The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Cognitive effects of insulin in the central nervous system
Abstract
Evidence has been accumulating recently that the hormone insulin may modulate cognitive activity by acting in the central nervous system. Initially derived from the observation that insulin and insulin receptors are found in specific brain areas, this evidence also includes cognitive assessments of humans in insulin-deficient and insulin-resistant disease states and experimental manipulation of rodent models. Additional support is derived from in vivo and in vitro systems that are used to investigate the neurophysiological basis of learning and memory. This article is a brief review of the literature that suggests a connection between insulin and memory and draws together some of the findings relevant to possible physiological mechanisms for this cognitive effect.
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“the risk of the metabolic syndrome[76]”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [76]
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Items 201–214 of 214
Insulin Selectively Downregulates α2-Adrenoceptors in the Arcuate and Dorsomedial Nucleus
Levin, B. E., Israel, P. A., & Lattemann, D. F. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00336-5 · Cited by 23
CCKB-Receptor Activation Augments the Long-Term Potentiation in Guinea Pig Hippocampal Slices
Yasui, M., & Kawasaki, K. (1995) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.68.441 · Cited by 23
Insulin as a probe of mitochondrial metabolism in situ
Bessman, S. P., & Mohan, C. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_14 · Cited by 20
Nie, L., Kanzaki, M., Shibata, H., & Kojima, I. (1998) · Endocrinology · doi:10.1210/endo.139.1.5674 · Cited by 20
Insulin stimulates inositol incorporation in hippocampus of lean but not obese Zucker rats
Figlewicz, D. P., Szot, P., & Greenwood, M. R. C. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90150-3 · Cited by 18
Marfaing-Jallat, P., Portha, B., & Pénicaud, L. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00060-r · Cited by 18
The role of brain insulin in the neurophysiology of serious mental disorders: review
Holden, R. J. (1999) · Medical Hypotheses · doi:10.1054/mehy.1997.0642 · Cited by 15
Insulin as a probe of mitochondrial metabolism in situ
Bessman, S. P., & Mohan, C. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006834408181 · Cited by 14
Alterations of brain insulin receptor characteristics in aging mice
Zaia, A., & PIANTANELLI, L. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)00705-4 · Cited by 13
Chik, C. L. (1997) · Endocrinology · doi:10.1210/en.138.5.2033 · Cited by 13
Nie, L. (1998) · Endocrinology · doi:10.1210/en.139.1.179 · Cited by 12
Resistance to Insulin Convulsions in Fasted Mice
Tamási, G., & Drenick, E. J. (1973) · Endocrinology · doi:10.1210/endo-92-4-1277 · Cited by 10
Dose-response testing of peptides by hippocampal brain slice recording
Phillips, M. I., & Palovcik, R. A. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(89)68010-x · Cited by 7
Venkatraman, J. T., & Fernandes, G. (1991) · AGE · doi:10.1007/bf02434837 · Cited by 5
Research works printed but not linked: 1
- Blair, 1997, IGF-I modulates N and L calcium channels in a PI-3-kinase-dependent manner, Neuron, 717
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Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
Reitz, C., & Mayeux, R. P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.024 · Cited by 1,271
Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,058
Aggregation of vascular risk factors and risk of incident Alzheimer disease
Luchsinger, J. A., Reitz, C., Honig, L. S., Tang, M. X., Shea, S., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000172914.08967.dc · Cited by 790
Hyperinsulinemia and risk of Alzheimer disease
Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140292.04932.87 · Cited by 683
Is Alzheimer’s disease a type 3 diabetes? A critical appraisal
Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621
Metadata
- Authors
- Park, C. R.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Park, C.R
- ORCID
- Park, C.R
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 25
- Issue
- 4
- Pages
- 311-323
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2013952491
- Cited by
- 270
- References
- 206
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 13 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 12
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- insulin, central nervous system, cognitive function, memory, learning, insulin receptor, insulin resistance, insulin deficiency, rodent models, neurophysiology
- MeSH terms
- Animals, Central Nervous System, Cognition, Cognition Disorders, Humans, Insulin, Receptor, Insulin, Somatomedins
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