Cited by 270Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

Goate, AlisonM., Owen, MichaelJ., James, LouiseA., Mullan, MichaelJ., Rossor, MartinN., Haynes, AndrewR., Farrall, Martin, Lai, LawrenceY.C. +3 more·1989·The Lancet

Abstract

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.

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Crossref · 10.1016/s0140-6736(89)91725-x

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20 of 20 references verified0 citation errors · 0 not checkable

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Authors
Goate, A., Owen, M., James, L., Mullan, M., Rossor, M., Haynes, A., Farrall, M., Lai, L. C., Roques, P., Williamson, R., & Hardy, J.
Affiliations
St Mary's Hospital (GB)
Venue
The Lancet
Publisher
Elsevier BV
Published
1989-02
Volume
333
Issue
8634
Pages
352-355
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2115363308
Cited by
270
References
20
Citations by year
2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 3 · 2015: 18 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
32.80
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
Alzheimer's disease, chromosome 21, genetic linkage, early-onset Alzheimer's disease, genetic susceptibility, familial Alzheimer's disease
MeSH terms
Adult, Alzheimer Disease, Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 21, Female, Humans, Genetic Linkage, Male, Middle Aged, Mutation, Recombination, Genetic, Polymorphism, Restriction Fragment Length, Blotting, Southern, Chromosome Disorders

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