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Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks
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IL-1β has complex effects on neurons including disruption of synaptic plasticity, promotion of excitotoxicity, and modulation of α- and γ-secretase activities while reducing β-secretase activity and Aβ levels.
“shows complex and divers effects on neurons including disruption of synaptic plasticity [21], promotion of excitotoxicity [22, 23] and α- and γ-secretase activities, while reducing β-secretase activity [24, 25] and Aβ levels [26, 27].”
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Metadata
- Authors
- Domingues, C., da Cruz e Silva, O. A. B., & Henriques, A. G.
- Affiliations
- Neurosciences and Signalling Laboratory, Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
- Neurosciences and Signalling Laboratory, Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, P.O. Box: 3810-193, Aveiro, Portugal
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2017-07-18
- Volume
- 14
- Issue
- 8
- ISSN
- 1567-2050
- PMC
- PMC5543563
- Cited by
- 203
- References
- 33
- Language
- en
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