Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961

Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,382

Human Chemokines: An Update

Baggiolini, M., Dewald, B., & Moser, B. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.675 · Cited by 2,193

A new class of membrane-bound chemokine with a CX3C motif

Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1422 · Cited by 1,359

Role for Neuronally Derived Fractalkine in Mediating Interactions between Neurons and CX3CR1-Expressing Microglia

Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

Sørensen, T. L., Tani, M., Jensen, J. S., Pierce, V., Lucchinetti, C. F., Folcik, V. A., Qin, S., Rottman, J., Sellebjerg, F. T., Strieter, R. M., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5150 · Cited by 994

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

He, J., Chen, Y., Farzan, M., Choe, H., Öhagen, Å., Gartner, S., Busciglio, J. A., Yang, X., Hofmann, W., Newman, W., et al. (1997) · Nature · doi:10.1038/385645a0 · Cited by 915

The neuropathogenesis of AIDS

González‐Scarano, F., & Martín‐García, J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1527 · Cited by 1,093

The blood-brain barrier in Alzheimer’s disease

Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767

Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain

Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

Gao, Y., & Ji, R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.002 · Cited by 636

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531

Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases

Cartier, L., Hartley, O., Dubois‐Dauphin, M., & Krause, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.021 · Cited by 521

Chemokines and Their Receptors in the Central Nervous System

Bajetto, A., Bonavia, R., Barbero, S., Florio, T., & Schettini, G. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0214 · Cited by 416

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death & Disease · doi:10.1038/cddis.2011.50 · Cited by 379

The multifaceted profile of activated microglia

Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 268

Characterization of chemokines and their receptors in the central nervous system: physiopathological implications

Bajetto, A., Bonavia, R., Barbero, S., & Schettini, G. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01091.x · Cited by 324

CXCR3 ligands in disease and therapy

Raemdonck, K. V., den Steen, P. E. V., Liekens, S., Damme, J. V., & Struyf, S. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.11.009 · Cited by 313

Chemokine receptors: signposts to brain development and disease

Tran, P. B., & Miller, R. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1116 · Cited by 295

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum

Müller, M., Carter, S., Hofer, M. J., & Campbell, I. L. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01089.x · Cited by 301

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

Li, C., Zhao, R., Gao, K., Wei, Z. Z., Yin, M. Y., Lau, L. T., Chui, D., & Yu, A. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604543 · Cited by 294

Intrathecal Chemokine Synthesis in Mild Cognitive Impairment and Alzheimer Disease

Galimberti, D., Schoonenboom, N., Scheltens, P., Fenoglio, C., Bouwman, F., Venturelli, E., Guidi, I., Blankenstein, M. A., Bresolin, N., & Scarpini, E. (2006) · Archives of Neurology · doi:10.1001/archneur.63.4.538 · Cited by 289

MCP‐1 (CCL2) protects human neurons and astrocytes from NMDA or HIV‐tat‐induced apoptosis

Eugenin, E. A., D’Aversa, T. G., Lopez, L., Calderon, T. M., & Berman, J. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01775.x · Cited by 288

Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer’s Disease

Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279

Fingolimod provides long‐term protection in rodent models of cerebral ischemia

Wei, Y., Yemişçi, M., Kim, H., Yung, L., Shin, H. K., Hwang, S., Guo, S., Qin, T., Alsharif, N., Brinkmann, V., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22186 · Cited by 281

Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

Bagyinszky, E., Giau, V. V., Shim, K., Suk, K., An, S. S. A., & Kim, S. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.03.031 · Cited by 276

CXCR3-Dependent Microglial Recruitment Is Essential for Dendrite Loss after Brain Lesion

Rappert, A., Bechmann, I., Pivneva, T., Mahlo, J., Biber, K., Nolte, C., Kovac, A. D., Gerard, C., Boddeke, H. W. G. M., Nitsch, R., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2451-04.2004 · Cited by 259

