Leukocyte networks and human endometrial remodelling
Abstract
Remodelling of the human endometrium occurs during the normal menstrual cycle. This process involves the disintegration of the superficial or functionalis layer of the endometrium following the fall in progesterone resulting from the demise of the corpus luteum and the reconstruction of a new layer without scarring. The degradative properties of matrix metalloproteinases (MMP) and their presence in the endometrium during remodelling events suggests that they are effector molecules in this process. The features of menstruation parallel those of an inflammatory response and the abundance of leukocytes in the endometrium prior to the onset of menstruation indicates a role for these cells in the remodelling process. This review examines the relationship between leukocytes and the local production and activation of MMP within the endometrium.
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Menstrual endometrium in all women is rich in leukocytes, chemokines, cytokines, VEGF, KDR, matrix metalloproteinases, and prostaglandins; some of these, if altered, likely contribute to nerve sprouting and persistent sensitization.
“In all women, menstrual endometrium is rich in leukocytes, chemokines, cytokines, VEGF, KDR, matrix metalloproteinases (MMPs) and prostaglandins”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Salamonsen et al., 2002
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- Authors
- Salamonsen, L. A., Zhang, J., & Brasted, M.
- Corresponding author
- Salamonsen, Lois A
- Venue
- Journal of Reproductive Immunology
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 57
- Issue
- 1-2
- Pages
- 95-108
- ISSN
- 0165-0378 (ISSN-L)
- OpenAlex
- W2042617363
- Cited by
- 181
- References
- 59
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- leukocytes, matrix metalloproteinases, menstrual cycle, endometrium, inflammation, progesterone, corpus luteum
- MeSH terms
- Endometrium, Female, Humans, Inflammation, Killer Cells, Natural, Leukocytes, Mast Cells, Menstrual Cycle, Progesterone, Chemokines, Matrix Metalloproteinases
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