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Selenium and human health
Abstract
Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone. In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to health. Low selenium status has been associated with increased risk of mortality, poor immune function, and cognitive decline. Higher selenium status or selenium supplementation has antiviral effects, is essential for successful male and female reproduction, and reduces the risk of autoimmune thyroid disease. Prospective studies have generally shown some benefit of higher selenium status on the risk of prostate, lung, colorectal, and bladder cancers, but findings from trials have been mixed, which probably emphasises the fact that supplementation will confer benefit only if intake of a nutrient is inadequate. Supplementation of people who already have adequate intake with additional selenium might increase their risk of type-2 diabetes. The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional selenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenium supplements.
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“The strategy of Se biofortification of food crops is practiced in Se-deficient regions by adding inorganic Se-containing fertilizers to soils, e.g., in Finland [26,27], UK [28,29], and New Zealand [30], or by adding organic sources of Se to soils, e.g., in the USA [23].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [29]
In the citing paper
“A European randomized trial which was not included in this analysis suggests that the clinical effect of a combination of antioxidants is already apparent after five days of administration (287).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [287]
In the citing paper
“Observational studies revealed that both high and low intake of Se is associated with an increased risk of cardiovascular disease (Rayman 2012).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rayman 2012
Citations
Cites
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Self-citationEffects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,385
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Dual Function of the Selenoprotein PHGPx During Sperm Maturation
Ursini, F., Heim, S., Kieß, M., Maiorino, M., Roveri, A., Wissing, J. B., & Flohé, L. (1999) · Science · doi:10.1126/science.285.5432.1393 · Cited by 902
Selenium in cancer prevention: a review of the evidence and mechanism of action
Rayman, M. P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005467 · Cited by 858
Self-citationFood-chain selenium and human health: emphasis on intake
Rayman, M. P. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508939830 · Cited by 798
Self-citationEffects of Long-Term Selenium Supplementation on the Incidence of Type 2 Diabetes
Stranges, S., Marshall, J. R., Natarajan, R., Donahue, R. P., Trevisan, M., Combs, G. F., Cappuccio, F. P., Ceriello, A., & Reid, M. E. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-4-200708210-00175 · Cited by 715
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Pillai, R., Uyehara‐Lock, J. H., & Bellinger, F. P. (2014) · IUBMB Life · doi:10.1002/iub.1262 · Cited by 201
Nutritionally Enhanced Food Crops; Progress and Perspectives
Hefferon, K. L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023895 · Cited by 202
Guo, P., Wang, W., Xiang, Q., Pan, C., Qiu, Y., Li, T., Wang, D., Ouyang, J., Jia, R., Shi, M., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.028 · Cited by 199
Yin, T., Yang, L., Liu, Y., Zhou, X., Sun, J., & Liu, J. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.06.035 · Cited by 198
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Bartalena, L., & Tanda, M. L. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13524 · Cited by 215
Chauhan, S. S., Celi, P., Leury, B. J., Clarke, I. J., & Dunshea, F. R. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-7714 · Cited by 195
Köhrle, J. (2015) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000190 · Cited by 195
Acute and subacute toxicity of novel biogenic selenium nanoparticles in mice
Shakibaie, M., Shahverdi, A. R., Faramarzi, M. A., Hassanzadeh, G. R., Rahimi, H. R., & Sabzevari, O. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2012.710241 · Cited by 194
Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle