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019101982 · Cited by 258

CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration

Koper‐Lenkiewicz, O. M., Kamińska, J., Sawicki, K., & Kemona, H. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/68846 · Cited by 217

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216

Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model

Jorfi, M., Park, J., Hall, C. K., Lin, C.-C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01415-3 · Cited by 214

Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks

Domingues, C., da Cruz e Silva, O. A. B., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 203

Neuronal Chemokines: Versatile Messengers In Central Nervous System Cell Interaction

Haas, A. H. D., van Weering, H. R. J., de Jong, E. K., Boddeke, H. W. G. M., & Biber, K. P. H. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0036-8 · Cited by 187

Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10.

van Marle, G., Henry, S., Todoruk, T., Sullivan, A., Silva, C., Rourke, S., Holden, J., McArthur, J. C., Gill, M., & Power, C. (2004) · Virology · doi:10.1016/j.virol.2004.08.024 · Cited by 184

Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.

(2014) · Europe PMC (PubMed Central) · Cited by 177

Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation

Croitoru‐Lamoury, J., Guillemin, G. J., Boussin, F. D., Mognetti, B., Gigout, L. I., Chéret, A., Vaslin, B., Grand, R. L., Brew, B. J., & Dormont, D. (2003) · Glia · doi:10.1002/glia.10181 · Cited by 177

CXCL10‐induced cell death in neurons: role of calcium dysregulation

Sui, Y., Stehno‐Bittel, L., Li, S., Loganathan, R., Dhillon, N. K., Pinson, D. M., Nath, A., Kolson, D. L., Narayan, O., & Buch, S. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04631.x · Cited by 173

Chemokines and Chemokine Receptors in Neurological Disease: Raise, Retain, or Reduce?

Savarin-Vuaillat, C., & Ransohoff, R. M. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.07.004 · Cited by 177

A role for human brain pericytes in neuroinflammation

Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 174

Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives

McGrowder, D. A., Miller, F. G., Vaz, K., Nwokocha, C. R., Wilson-Clarke, C. F., Anderson, M., Brown, J., Anderson-Jackson, L., Williams, L., Latore, L., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11020215 · Cited by 169

Selective estrogen receptor modulators decrease the production of interleukin‐6 and interferon‐γ‐inducible protein‐10 by astrocytes exposed to inflammatory challenge in vitro

Cerciat, M., Unkila, M., García‐Segura, L. M., & Arévalo, M. (2009) · Glia · doi:10.1002/glia.20904 · Cited by 160

CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model

Krauthausen, M., Kummer, M. P., Zimmermann, J., Reyes-Irisarri, E., Terwel, D., Bulic, B., Heneka, M. T., & Müller, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66771 · Cited by 152

Chemokine Receptor CXCR3: An Unexpected Enigma

Liu, L., Callahan, M. K., Huang, D., & Ransohoff, R. M. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)68006-4 · Cited by 145

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

Flores-Aguilar, L., Iulita, M. F., Kovecses, O., Torres, M. D., Levi, S. M., Zhang, Y., Askenazi, M., Wisniewski, T., Busciglio, J., & Cuello, A. C. (2020) · Brain · doi:10.1093/brain/awaa326 · Cited by 138

Cytokines and Myelination in the Central Nervous System

Schmitz, T., & Chew, L. (2008) · The Scientific World JOURNAL · doi:10.1100/tsw.2008.140 · Cited by 141

CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons

Qin, X., Wan, Y., & Wang, X. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20612 · Cited by 138

Neuronal Apoptosis Is Mediated by CXCL10 Overexpression in Simian Human Immunodeficiency Virus Encephalitis

Sui, Y., Potula, R., Dhillon, N. K., Pinson, D. M., Li, S., Nath, A., Anderson, C. F., Turchan, J., Kolson, D. L., Narayan, O., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63714-5 · Cited by 137

