Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 749

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial

Open access
·2013·The Lancet
DOI 10.1016/s0140-6736(13)60852-1
Open this paper in CoChat — free account

Abstract

BACKGROUND Lowering blood pressure (BP) prevents stroke, however optimal target levels of blood reduction to prevent stroke recurrence are lacking. We hypothesized that targeting systolic BP of <130 mmHg would reduce stroke recurrence in patients with recent lacunar stroke. METHODS The Secondary Prevention of Small Subcortical Strokes (SPS3) was a multi-center international trial, involving 3020 patients with recent symptomatic MRI-defined lacunar infarcts randomized to two target levels of systolic BP: a) higher group 130–149 mm Hg vs. b) lower group <130 mm Hg, and followed for a mean of 3.7 years. The primary outcome was all recurrent stroke (including ischemic strokes and intracranial hemorrhages). The study is registered, NCT 00059306. FINDINGS Mean participant age was 63 years; after 1 year mean systolic BP was 138 mm Hg (95% CI 137 to 139) in the higher group and 127 mm Hg (95% CI, 126 to 128) in the lower group. At last study visit, the difference in systolic BP between groups averaged 11 mm Hg (±SD 16). The annualized rate of recurrent stroke in the higher target group was 2.77% (n=152) compared with 2.25% (n=125) in the lower target group (HR 0.81, 95% CI 0.64, 1.03, p-value 0.08). Similar trends were observed for reductions in disabling/fatal stroke (HR 0.81, 95%CI 0.53, 1.23, p-value 0.32) and in the composite outcome of stroke, myocardial infarct or vascular death (HR 0.84, 95%CI 0.68,1.01, p-value 0.10). Intracerebral hemorrhage was reduced by 63% in those assigned to the lower target group (HR 0.37 95% CI, 0.14, 0.89, p-value 0.03). Serious complications of BP lowering were in frequent, and not significantly different in frequency between groups. INTERPRETATION In patients with recent lacunar stroke, targeting asystolic BP of< 130 mm Hg did not significantly reduce all stroke, but markedly reduced intracerebral hemorrhage. The lower target was safe and well tolerated.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(13)60852-1

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 17

  1. Gueyffier, 1997, Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. The INDANA (INdividual Data ANalysis of Antihypertensive intervention trials) Project Collaborators, Stroke, 28, 2557, 10.1161/01.STR.28.12.2557 · DOI
  2. Rashid, 2003, Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review, Stroke, 34, 2741, 10.1161/01.STR.0000092488.40085.15 · DOI · Paper page
  3. Sacco, 2006, A population-based study of the incidence and prognosis of lacunar stroke, Neurology, 66, 1335, 10.1212/01.wnl.0000210457.89798.0e · DOI · Paper page
  4. Benavente, 2011, The secondary prevention of small subcortical strokes (SPS3) study, Int J Stroke, 6, 164, 10.1111/j.1747-4949.2010.00573.x · DOI
  5. White, 2012, Clinical features and racial/ethnic differences among the 3020 participants in the secondary prevention of small subcortical strokes (SPS3) trial, J Stroke Cerebrovasc Dis
  6. Hansson, 1992, Prospective randomized open blinded end-point (PROBE) study. A novel design for intervention trials. Prospective randomized open blinded end-point, Blood Press, 1, 113, 10.3109/08037059209077502 · DOI · Paper page
  7. Pérgola, 2007, Reliability and validity of blood pressure measurement in the secondary prevention of small subcortical strokes study, Blood Press Monit, 12, 1, 10.1097/MBP.0b013e3280858d5b · DOI
  8. McClure, 2012, Sample size re-estimation in an on-going NIH-sponsored clinical trial: the secondary prevention of small subcortical stroke trial experience, Contemp Clin Trials, 33, 1088, 10.1016/j.cct.2012.06.007 · DOI
  9. 1974, Effect of antihypertensive treatment on stroke recurrence, JAMA, 229, 409, 10.1001/jama.1974.03230420021019 · DOI · Paper page
  10. Chapman, 2004, Effects of a perindopril-based blood pressure-lowering regimen on the risk of recurrent stroke according to stroke subtype and medical history: the PROGRESS Trial, Stroke, 35, 116, 10.1161/01.STR.0000106480.76217.6F · DOI · Paper page
  11. Eriksson, 1995, Atenolol in secondary prevention after stroke, Cerebrovasc Dis, 5, 21, 10.1159/000107813 · DOI
  12. Schrader, 2005, Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: principal results of a prospective randomized controlled study (MOSES), Stroke, 36, 1218, 10.1161/01.STR.0000166048.35740.a9 · DOI · Paper page
  13. 1995, Post-stroke antihypertensive treatment study. A preliminary result, Chin Med J (Engl), 108, 710
  14. Yusuf S, Healey JS, Pogue J, et al. Irbesartan in patients with atrial fibrillation. N Engl J Med 364: 928–38. · DOI
  15. Bousser, 2011, Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial, Lancet, 377, 2013, 10.1016/S0140-6736(11)60600-4 · DOI · Paper page
  16. Hong, 2011, Declining stroke and vascular event recurrence rates in secondary prevention trials over the past 50 years and consequences for current trial design, Circulation, 123, 2111, 10.1161/CIRCULATIONAHA.109.934786 · DOI
  17. Hansson, 1994, The hypertension optimal treatment (HOT) study—patient characteristics: randomization, risk profiles, and early blood pressure results, Blood Press, 3, 322, 10.3109/08037059409102281 · DOI

Cited by

See all 749

Metadata

Venue
The Lancet
Publisher
Elsevier BV
Published
2013-08
Volume
382
Issue
9891
Pages
507-515
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(13)60852-1
OpenAlex
W2127422554
Cited by
749
References
8
FWCI
42.16
Type
journal article
Language
en
Open access
bronze
Licence
Funders
US National Institutes of Health-National Institute of Neurological Disorders and Stroke (NIH-NINDS) (U01NS038529)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. https://app.cochat.ai/papers/10.1016/s0140-6736(13)60852-1
The paper
Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. (2013). The Lancet. https://doi.org/10.1016/s0140-6736(13)60852-1

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.