Cited by 448Mental Health Treatment and AccessPsychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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The Healthy Activity Program (HAP), a lay counsellor-delivered brief psychological treatment for severe depression, in primary care in India: a randomised controlled trial

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Patel, Vikram, Weobong, Benedict, Weiss, Helen A, Anand, Arpita, Bhat, Bhargav, Katti, Basavraj, Dimidjian, Sona, Araya, Ricardo, Hollon, Steve D, King, Michael, Vijayakumar, Lakshmi, Park, A-La, McDaid, David, Wilson, Terry, Velleman, Richard, Kirkwood, Betty R, Fairburn, Christopher G·2017·The Lancet

DOI 10.1016/s0140-6736(16)31589-6PMC PMC5236064

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Abstract

BACKGROUND: Although structured psychological treatments are recommended as first-line interventions for depression, only a small fraction of people globally receive these treatments because of poor access in routine primary care. We assessed the effectiveness and cost-effectiveness of a brief psychological treatment (Healthy Activity Program [HAP]) for delivery by lay counsellors to patients with moderately severe to severe depression in primary health-care settings. METHODS: In this randomised controlled trial, we recruited participants aged 18-65 years scoring more than 14 on the Patient Health Questionnaire 9 (PHQ-9) indicating moderately severe to severe depression from ten primary health centres in Goa, India. Pregnant women or patients who needed urgent medical attention or were unable to communicate clearly were not eligible. Participants were randomly allocated (1:1) to enhanced usual care (EUC) alone or EUC combined with HAP in randomly sized blocks (block size four to six [two to four for men]), stratified by primary health centre and sex, and allocation was concealed with use of sequential numbered opaque envelopes. Physicians providing EUC were masked. Primary outcomes were depression symptom severity on the Beck Depression Inventory version II and remission from depression (PHQ-9 score of <10) at 3 months in the intention-to-treat population, assessed by masked field researchers. Secondary outcomes were disability, days unable to work, behavioural activation, suicidal thoughts or attempts, intimate partner violence, and resource use and costs of illness. We assessed serious adverse events in the per-protocol population. This trial is registered with the ISRCTN registry, number ISRCTN95149997. FINDINGS: Between Oct 28, 2013, and July 29, 2015, we enrolled and randomly allocated 495 participants (247 [50%] to the EUC plus HAP group [two of whom were subsequently excluded because of protocol violations] and 248 [50%] to the EUC alone group), of whom 466 (95%) completed the 3 month primary outcome assessment (230 [49%] in the EUC plus HAP group and 236 [51%] in the EUC alone group). Participants in the EUC plus HAP group had significantly lower symptom severity (Beck Depression Inventory version II in EUC plus HAP group 19·99 [SD 15·70] vs 27·52 [13·26] in EUC alone group; adjusted mean difference -7·57 [95% CI -10·27 to -4·86]; p<0·0001) and higher remission (147 [64%] of 230 had a PHQ-9 score of <10 in the HAP plus EUC group vs 91 [39%] of 236 in the EUC alone group; adjusted prevalence ratio 1·61 [1·34-1·93]) than did those in the EUC alone group. EUC plus HAP showed better results than did EUC alone for the secondary outcomes of disability (adjusted mean difference -2·73 [-4·39 to -1·06]; p=0·001), days out of work (-2·29 [-3·84 to -0·73]; p=0·004), intimate partner physical violence in women (0·53 [0·29-0·96]; p=0·04), behavioural activation (2·17 [1·34-3·00]; p<0·0001), and suicidal thoughts or attempts (0·61 [0·45-0·83]; p=0·001). The incremental cost per quality-adjusted life-year gained was $9333 (95% CI 3862-28 169; 2015 international dollars), with an 87% chance of being cost-effective in the study setting. Serious adverse events were infrequent and similar between groups (nine [4%] in the EUC plus HAP group vs ten [4%] in the EUC alone group; p=1·00). INTERPRETATION: HAP delivered by lay counsellors plus EUC was better than EUC alone was for patients with moderately severe to severe depression in routine primary care in Goa, India. HAP was readily accepted by this previously untreated population and was cost-effective in this setting. HAP could be a key strategy to reduce the treatment gap for depressive disorders, the leading mental health disorder worldwide. FUNDING: Wellcome Trust.

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Figure 1 Trial profile CAP=Counselling for Alcohol Problems. EUC=enhanced usual care. HAP=Healthy Activity Program. PHQ-9=Patient Health Questionnaire 9.CC BY · PubMed Central

Figure 2 Effect of baseline PHQ-9 score on depression severity according to BDI-II score at 3 months BDI=Beck Depression Inventory. EUC=enhanced usual care. HAP=Healthy Activity Program. PHQ=Patient Health Questionnaire.CC BY · PubMed Central

Figure 3 Cost-effectiveness acceptability curve: willingness to pay per quality-adjusted life-year gained from the Healthy Activity Program from a health system perspectiveCC BY · PubMed Central

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Authors: Patel, V., Weobong, B., Weiss, H. A., Anand, A., Bhat, B., Katti, B., Dimidjian, S., Araya, R., Hollon, S. D., King, M., Vijayakumar, L., Park, A.-L., McDaid, D., Wilson, T., Velleman, R., Kirkwood, B. R., & Fairburn, C. G.
Affiliations: London School of Hygiene & Tropical Medicine (GB)
Sangath (IN)
University of Colorado Boulder (US)
Vanderbilt University (US)
University College London (GB)
The University of Melbourne (AU)
London School of Economics and Political Science (GB)
Rutgers, The State University of New Jersey (US)
University of Oxford (GB)
Corresponding author: Patel, Vikram
ORCID: Patel, Vikram
Weobong, Benedict
Weiss, Helen A
Bhat, Bhargav
Katti, Basavraj
Dimidjian, Sona
Araya, Ricardo
King, Michael
Vijayakumar, Lakshmi
Park, A-La
McDaid, David
Velleman, Richard
Kirkwood, Betty R
Fairburn, Christopher G
Venue: The Lancet
Publisher: Elsevier BV
Published: 2017-01
Volume: 389
Issue: 10065
Pages: 176-185
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(16)31589-6
PMC: PMC5236064
OpenAlex: W2563551484
Cited by: 448
References: 42
Citations by year: 2026: 35 · 2025: 47 · 2024: 42 · 2023: 51 · 2022: 54 · 2021: 64 · 2020: 51 · 2019: 52 · 2018: 25 · 2017: 25
FWCI: 54.96
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: The Lancet (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
London School of Economics and Political Science Research Online (London School of Economics and Political Science) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Portal (King's College London) (submittedVersion, cc-by)
Greater South Information System
Funders: Wellcome Trust Senior Research Fellowship grant to VP (091834)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: severe depression, primary care, access to mental health care, cost-effectiveness, behavioral activation, depression remission, suicidal ideation, intimate partner violence, resource utilization (health care), India, low- and middle-income countries, adverse events, PHQ-9
MeSH terms: Counselors, Adolescent, Adult, Aged, Major Depressive Disorder, Female, Humans, India, Male, Middle Aged, Primary Health Care, Psychiatric Status Rating Scales, Psychotherapy, Treatment Outcome

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The Healthy Activity Program (HAP), a lay counsellor-delivered brief psychological treatment for severe depression, in primary care in India: a randomised controlled trial

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