illness behaviour and increasing physical function is also considered an important element in the treatment and has been found effective for chronic fatigue syndrome [21].”
From Internet-delivered treatment for patients suffering from severe functional somatic disorders: Protocol for a randomized controlled trial (2023) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“CBT has been adapted and tested with CFS patients yielding superior results compared to standard medical treatment, relaxation, and adaptive pacing therapy (Sharpe et al., 1996; Deale et al., 1997; White et al., 2011), with moderate effect sizes (d = 0.48) (Malouff et al., 2008).”
From The relationship between improvement in insomnia severity and long-term outcomes in the treatment of chronic fatigue (2018) · cites this paper as White et al., 2011
The cited source says what the claim attributes to it.
In the citing paper
“In the first study, CBT and GET has been found to improve subjective sleep-disturbance significantly more than control-conditions at 1-year follow-up (White et al., 2011).”
From The relationship between improvement in insomnia severity and long-term outcomes in the treatment of chronic fatigue (2018) · cites this paper as White et al., 2011
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“However, post-exertional malaise – which has been proposed as a cardinal symptom for myalgic encephalomyelitis/CFS in the latest NICE-guidelines [14]– could not be systematically aggregated as it was seldom assessed and not uniformly reported [29, 35, 42].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [42]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
(1976) · Medical Entomology and Zoology · Cited by 8,899
MCHORNEY, C. A., JOHNE, W., & ANASTASIAE, R. (1993) · Medical Care · doi:10.1097/00005650-199303000-00006 · Cited by 6,681
Development of a fatigue scale
Chalder, T., Berelowitz, G., Pawlikowska, T., Watts, L., Wessely, S., Wright, D., & Wallace, E. P. (1993) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(93)90081-p · Cited by 3,032
Self-citationThe Work and Social Adjustment Scale: a simple measure of impairment in functioning
Mundt, J. C., Marks, I. M., Shear, M. K., & Greist, J. M. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.5.461 · Cited by 2,515
Two-, six-, and 12-minute walking tests in respiratory disease.
Butland, R. J., Pang, J., Gross, E. R., Woodcock, A. A., & Geddes, D. M. (1982) · BMJ · doi:10.1136/bmj.284.6329.1607 · Cited by 1,668
Methods to Explain the Clinical Significance of Health Status Measures
Guyatt, G. H., Osoba, D., Wu, A. W., Wyrwich, K. W., & Norman, G. R. (2002) · Mayo Clinic Proceedings · doi:10.4065/77.4.371 · Cited by 1,525
A scale for the estimation of sleep problems in clinical research
Jenkins, C. D., Stanton, B.-A., Niemcryk, S. J., & Rose, R. M. (1988) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(88)90138-2 · Cited by 1,216
A report—Chronic fatigue syndrome: Guidelines for research
Sharpe, M. C. (1991) · Journal of the Royal Society of Medicine · doi:10.1177/014107689108400224 · Cited by 1,026
Self-citationPrins, J. B., van der Meer, J. W., & Bleijenberg, G. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68073-2 · Cited by 974
Research works printed but not linked: 1
- White, 2007, BioMed Cent Neurol, 7, 6
Cited by
Sorted by citations
Items 701–800 of 893
Cognitive functioning in chronic fatigue syndrome
Cockshell, S. J. (2016) · Adelaide Research & Scholarship (AR&S) (University of Adelaide) · doi:10.4225/55/58dc8dc6dc266 · Cited by 2
Development of a psychological intervention for post-stroke fatigue
Wu, S. (2016) · ERA · Cited by 2
PACE chronic fatigue trial was properly conducted, says UK research watchdog
Hawkes, N. (2019) · BMJ · doi:10.1136/bmj.l639 · Cited by 2
Treatment harms to patients with ME/CFSPreprint