Vesicle-Mediated Transport and Release of CCL21 in Endangered Neurons: A Possible Explanation for Microglia Activation Remote from a Primary Lesion

de Jong, E. K., Dijkstra, I. M., Hensens, M., Brouwer, N., van Amerongen, M. J., Liem, R. S. B., Boddeke, H. W. G. M., & Biber, K. P. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-05.2005 · Cited by 136

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 134

Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1–42-infused mouse model of Alzheimer’s disease

Yun, H.-M., Kim, H. S., Kr, P., Shin, J., Kang, A.-R., Lee, K. I., Song, S., Kim, Y.-B., Han, S., Chung, H.-M., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.490 · Cited by 128

Role of chemokine systems in cancer and inflammatory diseases

Li, H., Wu, M., & Zhao, X. (2022) · MedComm · doi:10.1002/mco2.147 · Cited by 134

Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation

Maru, S., Holloway, K., Flynn, G., Lancashire, C. L., Loughlin, J., Male, D. K., & Romero, I. A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.029 · Cited by 121

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies

Guedes, J. R., Lao, T., Cardoso, A. L., & El Khoury, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00549 · Cited by 115

Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Miles, E. A., Rees, D., Banerjee, T., Cazzola, R., Lewis, S., Wood, R., Oates, R., Tallant, A., Cestaro, B., Yaqoob, P., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.002 · Cited by 112

Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia

Biber, K. P. H., Dijkstra, I. M., Trebst, C., Groot, C. J. A. D., Ransohoff, R. M., & Boddeke, H. W. G. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00114-8 · Cited by 111

GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease?

Xia, M., & Hyman, B. T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00463-5 · Cited by 102

Chemokines in the brain: neuroimmunology and beyond

Biber, K. P. H. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00122-9 · Cited by 104

Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation

Gimsa, U., Mitchison, N. A., & Brunner-Weinzierl, M. C. (2013) · Mediators of Inflammation · doi:10.1155/2013/320519 · Cited by 107

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

Ko, E. M., Ma, J. H., Guo, F., Miers, L. A., Lee, E., Bannerman, P. G. C., Burns, T., Ko, D., Sohn, J., Soulika, A. M., et al. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-105 · Cited by 107

Role of Atypical Chemokine Receptors in Microglial Activation and Polarization

Salvi, V., Sozio, F., Sozzani, S., & Prete, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00148 · Cited by 99

Ginger Extract Inhibits β-Amyloid Peptide–Induced Cytokine and Chemokine Expression in Cultured THP-1 Monocytes

Grzanna, R., Phan, P. V., Polotsky, A., Lindmark, L., & Frondoza, C. G. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.1009 · Cited by 97

Role of Interleukin-1 in Prion Disease-Associated Astrocyte Activation

Schultz, J., Schwarz, A., Neidhold, S., Burwinkel, M., Riemer, C., Simon, D., Köpf, M., Otto, M., & Baier, M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63331-7 · Cited by 100

Role of Chemokines in the Development and Progression of Alzheimer’s Disease

Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02047-1 · Cited by 97

Roles of SLC/CCL21 and CCR7 in Human Kidney for Mesangial Proliferation, Migration, Apoptosis, and Tissue Homeostasis

Banas, B., Wörnle, M., Berger, T., Nelson, P. J., Cohen, C. D., Kretzler, M., Pfirstinger, J., Mack, M., Lipp, M., Gröne, H., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4301 · Cited by 95

Cross-talk between microglia and neurons regulates HIV latency

Alvarez-Carbonell, D., Ye, F., Ramanath, N., García‐Mesa, Y., Knapp, P. E., Hauser, K. F., & Karn, J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008249 · Cited by 93

Chemokines and Alzheimer's disease

Streit, W. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00290-1 · Cited by 94

Neutralization of the chemokine CXCL10 reduces apoptosis and increases axon sprouting after spinal cord injury

Glaser, J., González, R., Sadr, E., & Keirstead, H. S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20982 · Cited by 93

Overexpression of IFN-Induced Protein 10 and Its Receptor CXCR3 in Myasthenia Gravis

