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Functional somatic syndromes: one or many?
Abstract
We review the concept and importance of functional somatic symptoms and syndromes such as irritable bowel syndrome and chronic fatigue syndrome. On the basis of a literature review, we conclude that a substantial overlap exists between the individual syndromes and that the similarities between them outweigh the differences. Similarities are apparent in case definition, reported symptoms, and in non-symptom association such as patients' sex, outlook, and response to treatment. We conclude that the existing definitions of these syndromes in terms of specific symptoms is of limited value; instead we believe a dimensional classification is likely to be more productive.
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“In the healthcare system, patients frequently receive medical specialty-specific syndrome diagnoses (FSS) such as fibromyalgia, chronic widespread pain, chronic fatigue syndrome, and irritable bowel syndrome [6,7].”
From Internet-delivered treatment for patients suffering from severe functional somatic disorders: Protocol for a randomized controlled trial (2023) · cites this paper as [6]
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Somatization and Conversion Disorder
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Unexplained Symptoms After Terrorism and War: An Expert Consensus Statement
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Factor analysis of symptoms among subjects with unexplained chronic fatigue
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Metadata
- Authors
- Wessely, S., Nimnuan, C., & Sharpe, M.
- Affiliations
- Royal Edinburgh Hospital (GB)
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 354
- Issue
- 9182
- Pages
- 936-939
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2137698397
- Cited by
- 1,211
- References
- 153
- Citations by year
- 2026: 20 · 2025: 29 · 2024: 36 · 2023: 26 · 2022: 24 · 2021: 36 · 2020: 37 · 2019: 36 · 2018: 36 · 2017: 53 · 2016: 38 · 2015: 53 · 2014: 36 · 2013: 38 · 2012: 49
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- functional somatic syndromes, irritable bowel syndrome, chronic fatigue syndrome, dimensional classification, case definition, symptom overlap, sex differences, treatment response
- MeSH terms
- Colonic Diseases, Functional, Combined Modality Therapy, Humans, Patient Care Team, Prognosis, Sick Role, Somatoform Disorders, Fatigue Syndrome, Chronic
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