Marks, D. F. (2021) · doi:10.32388/xug3pt · Cited by 2
Palliativmedizinische Aspekte der Pneumo-Onkologie
Heigener, D. F., & Delis, S. (2023) · Pneumologie · doi:10.1055/a-2206-5602 · Cited by 1
May, M., Milrad, S. F., Perdomo, D. M., Czaja, S. J., Jutagir, D. R., Hall, D. L., Klimas, N. G., & Antoni, M. H. (2024) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2024.2306801 · Cited by 1
Palliativmedizinische Aspekte der Pneumo-Onkologie
Heigener, D. F., & Delis, S. (2024) · Onkologische Welt · doi:10.1055/a-2358-9877 · Cited by 1
Hunt, J., & Blease, C. (2024) · Journal of Medical Ethics · doi:10.1136/jme-2023-109627 · Cited by 3
Ludwig, B., Hauer, L., Böck, M., Schillerwein-Kral, C., Weyer, L., Moser, D., Zehetmayer, S., Trimmel, K., & Seidel, S. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.03.003 · Cited by 2
Predictors of fatigue progression in long COVID among young people
Brodwall, E. M., Selvakumar, J. P., Havdal, L. B., Sommen, S. L., Berven, L. L., Cvejic, E., Wyller, V. B., & Pedersen, M. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100982 · Cited by 1
Islam, M. A., Ahmed, F., Hossain, K. M. A., Kabir, M. F., Jahan, S., Rahman, E., & Hossain, M. Z. (2025) · Bulletin of Faculty of Physical Therapy · doi:10.1186/s43161-025-00303-0 · Cited by 1
Somatic Symptom Disorder: Clinical Approach and Neurobiology
Singal, P., Nair, K., Kumar, M., & Patel, N. N. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_162 · Cited by 1
Lamberti, N., Baroni, A. V., Piva, G., Fregna, G., Schincaglia, N., Crepaldi, A., Gamberini, L., Occhi, A., Straudi, S., & Manfredini, F. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14196938 · Cited by 1
Wei, Z., Wu, H., Chong, C., Wang, Z., Xiong, H., Song, F., & Ren, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1681990 · Cited by 1
Liao, Z., Zhao, S., Fang, S., Ren, J., Wang, S., Kong, L., & Fang, M. (2025) · iScience · doi:10.1016/j.isci.2025.114178 · Cited by 1
Dahlberg, A. O., Aase, A., Reiso, H., Quarsten, H., Øines, Ø., & Midgard, R. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-12182-w · Cited by 1
Wilson, M., Pedersen, S. G., Langeland, N., Cox, R. J., Aukrust, P., Dahl, T. B., Sandvig, A., & Wilhelmsen, M. (2026) · JMIR Research Protocols · doi:10.2196/74113 · Cited by 1
Abrahamsen, C., Beadsworth, M., Bostock, W., Chalder, T., Flottorp, S. A., Fors, E. A., Garner, P., Hadfield, S., Kennedy, B., Kuehn, R., et al. (2026) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2026.2633765 · Cited by 1
Self-citationReframing ME/CFS: toward a unified mechanistic model of chronic post-infectious diseases
Watton, P. N., & Prusty, B. K. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08319-3 · Cited by 1
Friedberg, F., Milazzo, M., Ginex, P., Zhang, X., & Yang, J. (2026) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2025.2582920 · Cited by 1
Neuropathic Pain and Other Chronic Musculoskeletal Pain Conditions
Sykes, S. N., & Beydoun, S. R. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6567-6_80 · Cited by 1
Funktionelle somatische Syndrome – Konzeptualisierung, Epidemiologie und Behandlung
Fischer, S., & Nater, U. M. (2012) · Zeitschrift für Medizinische Psychologie · doi:10.3233/zmp-2012-210010 · Cited by 1
Glickman-Simon, R., & Tenkku, L. E. (2012) · EXPLORE · doi:10.1016/j.explore.2011.11.006 · Cited by 1
Shephard, R. J. (2012) · Yearbook of Sports Medicine · doi:10.1016/j.yspm.2011.08.037 · Cited by 1
Bleijenberg, G., Gielissen, M. F. M., Goedendorp, M. M., & Knoop, H. (2012) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-9890-4_12 · Cited by 1
Sunnquist, M. (2016) · Digital Commons-DePaul (DePaul University) · Cited by 1
Twisk, F. (2017) · Medical Research and Innovations · doi:10.15761/mri.1000118 · Cited by 1
Digitale mestringskurs kan gjøre det lettere å delta for CFS/ME-pasienter
