Cited by 45Glioma Diagnosis and TreatmentT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Poor survival in glioblastoma patients is associated with early signs of immunosenescence in the CD4 T-cell compartment after surgery

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Fornara, Olesja, Odeberg, Jenny, Wolmer Solberg, Nina, Tammik, Charlotte, Skarman, Petra, Peredo, Inti, Stragliotto, Giuseppe, Rahbar, Afsar +1 more·2015·OncoImmunology

Abstract

Patients with glioblastoma multiforme (GBM) are immunosuppressed and have a broad range of immunological defects in both innate and adaptive immune responses. GBMs are frequently infected with human cytomegalovirus (HCMV), a virus capable of causing immunosuppression. In 42 HCMV-positive GBM patients in a clinical trial (VIGAS), we investigated T-cell phenotypes in the blood and assessed their relation to survival. Blood was collected before and 3, 12, and 24 weeks after surgery, and the frequency of T-cell subsets was compared with that in 26 age-matched healthy controls. GBM patients had lower levels of CD3 cells than the controls, but had significantly higher levels of CD4+CD28− T cells before and 3 and 12 weeks after surgery and increased levels of CD4+CD57+ and CD4+CD57+CD28+ T cells at all-time points. These T-cell subsets were associated with both immunosenescence and HCMV infection. GBM patients also had higher levels of γδ T cells at all-times after surgery and lower levels of CD4+CD25+ cells before and 3 weeks after surgery than healthy controls. Overall survival was significantly shorter in patients with higher levels of CD4+CD28− T cells (p = 0.025), CD4+CD57+ T (p = 0.025) cells, and CD4+CD28−CD57+CD28− T cells (p < 0.0004) at 3 weeks after surgery. Our findings indicate that signs of immunosenescence in the CD4+ compartment are associated with poor prognosis in patients with HCMV-positive GBMs and may reflect the HCMV activity in their tumors.

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  • The low survival rate of patients with glioblastoma is associated with immunosenescence of postoperative CD4+ T cells.

    “The low survival rate of patients with glioblastoma is associated with immunosenescence of postoperative CD4+ T cells [128].”

    From Immunosenescence: a key player in cancer development (2020) · cites this paper as [128]

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Authors
Fornara, O., Odeberg, J., Wolmer Solberg, N., Tammik, C., Skarman, P., Peredo, I., Stragliotto, G., Rahbar, A., & Söderberg-Nauclér, C.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Rahbar, Afsar
Venue
OncoImmunology
Published
2015-06-05
Volume
4
Issue
9
Pages
e1036211
ISSN
  • 2162-4011 (ISSN-L)
  • 2162-402X
OpenAlex
W1569691540
Cited by
45
References
53
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 1
FWCI
1.87
Type
journal article
Language
en
Open access
Locations
  • OncoImmunology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Familjen Erling-Perssons Stiftelse
  • Swedish Cancer Foundation
  • Biltema Foundation
  • Svenska Sällskapet för Medicinsk Forskning
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
glioblastoma, immunosenescence, CD4+ T cells, human cytomegalovirus infection, CD4+CD28- T cells, γδ T cells, CD4+CD25+ T cells, prognostic factors, survival, T cell subsets, immunosuppression

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