The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Abstract
Analysis of the Kv3 subfamily of K(+) channel subunits has lead to the discovery of a new class of neuronal voltage-gated K(+) channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height. The short spike duration and the rapid deactivation of the Kv3 currents after spike repolarization maximize the quick recovery of resting conditions after an action potential. Several neurons in the mammalian CNS have incorporated into their repertoire of voltage-dependent conductances a relatively large number of Kv3 channels to enable repetitive firing at high frequencies - an ability that crucially depends on the special properties of Kv3 channels and their impact on excitability.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“One set of co-expressed genes encoded proteins that enable fast and persistent action potentials, including the Kcnc1–3 (Kv3.1), Kcna1 (Kv1.1) and Scn8a (Nav1.6) channels”
From Molecular diversity and specializations among the cells of the adult mouse brain (2018) · cites this paper as Rudy and McBain, 2001
In the citing paper
“Early attempts to match expression patterns of recent cloned channel transcripts with biophysical properties measured by whole cell recording techniques in in vitro slices did, however, yield some modest successes, particularly with channels formed by the Kv3 family of voltage-gated potassium channels (967) as discussed below.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
In the citing paper
“Delayed rectifier channels assembled from Kv3 subunits are instrumental components in conferring high-frequency action potential firing in numerous hippocampal and cortical interneuron subtypes (304, 967, 1187).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
In the citing paper
“This optimism was short lived as it became apparent that few channels expressed in recombinant systems perfectly matched the biophysical properties of native channels (967).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
In the citing paper
“Importantly, the rapid activation kinetics enforces a narrow temporal window that minimizes Na+ channel inactivation, and the consequent deep hyperpolarization serves to deinactivate other voltage-gated channels ensuring a high fraction are available for activation during trains of action potentials (967).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
In the citing paper
“Their rapid activation ensures efficient spike repolarization, and their rapid deactivation allows minimal K+ current accumulation during the interspike interval that would interfere with generation of subsequent action potentials.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
In the citing paper
“Dendritic Kv3 currents act to accelerate the decay time course of excitatory postsynaptic potentials (EPSPs), imposing a narrow window for temporal integration (504, 967), and minimize the impact of clustered excitatory input to favor distributed synaptic inputs (504).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]
Citations
Cites
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4 · Cited by 3,478
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Self-citationGray, C. M., & McCormick, D. A. (1996) · Science · doi:10.1126/science.274.5284.109 · Cited by 911
Grissmer, S., Nguyen, A. N., Aiyar, J., Hanson, D. C., Mather, R. J., Gutman, G. A., Karmilowicz, M. J., Auperin, D. D., & Chandy, K. G. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10594-4 · Cited by 777
McBain, C. J., & Fisahn, A. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049047 · Cited by 581
Self-citationModulation of ION Channels by Protein Phosphorylation and Dephosphorylation
Levitan, I. B. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.001205 · Cited by 531
Erisir, A., Lau, D., Rudy, B., & Leonard, C. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2476 · Cited by 458
Self-citation
Research works printed but not linked: 4
- Freund, 1996, Interneurons in the hippocampus, Hippocampus, 6, 345
- Ozaita, 2000, Role of alternatively-spliced C-termini in the subcellular localization of Kv3 potassium channels in neurons, Soc. Neurosci. Abstr., 26, 1636
- Vega-Saenz de Miera, 1994, Modulation of Kv3.3 K+ channels by oxidation and phosphorylation, Soc. Neurosci. Abstr., 20, 725
- Macica, 2000, Knockout of the Kv3.1 gene impairs high frequency firing in auditory neurons, Soc. Neurosci. Abstr., 26, 1705
Cited by
Sorted by citations
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
Self-citationThe action potential in mammalian central neurons
Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531
Metadata
- Authors
- Rudy, B., & McBain, C. J.
- Affiliations
- New York University (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Corresponding author
- Rudy, Bernardo
- McBain, Chris J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 24
- Issue
- 9
- Pages
- 517-526
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2034132958
- Cited by
- 781
- References
- 76
- Citations by year
- 2026: 36 · 2025: 27 · 2024: 45 · 2023: 27 · 2022: 36 · 2021: 33 · 2020: 39 · 2019: 32 · 2018: 32 · 2017: 34 · 2016: 20 · 2015: 26 · 2014: 23 · 2013: 30 · 2012: 32
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ns035215-01a1, 5r01ns030989-22)
- National Institute of Neurological Disorders and Stroke (NS-30989, NS-35215)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- voltage-gated potassium channels, action potential repolarization, repetitive firing, neuronal excitability, spike initiation, central nervous system neurons
- MeSH terms
- Action Potentials, Animals, Brain, Humans, Neurons, Potassium Channels, Potassium Channels, Voltage-Gated, Shaw Potassium Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