Eriksen, A. A., Woldseth, G. M., & Jordbru, A. (2021) · Sykepleien Forskning · doi:10.4220/sykepleiens.2021.84329 · Cited by 1
سالم, ر., السليماني, ح., & إمام, م. (2018) · مجلة التربية الخاصة · doi:10.21608/mtkh.2018.168382 · Cited by 1
Valuing the role of educators in practice: Greater Manchester's framework
Williams, C., Leigh, J., Burns, D., Halse, J., Haydri, S., Collins, S., McManus, E., Grundy, J., Sutcliffe, K., Bowler, H., et al. (2022) · British Journal of Nursing · doi:10.12968/bjon.2022.31.3.174 · Cited by 1
(2019) · Archives of Physiotherapy · doi:10.1186/s40945-019-0069-0 · Cited by 1
Graded exercise therapy: Chronic fatigue syndrome
The HANDI Working Group (2019) · InnovAiT Education and inspiration for general practice · doi:10.1177/1755738019852393 · Cited by 1
Bennett, S., Almeida, C., Bachmair, E., Gray, S. R., Lovell, K., Paul, L., Wearden, A. J., Macfarlane, G. J., Basu, N., Dures, E. K., et al. (2022) · Rheumatology Advances in Practice · doi:10.1093/rap/rkac051 · Cited by 1
Self-citationCognitive Behavioral Therapy in the United Kingdom
Moorey, S. (2022) · Springer eBooks · doi:10.1007/978-3-030-82555-3_32 · Cited by 2
Stalmeisters, D. (2012) · Counselling Psychology Review · doi:10.53841/bpscpr.2012.27.3.29 · Cited by 1
Boruch, A. E., Branchaw, G. E., O’Connor, P. J., & Cook, D. B. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_502 · Cited by 1
Vink, M., & Partyka-Vink, K. (2025) · Life · doi:10.3390/life15040584 · Cited by 1
Core Treatment Approaches for Long COVID Fatigue
Rudroff, T. (2025) · Springer eBooks · doi:10.1007/978-3-031-89474-9_15 · Cited by 1
Syndrome de Fatigue Chronique : une entité à part entière ?
Prochalska, C., Gressier, F., & Corruble, E. (2013) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2012.11.012 · Cited by 1
Bewegung und Erkrankungen des Immunsystems
Scherr, J. (2016) · Springer eBooks · doi:10.1007/978-3-662-50335-5_17 · Cited by 1
A Break from Pain! Interruption Management in the Context of Pain
Gatzounis, R., Crombez, G., Schrooten, M. G. S., & Vlaeyen, J. W. S. (2018) · Pain Management · doi:10.2217/pmt-2018-0038 · Cited by 1
Lubet, S., & Tuller, D. (2020) · Medical Humanities · doi:10.1136/medhum-2019-011807 · Cited by 1
Systemtherapie des Leberzellkarzinoms
Wege, H., & Arnold, D. (2012) · Der Onkologe · doi:10.1007/s00761-012-2246-6 · Cited by 1
Long-Term Management of Data and Secondary Use
Canham, S. (2020) · Springer eBooks · doi:10.1007/978-3-319-52677-5_286-1 · Cited by 1
Når dårlig ME-forskning forsvares ved å skyte på pasientene
Angelsen, A. (2021) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.21.0305 · Cited by 1
Wrightson, J. G., & Twomey, R. (2021) · Society for Transparency, Openness, and Replication in Kinesiology eBooks · doi:10.51224/b1018 · Cited by 1
Marshall, G. S., & Carter, B. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-40181-4.00200-0 · Cited by 1
Godefroy, O. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139058988.025 · Cited by 1
Long-Term Management of Data and Secondary Use
Canham, S. (2022) · Springer eBooks · doi:10.1007/978-3-319-52636-2_286 · Cited by 1
Autoimmune Lebererkrankungen – ein Update (Teil 2)
Schregel, I., Steinmann, S., & Schramm, C. (2022) · Gastroenterologie up2date · doi:10.1055/a-1922-9264 · Cited by 1
Bauer, T., Ortiz, M., Bellmann–Strobl, J., Engelhardt, U., Nögel, R., Hummelsberger, J., Michalsen, A., Roll, S., Grabowska, W. A., Stöckigt, B., et al. (2023) · Current Research in Complementary & Alternative Medicine · doi:10.29011/2577-2201.100214 · Cited by 1
Fellenor, J. (2015) · The University of Bath Online Publications Store (The University of Bath) · Cited by 1
Harms and benefits associated with exercise therapy for CFS/ME
Courtney, R. H. (2014) · Disability and Rehabilitation · doi:10.3109/09638288.2014.952453 · Cited by 1
Response to Gladwell et al.: concerns about safety for GET
