Grand challenges in global mental health
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In LMICs, as in much of the world, mental health is consistently relegated to a secondary or even tertiary concern.
“In LMICs, as in much of the world, mental health is consistently relegated to a secondary or even tertiary concern [1, 100, 101]”
From Barriers and facilitators to implementation of evidence-based task-sharing mental health interventions in low- and middle-income countries: a systematic review using implementation science frameworks (2022) · cites this paper as [1]
The Additional information section calls for parity between mental and physical illness in investment and for mental health to be included in international aid, supporting the broader point that mental health needs greater priority. It does not establish that mental health is consistently a secondary or tertiary concern in LMICs or across much of the world. No page number is provided for the passage. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe integration of mental health into primary health care and task-shifting were quickly identified as one of the five grand challenges in global mental health in the field's early years.
“the integration of mental health into primary health care, and the related idea of task-shifting, were quickly identified as one of the five 'grand challenges' in global mental health in the field's early years (Collins et al. 2011)”
From Throwing therapy at the problem mental health and humanitarian intervention in Palabek refugee settlement, northern Uganda (2023) · cites this paper as Collins et al. 2011
Table 2 (Additional information; page unavailable) calls for integrating mental-health care with other care and asks how primary health-care workers can deliver evidence-based care. NEXT STEPS (page unavailable) also discusses research on non-specialist mental-health-care providers. The copy distinguishes a top 25 from a top five, but the available table text does not establish that integration and task-shifting together were one of the five highest-ranked challenges. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn 2011, the Grand Challenges in Global Mental Health Initiative (GCMHI) defined a set of 25 urgent research priorities.
“In 2011, the Grand Challenges in Global Mental Health Initiative (GCMHI) defined a set of 25 urgent research priorities 237 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [237]
Treatment of central nervous system diseases is severely constrained by the blood-brain barrier.
“The treatment of central nervous system (CNS) diseases, such as neurodegenerative disorders, brain tumors, brain infections, and stroke, is severely constrained by the blood-brain barrier (BBB) because it prevents the transfer of most of small-molecule drugs and macromolecules (e.g., peptides, gene drugs, and protein drugs) into the brain (1–6).”
From Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection (2020) · cites this paper as [3]
The List and Next Steps sections discuss treatment priorities for mental, neurological and substance-use disorders, but do not address the blood-brain barrier. Searches for blood-brain barrier and drug delivery into the brain found no passage supporting the attributed constraint on CNS treatment. (LLM, conf=0.74)
Experimental — accuracy not yet measuredThe blood-brain barrier prevents the transfer of most small-molecule drugs and macromolecules into the brain.
“it prevents the transfer of most of small-molecule drugs and macromolecules (e.g., peptides, gene drugs, and protein drugs) into the brain (1–6).”
From Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection (2020) · cites this paper as [3]
The List and Next Steps sections discuss research priorities and treatment of mental, neurological and substance-use disorders, but do not address whether the blood-brain barrier blocks drugs from entering the brain. Searches for the blood-brain barrier, small-molecule drugs, peptides and protein or gene drugs found no relevant passage in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Cognitive Impairment in Major Depressive Disorder
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“In LMICs, as in much of the world, mental health is consistently relegated to a secondary or even tertiary concern [1, 100, 101], and governmental-level forces and policies that perpetuate this lack of parity have exerted pervasive negative impact on resources allotted to mental healthcare and the individual lives of…”
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From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder
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“The identification of ‘modifiable social and biological risk factors across the life course’ and the need to ‘advance prevention and implementation of early interventions’ were recently nominated as the first two grand challenges in global mental health [58].”
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Global Mental Health: Where We Are and Where We Are Going
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A systematic review of the health and well-being benefits of biodiverse environments.
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The Economic Case for the Prevention of Mental Illness
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Self-citation
- Authors
- Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., Glass, R. I., Hall, W., Huang, Y., Hyman, S. E., Jamison, K., Kaaya, S., Kapur, S., Kleinman, A., Ogunniyi, A., Otero-Ojeda, A., Poo, M.-M., Ravindranath, V., Sahakian, B. J., Saxena, S., Singer, P. A., Stein, D. J., Anderson, W., Dhansay, M. A., Ewart, W., Phillips, A., Shurin, S., & Walport, M.
- Affiliations
- National Institute of Mental Health (US)
- London School of Hygiene & Tropical Medicine (GB)
- University of Toronto (CA)
- Universidade Federal de São Paulo (BR)
- Duke University (US)
- University of Oxford (GB)
- Fogarty International Center (US)
- The University of Queensland (AU)
- Chinese Center For Disease Control and Prevention (CN)
- Harvard University (US)
- Johns Hopkins University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- King's College London (GB)
- University of Ibadan (NG)
- Universidad Peruana Cayetano Heredia (PE)
- University of California, Berkeley (US)
- Indian Institute of Science Bangalore (IN)
- University of Cambridge (GB)
- World Health Organization (CH)
- University of Cape Town (ZA)
- National Health and Medical Research Council (AU)
- Medical Research Council (GB)
- Canadian Institutes of Health Research (CA)
- National Heart, Lung, and Blood Institute (US)
- Wellcome Trust (GB)
- Corresponding author
- Collins, Pamela Y.
- Daar, Abdallah S.
- ORCID
- Collins, Pamela Y.
- Patel, Vikram
- Insel, Thomas R.
- Daar, Abdallah S.
- Bordin, Isabel A.
- Costello, E. Jane
- Durkin, Maureen
- Glass, Roger I.
- Hall, Wayne
- Huang, Yueqin
- Hyman, Steven E.
- Kaaya, Sylvia
- Kapur, Shitij
- Kleinman, Arthur
- Ogunniyi, Adesola
- Poo, Mu-Ming
- Ravindranath, Vijayalakshmi
- Sahakian, Barbara J.
- Saxena, Shekhar
- Stein, Dan J.
- Anderson, Warwick
- Dhansay, Muhammad A.
- Phillips, Anthony
- Walport, Mark
- Venue
- Nature
- Published
- 2011-07-06
- Volume
- 475
- Issue
- 7354
- Pages
- 27-30
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3173804
- OpenAlex
- W2148602524
- Cited by
- 2,043
- References
- 15
- Citations by year
- 2026: 58 · 2025: 82 · 2024: 87 · 2023: 129 · 2022: 141 · 2021: 182 · 2020: 152 · 2019: 133 · 2018: 142 · 2017: 155 · 2016: 180 · 2015: 176 · 2014: 165 · 2013: 140 · 2012: 96
- FWCI
- 171.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Wellcome Trust (079113, 079113/Z/06/Z, 091834)
- University of Toronto
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003352)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- global mental health, mental illness, research priorities, research funding, mental health advocacy, mental health policy
- MeSH terms
- Mental Disorders, Humans, Mental Health, Global Health, World Health Organization, Substance-Related Disorders
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