Mast Cell Regulation of Human Endometrial Matrix Metalloproteinases: A Mechanism Underlying Menstruation1

Zhang, Jin; Nie, Guiying; Jian, Wang; Woolley, David E.; Salamonsen, Lois A.

doi:10.1095/biolreprod59.3.693

Cited by 69Protease and Inhibitor MechanismsMast cells and histamineMenstrual Health and Disorders

Mast Cell Regulation of Human Endometrial Matrix Metalloproteinases: A Mechanism Underlying Menstruation1

Zhang, Jin, Nie, Guiying, Jian, Wang, Woolley, David E., Salamonsen, Lois A.·1998·Biology of Reproduction

DOI 10.1095/biolreprod59.3.693

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Abstract

Endometrial matrix metalloproteinases (MMPs), which increase dramatically at menstruation, are purported to cause the focal tissue breakdown at menstruation, but how their expression or activation is locally regulated is unknown. Mast cell activation occurs within perimenstrual endometrium, and we postulated that mast cell products would regulate endometrial MMPs. We have examined the interaction between human mast cells and endometrial stromal cells with regard to MMP production and activation. The human mast cell line (HMC-1) in coculture with stromal cells stimulated stromal cell proMMP-1 and proMMP-3, and to a lesser extent proMMP-2 production, with increasing stimulation as mast cell number increased. Mast cell-conditioned medium also increased both protein and mRNA for stromal proMMP-1 and proMMP-3, this being abrogated by preadsorption of mast cell-conditioned medium with antisera to interleukin-1 and tumor necrosis factor alpha. Mast cell-conditioned medium added to stromal cell culture medium in vitro along with added heparin (which stabilizes tryptase activity) resulted in the appearance of molecular weight forms indicative of active MMP-3 and MMP-1. Thus activated mast cells within the endometrium prior to menstruation have the potential to stimulate MMP production by endometrial stromal cells and to initiate precursor activation, and are likely to account for the local nature of endometrial MMP action resulting in foci of tissue breakdown at menstruation.

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Mast cells present in the human uterus are able to induce the expression of MMPs in both endometrial stromal and decidual cells.
“Zhang and co-authors showed that MCs present in the human uterus are able to induce the expression of MMPs both, in endometrial stromal and decidual cells [48].”
From Estradiol and Progesterone Regulate the Migration of Mast Cells from the Periphery to the Uterus and Induce Their Maturation and Degranulation (2010) · cites this paper as [48]

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Authors: Zhang, J., Nie, G., Jian, W., Woolley, D. E., & Salamonsen, L. A.
Affiliations: Manchester Royal Infirmary (GB)
Corresponding author: Salamonsen, Lois A.
ORCID: Zhang, Jin
Nie, Guiying
Salamonsen, Lois A.
Venue: Biology of Reproduction
Publisher: Oxford University Press (OUP)
Published: 1998-09-01
Volume: 59
Issue: 3
Pages: 693-703
ISSN: 0006-3363 (ISSN-L)
1529-7268
DOI: 10.1095/biolreprod59.3.693
OpenAlex: W2126344014
Cited by: 69
References: 57
Citations by year: 2025: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2013: 4
FWCI: 2.66
Type: journal article
Language: en
Open access: closed
Locations: Biology of Reproduction (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd033233-02)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-33233-02)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
Keywords: mast cells, matrix metalloproteinases, endometrium, menstruation, endometrial stromal cells, MMP-1, MMP-3, MMP-2, mast cell activation, tryptase, interleukin-1, TNF-α, HMC-1 cells
MeSH terms: Animals, Cell Line, Endometrium, Female, Gene Expression Regulation, Cricetinae, Humans, Interleukin-1, Mast Cells, Menstruation, Metalloendopeptidases, RNA, Messenger, Serine Endopeptidases, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Stromal Cells, Collagenases, Coculture Techniques, Matrix Metalloproteinase 3, Matrix Metalloproteinase 1, Tryptases, Chymases

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Mast Cell Regulation of Human Endometrial Matrix Metalloproteinases: A Mechanism Underlying Menstruation1

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