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Cited by 39Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsHeparin-Induced Thrombocytopenia and Thrombosis

Laboratory Diagnosis of Lupus Anticoagulants

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Triplett, Douglas·1990·Seminars in Thrombosis and Hemostasis
DOI 10.1055/s-2007-1002667
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Abstract

Laboratories are now receiving requests to evaluate patients for the presence of LA. This review will focus on the characterization, clinical associations, and laboratory diagnosis of LA

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Registry

Crossref · 10.1055/s-2007-1002667

Cites

65 of 65 references verified0 citation errors · 0 not checkable

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  • The normal range is usually used as a guide for correction but is often inadequate because a circulating anticoagulant with minimally prolonged PT or aPTT may be corrected to normal in a 1:1 mix.

    “The normal range usually is used as the guide for correction.However, it often is inadequate because a circulating anticoagulant with a minimally prolonged PT or aPTT may be corrected to normal in a 1:1 mix of PP with CNP. 8”

    From A “Percent Correction” Formula for Evaluation of Mixing Studies (2002) · cites this paper as [8]

    In “FIG. 1. Approach to prolonged APTT” (page unavailable), the paper says a 1:1 mix of lupus-anticoagulant plasma and normal plasma can correct to within the normal range, particularly with a borderline APTT. It also warns that correction can be hard to distinguish from dilution when the APTT is minimally prolonged. These passages support the concern about using the normal range to judge correction for APTT, but do not establish the same point for PT. (LLM, conf=0.85)

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  • It was not clear from the publications which of the 1:1 or 4:1 mixing procedures was preferred.

    “However, it was not clear from the publications which of the 2 procedures was preferred.”

    From A “Percent Correction” Formula for Evaluation of Mixing Studies (2002) · cites this paper as [8]

    In “FIG. 1. Approach to prolonged APTT” (page unavailable), the paper says most laboratories use a 1:1 mix, while a 4:1 mix is more sensitive when APTT is minimally prolonged. This supports a condition-dependent distinction rather than one universally preferred procedure, but the paper does not say that the publications left the preference unclear. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • This phenomenon has been termed the lupus cofactor effect.

    “This phenomenon has been termed the lupus cofactor effect.8,9”

    From A “Percent Correction” Formula for Evaluation of Mixing Studies (2002) · cites this paper as [8]

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Cites

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Research works printed but not linked: 1

  1. Feinstein DI: Acquired inhibitors against factor VIII and other clotting proteins. In: (Eds) Colman RW, J Hirsh, VJ Marder, EW Salzman: Hemostasis and Thrombosis, Basic Principles and Clin- ical Practice. JB Lippincott, Philadelphia, 1982, pp. 563-576.

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Authors
Triplett, D.
Affiliations
Indiana University School of Medicine (US)
Corresponding author
Triplett, Douglas
Venue
Seminars in Thrombosis and Hemostasis
Publisher
Georg Thieme Verlag KG
Published
1990-04
Volume
16
Issue
02
Pages
182-192
ISSN
  • 0094-6176 (ISSN-L)
  • 1098-9064
DOI
10.1055/s-2007-1002667
OpenAlex
W2045499358
Cited by
39
References
65
Citations by year
2018: 1 · 2015: 1 · 2014: 2
FWCI
0.62
Type
journal article
Language
en
Open access
Locations
  • Seminars in Thrombosis and Hemostasis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Surgery › Heparin-Induced Thrombocytopenia and Thrombosis
Keywords
lupus anticoagulant, laboratory diagnosis, antiphospholipid antibodies, clinical associations, thrombosis, hemostasis
MeSH terms
Autoantibodies, Blood Coagulation Disorders, Blood Coagulation Factors, Humans, Thromboembolism, Lupus Coagulation Inhibitor

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