Cited by 318Growth Hormone and Insulin-like Growth FactorsDiabetes Management and ResearchDiabetes and associated disorders

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Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment

Cutfield, Wayne S, Wilton, Patrick, Bennmarker, Helge, Albertsson-Wikland, Kerstin, Chatelain, Pierre, Ranke, Michael B, Price, David A·2000·The Lancet

DOI 10.1016/s0140-6736(99)04055-6

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Abstract

Background Growth hormone (GH) contributes to insulin resistance, but whether children treated with GH are at increased risk of diabetes has not been established. We undertook a retrospective analysis of data from an international pharmacoepidemiological survey of children treated with GH to find out the incidence of impaired glucose tolerance and types 1 and 2 diabetes mellitus.Methods Reports to the survey of abnormal glucose metabolism were investigated and classified. The incidence and age-distribution of type 1 diabetes were compared with values from a model of reference data. The incidence of type 2 diabetes was compared with data from two reports of children not treated with GH.Findings 85 (0.36%) of 23333 children were reported with abnormal glucose metabolism. After investigation, 43 had confirmed glucose disorders (11 with type 1 diabetes, 18 with type 2 diabetes, and 14 with impaired glucose tolerance). The incidence and age at diagnosis of type 1 diabetes in children treated with GH did not differ from expected values. The incidence of type 2 diabetes was 34.4 cases per 100000 years of GH treatment which was six-fold higher than reported in children not treated with GH. Type 2 diabetes did not resolve after GH therapy was stopped.Interpretation GH treatment did not affect the incidence of type 1 diabetes mellitus in any age group. We postulate that the higher than expected incidence of type 2 diabetes mellitus with GH treatment may be an acceleration of the disorder in predisposed individuals.

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Authors: Cutfield, W. S., Wilton, P., Bennmarker, H., Albertsson-Wikland, K., Chatelain, P., Ranke, M. B., & Price, D. A.
Affiliations: University of Auckland (NZ)
Hôpital Debrousse (FR)
University Children's Hospital Tübingen (DE)
St Mary's Hospital (GB)
Corresponding author: Cutfield, Wayne S
ORCID: Cutfield, Wayne S
Albertsson-Wikland, Kerstin
Ranke, Michael B
Venue: The Lancet
Publisher: Elsevier BV
Published: 2000-02
Volume: 355
Issue: 9204
Pages: 610-613
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(99)04055-6
OpenAlex: W2163954745
Cited by: 318
References: 27
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 22 · 2018: 10 · 2017: 17 · 2016: 13 · 2015: 18 · 2014: 11 · 2013: 10 · 2012: 9
FWCI: 13.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
European Society for Paediatric Endocrinology
European Society of Endocrinology
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: growth hormone therapy, type 2 diabetes, type 1 diabetes, impaired glucose tolerance, insulin resistance, abnormal glucose metabolism, children and adolescents, diabetes incidence, adverse drug reactions
MeSH terms: Adolescent, Child, Child, Preschool, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Growth Disorders, Humans, Insulin Resistance, Male, Retrospective Studies, Incidence, Databases, Factual, Glucose Intolerance, Human Growth Hormone

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Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment

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