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Zhao, Y., Hu, C., Wang, X., Qing, X., Wang, P., Zhang, Y., Zhang, X., & Zhao, X. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.01.090 · Cited by 191
Mineral Biofortification of Vegetables as a Tool to Improve Human Diet
Buturi, C. V., Mauro, R. P., Fogliano, V., Leonardi, C., & Giuffrida, F. (2021) · Foods · doi:10.3390/foods10020223 · Cited by 191
Rayman, M. P., Winther, K. H., Pastor‐Barriuso, R., Cold, F., Thvilum, M., Stranges, S., Güallar, E., & Cold, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.015 · Cited by 195
Self-citationThe role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
Kang, D., Lee, J., Wu, C., Guo, X., Lee, B. J., Chun, J., & Kim, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0408-y · Cited by 192
Qazi, I. H., Angel, C., Yang, H., Zoidis, E., Pan, B., Wu, Z., Ming, Z., Zeng, C., Meng, Q., Han, H., et al. (2019) · Antioxidants · doi:10.3390/antiox8080268 · Cited by 189
Effects and Impact of Selenium on Human Health, A Review
Bai, S., Zhang, M., Tang, S., Li, M., Wu, R., Wan, S., Chen, L., Wei, X. H., & Feng, S. (2024) · Molecules · doi:10.3390/molecules30010050 · Cited by 194
Selenium supplementation for the primary prevention of cardiovascular disease
Rees, K., Hartley, L., Day, C., Flowers, N., Clarke, A., & Stranges, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009671.pub2 · Cited by 193
Yuan, Y. L., Xiao, Y., Feng, W., Liu, Y., Yu, Y., Zhou, L., Qiu, G., Wang, H., Liu, B., Liu, K., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp1521 · Cited by 188
Islam, M. R., Akash, S., Jony, M. H., Alam, M. N. A., Nowrin, F. T., Rahman, M. M., Rauf, A., & Thiruvengadam, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04638-3 · Cited by 202
RetractedFeng, W. H., Cui, X., Liu, B., Liu, C., Xiao, Y., Lü, W., Guo, H., He, M., Zhang, X., Yuan, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123742 · Cited by 186
Bañuelos, G. S., Arroyo, I., Pickering, I. J., Yang, S. I., & Freeman, J. L. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.071 · Cited by 184
Selenium and selenoproteins in viral infection with potential relevance to COVID-19
Zhang, J., Saad, R., Taylor, E. W., & Rayman, M. P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101715 · Cited by 191
Self-citationSelenium and Selenoproteins: An Overview on Different Biological Systems
Mangiapane, E., Pessione, A., & Pessione, E. (2014) · Current Protein and Peptide Science · doi:10.2174/1389203715666140608151134 · Cited by 182
Yin, H., Qi, Z., Li, M., Ahammed, G. J., Chu, X., & Zhou, J. (2018) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2018.11.080 · Cited by 179
Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment
Yasueda, A., Urushima, H., & Ito, T. (2015) · Integrative Cancer Therapies · doi:10.1177/1534735415610427 · Cited by 189
Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity
Álvarez-Pérez, M., Ali, W., Marć, M. A., Handzlik, J., & Domínguez‐Álvarez, E. (2018) · Molecules · doi:10.3390/molecules23030628 · Cited by 187
Minerals in edible seaweed: health benefits and food safety issues
Lozano‐Muñoz, I., & Díaz, N. F. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1844637 · Cited by 191
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance
Samsel, A., & Seneff, S. (2013) · Interdisciplinary Toxicology · doi:10.2478/intox-2013-0026 · Cited by 177
Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome
Bielik, V., & Kolísek, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136803 · Cited by 175
Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease
Wiersinga, W. M. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.2.213 · Cited by 173
Schiavon, M., Dall’Acqua, S., Mietto, A., Pilon‐Smits, E. A. H., Sambo, P., Masi, A., & Malagoli, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4031822 · Cited by 172
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Petta, S., Gastaldelli, A., Rebelos, E., Bugianesi, E., Messa, P., Miele, L., Svegliati‐Baroni, G., Valenti, L. V. C., & Bonino, F. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122082 · Cited by 182
Liu, Y., Chen, X., Sun, K., Li, X., Zeng, F., Liu, X., Qu, L., Zhao, Y., & Yu, B. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b01175 · Cited by 171
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Selenium Enrichment of Horticultural Crops
Puccinelli, M., Malorgio, F., & Pezzarossa, B. (2017) · Molecules · doi:10.3390/molecules22060933 · Cited by 164