Sheridan, A. (2014) · Disability and Rehabilitation · doi:10.3109/09638288.2014.952455 · Cited by 1
Doubts over the validity of the PACE hypothesis
Courtney, R. H. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00054-1 · Cited by 1
Methods and outcome reporting in the PACE trial–Author's reply
Chalder, T., Goldsmith, K., White, P. D., Sharpe, M., & Pickles, A. R. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00114-5 · Cited by 1
Self-citationMorriss, R. K. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304824 · Cited by 1
Comment on: ‘Reports of recovery in chronic fatigue syndrome may present less than meets the eye’
White, P. D., Chalder, T., & Sharpe, M. (2016) · Evidence-Based Mental Health · doi:10.1136/eb-2015-102300 · Cited by 1
Self-citationExploring the emotional conflict task: associations with clinical status and age
Høst, K. H. (2015) · NORA - Norwegian Open Research Archives · Cited by 1
aanhoudende vermoeidheid na een Q-koortsinfectie
Keijmel, S. P., Morroy, G., Delsing, C. E., Bleijenberg, G., Bleeker‐Rovers, C. P., & Timen, A. (2012) · Data Archiving and Networked Services (DANS) · Cited by 1
Armstrong, C. W. (2017) · Minerva Access (University of Melbourne) · Cited by 1
Medically Unexplained Symptoms
FHEA, G. G. M. M. F. F. P. (., GradDipUTL, W. C. M. B. B. D. D. M. M. M., & FTCD, B. D. K. M. B. B. M. M. M. M. P. D. P. M. (. O. M. F. F. (2021) · Wiley eBooks · doi:10.1002/9781394322978.ch23 · Cited by 1
Nacul, L., O’Boyle, S., Nácul, F. E., Mudie, K., Kingdon, C. C., Cliff, J. M., Clark, T. G., Dockrell, H. M., & Lacerda, E. (2019) · Preprints.org · doi:10.20944/preprints201909.0188.v1
CFS patients remain severely disabled after specialist treatment with CBT in the UK
Vink, M., & Vink-Niese, A. (2021) · Journal of the Royal Society of Medicine · doi:10.1177/01410768211013447 · Cited by 1
Nater, U. M., & Ali, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_7 · Cited by 1
The PACE trial in chronic fatigue syndrome
Mitchell, J. T. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60683-1 · Cited by 1
Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Kirby, S. B. M. (2015) · Annals of Internal Medicine · doi:10.7326/l15-5172 · Cited by 1
Hunt, J., & Blease, C. (2023) · SocArXiv (OSF Preprints) · doi:10.31235/osf.io/3vu8e · Cited by 1
Jones, C. M. P., Lin, C. C., Blease, C. R., Lawson, J., Shaheed, C. A., & Maher, C. G. (2024) · Pain · doi:10.1097/j.pain.0000000000003146 · Cited by 1
Early Intervention in the General Hospital
Byrne, P., & Assalman, I. (2014) · Early Intervention in Psychiatry · doi:10.1002/9781118557174.ch14
The burden of Sjögren's syndrome, dryness and fatigue
van Leeuwen, N. (2014) · Utrecht University Repository (Utrecht University)
Wiborg, J. F. (2012) · Radboud Repository (Radboud University)
Systemtherapie des Leberzellkarzinoms
Wege, H., & Arnold, D. (2012) · Wiener klinisches Magazin · doi:10.1007/s00740-012-0040-0
ME/CVS, de psychotherapeut en de (on)macht van het evidencebeest
Twisk, F., Arnoldus, R., & Maes, M. H. J. (2011) · Tijdschrift voor Psychotherapie · doi:10.1007/s12485-011-0042-1
Houlton, A., Christie, M. M., Smith, B., & Gardiner, E. (2015) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2014.993873
Kronisk utmattelsessyndrom. Kunnskap, aktivitet og utfordringer
Larun, L. (2011) · NORA - Norwegian Open Research Archives
Nijs, J., Cauwenbergh, D. V., Kooning, M. D., & Ickmans, K. (2012) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2012.02722.x
What makes a difference in chronic fatigue syndrome
Lord, C. (2015)
Marlin, R. G. (2015) · Canadian Journal of General Internal Medicine · doi:10.22374/cjgim.v10i4.88
L. Larun & K. Malterud svarer:
Larun, L., & Malterud, K. (2011) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.11.0407
Why are patients with anca-associated vasculitis fatigued?
