Cited by 1,211Psychosomatic Disorders and Their TreatmentsFibromyalgia and Chronic Fatigue Syndrome ResearchGastrointestinal motility and disorders

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Functional somatic syndromes: one or many?

Wessely, S, Nimnuan, C, Sharpe, M·1999·The Lancet

DOI 10.1016/s0140-6736(98)08320-2

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Abstract

We review the concept and importance of functional somatic symptoms and syndromes such as irritable bowel syndrome and chronic fatigue syndrome. On the basis of a literature review, we conclude that a substantial overlap exists between the individual syndromes and that the similarities between them outweigh the differences. Similarities are apparent in case definition, reported symptoms, and in non-symptom association such as patients' sex, outlook, and response to treatment. We conclude that the existing definitions of these syndromes in terms of specific symptoms is of limited value; instead we believe a dimensional classification is likely to be more productive.

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Authors: Wessely, S., Nimnuan, C., & Sharpe, M.
Affiliations: Royal Edinburgh Hospital (GB)
ORCID: Wessely, S
Sharpe, M
Venue: The Lancet
Publisher: Elsevier BV
Published: 1999-09
Volume: 354
Issue: 9182
Pages: 936-939
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(98)08320-2
OpenAlex: W2137698397
Cited by: 1,211
References: 153
Citations by year: 2026: 20 · 2025: 29 · 2024: 36 · 2023: 26 · 2022: 24 · 2021: 36 · 2020: 37 · 2019: 36 · 2018: 36 · 2017: 53 · 2016: 38 · 2015: 53 · 2014: 36 · 2013: 38 · 2012: 49
FWCI: 5.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: functional somatic syndromes, irritable bowel syndrome, chronic fatigue syndrome, dimensional classification, case definition, symptom overlap, sex differences, treatment response
MeSH terms: Colonic Diseases, Functional, Combined Modality Therapy, Humans, Patient Care Team, Prognosis, Sick Role, Somatoform Disorders, Fatigue Syndrome, Chronic

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Functional somatic syndromes: one or many?

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