Selenium Nanoparticles as an Efficient Nanomedicine for the Therapy of Huntington’s Disease
Cong, W., Bai, R., Li, Y., Wang, L., & Chen, C. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b12319 · Cited by 165
Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis
Pitts, M. W., & Hoffmann, P. R. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.05.001 · Cited by 164
Ullah, H., Liu, G., Yousaf, B., Ali, M. U., Irshad, S., Abbas, Q., & Ahmad, R. (2018) · Environmental Geochemistry and Health · doi:10.1007/s10653-018-0195-8 · Cited by 160
Yu, L., Li, H., Zhang, X., Ye, J., Liu, J., Xu, Q., & Lautens, M. (2014) · Organic Letters · doi:10.1021/ol500075h · Cited by 157
The Epidemiology of Selenium and Human Cancer
Vinceti, M., Filippini, T., Cilloni, S., & Crespi, C. M. (2017) · Advances in cancer research · doi:10.1016/bs.acr.2017.07.001 · Cited by 160
Guisbiers, G., Wang, Q., Khachatryan, E., Mimun, L. C., Mendoza‐Cruz, R., Larese-Casanova, P., Webster, T. J., & Nash, K. L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s106289 · Cited by 158
Redox-active nanomaterials for nanomedicine applications
Sims, C. M., Hanna, S. K., Heller, D. A., Horoszko, C. P., Johnson, M. E., Bustos, A. R. M., Reipa, V., Riley, K. R., & Nelson, B. C. (2017) · Nanoscale · doi:10.1039/c7nr05429g · Cited by 155
Scientific opinion on the tolerable upper intake level for selenium
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Selenium accumulation and metabolism in algae
Schiavon, M., Ertani, A., Parrasia, S., & Vecchia, F. D. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.05.011 · Cited by 158
Zhang, X., Liu, C., Guo, J., & Song, Y. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.78 · Cited by 154
Estévez, H., Garcia-Lidon, J. C., Luque-Garcia, J. L., & Cámara, C. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.06.062 · Cited by 153
Selenium and nano-selenium in agroecosystems
El-Ramady, H. R., Domokos-Szabolcsy, É., Abdalla, N. A., Alshaal, T., Shalaby, T., Sztrik, A., Prokisch, J., & Fári, M. (2014) · Environmental Chemistry Letters · doi:10.1007/s10311-014-0476-0 · Cited by 157
Selenium and Outcome in Heart Failure
Bömer, N., Beverborg, N. G., Hoes, M. F., Streng, K. W., Vermeer, M. C. S. C., Dokter, M. M., IJmker, J., Anker, S. D., Cleland, J. G. F., Hillege, H. L., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1644 · Cited by 153
Update on Selenoprotein Biosynthesis
Bulteau, A., & Chavatte, L. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6391 · Cited by 161
Lee, J., Jo, D., Park, D., Chung, H. Y., & Mattson, M. P. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007757 · Cited by 155
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Vinceti, M., Dennert, G., Crespi, C. M., Zwahlen, M., Brinkman, M. T., Zeegers, M. P., Horneber, M., D’Amico, R., & Giovane, C. D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub3 · Cited by 151
Recent research progress on the synthesis and biological effects of selenium nanoparticles
Zhang, T., Qi, M., Wu, Q., Xiang, P., Tang, D., & Li, Q. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1183487 · Cited by 149
Schiavon, M., Pilon, M., Malagoli, M., & Pilon-Smits, E. A. H. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00002 · Cited by 148
Zhu, Z., Chen, Y., Shi, G., & Zhang, X. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.09.138 · Cited by 147
Bachiega, P., Salgado, J. M., de Carvalho, J. E., Ruiz, A. L. T. G., Schwarz, K., Tezotto, T., & Morzelle, M. C. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.06.024 · Cited by 150
Zhao, G., Wu, X., Chen, P., Zhang, L., Yang, C. S., & Zhang, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.017 · Cited by 146
Luo, H., Yang, Y., Duan, J., Wu, P., Jiang, Q., & Xu, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.3 · Cited by 145
Gao, X., Li, X., Mu, J., Ho, C., Su, J., Zhang, Y., Lin, X., Chen, Z., Li, B., & Xie, Y. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.199 · Cited by 145
Wang, K., Wang, Y., Li, K., Wan, Y., Wang, Q., Zhuang, Z., Guo, Y., & Li, H. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00659-6 · Cited by 147
Yamdeu, J. H. G., Orfila, C., & Gong, Y. Y. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1844636 · Cited by 150
Modak, A., Pinter, E. N., & Cook, S. P. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10316 · Cited by 143
Is Selenium a Potential Treatment for Cancer Metastasis?