McClean, A. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)
Funktionelle Syndrome und Beschwerden
Nater, U. M., Fischer, S., & Mewes, R. (2015) · Springer-Lehrbuch · doi:10.1007/978-3-662-48035-9_12
Policy Chronic Fatigue Syndrome
Ccg, H., & Ccg, W. L. (2014)
Shepherd, C. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-0790-4.00048-2
Ever since neurologist George Miller Beard coined the term neurasthenia in the 19th century
Sharpe, M. (2015)
Self-citationFibromyalgia and Chronic Fatigue Syndrome
Bennett, R. M. (2012) · Goldman's Cecil Medicine · doi:10.1016/b978-1-4377-1604-7.00282-7
Diary-based outcome predictors in a self-management trial in chronic fatigue syndrome
Adamowicz, J. L., & Caikauskaite, I. (2016) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2016.1217666
Müdigkeit und Chronic-Fatigue-Syndrom
Keel, P. (2016) · Elsevier eBooks · doi:10.1016/b978-3-437-21833-0.00067-x
Solomons, W. (2017) · University of Hertfordshire Research Archive (University of Hertfordshire) · doi:10.18745/th.17597
Research Waste in ME/CFSPreprint
Lee, S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/133926
Bhat, S., & Chokroverty, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_42
Behavioral Interventions Lead to Modestly Better Outcomes in CFS Patients
Soloway, B. (2011) · Journal watch · doi:10.1056/jw201103010000004
Skeletal muscle fatigue: Investigating the role of cytokines, ROS and mitochondrial function.
Earl, K. E. (2016) · University of Liverpool · doi:10.17638/03001668
Chronic Fatigue Syndrome: Pessimism Doesn't Help
Silver, J. (2011) · Journal watch · doi:10.1056/jp201103210000005
Heeft de keizer wel kleren aan?
Faas, J. (2017) · Tijdschrift voor bedrijfs- en verzekeringsgeneeskunde · doi:10.1007/s12498-017-0501-x
Metadata
- Authors
- White, P., Goldsmith, K., Johnson, A., Potts, L., Walwyn, R., DeCesare, J., Baber, H., Burgess, M., Clark, L., Cox, D., Bavinton, J., Angus, B., Murphy, G., Murphy, M., O'Dowd, H., Wilks, D., McCrone, P., Chalder, T., & Sharpe, M.
- Affiliations
- King's College London (GB)
- Queen Mary University of London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- John Radcliffe Hospital (GB)
- The Royal Free Hospital (GB)
- Western General Hospital (GB)
- University of Edinburgh (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 377
- Issue
- 9768
- Pages
- 823-836
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC3065633
- OpenAlex
- W2136415723
- Cited by
- 897
- References
- 37
- Citations by year
- 2026: 22 · 2025: 44 · 2024: 54 · 2023: 47 · 2022: 48 · 2021: 61 · 2020: 56 · 2019: 55 · 2018: 52 · 2017: 84 · 2016: 75 · 2015: 78 · 2014: 52 · 2013: 67 · 2012: 60
- FWCI
- 47.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Insight (University of Cumbria) (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- the UK Medical Research Council (MRC G0200434)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- chronic fatigue syndrome, cognitive behavioral therapy, graded exercise therapy, specialist care, fatigue, physical function, treatment safety, adverse events, PACE trial, treatment effectiveness comparison, patient-reported outcomes, Chalder Fatigue Questionnaire, SF-36 physical functioning, serious adverse events
- MeSH terms
- Activities of Daily Living, Adaptation, Physiological, Adult, Exercise Therapy, Female, Humans, Male, Surveys and Questionnaires, Specialization, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