Feferman, T., Maiti, P. K., Berrih‐Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., & Souroujon, M. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5324 · Cited by 92

A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis

Doron, H., Pukrop, T., & Erez, N. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1805 · Cited by 95

Cerebrospinal fluid interferon-γ-inducible protein 10 (IP-10, CXCL10) in HIV-1 infection

Cinque, P. M., Bestetti, A., Marenzi, R., Sala, S., Gisslén, M., Hagberg, L., & Price, R. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.07.002 · Cited by 89

Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients

Westhoff, D., Witlox, J., Koenderman, L., Kalisvaart, K. J., de Jonghe, J. F. M., van Stijn, M. F. M., Houdijk, A. P. J., Hoogland, I. C. M., MacLullich, A. M. J., van Westerloo, D. J., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-122 · Cited by 90

Effect of Anti-CXCL10 Monoclonal Antibody on Herpes Simplex Virus Type 1 Keratitis and Retinal Infection

Carr, D. J. J., Chodosh, J., Ash, J. D., & Lane, T. E. (2003) · Journal of Virology · doi:10.1128/jvi.77.18.10037-10046.2003 · Cited by 90

Macrophage Inflammatory Protein 2 Inhibits β-Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways

Watson, K., & Fan, G.-H. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.004812 · Cited by 88

TNF-α-induced chemokine production and apoptosis in human neural precursor cells

Sheng, W. S., Hu, S., Ni, H. T., Rowen, T. N., Lokensgard, J. R., & Peterson, P. K. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0405221 · Cited by 86

The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons

Nelson, T. E., & Gruol, D. L. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.07.009 · Cited by 84

Decreased Fractalkine and Increased IP-10 Expression in Aged Brain of APPswe Transgenic Mice

Duan, R., Yang, X., Chen, Z., Lu, M., Morris, C. M., Winblad, B. G., & Zhu, J. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9554-z · Cited by 82

Interferon-Inducible Protein 9 (CXCL11)-Induced Cell Motility in Keratinocytes Requires Calcium Flux-Dependent Activation of μ-Calpain

Satish, L., Blair, H. C., Glading, A., & Wells, A. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1922-1941.2005 · Cited by 81

Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis

Phares, T. W., Stohlman, S. A., Hinton, D. R., & Bergmann, C. C. (2013) · Journal of Virology · doi:10.1128/jvi.03307-12 · Cited by 80

Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10

Antonelli, A., Ferrari, S. M., Frascerra, S., Galetta, F., Franzoni, F., Corrado, A., Miccoli, M., Benvenga, S., Paolicchi, A., Ferrannini, E., et al. (2011) · Cytokine · doi:10.1016/j.cyto.2011.04.022 · Cited by 76

MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1

Cheng, Z., Qiu, S., Jiang, L., Zhang, A., Bao, W., Liu, P., & Liu, J. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9834-5 · Cited by 73

Leukocyte Infiltration, But Not Neurodegeneration, in the CNS of Transgenic Mice with Astrocyte Production of the CXC Chemokine Ligand 10

Boztuǧ, K., Carson, M. J., Pham-Mitchell, N., Asensio, V. C., DeMartino, J. A., & Campbell, I. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1505 · Cited by 71

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

Zhao, Q., Kim, T., Pang, J., Sun, W. Y., Yang, X., Wang, J., Song, Y., Zhang, H., Sun, H., Rangan, V. S., et al. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a0717-302 · Cited by 71

Role of CXCL10 in central nervous system inflammation

McKimmie, C. S., & Michlmayr, D. (2014) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s35953 · Cited by 71

Connecting Neuroinflammation and Neurodegeneration in Multiple Sclerosis: Are Oligodendrocyte Precursor Cells a Nexus of Disease?

Psenicka, M. W., Smith, B. C., Tinkey, R. A., & Williams, J. L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.654284 · Cited by 73

Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease

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Wu, J., Bie, B., Yang, H., Xu, J. J., Brown, D. L., & Naguib, M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.003 · Cited by 62

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