Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals
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The objective of this study was to test the hypothesis that the effect of a high-fat meal (HFm) on plasma lipid-soluble antioxidants and biomarkers of vascular oxidative stress and inflammation would be attenuated by short-term lycopene supplementation in young healthy subjects. Following restriction of lycopene-containing foods for 1-wk (LYr), blood was collected in a fasting state and 3 h after a HFm and a low-fat meal (LFm) in N = 18 men aged 23 +/- 2 years, and after a HFm only in N = 9 women aged 23 +/- 1 years. Blood was also sampled pre- and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr. In the fasting state, LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma beta-carotene and alpha-tocopherol (p < 0.01), though LYs did not affect plasma nitrate/nitrite (biomarker of nitric oxide), malondialdehyde (biomarker of lipid oxidative stress), vascular- and intercellular-adhesion molecules or C-reactive protein (biomarkers of inflammation). Contrary to the hypothesis, the HFm-induced dyslipidemic state did not affect plasma malondialdehyde, C-reactive protein, or adhesion molecules in either LYr or LYs. Both the HFm and LFm were associated with decreases in the nitric oxide metabolites nitrate/nitrite and lipid-soluble antioxidants (p < 0.05). The data revealed that 1-wk of LYs increased plasma lycopene, beta-carotene, and alpha-tocopherol yet despite these marked changes to the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation were unaffected in the fasted state as well as during dyslipidemia induced by a HFm in young healthy subjects.
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Of ten cross-sectional studies, seven reported an inverse association between high vegetable and fruit intake, alone or combined, and blood CRP concentrations.
“Of the ten cross-sectional studies, seven reported an inverse association between a high intake of vegetables and fruits, either in combination or alone, and blood CRP concentrations (322 -325,327 -329) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [323]
A more recent cross-sectional study using a comprehensive flavonoid database reported that total flavonoid, flavonol and anthocyanidin intakes were inversely associated with plasma CRP concentrations.
“While this study used a rather limited flavonoid database, a more recent crosssectional study applying a comprehensive flavonoid database reported anti-inflammatory effects associated with a high flavonoid intake: total flavonoid, flavonol and anthocyanidin intakes were inversely associated with plasma CRP concentrations (323) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [323]
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- Authors
- Denniss, S. G.
- Affiliations
- University of Waterloo (CA)
- Corresponding author
- Denniss, Steven G
- Venue
- Vascular Health and Risk Management
- Publisher
- Informa UK Limited
- Published
- 2008
- Volume
- 4
- Issue
- 1
- Pages
- 213-222
- ISSN
- 1176-6344 (ISSN-L)
- PMC
- PMC2464768
- OpenAlex
- W1987145604
- Cited by
- 37
- References
- 54
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Vascular Health and Risk Management (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Heart and Stroke Foundation of Canada
- University of Waterloo
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- lycopene supplementation, postprandial dyslipidemia, high-fat meal, lipid-soluble antioxidants, beta-carotene, alpha-tocopherol, nitric oxide, malondialdehyde, vascular oxidative stress, inflammatory markers, endothelial function, C-reactive protein, adhesion molecules
- MeSH terms
- Lycopene, Adult, Analysis of Variance, Antioxidants, Carotenoids, Dietary Fats, Endothelium, Vascular, Female, Humans, Inflammation, Male, Biomarkers, Oxidative Stress, Postprandial Period, Dyslipidemias
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