Involvement of the amygdaloid complex in neuromodulatory influences on memory storage
Abstract
Neuromodulatory systems activated by training experiences appear to play a role in influencing memory storage processes. The research summarized in this paper examined the effects, on memory, of posttraining administration of treatments affecting adrenergic, opioid peptidergic and GABAergic systems. When administered after training, drugs affecting these systems all produce dose- and time-dependent effects on memory storage. The drug effects on memory are blocked by lesions of the amygdaloid complex as well as lesions of the stria terminalis, a major amygdala pathway. The effects of drugs affecting these neuromodulatory systems are also blocked by injections of beta-adrenergic antagonists administered to the amygdaloid complex. Thus, the findings suggest that the neuromodulatory systems affect memory storage through influences involving the activation of beta-adrenergic receptors within the amygdala. These findings are consistent with the view that the amygdala is involved in regulating the storage of memory in other brain regions.
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Activation of the amygdala exerts a facilitating effect on memory-related processing by other brain regions, including the hippocampus.
“Researchers outside of the stress-LTP field have long contended that activation of the amygdala exerts a facilitating effect on memory-related processing by other brain regions, including the hippocampus (McGaugh et al. [187]; Roozendaal et al. [188]; Nathan et al. [189]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as McGaugh et al. [187]
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- Authors
- McGaugh, J. L., Introini-Collison, I. B., Nagahara, A. H., Cahill, L., Brioni, J. D., & Castellano, C.
- Affiliations
- University of California, Irvine (US)
- Universidad Nacional de Córdoba (AR)
- ORCID
- Castellano, Claudio
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 14
- Issue
- 4
- Pages
- 425-431
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2002953387
- Cited by
- 117
- References
- 58
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Naval Research
- National Institute of Mental Health (MH12526)
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amygdala, memory storage, neuromodulation, adrenergic system, beta-adrenergic receptors, opioid peptides, GABAergic system, stria terminalis, memory consolidation
- MeSH terms
- Amygdala, Animals, Humans, Memory, Neurotransmitter Agents
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