Cited by 1,091Sexual function and dysfunction studiesUrological Disorders and TreatmentsUrinary Bladder and Prostate Research

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Erectile dysfunction

Shamloul, Rany, Ghanem, Hussein·2013·The Lancet

DOI 10.1016/s0140-6736(12)60520-0

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Abstract

Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years. In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and hypertension, several common lifestyle factors, such as obesity, limited or an absence of physical exercise, and lower urinary tract symptoms, have been linked to the development of erectile dysfunction. Substantial steps have been taken in the study of the association between erectile dysfunction and cardiovascular disease. Erectile dysfunction is a strong predictor for coronary artery disease, and cardiovascular assessment of a non-cardiac patient presenting with erectile dysfunction is now recommended. Substantial advances have occurred in the understanding of the pathophysiology of erectile dysfunction that ultimately led to the development of successful oral therapies, namely the phosphodiesterase type 5 inhibitors. However, oral phosphodiesterase type 5 inhibitors have limitations, and present research is thus investigating cutting-edge therapeutic strategies including gene and cell-based technologies with the aim of discovering a cure for erectile dysfunction.

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Authors: Shamloul, R., & Ghanem, H.
Affiliations: University of Ottawa (CA)
Cairo University (EG)
Corresponding author: Shamloul, Rany
Venue: The Lancet
Publisher: Elsevier BV
Published: 2013-01
Volume: 381
Issue: 9861
Pages: 153-165
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(12)60520-0
OpenAlex: W3108094084
Cited by: 1,091
References: 257
Citations by year: 2026: 69 · 2025: 104 · 2024: 125 · 2023: 117 · 2022: 95 · 2021: 105 · 2020: 94 · 2019: 78 · 2018: 71 · 2017: 56 · 2016: 58 · 2015: 42 · 2014: 53 · 2013: 22
FWCI: 5.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: The Lancet (publishedVersion)
Colloquium Series on Integrated Systems Physiology From Molecule to Function (publishedVersion)
PubMed (publishedVersion)
Funders: European Association of Urology
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords: erectile dysfunction, cardiovascular disease, coronary artery disease, phosphodiesterase-5 inhibitors, pathophysiology, lifestyle factors, obesity, diabetes mellitus, hypertension, lower urinary tract symptoms, physical activity, gene therapy, cell therapy
MeSH terms: Humans, Erectile Dysfunction, Male, Penis, Penile Prosthesis, Impotence, Vasculogenic, Phosphodiesterase 5 Inhibitors

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