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Wang, X.-L., Yang, T., Wei, J., Lei, G., & Zeng, C. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0169-6 · Cited by 139
Natural variation of selenium in Brazil nuts and soils from the Amazon region
Junior, E. C. S., Wadt, L. H. D. O., Silva, K. E., de Lima, R. M. B., Batista, K. D., Guedes, M. C., Carvalho, G. S., de Carvalho, T. S., dos Reis, A. R., Lopes, G., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.08.158 · Cited by 143
Eiche, E., Bardelli, F., Nothstein, A. K., Charlet, L., Göttlicher, J., Steininger, R., Dhillon, K. S., & Sadana, U. S. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.10.080 · Cited by 146
Selenium nanoparticles are less toxic than inorganic and organic selenium to mice in vivo
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Song, X., Chen, Y., Zhao, G., Sun, H., Che, H., & Leng, X. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115689 · Cited by 140
Designing selenium functional foods and beverages: A review
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Martínez, F. G., Moreno-Martín, G., Pescuma, M., Madrid, Y., & Mozzi, F. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00506 · Cited by 137
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Asemi, Z., Jamilian, M., Mesdaghinia, E., & Esmaillzadeh, A. (2015) · Nutrition · doi:10.1016/j.nut.2015.04.014 · Cited by 135
Silva, V. M., Tavanti, R. F. R., Gratão, P. L., Alcock, T. D., & dos Reis, A. R. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110777 · Cited by 136
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Selenium in the prevention of atherosclerosis and its underlying mechanisms
Liu, H., Xu, H., & Huang, K. (2016) · Metallomics · doi:10.1039/c6mt00195e · Cited by 136
Khan, K. U., Zuberi, A., Fernandes, J. B. K., Ullah, I., & Sarwar, H. (2017) · Fish Physiology and Biochemistry · doi:10.1007/s10695-017-0402-z · Cited by 134
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Lara, T. S., Lessa, J. H. D. L., de Souza, K. R. D., Corguinha, A. P. B., Martins, F. A. D., Lopes, G., & Guilherme, L. R. G. (2019) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2019.05.002 · Cited by 139
Selenium transformation and selenium-rich foods
Chen, N., Zhao, C., & Zhang, T. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100875 · Cited by 138
Xia, X., Wu, S., Li, N., Wang, D., Zheng, S., & Wang, G. (2017) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.08.051 · Cited by 133
The Advancing of Selenium Nanoparticles Against Infectious Diseases
Lin, W., Zhang, J., Xu, J., & Pi, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.682284 · Cited by 132
Kang, D., Lee, J., Jung, J., Carlson, B. A., Chang, M. J., Chang, C. B., Kang, S., Lee, B. C., Gladyshev, V. N., Hatfield, D. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28385-7 · Cited by 132
Sholkamy, E. N., Ahmad, M., Yasser, M. M., Ali, A. M., & Mehanni, M. M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s82707 · Cited by 131
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Gröber, U., Holzhauer, P., Kisters, K., Holick, M. F., & Adamietz, I. A. (2016) · Nutrients · doi:10.3390/nu8030163 · Cited by 140
Zhang, H., Zhao, Z., Zhang, X., Zhang, W., Huang, L., Zhang, Z., Yuan, L., & Liu, X. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.185 · Cited by 128
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Weikert, C., Trefflich, I., Menzel, J., Obeid, R., Longree, A., Dierkes, J., Meyer, K., Herter‐Aeberli, I., Mai, K., Stangl, G. I., et al. (2020) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2020.0575 · Cited by 131
Lima, L. W., Pilon-Smits, E. A. H., & Schiavon, M. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.03.028 · Cited by 129
Wiesner‐Reinhold, M., Schreiner, M., Baldermann, S., Schwarz, D., Hanschen, F. S., Kipp, A. P., Rowan, D. D., Bentley‐Hewitt, K. L., & McKenzie, M. J. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01365 · Cited by 130
Selenium biofortification in food crops: Key mechanisms and future perspectives
Sarwar, N., Akhtar, M., Kamran, M. A., Imran, M., Riaz, M. A., Kamran, K., & Hussain, S. (2020) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2020.103615 · Cited by 131
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Metadata
- Authors
- Rayman, M. P.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- Rayman, Margaret P
- ORCID
- Rayman, Margaret P
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 379
- Issue
- 9822
- Pages
- 1256-1268
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2013131201
- Cited by
- 3,563
- References
- 136
- Citations by year
- 2026: 305 · 2025: 334 · 2024: 310 · 2023: 339 · 2022: 369 · 2021: 337 · 2020: 311 · 2019: 221 · 2018: 199 · 2017: 173 · 2016: 187 · 2015: 153 · 2014: 158 · 2013: 120 · 2012: 33
- FWCI
- 137.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- selenium, selenoproteins, selenium status, selenium supplementation, antioxidant activity, thyroid hormones, immune function, cognitive decline, antiviral activity, reproductive health, autoimmune thyroid disease, cancer risk, type 2 diabetes, U-shaped dose-response
- MeSH terms
- Adult, Animals, Cause of Death, Cross-Cultural Comparison, Female, Humans, Immunocompetence, Longitudinal Studies, Male, Middle Aged, Neoplasms, Nutritional Requirements, Reference Values, Selenium, Survival Rate, Proportional Hazards Models, Selenoproteins
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