Cited by 125Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

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Clinical application of apolipoprotein E genotyping to Alzheimer's disease

Roses, AllenD., Strittmatter, WarrenJ., Pericak-Vance, MargaretA., Corder, ElizabethH., Saunders, AnnM., Schmechel, DonaldE.·1994·The Lancet

DOI 10.1016/s0140-6736(94)92960-2

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Self-citation
Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease
van Duijn, C. M., de Knijff, P., Cruts, M., Wehnert, A., Havekes, L. M., Albert Hofman, D., & Broeckhoven, C. V. (1994) · Nature Genetics · doi:10.1038/ng0594-74 · Cited by 459
ApoE–ε4 and early–onset Alzheimer's
Okuizumi, K., Onodera, O., Tanaka, H., Kobayashi, H., Tsuji, S., Takahashi, H., Oyanagi, K., Seki, K., Tanaka, M., Naruse, S., et al. (1994) · Nature Genetics · doi:10.1038/ng0594-10b · Cited by 132
Apolipoprotein E and Alzheimer's disease
Scott, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91704-p · Cited by 40

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Mihill, 1993, Test for "Alzheimer's timebomb" prompts social risk warning, Guardian

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“Indeed, ApoE4 is well known to be deposited in the Ab plaques and is a genetic risk factor for Alzheimer’s disease (Roses et al. 1994).”
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O'Hara, R. M., Sommer, B. R., Way, N., KRAEMER, H. C., Taylor, J. L., & Murphy, G. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.12.001 · Cited by 24
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Cuello, A. C., Hall, H., & Carmo, S. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00189 · Cited by 21
“This is of significance considering that polymorphism in ApoE is a strong genetic risk factor for AD, with ApoE4 showing the strongest association with the disease (Poirier et al., 1993; Strittmatter et al., 1993; Roses et al., 1994).”
Background
Rapid and Direct Detection of Apolipoprotein E Genotypes Using Whole Blood from Humans
Kim, S. W., Heo, J. H., Kim, C. H., Yoo, D. C., Won, D. H., Lee, S. G., Cho, K. J., Song, J. H., Park, S. J., Yang, Y. G., et al. (2010) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2010.511573 · Cited by 18
“The APOE isoforms are associated with several pathological processes, including high cholesterol levels and coronary disease at an early age ( Menzel et al, 1983 ), type III hyperlipidemia ( Breslow et al, 1982 ), and development of late-onset Alzheimer's disease ( Rose et al, 1994 ; Molloy et al, 2007 ).”
Background
APOE-TOMM40 in the Pharmacogenomics of Dementia
Cacabelos, R. (2013) · Journal of Pharmacogenomics & Pharmacoproteomics · doi:10.4172/2153-0645.1000135 · Cited by 17
“2) (AD2) is the most prevalent as a risk factor for AD, especially in those subjects harboring the APOE4 allele [12,13], whereas carriers of the APOE-2 allele are prone to longevity [14] and might be protected against dementia [15-17].”
Background
Psychogeriatric Research: A Conceptual Introduction to Aging and Geriatric Neuroscience
Cacabelos, R. (2001) · Psychogeriatrics · doi:10.1111/j.1479-8301.2001.tb00046.x · Cited by 17
Roles of glia cells in cholesterol homeostasis in the brain
Ito, J., & Yokoyama, S. (2003) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(03)31023-9 · Cited by 17
“It is a well established observation that e4 is a strong risk factor for Alzheimer’s disease (Corder et al., 1993; Poirier et al., 1993; Strittmatter et al., 1993a,b; Nathan et al., 1994; Roses et al., 1994), and for the deposition of amyloid protein after head injury (Nicoll et al.”
Background
Single-nucleotide polymorphism analysis by hybridization protection assay on solid support
Goto, S., Takahashi, A., Kamisango, K., & Matsubara, K. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00019-2 · Cited by 15
D2 dopamine receptor polymorphism and brain regional glucose metabolism
Noble, E. P., Gottschalk, L. A., Fallon, J. H., Ritchie, T. L., & Wu, J. C. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970418)74:2 · Cited by 165
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Al-Thani, H. F., Ahmad, M. N., Younes, S. N., & Zayed, H. (2021) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000447 · Cited by 11
Report Card on Molecular Genetic Testing
Grody, W. W., & Pyeritz, R. E. (1999) · JAMA · doi:10.1001/jama.281.9.845 · Cited by 11
Diagnostic usefulness of apolipoprotein E epsilon 4 in the diagnosis of the dementias.
Frisoni, G. B., Bianchetti, A., Trabucchi, M., & Govoni, S. M. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.6.699-a · Cited by 11
The Prevention of Neurogenetic Disease
Rosenberg, R. N., & Iannaccone, S. T. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540280038016 · Cited by 10
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Association analysis of ApoE gene polymorphisms among Egyptian patients with Alzheimer's disease
Ramadan, A., Foda, B. M., Sabry, N. A., Refaat, O., Saleh, A. A., & Fawzy, A. (2018) · Gene Reports · doi:10.1016/j.genrep.2018.10.017 · Cited by 9
Allele doses of apolipoprotein E type ϵ4 in sporadic late‐onset Alzheimer's disease
Lucotte, G., Aouizérate, A., Gérard, N., Turpin, J. C., & Landais, P. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600617 · Cited by 9
Understanding Alzheimer's disease: Expect more genes and other things
Mayeux, R. P. (1996) · Annals of Neurology · doi:10.1002/ana.410390602 · Cited by 9
Dementia among elderly apolipoprotein E type 4/4 homozygotes: A prospective study
Ganguli, M., Cauley, J. A., DeKosky, S. T., & Kamboh, M. I. (1995) · Genetic Epidemiology · doi:10.1002/gepi.1370120308 · Cited by 8
Apolipoprotein E and Alzheimer’s Disease: State of the Field After Two Years
Roses, A. D., Strittmatter, W. J., Saunders, A. M., Schmechel, D. E., & Pericak‐Vance, M. A. (1996) · Springer eBooks · doi:10.1007/978-3-642-80109-9_1 · Cited by 8
Self-citation
Apolipoprotein E: Emerging Story in the Pathogenesis of Alzheimer's Disease
Strittmatter, W. J., & Roses, A. D. (1995) · The Neuroscientist · doi:10.1177/107385849500100507 · Cited by 8
Self-citation
Altered β‐Amyloid Precursor Protein Isoforms in Mexican Alzheimer’s Disease Patients
Sánchez-González, V., Ortíz, G. G., Gallegos-Arreola, P., Macías-Islas, M. Á., Arias‐Merino, E. D., Loera‐Castañeda, V., Martínez-Cano, E., Velázquez-Brizuela, I. E., Rosales‐Corral, S., Curiel-Ortega, C. R., et al. (2006) · Disease Markers · doi:10.1155/2006/347502 · Cited by 7
Putative Risk Factors for Alzheimer’s Disease
Mayeux, R. P. (2019) · CRC Press eBooks · doi:10.1201/9780429260353-7 · Cited by 7

Authors: Roses, A., Strittmatter, W., Pericak-Vance, M., Corder, E., Saunders, A., & Schmechel, D.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1994-06
Volume: 343
Issue: 8912
Pages: 1564-1565
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(94)92960-2
OpenAlex: W2049634901
Cited by: 125
References: 4
Citations by year: 2025: 1 · 2023: 1 · 2021: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
FWCI: 11.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: apolipoprotein E, APOE genotyping, Alzheimer's disease, genetic risk factors, diagnosis
MeSH terms: Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Genotype, Humans, Middle Aged

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